PMC:7377212 / 17866-18815 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T138","span":{"begin":10,"end":21},"obj":"NCBITaxon:5052"},{"id":"T139","span":{"begin":206,"end":211},"obj":"CHEBI:68452;CHEBI:68452"},{"id":"T140","span":{"begin":264,"end":269},"obj":"UBERON:0001977"},{"id":"T141","span":{"begin":396,"end":401},"obj":"UBERON:0001977"},{"id":"T142","span":{"begin":402,"end":413},"obj":"NCBITaxon:5052"},{"id":"T143","span":{"begin":414,"end":421},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T144","span":{"begin":659,"end":662},"obj":"PR:Q8LFX7"},{"id":"T145","span":{"begin":872,"end":883},"obj":"NCBITaxon:5052"},{"id":"T146","span":{"begin":884,"end":891},"obj":"CHEBI:59132;CHEBI:59132"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T47","span":{"begin":35,"end":40},"obj":"Body_part"},{"id":"T48","span":{"begin":168,"end":173},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma63083"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T44","span":{"begin":35,"end":40},"obj":"Body_part"},{"id":"T45","span":{"begin":168,"end":173},"obj":"Body_part"}],"attributes":[{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PubTator","denotations":[{"id":"551","span":{"begin":391,"end":399},"obj":"Species"},{"id":"552","span":{"begin":510,"end":517},"obj":"Species"},{"id":"553","span":{"begin":174,"end":185},"obj":"Species"},{"id":"554","span":{"begin":680,"end":691},"obj":"Species"},{"id":"555","span":{"begin":2,"end":18},"obj":"Chemical"},{"id":"556","span":{"begin":20,"end":23},"obj":"Chemical"},{"id":"557","span":{"begin":244,"end":247},"obj":"Chemical"},{"id":"558","span":{"begin":450,"end":453},"obj":"Chemical"},{"id":"559","span":{"begin":785,"end":788},"obj":"Chemical"},{"id":"560","span":{"begin":938,"end":941},"obj":"Chemical"},{"id":"561","span":{"begin":286,"end":295},"obj":"Disease"}],"attributes":[{"id":"A551","pred":"tao:has_database_id","subj":"551","obj":"Tax:9606"},{"id":"A552","pred":"tao:has_database_id","subj":"552","obj":"Tax:9606"},{"id":"A553","pred":"tao:has_database_id","subj":"553","obj":"Tax:746128"},{"id":"A554","pred":"tao:has_database_id","subj":"554","obj":"Tax:746128"},{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"MESH:C480180"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T189","span":{"begin":286,"end":295},"obj":"Disease"},{"id":"T190","span":{"begin":368,"end":390},"obj":"Disease"},{"id":"T191","span":{"begin":377,"end":390},"obj":"Disease"},{"id":"T192","span":{"begin":420,"end":424},"obj":"Disease"}],"attributes":[{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T158","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T159","span":{"begin":25,"end":29},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T160","span":{"begin":33,"end":34},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T161","span":{"begin":87,"end":91},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T162","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T163","span":{"begin":194,"end":201},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T164","span":{"begin":302,"end":303},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T165","span":{"begin":338,"end":339},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T166","span":{"begin":482,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T167","span":{"begin":550,"end":555},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T168","span":{"begin":596,"end":597},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T169","span":{"begin":668,"end":675},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T170","span":{"begin":719,"end":721},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T171","span":{"begin":914,"end":919},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T274","span":{"begin":12,"end":18},"obj":"Chemical"},{"id":"T275","span":{"begin":121,"end":124},"obj":"Chemical"},{"id":"T277","span":{"begin":186,"end":193},"obj":"Chemical"},{"id":"T278","span":{"begin":223,"end":226},"obj":"Chemical"},{"id":"T280","span":{"begin":692,"end":699},"obj":"Chemical"},{"id":"T281","span":{"begin":741,"end":751},"obj":"Chemical"}],"attributes":[{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_37163"},{"id":"A275","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A276","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A279","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"MyTest","denotations":[{"id":"32703771-27475024-29390919","span":{"begin":239,"end":241},"obj":"27475024"},{"id":"32703771-21880959-29390920","span":{"begin":719,"end":721},"obj":"21880959"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"LitCovid-sentences","denotations":[{"id":"T92","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T93","span":{"begin":126,"end":449},"obj":"Sentence"},{"id":"T94","span":{"begin":450,"end":723},"obj":"Sentence"},{"id":"T95","span":{"begin":724,"end":949},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}

{"project":"2_test","denotations":[{"id":"32703771-27475024-29390919","span":{"begin":239,"end":241},"obj":"27475024"},{"id":"32703771-21880959-29390920","span":{"begin":719,"end":721},"obj":"21880959"}],"text":"A (1–3)-β-D-glucan (BDG) test on a serum sample is an easily obtained, early screening test when there is a suspicion of IPA. Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU [33], BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of invasive aspergillosis patients, and performance in CAPA as yet to be determined. BDG positivity can occur due to a number of reasons in this patient cohort, however serial positive tests increases specificity and should prompt a diagnostic work-up including computed tomography and bronchoscopy and testing for Aspergillus antigen as outlined above [34]. While initiating antifungal treatment pre-emptively based on BDG positivity may be an improvement on empirical therapy, every effort should be made to utilise other more specific diagnostic tests to complement the BDG result."}