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PMC:7376974 / 22954-24301 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T111 261-268 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
326 457-463 Chemical denotes silver MESH:D012834
327 540-545 Chemical denotes AgNPs
328 852-856 Chemical denotes AgNP
329 1047-1051 Chemical denotes AgNP
330 678-690 Disease denotes cytotoxicity MESH:D064420
331 732-744 Disease denotes cytotoxicity MESH:D064420

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T226 106-107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T227 149-157 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T228 308-316 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T229 867-875 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T230 1285-1293 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T252 118-127 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T253 261-268 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T254 298-307 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T255 457-463 Chemical denotes silver http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141
T257 464-468 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T258 561-573 Chemical denotes disinfectant http://purl.obolibrary.org/obo/CHEBI_48219
T259 771-783 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803
T260 852-856 Chemical denotes AgNP http://purl.obolibrary.org/obo/CHEBI_50826
T261 857-866 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T262 927-938 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T263 1047-1051 Chemical denotes AgNP http://purl.obolibrary.org/obo/CHEBI_50826
T264 1134-1143 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T265 1275-1284 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 261-281 http://purl.obolibrary.org/obo/GO_0030164 denotes protein denaturation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T152 0-83 Sentence denotes Overall different studies have reported the capacity of AgNPs to block viral entry.
T153 84-282 Sentence denotes However, there is not a concerted antiviral mechanism, but their activity differs from case to case, based on viral particle adsorption, capsid structure alteration, or surface protein denaturation.
T154 283-513 Sentence denotes For AgNPs, the antiviral activity can be associated with different parameters including size, shape, surface charge, and functionalization but also to the topical release of silver ions able to disturb the viral cycle replication.
T155 514-691 Sentence denotes As described before, bare AgNPs can be used as disinfectant agents, however their use in biological media is limited by their low colloidal stability and potential cytotoxicity.
T156 692-876 Sentence denotes Surface functionalization can alleviate cytotoxicity, but it can also mask the nanoparticle surface, reducing their affinity for viral particles, thus reducing AgNP antiviral activity.
T157 877-1002 Sentence denotes For these reasons, AgNPs at the moment could find application mainly for surface disinfection and for topical administration.
T158 1003-1093 Sentence denotes Further studies are needed to prepare safer AgNP formulations for systemic administration.
T159 1094-1347 Sentence denotes In particular, the clarification of the antiviral mechanisms and the use of surface functional groups able to stabilize AgNPs in biological fluids without affecting their prominent antiviral activity are probably the most important challenges to tackle.