PMC:7376974 / 41517-42447 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T185","span":{"begin":490,"end":498},"obj":"Body_part"},{"id":"T186","span":{"begin":525,"end":537},"obj":"Body_part"},{"id":"T187","span":{"begin":641,"end":649},"obj":"Body_part"},{"id":"T188","span":{"begin":668,"end":676},"obj":"Body_part"}],"attributes":[{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma82801"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-PubTator","denotations":[{"id":"699","span":{"begin":582,"end":593},"obj":"Species"},{"id":"700","span":{"begin":64,"end":92},"obj":"Chemical"},{"id":"701","span":{"begin":319,"end":334},"obj":"Chemical"},{"id":"702","span":{"begin":525,"end":537},"obj":"Chemical"},{"id":"703","span":{"begin":776,"end":791},"obj":"Chemical"}],"attributes":[{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"Tax:1570291"},{"id":"A702","pred":"tao:has_database_id","subj":"702","obj":"MESH:D002241"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T114","span":{"begin":582,"end":587},"obj":"Disease"}],"attributes":[{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0005737"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T380","span":{"begin":35,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T381","span":{"begin":149,"end":155},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T382","span":{"begin":182,"end":183},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T383","span":{"begin":287,"end":288},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T384","span":{"begin":507,"end":508},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T385","span":{"begin":588,"end":593},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T386","span":{"begin":743,"end":744},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T387","span":{"begin":922,"end":929},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T536","span":{"begin":525,"end":537},"obj":"Chemical"},{"id":"T537","span":{"begin":878,"end":887},"obj":"Chemical"}],"attributes":[{"id":"A536","pred":"chebi_id","subj":"T536","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A537","pred":"chebi_id","subj":"T537","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T62","span":{"begin":109,"end":118},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T63","span":{"begin":300,"end":309},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"LitCovid-sentences","denotations":[{"id":"T264","span":{"begin":0,"end":232},"obj":"Sentence"},{"id":"T265","span":{"begin":233,"end":437},"obj":"Sentence"},{"id":"T266","span":{"begin":438,"end":701},"obj":"Sentence"},{"id":"T267","span":{"begin":702,"end":792},"obj":"Sentence"},{"id":"T268","span":{"begin":793,"end":930},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}

{"project":"2_test","denotations":[{"id":"32667191-32264418-153335","span":{"begin":156,"end":158},"obj":"32264418"}],"text":"Following an alternative strategy, a supramolecular assembly of monodisperse glycofullerenes, leading to the formation of micelles, was achieved and tested.72 These micelles present a uniform and spherical shape (Figure 6, route C). The aggregation synthetic route is faster compared to a controlled synthesis of giant glycofullerenes, but it might suffer from low reproducibility and batch-to-batch differences between each formulation. This self-assembled C60 functionalized with 6 or 12 mannoses exposes a large amount of carbohydrate at the surface, leading to an inhibition of Ebola virus in the nanomolar range (IC50 of 424 nM for six mannoses and 196 nM for 12 mannoses, respectively, Table 3). Further in vitro studies evidenced again a good biocompatibility of these glycofullerenes. While there are no in vivo studies yet, these promising results enlarge the panel of molecules in the fight against new emerging viruses."}