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PMC:7376845 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 434-438 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T2 543-555 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T3 559-566 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 737-744 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5 799-806 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 972-979 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 1008-1015 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T8 1053-1058 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 1070-1075 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T10 1110-1117 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T11 1233-1240 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T12 1307-1314 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 1489-1496 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 1520-1524 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T15 1584-1591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 1615-1620 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 2780-2792 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T18 2796-2803 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 2852-2856 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 2888-2895 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 3037-3042 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 3356-3363 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T23 3832-3836 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T24 3847-3857 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T25 4033-4039 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T26 4430-4437 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 4580-4587 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 4903-4906 Body_part denotes Lip http://purl.org/sig/ont/fma/fma59816
T29 4963-4970 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 5034-5045 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T31 5139-5146 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T32 5404-5411 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 5449-5453 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T34 5530-5537 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 5561-5566 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 5582-5589 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 5697-5702 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T38 5721-5726 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39 5960-5965 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T40 6093-6098 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T41 6305-6310 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T42 6377-6385 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T43 6475-6479 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T44 6514-6521 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T45 6807-6814 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 6896-6903 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 6931-6938 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 6997-7001 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T49 7152-7159 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 7209-7216 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 7528-7533 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T52 7623-7626 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T53 7749-7754 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T54 7859-7864 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T55 7975-7982 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 8029-8033 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 8077-8081 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T58 8164-8168 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 8374-8378 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T60 8638-8646 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T61 8982-8987 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T62 9229-9234 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T63 9299-9304 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T64 9431-9434 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T65 9435-9443 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T66 9805-9809 Body_part denotes lens http://purl.org/sig/ont/fma/fma58241
T67 9987-9994 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T68 10163-10170 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 10384-10389 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T70 10627-10630 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T71 11215-11223 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T72 11470-11474 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T73 11679-11684 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74 11751-11758 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 11924-11932 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T76 12180-12187 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 12433-12441 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T78 12584-12587 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T79 13189-13194 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T80 13410-13415 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T81 13465-13470 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T82 13502-13507 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T83 13633-13638 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T84 13748-13751 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T85 13752-13760 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T86 13843-13848 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T87 