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PMC:7376974 / 30452-32545 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T128 355-363 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T129 1431-1436 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 1937-1942 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
421 626-641 Species denotes influenza virus Tax:11308
422 1241-1259 Species denotes feline calicivirus Tax:11978
423 1266-1270 Species denotes H1N1 Tax:114727
424 1280-1295 Species denotes influenza virus Tax:11308
425 2014-2019 Species denotes HSV-1 Tax:10298
426 216-221 Chemical denotes metal MESH:D008670
427 237-239 Chemical denotes Cu MESH:D003300
428 243-245 Chemical denotes Fe MESH:D007501
429 440-446 Chemical denotes copper MESH:D003300
430 466-474 Chemical denotes sulfates MESH:D013431
431 478-490 Chemical denotes iodide salts MESH:D007454
432 752-755 Chemical denotes Cu+ MESH:D003300
433 813-830 Chemical denotes hydroxyl radicals MESH:D017665
434 854-860 Chemical denotes copper MESH:D003300
435 996-999 Chemical denotes Cu+ MESH:D003300
436 1022-1025 Chemical denotes Cu+ MESH:D003300
437 1043-1049 Chemical denotes copper MESH:D003300
438 1319-1325 Chemical denotes copper MESH:D003300
439 1378-1401 Chemical denotes reactive oxygen species MESH:D017382
440 1403-1406 Chemical denotes ROS MESH:D017382
441 1559-1572 Chemical denotes cupric oxides MESH:C030973
442 1670-1683 Chemical denotes cuprous oxide MESH:C000520
443 394-409 Disease denotes viral infection MESH:D001102
444 1458-1466 Disease denotes toxicity MESH:D064420
445 1910-1925 Disease denotes viral infection MESH:D001102

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T67 394-409 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T68 400-409 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T69 626-635 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T70 648-662 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T71 678-689 Disease denotes hepatitis A http://purl.obolibrary.org/obo/MONDO_0005790
T72 678-687 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T73 1280-1289 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T74 1742-1753 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T75 1742-1751 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T76 1910-1925 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T77 1916-1925 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T298 181-189 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T299 551-559 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T300 608-615 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T301 636-641 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T302 688-689 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T303 690-695 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T304 911-914 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T305 926-927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T306 1084-1090 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T307 1290-1295 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T308 1431-1436 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T309 1448-1449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 1475-1483 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T311 1475-1483 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T312 1808-1809 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T313 1830-1838 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T314 1937-1942 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T333 36-39 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T334 61-67 Chemical denotes metals http://purl.obolibrary.org/obo/CHEBI_33521
T335 98-102 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T336 171-180 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T337 222-225 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T338 237-239 Chemical denotes Cu http://purl.obolibrary.org/obo/CHEBI_28694
T339 243-245 Chemical denotes Fe http://purl.obolibrary.org/obo/CHEBI_18248
T340 288-296 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T341 355-363 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T342 440-446 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T344 447-451 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T345 466-474 Chemical denotes sulfates http://purl.obolibrary.org/obo/CHEBI_26820|http://purl.obolibrary.org/obo/CHEBI_35175
T347 478-490 Chemical denotes iodide salts http://purl.obolibrary.org/obo/CHEBI_24858
T348 478-484 Chemical denotes iodide http://purl.obolibrary.org/obo/CHEBI_16382
T349 485-490 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T350 517-533 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T351 752-754 Chemical denotes Cu http://purl.obolibrary.org/obo/CHEBI_28694
T352 756-760 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T353 775-780 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T354 784-797 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T355 813-821 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T357 822-830 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T358 854-860 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T360 996-998 Chemical denotes Cu http://purl.obolibrary.org/obo/CHEBI_28694
T361 1022-1024 Chemical denotes Cu http://purl.obolibrary.org/obo/CHEBI_28694
T362 1026-1031 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T363 1043-1049 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T365 1050-1054 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T366 1148-1161 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T367 1319-1325 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T369 1326-1331 Chemical denotes salts http://purl.obolibrary.org/obo/CHEBI_24866
T370 1378-1401 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T371 1387-1393 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T372 1403-1406 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T373 1566-1572 Chemical denotes oxides http://purl.obolibrary.org/obo/CHEBI_25741
T374 1612-1628 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T375 1670-1683 Chemical denotes cuprous oxide http://purl.obolibrary.org/obo/CHEBI_81908
T376 1678-1683 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T378 1684-1697 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T379 1796-1799 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T380 1820-1829 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T381 2071-2080 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T48 394-409 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T49 739-748 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T50 1408-1419 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T51 1910-1925 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T193 0-190 Sentence denotes One of the main advantages of using NPs compared to oxidized metals relies on the slow release of ions and clusters from these particles, leading to an enhancement of the antiviral activity.
T194 191-425 Sentence denotes Additionally, the use of metal NPs containing Cu or Fe in ionic form catalyzes the generation of radicals via Fenton and Fenton-like reactions oxidizing the capsid proteins and consequently blocking the viral infection at early stage.
T195 426-1128 Sentence denotes For instance, copper ions (derived from sulfates or iodide salts) have been widely used as antiviral agents because of their activity on several kinds of enveloped and non-enveloped viruses including influenza virus,49−51 herpes simplex virus52−54 and hepatitis A virus.55 Their mechanism of action relies on the formation of Cu+ ions (from soluble salts or nanoparticles) that generate hydroxyl radicals.56 The use of metallic copper nanostructures in the form of particles or sheets has shown only a moderate efficiency due to the low concentration and low release of Cu+.56 For these reasons, Cu+ salts, where the copper ions are readily present in their active monocationic form, have been favored.
T196 1129-1655 Sentence denotes In particular, CuI nanoparticles (stable at room temperature) have been extensively studied for deactivation of feline calicivirus56 and H1N1 pandemic influenza virus.57 However, the use of copper salts at high concentrations can irreversibly alter reactive oxygen species (ROS) homeostasis of healthy cells, provoking a general toxicity for the organism, limiting their applications to disinfection.56 Nanostructured cuprous and cupric oxides have been also extensively employed as antiviral agents for in vitro applications.
T197 1656-1865 Sentence denotes For instance, cuprous oxide nanoparticles (CuONPs) were successfully employed against hepatitis C.58 In particular, it was found that these NPs exerted a favorable antiviral activity with no cytotoxic effects.
T198 1866-1954 Sentence denotes CuONPs target the binding and entry step of viral infection to hepatic cells (Figure 5).
T199 1955-2093 Sentence denotes Similar results were reported on the use of CuONPs against HSV-1, however without any profound investigation on the antiviral mechanism.59

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T5 678-687 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T6 1742-1751 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32667191-17259354-153303 642-644 17259354 denotes 49
32667191-18592130-153304 645-647 18592130 denotes 51
32667191-15288958-153305 668-670 15288958 denotes 52
32667191-3021808-153306 671-673 3021808 denotes 54
32667191-8074518-153307 696-698 8074518 denotes 55
32667191-22227118-153308 831-833 22227118 denotes 56
32667191-22227118-153309 1000-1002 22227118 denotes 56
32667191-22227118-153310 1259-1261 22227118 denotes 56
32667191-22156433-153311 1296-1298 22156433 denotes 57
32667191-22227118-153312 1529-1531 22227118 denotes 56
32667191-26116793-153313 1754-1756 26116793 denotes 58
32667191-31271792-153314 2091-2093 31271792 denotes 59