PMC:7376974 / 19423-20646 JSONTXT

Annnotations TAB JSON ListView MergeView

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T87","span":{"begin":135,"end":138},"obj":"Body_part"},{"id":"T88","span":{"begin":262,"end":269},"obj":"Body_part"},{"id":"T89","span":{"begin":301,"end":310},"obj":"Body_part"},{"id":"T90","span":{"begin":695,"end":709},"obj":"Body_part"},{"id":"T91","span":{"begin":731,"end":735},"obj":"Body_part"},{"id":"T92","span":{"begin":787,"end":801},"obj":"Body_part"},{"id":"T93","span":{"begin":950,"end":954},"obj":"Body_part"}],"attributes":[{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma61788"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"254","span":{"begin":203,"end":208},"obj":"Gene"},{"id":"255","span":{"begin":419,"end":432},"obj":"Gene"},{"id":"256","span":{"begin":1081,"end":1084},"obj":"Gene"},{"id":"257","span":{"begin":1089,"end":1092},"obj":"Gene"},{"id":"258","span":{"begin":135,"end":140},"obj":"Species"},{"id":"259","span":{"begin":338,"end":342},"obj":"Species"},{"id":"260","span":{"begin":343,"end":358},"obj":"Species"},{"id":"261","span":{"begin":856,"end":861},"obj":"Species"},{"id":"262","span":{"begin":961,"end":975},"obj":"Species"},{"id":"263","span":{"begin":977,"end":981},"obj":"Species"},{"id":"264","span":{"begin":1099,"end":1104},"obj":"Species"},{"id":"265","span":{"begin":215,"end":218},"obj":"Species"},{"id":"266","span":{"begin":672,"end":675},"obj":"Species"},{"id":"267","span":{"begin":766,"end":770},"obj":"Species"}],"attributes":[{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"Gene:3700"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"Gene:4758"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"Gene:207"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"Gene:7157"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"Tax:11676"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"Tax:114727"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"Tax:11308"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"Tax:10298"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"Tax:39054"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"Tax:39054"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"Tax:10310"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"Tax:12814"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:10244"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:11631"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T48","span":{"begin":338,"end":352},"obj":"Disease"},{"id":"T49","span":{"begin":343,"end":352},"obj":"Disease"}],"attributes":[{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005460"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T183","span":{"begin":76,"end":81},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T184","span":{"begin":211,"end":213},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T185","span":{"begin":274,"end":277},"obj":"http://purl.obolibrary.org/obo/CLO_0001360"},{"id":"T186","span":{"begin":318,"end":323},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T187","span":{"begin":353,"end":358},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T188","span":{"begin":407,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T189","span":{"begin":453,"end":455},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T190","span":{"begin":470,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T191","span":{"begin":486,"end":488},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T192","span":{"begin":720,"end":725},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T193","span":{"begin":731,"end":735},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T194","span":{"begin":762,"end":764},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T195","span":{"begin":819,"end":824},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T196","span":{"begin":937,"end":942},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T197","span":{"begin":950,"end":954},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T198","span":{"begin":973,"end":975},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T199","span":{"begin":1067,"end":1077},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T200","span":{"begin":1177,"end":1182},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T194","span":{"begin":69,"end":75},"obj":"Chemical"},{"id":"T195","span":{"begin":165,"end":171},"obj":"Chemical"},{"id":"T197","span":{"begin":173,"end":176},"obj":"Chemical"},{"id":"T199","span":{"begin":234,"end":237},"obj":"Chemical"},{"id":"T201","span":{"begin":262,"end":269},"obj":"Chemical"},{"id":"T202","span":{"begin":271,"end":273},"obj":"Chemical"},{"id":"T203","span":{"begin":303,"end":310},"obj":"Chemical"},{"id":"T204","span":{"begin":376,"end":387},"obj":"Chemical"},{"id":"T205","span":{"begin":457,"end":467},"obj":"Chemical"},{"id":"T206","span":{"begin":520,"end":543},"obj":"Chemical"},{"id":"T207","span":{"begin":529,"end":535},"obj":"Chemical"},{"id":"T208","span":{"begin":545,"end":548},"obj":"Chemical"},{"id":"T209","span":{"begin":695,"end":709},"obj":"Chemical"},{"id":"T210","span":{"begin":787,"end":801},"obj":"Chemical"},{"id":"T211","span":{"begin":1000,"end":1003},"obj":"Chemical"},{"id":"T213","span":{"begin":1008,"end":1017},"obj":"Chemical"},{"id":"T214","span":{"begin":1059,"end":1062},"obj":"Chemical"},{"id":"T215","span":{"begin":1129,"end":1140},"obj":"Chemical"},{"id":"T216","span":{"begin":1136,"end":1140},"obj":"Chemical"}],"attributes":[{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_5133"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A196","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A197","pred":"chebi_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/CHEBI_53245"},{"id":"A198","pred":"chebi_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/CHEBI_53248"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_53245"},{"id":"A200","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_53248"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_73818"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_7798"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_2618"},{"id":"A206","pred":"chebi_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A211","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_144613"},{"id":"A212","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_53231"},{"id":"A213","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A215","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_75211"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T124","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"T125","span":{"begin":76,"end":134},"obj":"Sentence"},{"id":"T126","span":{"begin":135,"end":214},"obj":"Sentence"},{"id":"T127","span":{"begin":215,"end":337},"obj":"Sentence"},{"id":"T128","span":{"begin":338,"end":456},"obj":"Sentence"},{"id":"T129","span":{"begin":457,"end":473},"obj":"Sentence"},{"id":"T130","span":{"begin":474,"end":489},"obj":"Sentence"},{"id":"T131","span":{"begin":490,"end":555},"obj":"Sentence"},{"id":"T132","span":{"begin":556,"end":671},"obj":"Sentence"},{"id":"T133","span":{"begin":672,"end":765},"obj":"Sentence"},{"id":"T134","span":{"begin":766,"end":855},"obj":"Sentence"},{"id":"T135","span":{"begin":856,"end":960},"obj":"Sentence"},{"id":"T136","span":{"begin":961,"end":1098},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}