13981-13988 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 14601-14611 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T89 14704-14711 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90 14789-14796 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T91 14816-14826 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T92 14891-14898 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T93 15326-15333 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 15377-15384 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T95 15389-15399 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T96 16111-16121 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T97 16227-16234 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T98 16475-16487 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T99 16886-16897 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T100 16987-16995 Body_part denotes glycines http://purl.org/sig/ont/fma/fma82753
T101 17004-17013 Body_part denotes cysteines http://purl.org/sig/ont/fma/fma82751
T102 17047-17055 Body_part denotes prolines http://purl.org/sig/ont/fma/fma82761
T103 17094-17104 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T104 17182-17194 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T105 17231-17239 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T106 17278-17290 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T107 17317-17327 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T108 17441-17443 Body_part denotes V2 http://purl.org/sig/ont/fma/fma13443|http://purl.org/sig/ont/fma/fma68615
T110 17867-17874 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 18482-18492 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T112 18774-18784 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T113 18836-18840 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T114 18918-18926 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T115 19000-19010 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T116 19052-19060 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T117 19124-19131 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T118 19175-19185 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T119 19368-19375 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T120 19643-19650 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T121 19674-19679 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T122 19968-19973 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T123 19981-19986 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 20074-20079 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T125 20122-20129 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T126 20224-20231 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T127 20388-20395 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T128 20481-20486 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T129 20545-20555 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T130 20696-20703 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T131 20711-20718 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T132 20841-20849 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T133 20932-20936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T134 21006-21011 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T135 21047-21054 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T136 21328-21336 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T137 21500-21508 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T138 21525-21533 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T139 21626-21631 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T140 21728-21735 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 21841-21849 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T142 21869-21873 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T143 21999-22006 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T144 22045-22052 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T145 22104-22109 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 22234-22241 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 22279-22289 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T148 22322-22329 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T149 22362-22369 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 22403-22410 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T151 22438-22443 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T152 22459-22466 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T153 22551-22559 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T154 22645-22652 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T155 22660-22667 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T156 22790-22798 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T157 22876-22880 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T158 22950-22955 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T159 22992-22999 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T160 23194-23202 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T161 23382-23389 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T162 23471-23478 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 23607-23615 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T164 23790-23798 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T165 23815-23823 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T166 23951-23956 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T167 23974-23979 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T168 24016-24023 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 24133-24141 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T170 24151-24155 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T171 