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PMC:7376974 / 26027-29272 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T120 794-807 Body_part denotes cell surfaces http://purl.org/sig/ont/fma/fma67653
T121 794-798 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T122 925-938 Body_part denotes cell surfaces http://purl.org/sig/ont/fma/fma67653
T123 925-929 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T124 1116-1123 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T125 2060-2063 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
378 1554-1581 Species denotes bovine viral diarrhea virus Tax:11099
379 2983-2998 Species denotes influenza virus Tax:11308
380 1237-1246 Species denotes influenza Tax:11320
381 39-43 Chemical denotes AuNP
382 455-466 Chemical denotes gallic acid MESH:D005707
383 1018-1028 Chemical denotes sulfonates MESH:D000476
384 1191-1201 Chemical denotes sulfonates MESH:D000476
385 1291-1304 Chemical denotes succinic acid MESH:D019802
386 1495-1500 Chemical denotes Thiol MESH:D013438
387 1984-2003 Chemical denotes Sulfonated dendrons
388 2020-2025 Chemical denotes AuNPs
389 2032-2039 Chemical denotes sulfide MESH:D013440
390 2233-2241 Chemical denotes dendrons MESH:D050091
391 2492-2501 Chemical denotes sulfonate MESH:D000476
392 2907-2914 Chemical denotes dendron MESH:C501244
393 533-548 Disease denotes virus infection MESH:D001102