    2_test

    {"project":"2_test","denotations":[{"id":"32667191-27588566-153285","span":{"begin":453,"end":455},"obj":"27588566"},{"id":"32667191-31582052-153286","span":{"begin":668,"end":670},"obj":"31582052"},{"id":"32667191-25117537-153287","span":{"begin":1220,"end":1222},"obj":"25117537"}],"text":"Table 2 Surface-Modified Antiviral AgNPs and Possible Mechanisms of Action\nvirus shape size (nm) coating mechanism of action ref\nHIV-1 spherical 1–10 foamy carbon, PVP and BSA interaction with gp120 (11)\nRSV spherical – PVP, BSA, and recombinant F protein (RF 412) interaction with the G-protein on the virus surface (26)\nH1N1 influenza virus spherical 2–5 Oseltamivir inhibition of the activity of neuraminidase and hemagglutinin (34)\nAmantadine (35)\nZanamivir (36)\ninhibition of accumulation of reactive oxygen species (ROS)    \nHAV, NoV and CoxB4 spherical – polyphosphonium-oligochitosans preventing viral attachment and penetration (29)\nMPV spherical 10–80 polysaccharide blocking virus-host cell binding and penetration (22)\nTCRV spherical 10 polysaccharide inactivation of virus particles prior to entry (23)\nHSV-1 spherical 4 mercaptoethanesulfonate competition for the binding of the virus to the cell (30)\nEnterovirus 71 (EV71) spherical 2–5 PEI and antiviral siRNA inhibition of the accumulation of ROS and activation of AKT and p53 (37)\nHSV-2 spherical 13, 33, 46 tannic acid direct interaction and blocking of virus attachment, penetration and spread (28)"}