24272-24279 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 24402-24409 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T173 24545-24552 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 24685-24692 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T175 24756-24764 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T176 24788-24795 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 24850-24855 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 24925-24932 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T179 25164-25171 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T180 25240-25248 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T181 25283-25291 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T182 25305-25312 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 25362-25369 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T184 25482-25489 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T185 25552-25559 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 25636-25644 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T187 25672-25679 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 25735-25740 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 25803-25811 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T190 26065-26072 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T191 26162-26169 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T192 26437-26445 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T193 26468-26475 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T194 26534-26539 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T195 26656-26661 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T196 26747-26755 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T197 26893-26898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T198 26984-26989 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T199 27083-27090 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T200 27149-27156 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T201 27290-27297 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T202 27680-27687 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T203 28322-28329 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 28406-28413 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T205 28594-28601 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T206 28705-28710 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T207 28804-28811 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T208 29006-29028 Body_part denotes cytotoxic T-lymphocyte http://purl.org/sig/ont/fma/fma70573
T209 29016-29028 Body_part denotes T-lymphocyte http://purl.org/sig/ont/fma/fma62870
T210 29030-29033 Body_part denotes CTL http://purl.org/sig/ont/fma/fma70573
T211 29158-29161 Body_part denotes CTL http://purl.org/sig/ont/fma/fma70573
T212 29317-29321 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T213 29669-29676 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3832-3836 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T2 5960-5965 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T3 8374-8378 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T4 10384-10389 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T5 21919-21924 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T6 24201-24206 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 44-49 Gene denotes spike Gene:43740568
3 53-61 Species denotes SARS-CoV Tax:694009
17 473-504 Gene denotes angiotensin-converting enzyme 2 Gene:59272
18 506-510 Gene denotes ACE2 Gene:59272
19 557-566 Gene denotes S protein
20 590-594 Gene denotes ACE2 Gene:59272
21 133-150 Species denotes novel coronavirus Tax:2697049
22 152-162 Species denotes SARS-CoV-2 Tax:2697049
23 244-249 Species denotes human Tax:9606
24 290-298 Species denotes SARS-CoV Tax:694009
25 451-461 Species denotes SARS-CoV-2 Tax:2697049
26 526-534 Species denotes SARS-CoV Tax:694009
27 616-626 Species denotes SARS-CoV-2 Tax:2697049
28 208-216 Disease denotes COVID-19 MESH:C000657245
29 250-260 Disease denotes infections MESH:D007239
33 735-736 Gene denotes S Gene:43740568
34 748-756 Species denotes SARS-CoV Tax:694009
35 659-669 Species denotes SARS-CoV-2 Tax:2697049
45 1231-1240 Gene denotes S protein
46 786-796 Species denotes SARS-CoV-2 Tax:2697049
47 840-848 Species denotes SARS-CoV Tax:694009
48 908-921 Species denotes coronaviruses Tax:11118
49 959-967 Species denotes SARS-CoV Tax:694009
50 988-998 Species denotes SARS-CoV-2 Tax:2697049
51 852-884 Disease denotes Middle East respiratory syndrome MESH:D018352
52 886-890 Disease denotes MERS MESH:D018352
53 1033-1052 Disease denotes SARS-CoV-2 infected MESH:C000657245
63 1294-1302 Species denotes SARS-CoV Tax:694009
64 1338-1348 Species denotes SARS-CoV-2 Tax:2697049
65 1369-1374 Species denotes human Tax:9606
66 1387-1400 Species denotes coronaviruses Tax:11118
67 1407-1413 Species denotes murine Tax:10090
68 1476-1486 Species denotes SARS-CoV-2 Tax:2697049
69 1510-1519 Species denotes mammalian Tax:9606
70 1360-1364 Disease denotes MERS MESH:D018352
71 1600-1614 Disease denotes CoV-2-infected MESH:C000657245
74 1739-1749 Species denotes SARS-CoV-2 Tax:2697049
75 1808-1816 Disease denotes COVID-19 MESH:C000657245
87 1836-1881 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
88 1883-1891 Species denotes SARS-CoV Tax:694009
89 2071-2088 Species denotes novel coronavirus Tax:2697049
90 2090-2100 Species denotes SARS-CoV-2 Tax:2697049
91 2200-2206 Species denotes humans Tax:9606
92 2447-2457 Species denotes SARS-CoV-2 Tax:2697049
93 1925-1933 Disease denotes zoonotic MESH:D015047
94 1976-1994 Disease denotes infectious disease MESH:D003141
95 2116-2135 Disease denotes coronavirus disease MESH:D018352
96 2137-2145 Disease denotes COVID-19 MESH:C000657245
