PMC:7376974 / 71981-72373 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T329","span":{"begin":201,"end":204},"obj":"Body_part"}],"attributes":[{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1286","span":{"begin":91,"end":94},"obj":"Chemical"},{"id":"1298","span":{"begin":181,"end":187},"obj":"Disease"},{"id":"1299","span":{"begin":381,"end":391},"obj":"Disease"}],"attributes":[{"id":"A1286","pred":"tao:has_database_id","subj":"1286","obj":"MESH:D017382"},{"id":"A1298","pred":"tao:has_database_id","subj":"1298","obj":"MESH:D006323"},{"id":"A1299","pred":"tao:has_database_id","subj":"1299","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T194","span":{"begin":381,"end":391},"obj":"Disease"}],"attributes":[{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T667","span":{"begin":227,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T48087","span":{"begin":91,"end":94},"obj":"Chemical"},{"id":"T30232","span":{"begin":201,"end":204},"obj":"Chemical"},{"id":"T4807","span":{"begin":328,"end":331},"obj":"Chemical"},{"id":"T77715","span":{"begin":342,"end":353},"obj":"Chemical"}],"attributes":[{"id":"A76370","pred":"chebi_id","subj":"T48087","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A9149","pred":"chebi_id","subj":"T30232","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A86381","pred":"chebi_id","subj":"T4807","obj":"http://purl.obolibrary.org/obo/CHEBI_36560"},{"id":"A17256","pred":"chebi_id","subj":"T77715","obj":"http://purl.obolibrary.org/obo/CHEBI_33232"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T132","span":{"begin":78,"end":87},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T133","span":{"begin":135,"end":152},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T134","span":{"begin":135,"end":152},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"LitCovid-sentences","denotations":[{"id":"T453","span":{"begin":0,"end":392},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}

{"project":"2_test","denotations":[{"id":"32667191-30346253-153374","span":{"begin":276,"end":279},"obj":"30346253"},{"id":"32667191-31500628-153375","span":{"begin":280,"end":283},"obj":"31500628"}],"text":"These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections."}