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PMC:7376974 / 70374-72752 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T319 184-189 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T320 321-338 Body_part denotes cell compartments http://purl.org/sig/ont/fma/fma223408
T321 321-325 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T322 326-338 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T323 551-559 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T324 1334-1351 Body_part denotes cell compartments http://purl.org/sig/ont/fma/fma223408
T325 1334-1338 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 1339-1351 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T327 1415-1419 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 1538-1543 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 1808-1811 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1267 764-768 Species denotes H1N1 Tax:114727
1268 769-784 Species denotes influenza virus Tax:11308
1269 84-89 Chemical denotes metal MESH:D008670
1270 93-104 Chemical denotes metal oxide
1271 310-313 Chemical denotes ROS MESH:D017382
1272 359-370 Chemical denotes metal oxide
1273 395-405 Chemical denotes superoxide MESH:D013481
1274 430-446 Chemical denotes hydroxyl radical MESH:D017665
1275 506-516 Chemical denotes superoxide MESH:D013481
1276 857-860 Chemical denotes ZnO MESH:D015034
1277 944-953 Chemical denotes acyclovir MESH:D000212
1278 985-988 Chemical denotes ZnO MESH:D015034
1279 1029-1032 Chemical denotes PEG MESH:D011092
1280 1110-1114 Chemical denotes Zn2+
1281 1132-1135 Chemical denotes ROS MESH:D017382
1282 1155-1158 Chemical denotes ROS MESH:D017382
1283 1166-1176 Chemical denotes superoxide MESH:D013481
1284 1181-1198 Chemical denotes hydroxyl radicals MESH:D017665
1285 1371-1374 Chemical denotes ROS MESH:D017382
1286 1698-1701 Chemical denotes ROS MESH:D017382
1287 2099-2101 Chemical denotes Fe MESH:D007501
1288 2103-2105 Chemical denotes Cu MESH:D003300
1289 2203-2208 Chemical denotes metal MESH:D008670
1290 2239-2242 Chemical denotes ROS MESH:D017382
1291 51-67 Disease denotes viral infections MESH:D001102
1292 170-178 Disease denotes infected MESH:D007239
1293 599-630 Disease denotes efficiently block the infection MESH:D006327
1294 907-922 Disease denotes viral infection MESH:D001102
1295 973-981 Disease denotes toxicity MESH:D064420
1296 1420-1425 Disease denotes death MESH:D003643
1297 1488-1497 Disease denotes infection MESH:D007239
1298 1788-1794 Disease denotes arrest MESH:D006323
1299 1988-1998 Disease denotes infections MESH:D007239

