PMC:7376974 / 86185-86814 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T405","span":{"begin":15,"end":22},"obj":"Body_part"},{"id":"T406","span":{"begin":113,"end":116},"obj":"Body_part"},{"id":"T407","span":{"begin":214,"end":217},"obj":"Body_part"},{"id":"T408","span":{"begin":373,"end":376},"obj":"Body_part"},{"id":"T409","span":{"begin":423,"end":428},"obj":"Body_part"},{"id":"T410","span":{"begin":460,"end":463},"obj":"Body_part"},{"id":"T411","span":{"begin":536,"end":539},"obj":"Body_part"},{"id":"T412","span":{"begin":553,"end":556},"obj":"Body_part"},{"id":"T413","span":{"begin":568,"end":575},"obj":"Body_part"}],"attributes":[{"id":"A405","pred":"fma_id","subj":"T405","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A406","pred":"fma_id","subj":"T406","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A407","pred":"fma_id","subj":"T407","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A408","pred":"fma_id","subj":"T408","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A409","pred":"fma_id","subj":"T409","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A410","pred":"fma_id","subj":"T410","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A411","pred":"fma_id","subj":"T411","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A412","pred":"fma_id","subj":"T412","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A413","pred":"fma_id","subj":"T413","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1550","span":{"begin":373,"end":378},"obj":"Species"},{"id":"1551","span":{"begin":553,"end":558},"obj":"Species"},{"id":"1558","span":{"begin":281,"end":291},"obj":"Chemical"},{"id":"1559","span":{"begin":380,"end":390},"obj":"Chemical"},{"id":"1560","span":{"begin":511,"end":521},"obj":"Chemical"}],"attributes":[{"id":"A1550","pred":"tao:has_database_id","subj":"1550","obj":"Tax:11676"},{"id":"A1551","pred":"tao:has_database_id","subj":"1551","obj":"Tax:11676"},{"id":"A1558","pred":"tao:has_database_id","subj":"1558","obj":"MESH:C108127"},{"id":"A1559","pred":"tao:has_database_id","subj":"1559","obj":"MESH:C108127"},{"id":"A1560","pred":"tao:has_database_id","subj":"1560","obj":"MESH:C108127"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T792","span":{"begin":27,"end":34},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T793","span":{"begin":355,"end":356},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T794","span":{"begin":423,"end":428},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T795","span":{"begin":497,"end":498},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T34519","span":{"begin":15,"end":22},"obj":"Chemical"},{"id":"T78893","span":{"begin":27,"end":34},"obj":"Chemical"},{"id":"T2915","span":{"begin":69,"end":76},"obj":"Chemical"},{"id":"T90179","span":{"begin":113,"end":116},"obj":"Chemical"},{"id":"T54242","span":{"begin":214,"end":217},"obj":"Chemical"},{"id":"T88871","span":{"begin":329,"end":338},"obj":"Chemical"},{"id":"T5137","span":{"begin":460,"end":463},"obj":"Chemical"},{"id":"T33659","span":{"begin":536,"end":539},"obj":"Chemical"},{"id":"T83608","span":{"begin":568,"end":575},"obj":"Chemical"}],"attributes":[{"id":"A66251","pred":"chebi_id","subj":"T34519","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A71214","pred":"chebi_id","subj":"T78893","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A32924","pred":"chebi_id","subj":"T2915","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A23630","pred":"chebi_id","subj":"T90179","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A11493","pred":"chebi_id","subj":"T54242","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A8861","pred":"chebi_id","subj":"T88871","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A97639","pred":"chebi_id","subj":"T5137","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A50137","pred":"chebi_id","subj":"T33659","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A40787","pred":"chebi_id","subj":"T83608","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T203","span":{"begin":86,"end":111},"obj":"http://purl.obolibrary.org/obo/GO_0002250"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"LitCovid-sentences","denotations":[{"id":"T526","span":{"begin":340,"end":477},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}

{"project":"2_test","denotations":[{"id":"32667191-11697222-153398","span":{"begin":277,"end":280},"obj":"11697222"},{"id":"32667191-23963730-153399","span":{"begin":594,"end":597},"obj":"23963730"}],"text":"o conventional protein- or peptide-based vaccines intended to induce antigen-specific adaptive immune responses, DNA vaccines are more stable, cost-effective, easy to manufacture, and safe in handling.143 However, DNA vaccines have the disadvantage of being poorly immunogenic.144 Fullerenol VLPs allow to avoid the use of other adjuvants. In the case of a vaccine against HIV-1, fullerenol VLPs penetrated easily into the cells resulting in an enhancement of DNA transfection. This was proved in a study using fullerenol encapsulating DNA encoding the HIV-1 envelope protein gp145 (Figure 17).141In vitro assays were performed i"}