PMC:7376974 / 773-1378 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7376974","sourcedb":"PMC","sourceid":"7376974","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7376974","text":"agents, potentially being next-generation drugs to fight viral infections. HNMs can block infection at early (disinfection, entrance inhibition) and middle (inside the host cells) stages and are also able to mitigate the immune response. This review is focused on the application of HNMs as antiviral agents. In particular, mechanisms of actions, biological outputs, and limitations for each HNM will be systematically presented and analyzed from a material chemistry point-of-view. The antiviral activity will be discussed in the context of the different pandemic viruses. We acknowledge that HNM antivir","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T96517","span":{"begin":173,"end":178},"obj":"Body_part"}],"attributes":[{"id":"A93109","pred":"fma_id","subj":"T96517","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T96517","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"14","span":{"begin":57,"end":73},"obj":"Disease"},{"id":"15","span":{"begin":75,"end":99},"obj":"Disease"}],"attributes":[{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"MESH:D001102"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"MESH:D007239"},{"subj":"14","pred":"source","obj":"LitCovid-PubTator"},{"subj":"15","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":57,"end":73},"obj":"Disease"},{"id":"T8","span":{"begin":90,"end":99},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T82281","span":{"begin":173,"end":178},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T53798","span":{"begin":250,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T8703","span":{"begin":447,"end":448},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":497,"end":505},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T12","span":{"begin":565,"end":572},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T82281","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53798","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8703","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":42,"end":47},"obj":"Chemical"},{"id":"T3","span":{"begin":268,"end":279},"obj":"Chemical"},{"id":"T4","span":{"begin":291,"end":307},"obj":"Chemical"},{"id":"T5","span":{"begin":487,"end":496},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_33232"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T80802","span":{"begin":57,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T18352","span":{"begin":221,"end":236},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T80802","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T18352","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":75,"end":237},"obj":"Sentence"},{"id":"T9","span":{"begin":238,"end":308},"obj":"Sentence"},{"id":"T10","span":{"begin":309,"end":482},"obj":"Sentence"},{"id":"T11","span":{"begin":483,"end":573},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9893","default":true},{"id":"LitCovid-PubTator","color":"#93a8ec"},{"id":"LitCovid-PD-MONDO","color":"#c2ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93dc"},{"id":"LitCovid-PD-CHEBI","color":"#93ece2"},{"id":"LitCovid-PD-GO-BP","color":"#ecc893"},{"id":"LitCovid-sentences","color":"#ae93ec"}]}]}}