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T186 51-67 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T187 621-630 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T188 764-778 Disease denotes H1N1 influenza http://purl.obolibrary.org/obo/MONDO_0005460
T189 769-778 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T190 789-803 Disease denotes Herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T191 907-922 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T192 913-922 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T193 1488-1497 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T194 1988-1998 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T652 184-189 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T653 284-292 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T654 321-325 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T655 646-649 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T656 779-784 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T657 804-809 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T658 1048-1049 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T659 1081-1082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T660 1334-1338 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T661 1386-1391 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T662 1415-1419 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T663 1538-1543 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T664 1549-1550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T665 1551-1556 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T666 1576-1584 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T667 1834-1840 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T668 2115-2118 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T669 2262-2270 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T75153 93-104 Chemical denotes metal oxide http://purl.obolibrary.org/obo/CHEBI_133331
T31188 99-104 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T82861 146-153 Chemical denotes radical http://purl.obolibrary.org/obo/CHEBI_26519
T73572 276-283 Chemical denotes radical http://purl.obolibrary.org/obo/CHEBI_26519
T94867 310-313 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T39953 359-370 Chemical denotes metal oxide http://purl.obolibrary.org/obo/CHEBI_133331
T54565 365-370 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T61158 395-405 Chemical denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421
T38145 406-410 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T43842 430-446 Chemical denotes hydroxyl radical http://purl.obolibrary.org/obo/CHEBI_29191
T69377 430-438 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_43176
T29942 439-446 Chemical denotes radical http://purl.obolibrary.org/obo/CHEBI_26519
T68162 506-516 Chemical denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421
T67477 517-521 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T64417 551-559 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T61614 670-673 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T78326 704-707 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T8363 857-860 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T73030 944-953 Chemical denotes acyclovir http://purl.obolibrary.org/obo/CHEBI_2453
T54344 985-988 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T93542 1029-1032 Chemical denotes PEG http://purl.obolibrary.org/obo/CHEBI_46793
T3911 1110-1113 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T27718 1115-1119 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T95416 1132-1135 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T81599 1155-1158 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T39552 1166-1176 Chemical denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421
T5113 1181-1189 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T59131 1190-1198 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T33127 1298-1307 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T16546 1371-1374 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T48087 1698-1701 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T30232 1808-1811 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T4807 1935-1938 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T77715 1949-1960 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T29133 2038-2044 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T93167 2099-2101 Chemical denotes Fe http://purl.obolibrary.org/obo/CHEBI_18248
T1123 2103-2105 Chemical denotes Cu http://purl.obolibrary.org/obo/CHEBI_28694
T343 2111-2113 Chemical denotes Mn http://purl.obolibrary.org/obo/CHEBI_18291
T25704 2209-2212 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T74642 2239-2242 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T346 2252-2261 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T95639 2341-2350 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T127 51-67 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T128 907-922 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T129 1132-1145 http://purl.obolibrary.org/obo/GO_1903409 denotes ROS formation
T130 1136-1145 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T131 1415-1425 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T132 1685-1694 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T133 1742-1759 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T134 1742-1759 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T135 2327-2333 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T442 0-68 Sentence denotes HNMs have been shown to be powerful allies against viral infections.
T443 69-190 Sentence denotes In particular, metal or metal oxide NMs, once internalized, can regulate the radical production into infected host cells.
T444 191-339 Sentence denotes In this scenario, the NMs can work following two different mechanisms: (1) enhancing radical activity or (2) quenching ROS inside cell compartments.
T445 340-491 Sentence denotes In the first case, metal oxide NPs are able to convert superoxide ions into more reactive hydroxyl radical species via Fenton or Fenton-like reactions.
T446 492-631 Sentence denotes The excess of superoxide ions is able to oxidize the viral proteins and the genetic material and therefore efficiently block the infection.
T447 632-810 Sentence denotes This approach has been reported using ZnO NPs.117,118 In these studies, ZnO NPs have been successfully applied for the treatment of H1N1 influenza virus and Herpes simplex virus.
T448 811-954 Sentence denotes The preliminary results showed that PEGylated ZnO particles were able to efficiently reduce the viral infection with IC50 similar to acyclovir.
T449 955-1146 Sentence denotes More importantly, toxicity of ZnO was modulated by functionalization with PEG, which allowed a higher colloidal stability and a more controlled release of Zn2+ ions to catalyze ROS formation.
T450 1147-1352 Sentence denotes Indeed, ROS (e.g., superoxide and hydroxyl radicals) produced by the NPs should be highly reactive and should not only damage the exogenous biological molecules but also attack different cell compartments.
T451 1353-1426 Sentence denotes Overproduction of ROS may reduce virus spread but also induce cell death.
T452 1427-1606 Sentence denotes Interestingly, this approach is applicable only at the early infection stage (after 1 h incubation of the host cells with a virus), but it loses its activity at later time points.
T453 1607-1999 Sentence denotes These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections.
T454 2000-2141 Sentence denotes However, the same approach with other metals able to induce Fenton or Fenton-like reactions (e.g., Fe, Cu, and Mn) has not been reported yet.
T455 2142-2271 Sentence denotes The choice of proper capping agents may allow to control the metal ion release and thus tune the ROS-mediated antiviral activity.
T456 2272-2378 Sentence denotes We would like to take an advantage here to suggest the growth of the antiviral research in this direction.

2_test

Id Subject Object Predicate Lexical cue
32667191-30346253-153372 678-681 30346253 denotes 117
32667191-31500628-153373 682-685 31500628 denotes 118
32667191-30346253-153374 1883-1886 30346253 denotes 117
32667191-31500628-153375 1887-1890 31500628 denotes 118