PMC:7376974 / 64639-65491 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T287","span":{"begin":6,"end":9},"obj":"Body_part"},{"id":"T288","span":{"begin":61,"end":64},"obj":"Body_part"},{"id":"T289","span":{"begin":96,"end":106},"obj":"Body_part"},{"id":"T290","span":{"begin":155,"end":158},"obj":"Body_part"},{"id":"T291","span":{"begin":727,"end":730},"obj":"Body_part"}],"attributes":[{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1137","span":{"begin":453,"end":468},"obj":"Species"},{"id":"1138","span":{"begin":479,"end":483},"obj":"Species"},{"id":"1139","span":{"begin":485,"end":489},"obj":"Species"},{"id":"1140","span":{"begin":280,"end":303},"obj":"Chemical"},{"id":"1141","span":{"begin":396,"end":417},"obj":"Chemical"},{"id":"1142","span":{"begin":535,"end":542},"obj":"Chemical"},{"id":"1143","span":{"begin":544,"end":555},"obj":"Chemical"},{"id":"1144","span":{"begin":557,"end":566},"obj":"Chemical"},{"id":"1145","span":{"begin":572,"end":582},"obj":"Chemical"}],"attributes":[{"id":"A1137","pred":"tao:has_database_id","subj":"1137","obj":"Tax:11308"},{"id":"A1138","pred":"tao:has_database_id","subj":"1138","obj":"Tax:114727"},{"id":"A1139","pred":"tao:has_database_id","subj":"1139","obj":"Tax:119210"},{"id":"A1142","pred":"tao:has_database_id","subj":"1142","obj":"MESH:D053139"},{"id":"A1143","pred":"tao:has_database_id","subj":"1143","obj":"MESH:D012299"},{"id":"A1144","pred":"tao:has_database_id","subj":"1144","obj":"MESH:D012254"},{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"MESH:D000547"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T170","span":{"begin":143,"end":154},"obj":"Disease"},{"id":"T171","span":{"begin":143,"end":152},"obj":"Disease"},{"id":"T172","span":{"begin":453,"end":462},"obj":"Disease"}],"attributes":[{"id":"A170","pred":"mondo_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/MONDO_0005231"},{"id":"A171","pred":"mondo_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A172","pred":"mondo_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T591","span":{"begin":10,"end":17},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T592","span":{"begin":179,"end":182},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T593","span":{"begin":244,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T594","span":{"begin":305,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T595","span":{"begin":390,"end":391},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T596","span":{"begin":463,"end":468},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T597","span":{"begin":476,"end":477},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T598","span":{"begin":495,"end":496},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T599","span":{"begin":741,"end":748},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T600","span":{"begin":836,"end":837},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T18696","span":{"begin":96,"end":117},"obj":"Chemical"},{"id":"T32188","span":{"begin":96,"end":106},"obj":"Chemical"},{"id":"T66991","span":{"begin":96,"end":101},"obj":"Chemical"},{"id":"T93275","span":{"begin":102,"end":106},"obj":"Chemical"},{"id":"T68305","span":{"begin":175,"end":177},"obj":"Chemical"},{"id":"T24127","span":{"begin":323,"end":332},"obj":"Chemical"},{"id":"T86919","span":{"begin":340,"end":342},"obj":"Chemical"},{"id":"T99115","span":{"begin":401,"end":416},"obj":"Chemical"},{"id":"T62478","span":{"begin":412,"end":416},"obj":"Chemical"},{"id":"T196","span":{"begin":535,"end":542},"obj":"Chemical"},{"id":"T198","span":{"begin":544,"end":555},"obj":"Chemical"},{"id":"T20997","span":{"begin":557,"end":566},"obj":"Chemical"},{"id":"T200","span":{"begin":572,"end":582},"obj":"Chemical"},{"id":"T12337","span":{"begin":661,"end":671},"obj":"Chemical"},{"id":"T48501","span":{"begin":707,"end":722},"obj":"Chemical"},{"id":"T60422","span":{"begin":707,"end":716},"obj":"Chemical"},{"id":"T29823","span":{"begin":717,"end":722},"obj":"Chemical"}],"attributes":[{"id":"A66810","pred":"chebi_id","subj":"T18696","obj":"http://purl.obolibrary.org/obo/CHEBI_83821"},{"id":"A2125","pred":"chebi_id","subj":"T32188","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A30349","pred":"chebi_id","subj":"T66991","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A57824","pred":"chebi_id","subj":"T93275","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A94491","pred":"chebi_id","subj":"T68305","obj":"http://purl.obolibrary.org/obo/CHEBI_141419"},{"id":"A57566","pred":"chebi_id","subj":"T24127","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A47469","pred":"chebi_id","subj":"T86919","obj":"http://purl.obolibrary.org/obo/CHEBI_141419"},{"id":"A5660","pred":"chebi_id","subj":"T99115","obj":"http://purl.obolibrary.org/obo/CHEBI_33575"},{"id":"A7365","pred":"chebi_id","subj":"T62478","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A90809","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_7798"},{"id":"A31372","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_7799"},{"id":"A32179","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_49886"},{"id":"A49286","pred":"chebi_id","subj":"T20997","obj":"http://purl.obolibrary.org/obo/CHEBI_63580"},{"id":"A45494","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_2618"},{"id":"A49046","pred":"chebi_id","subj":"T12337","obj":"http://purl.obolibrary.org/obo/CHEBI_33416"},{"id":"A14881","pred":"chebi_id","subj":"T48501","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A91852","pred":"chebi_id","subj":"T60422","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A14529","pred":"chebi_id","subj":"T29823","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T115","span":{"begin":32,"end":49},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T116","span":{"begin":32,"end":49},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T117","span":{"begin":209,"end":226},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T118","span":{"begin":209,"end":226},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-sentences","denotations":[{"id":"T411","span":{"begin":0,"end":343},"obj":"Sentence"},{"id":"T412","span":{"begin":344,"end":634},"obj":"Sentence"},{"id":"T413","span":{"begin":635,"end":749},"obj":"Sentence"},{"id":"T414","span":{"begin":750,"end":852},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T17","span":{"begin":143,"end":152},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}

{"project":"2_test","denotations":[{"id":"32667191-20661480-153364","span":{"begin":65,"end":68},"obj":"20661480"},{"id":"32667191-15686922-153365","span":{"begin":179,"end":182},"obj":"15686922"}],"text":"Other RNA viruses share ways of viral replication similar to HIV.106 C60 functionalized with an amino acid derivative was investigated against Hepatitis C RNA polymerase (HCV-RP).102 This essential enzyme for viral replication was inhibited in a submicromolar range, similarly to benzo-1,2,4-thiadiazine, a potent specific inhibitor of HCV-RP. Another publication highlighted the effect of a C70 poly(carboxylic acid) derivative on different strains of influenza virus (e.g., A, H1N1, H3N2, and B).107 The inhibition was comparable to Tamiflu, rimantadine, ribavirin, and amantadine, but the mechanism of action remains still unclear. These data emphasize that fullerenes C60 or C70 can be potent universal antiviral drugs for RNA enveloped viruses. However, clear elucidations of the mechanisms of action and in vivo studies are still a missing point."}