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T61 518-532 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T62 533-548 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T63 539-548 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64 1237-1246 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T65 1567-1575 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T66 2983-2992 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T254 29-37 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T255 198-201 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 533-538 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T257 763-777 http://purl.obolibrary.org/obo/CHEBI_33247 denotes organic groups
T258 794-798 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T259 873-878 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T260 925-929 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T261 1033-1040 http://purl.obolibrary.org/obo/OBI_0100026 denotes organic
T262 1033-1040 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organic
T263 1099-1104 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T264 1153-1161 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T265 1162-1164 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T266 1247-1248 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T267 1355-1356 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 1415-1423 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T269 1474-1488 http://purl.obolibrary.org/obo/CHEBI_33247 denotes organic groups
T270 1576-1581 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T271 1607-1610 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T272 2030-2031 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T273 2049-2055 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T274 2130-2131 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 2155-2160 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T276 2254-2255 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 2559-2560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 2723-2725 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T279 2751-2752 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 2887-2890 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T281 2943-2944 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 2970-2978 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T283 2993-2998 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T284 3032-3033 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T285 3074-3077 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T282 19-28 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T283 39-43 Chemical denotes AuNP http://purl.obolibrary.org/obo/CHEBI_50825
T284 190-197 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T285 239-248 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T286 272-279 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T287 341-347 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T288 370-376 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T289 426-430 Chemical denotes gold http://purl.obolibrary.org/obo/CHEBI_29287|http://purl.obolibrary.org/obo/CHEBI_30050
T291 431-435 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T292 455-466 Chemical denotes gallic acid http://purl.obolibrary.org/obo/CHEBI_30778
T293 462-466 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T294 578-584 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T295 585-588 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T296 763-777 Chemical denotes organic groups http://purl.obolibrary.org/obo/CHEBI_33247
T297 1018-1028 Chemical denotes sulfonates http://purl.obolibrary.org/obo/CHEBI_33543
T298 1033-1049 Chemical denotes organic sulfates http://purl.obolibrary.org/obo/CHEBI_25704
T299 1041-1049 Chemical denotes sulfates http://purl.obolibrary.org/obo/CHEBI_26820|http://purl.obolibrary.org/obo/CHEBI_35175
T301 1116-1123 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T302 1150-1152 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T303 1191-1201 Chemical denotes sulfonates http://purl.obolibrary.org/obo/CHEBI_33543
T304 1265-1278 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T305 1291-1304 Chemical denotes succinic acid http://purl.obolibrary.org/obo/CHEBI_15741
T306 1300-1304 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T307 1405-1414 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T308 1474-1488 Chemical denotes organic groups http://purl.obolibrary.org/obo/CHEBI_33247
T309 1495-1500 Chemical denotes Thiol http://purl.obolibrary.org/obo/CHEBI_29256
T310 1753-1759 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T311 1838-1851 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T312 1892-1901 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T313 2032-2039 Chemical denotes sulfide http://purl.obolibrary.org/obo/CHEBI_26822
T314 2492-2501 Chemical denotes sulfonate http://purl.obolibrary.org/obo/CHEBI_33543
T315 2539-2542 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T316 2694-2701 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T317 2742-2745 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T318 2907-2914 Chemical denotes dendron http://purl.obolibrary.org/obo/CHEBI_51338
T319 2960-2969 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T320 3144-3157 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T321 3223-3229 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T43 327-336 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T44 348-356 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T45 1087-1094 http://purl.obolibrary.org/obo/GO_0042056 denotes attract
T46 2390-2401 http://purl.obolibrary.org/obo/GO_0006412 denotes translation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T171 0-141 Sentence denotes Besides the per se antiviral activity, AuNP surface modifications have been developed in order to enhance their overall therapeutic benefits.
T172 142-260 Sentence denotes The engineering of tailored AuNPs with selected ligands has allowed the preparation of efficient antiviral nanoagents.
T173 261-391 Sentence denotes The target ligands can be introduced directly during the particle synthesis via ligand exchange reactions or ligand modifications.
T174 392-879 Sentence denotes For instance, direct reduction of gold ions in the presence of gallic acid produced homogeneous AuNPs able to sensibly reduce herpes simplex virus infection in vitro.40 Compared to free ligand NPs, functionalized AuNPs benefit from the multivalency effect and higher circulation times, decreasing the needed therapeutic concentrations.39 Functionalized AuNPs can present organic groups that mimic host cell surfaces or other specific molecular patterns that selectively target the virus.
T175 880-1002 Sentence denotes Normally, negative charges are used to mimic cell surfaces and favor the interaction between the particles and the capsid.
T176 1003-1494 Sentence denotes In particular, sulfonates and organic sulfates have been used for their capacity to attract the virus via capsid protein interaction and block the HA activity.41 AuNPs functionalized with sulfonates showed an increasing inhibition of influenza A compared to the nanoparticles capped with succinic acid.42 This study also demonstrated that there is not a correlation between the negative charge and the antiviral activity, but instead the inhibition depends mainly on the organic groups used.
T177 1495-1683 Sentence denotes Thiol-capped AuNPs also displayed powerful inactivation of bovine viral diarrhea virus in vitro.43 Multivalency has been exploited in more complex systems using dendrons as capping agents.
T178 1684-1866 Sentence denotes This strategy allows to generate higher concentrations of the target ligand in close proximity to the AuNPs and to increase the binding efficiency of the nanoparticles to the capsid.
T179 1867-1983 Sentence denotes The driving force of the antiviral efficiency relies on the concentration of the targeting agent onto the particles.
T180 1984-2161 Sentence denotes Sulfonated dendrons were grafted to AuNPs via a sulfide bond and tested for HIV inhibition.44 The results showed that the decorated AuNPs exerted a higher affinity to the virus.
T181 2162-2402 Sentence denotes Additionally, comparing AuNPs functionalized with different generation dendrons, those with a third generation displayed the highest inhibition performance with an IC50 below 0.1 μmol/mL, thus making them attractive for in vivo translation.
T182 2403-2869 Sentence denotes It is worth noting that the inhibition efficiency is strictly dependent on the available sulfonate groups present on the surface of the NPs, making crucial a thorough characterization of the material.44 The size of the AuNPs clearly plays an important role in the concentration of targeting ligands exposed per particle.45 Indeed, too big NPs have a limited surface area, while too small would not allow an efficient grafting of the dendrons due to steric hindrance.
T183 2870-3068 Sentence denotes For instance, it has been shown that dendron-functionalized AuNPs showed a size-dependent antiviral activity for influenza virus, where 14 nm particles exhibited a higher efficiency than 2 nm AuNPs.
T184 3069-3245 Sentence denotes This has been associated with the low functionalization grade of the small nanoparticles and to the inappropriate spatial distribution of the interacting ligand/receptor pairs.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 1567-1575 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014

2_test

Id Subject Object Predicate Lexical cue
32667191-10966468-153296 1162-1164 10966468 denotes 41
32667191-26875938-153297 2075-2077 26875938 denotes 44
32667191-26875938-153298 2603-2605 26875938 denotes 44
32667191-21104827-153299 2723-2725 21104827 denotes 45