PMC:7376974 / 29381-30083 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T126","span":{"begin":589,"end":592},"obj":"Body_part"}],"attributes":[{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T287","span":{"begin":33,"end":41},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T288","span":{"begin":407,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T289","span":{"begin":445,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T290","span":{"begin":462,"end":465},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T291","span":{"begin":552,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T292","span":{"begin":560,"end":568},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T293","span":{"begin":647,"end":650},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T294","span":{"begin":655,"end":663},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T323","span":{"begin":19,"end":28},"obj":"Chemical"},{"id":"T324","span":{"begin":33,"end":41},"obj":"Chemical"},{"id":"T325","span":{"begin":160,"end":164},"obj":"Chemical"},{"id":"T326","span":{"begin":187,"end":196},"obj":"Chemical"},{"id":"T327","span":{"begin":374,"end":383},"obj":"Chemical"},{"id":"T328","span":{"begin":426,"end":430},"obj":"Chemical"},{"id":"T329","span":{"begin":576,"end":585},"obj":"Chemical"}],"attributes":[{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A324","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A325","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A326","pred":"chebi_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_50825"},{"id":"A329","pred":"chebi_id","subj":"T329","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T47","span":{"begin":560,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}

{"project":"LitCovid-sentences","denotations":[{"id":"T187","span":{"begin":120,"end":301},"obj":"Sentence"},{"id":"T188","span":{"begin":302,"end":444},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}

{"project":"2_test","denotations":[{"id":"32667191-18473457-153300","span":{"begin":593,"end":595},"obj":"18473457"}],"text":" particular, small molecules and peptides able to target and block the viral biochemical machinery have been developed. However, despite these efforts into the drug design, many of these molecules suffer from poor biological effect, low concentration in the diseased areas, and undesired side effects. In this context, AuNPs have been coupled to biologically inactive small molecules to create biologically active multivalent AuNP therapeutics. A bright example has been reported by Bowman et al., where the authors functionalized AuNPs with SDC-1721, a small membrane fusion inhibitor of HIV.46 The results demonstrated that, while pure SDC-1721 has low activity, functionalized AuNPs are able to inhi"}