PMC:7376974 / 68107-68714 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T303","span":{"begin":248,"end":251},"obj":"Body_part"},{"id":"T304","span":{"begin":366,"end":371},"obj":"Body_part"},{"id":"T305","span":{"begin":455,"end":460},"obj":"Body_part"},{"id":"T306","span":{"begin":520,"end":523},"obj":"Body_part"},{"id":"T307","span":{"begin":569,"end":573},"obj":"Body_part"}],"attributes":[{"id":"A303","pred":"fma_id","subj":"T303","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A304","pred":"fma_id","subj":"T304","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A305","pred":"fma_id","subj":"T305","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A306","pred":"fma_id","subj":"T306","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A307","pred":"fma_id","subj":"T307","obj":"http://purl.org/sig/ont/fma/fma67122"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1190","span":{"begin":0,"end":8},"obj":"Chemical"},{"id":"1191","span":{"begin":142,"end":150},"obj":"Chemical"},{"id":"1192","span":{"begin":378,"end":390},"obj":"Disease"},{"id":"1193","span":{"begin":473,"end":504},"obj":"Disease"}],"attributes":[{"id":"A1190","pred":"tao:has_database_id","subj":"1190","obj":"MESH:D006108"},{"id":"A1191","pred":"tao:has_database_id","subj":"1191","obj":"MESH:D006108"},{"id":"A1192","pred":"tao:has_database_id","subj":"1192","obj":"MESH:D009800"},{"id":"A1193","pred":"tao:has_database_id","subj":"1193","obj":"MESH:D006526"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T175","span":{"begin":483,"end":504},"obj":"Disease"},{"id":"T176","span":{"begin":483,"end":492},"obj":"Disease"},{"id":"T177","span":{"begin":495,"end":504},"obj":"Disease"}],"attributes":[{"id":"A175","pred":"mondo_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/MONDO_0005231"},{"id":"A176","pred":"mondo_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T625","span":{"begin":95,"end":96},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T626","span":{"begin":224,"end":230},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T627","span":{"begin":325,"end":326},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T628","span":{"begin":342,"end":350},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T629","span":{"begin":366,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T630","span":{"begin":395,"end":398},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T631","span":{"begin":455,"end":460},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T632","span":{"begin":604,"end":607},"obj":"http://purl.obolibrary.org/obo/CLO_0053001"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1096","span":{"begin":56,"end":70},"obj":"Chemical"},{"id":"T33730","span":{"begin":56,"end":65},"obj":"Chemical"},{"id":"T22905","span":{"begin":66,"end":70},"obj":"Chemical"},{"id":"T14566","span":{"begin":80,"end":88},"obj":"Chemical"},{"id":"T98581","span":{"begin":185,"end":189},"obj":"Chemical"},{"id":"T14798","span":{"begin":265,"end":269},"obj":"Chemical"},{"id":"T80445","span":{"begin":332,"end":341},"obj":"Chemical"},{"id":"T59289","span":{"begin":520,"end":523},"obj":"Chemical"}],"attributes":[{"id":"A51681","pred":"chebi_id","subj":"T1096","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A29143","pred":"chebi_id","subj":"T33730","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A85383","pred":"chebi_id","subj":"T22905","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A28998","pred":"chebi_id","subj":"T14566","obj":"http://purl.obolibrary.org/obo/CHEBI_78059"},{"id":"A37985","pred":"chebi_id","subj":"T98581","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A45734","pred":"chebi_id","subj":"T14798","obj":"http://purl.obolibrary.org/obo/CHEBI_50594"},{"id":"A53539","pred":"chebi_id","subj":"T80445","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A65596","pred":"chebi_id","subj":"T59289","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-sentences","denotations":[{"id":"T427","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T428","span":{"begin":90,"end":141},"obj":"Sentence"},{"id":"T429","span":{"begin":142,"end":391},"obj":"Sentence"},{"id":"T430","span":{"begin":392,"end":505},"obj":"Sentence"},{"id":"T431","span":{"begin":506,"end":607},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":483,"end":492},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"Graphene-based materials have been limitedly studied as antiviral drug delivery carriers. Only a few examples can be found in the literature. Graphene quantum dots (GQDs) were used for drug delivery of CHI360 and CHI415 and tested in vitro against HIV similarly to CNTs.109 Both the prepared GQD-CHI360 and GQD-CHI415 showed a high antiviral activity once into host cells, with low toxicity. GO has been also used for the delivery of DNAzyme into hepatic cells allowing to block the hepatitis C infection. This specific DNA single strand is able to recognize the viral mRNA and to silence its expression.114"}