97 2539-2547 Disease denotes COVID-19 MESH:C000657245
100 2648-2658 Species denotes SARS-CoV-2 Tax:2697049
101 2705-2714 Disease denotes infection MESH:D007239
117 3180-3188 Species denotes SARS-CoV Tax:694009
118 3217-3230 Species denotes coronaviruses Tax:11118
119 3235-3239 Species denotes CoVs Tax:11118
120 3242-3252 Species denotes SARS-CoV-2 Tax:2697049
121 3281-3296 Species denotes betacoronavirus Tax:694002
122 3345-3355 Species denotes SARS-CoV-2 Tax:2697049
123 3387-3395 Species denotes patients Tax:9606
124 3508-3513 Species denotes human Tax:9606
125 3561-3571 Species denotes SARS-CoV-2 Tax:2697049
126 3586-3594 Species denotes SARS-CoV Tax:694009
127 3636-3640 Species denotes CoVs Tax:11118
128 3690-3694 Species denotes CoVs Tax:11118
129 3748-3756 Species denotes SARS-CoV Tax:694009
130 3378-3386 Disease denotes COVID-19 MESH:C000657245
131 3953-3968 Disease denotes virus infection MESH:D001102
140 4311-4342 Gene denotes angiotensin-converting enzyme 2 Gene:59272
141 4344-4348 Gene denotes ACE2 Gene:59272
142 4002-4012 Species denotes SARS-CoV-2 Tax:2697049
143 4117-4125 Species denotes SARS-CoV Tax:694009
144 4149-4159 Species denotes SARS-CoV-2 Tax:2697049
145 4179-4187 Species denotes SARS-CoV Tax:694009
146 4267-4277 Species denotes SARS-CoV-2 Tax:2697049
147 4354-4362 Species denotes SARS-CoV Tax:694009
162 4567-4575 Species denotes SARS-CoV Tax:694009
163 4600-4607 Species denotes rabbits Tax:9986
164 4680-4688 Species denotes SARS-CoV Tax:694009
165 4746-4754 Species denotes SARS-CoV Tax:694009
166 4822-4828 Species denotes murine Tax:10090
167 5150-5155 Species denotes human Tax:9606
168 5156-5164 Species denotes SARS-CoV Tax:694009
169 5174-5182 Species denotes SARS-CoV Tax:694009
170 5194-5197 Species denotes CoV Tax:11118
171 5358-5371 Species denotes coronaviruses Tax:11118
172 5415-5425 Species denotes SARS-CoV-2 Tax:2697049
173 5439-5448 Species denotes mammalian Tax:9606
174 5675-5685 Species denotes SARS-CoV-2 Tax:2697049
175 5546-5560 Disease denotes CoV-2 infected MESH:C000657245
186 5830-5864 Chemical denotes Dulbecco’s Modified Eagle’s Medium
187 5866-5870 Chemical denotes DMEM
188 6021-6031 Chemical denotes penicillin MESH:D010406
189 6046-6058 Chemical denotes streptomycin MESH:D013307
190 6173-6177 Chemical denotes DMEM
191 6218-6228 Chemical denotes penicillin MESH:D010406
192 6240-6252 Chemical denotes streptomycin MESH:D013307
193 6344-6347 Chemical denotes CO2 MESH:D002245
194 5715-5720 CellLine denotes COS-7 CVCL:0224
195 6087-6092 CellLine denotes 293FT CVCL:6911
200 6649-6672 Chemical denotes sodium dodecyl sulphate MESH:D012967
201 6673-6687 Chemical denotes polyacrylamide MESH:C016679
202 6709-6712 Chemical denotes SDS MESH:D012967
203 6792-6806 Disease denotes Coomassie Plus MESH:D007625
205 6890-6895 Gene denotes spike Gene:43740568
216 7196-7199 Gene denotes Myc Gene:4609
217 7207-7216 Gene denotes S-protein Gene:43740568
218 7293-7296 Gene denotes Myc Gene:4609
219 7390-7393 Gene denotes Myc Gene:4609
220 7361-7364 Gene denotes Myc Gene:4609
221 6929-6938 Gene denotes S-protein Gene:43740568
222 6918-6928 Species denotes SARS-CoV-2 Tax:2697049
223 7260-7270 Species denotes SARS-CoV-2 Tax:2697049
224 7433-7438 Chemical denotes HBcAg
225 7401-7410 Disease denotes hepatitis MESH:D056486
237 8300-8303 Gene denotes Rad Gene:6236
238 8876-8879 Gene denotes Rad Gene:6236
239 8588-8599 Species denotes horseradish Tax:3704
240 7820-7845 Chemical denotes phosphate buffered saline
241 7847-7850 Chemical denotes PBS
242 7890-7914 Chemical denotes 2× Laemmli sample buffer
243 8236-8239 Chemical denotes SDS MESH:D012967
244 8382-8402 Chemical denotes Tris-buffered saline
245 8414-8422 Chemical denotes Tween 20 MESH:D011136
246 8424-8428 Chemical denotes TBST
247 7522-7527 CellLine denotes 293FT CVCL:6911
256 9361-9367 Species denotes murine Tax:10090
257 9080-9096 Chemical denotes paraformaldehyde MESH:C003043
258 9153-9165 Chemical denotes Triton X-100 MESH:D017830
259 9258-9261 Chemical denotes PBS
260 9388-9403 Chemical denotes Alexa Fluor 488
261 9545-9574 Chemical denotes 4′,6-diamidino-2-phenylindole MESH:C007293
262 9576-9580 Chemical denotes DAPI MESH:C007293
263 8976-8981 CellLine denotes COS-7 CVCL:0224
270 10384-10397 Gene denotes serum albumin Gene:11657
271 9974-9984 Species denotes SARS-CoV-2 Tax:2697049
272 10427-10433 Species denotes murine Tax:10090
273 10812-10842 Chemical denotes 3,3',5,5'-tetramethylbenzidine MESH:C021758
274 10844-10847 Chemical denotes TMB MESH:C021758
275 10958-10972 Chemical denotes sulphuric acid MESH:C033158
279 11235-11240 Species denotes human Tax:9606
280 11245-11251 Chemical denotes CR3022
281 11675-11684 CellLine denotes 293 cells CVCL:0045
289 12167-12177 Species denotes SARS-CoV-2 Tax:2697049
290 12257-12261 Species denotes H7N7 Tax:119218
291 12578-12583 Species denotes human Tax:9606
292 11888-11894 Chemical denotes NaHCO3 MESH:D017693
293 11902-11908 Chemical denotes Na2CO3
294 12680-12683 Chemical denotes TMB MESH:C021758
295 12756-12770 Chemical denotes sulphuric acid MESH:C033158
297 13023-13038 Disease denotes Virus infection MESH:D001102
314 13214-13224 Species denotes SARS-CoV-2 Tax:2697049
315 13226-13236 Species denotes SARS-CoV-2 Tax:2697049
316 13244-13249 Species denotes human Tax:9606
317 13343-13347 Chemical denotes DMEM
318 13440-13448 Chemical denotes methanol MESH:D000432
319 13449-13456 Chemical denotes acetone MESH:D000096
320 13595-13606 Chemical denotes Triton ×100 MESH:D017830
321 13615-13618 Chemical denotes PBS
322 13668-13671 Chemical denotes PBS
323 13705-13720 Chemical denotes Alexa Fluor 488
324 13812-13816 Chemical denotes DAPI MESH:C007293
325 13878-13881 Chemical denotes PBS
326 13200-13208 Disease denotes infected MESH:D007239
327 13317-13326 Disease denotes infection MESH:D007239
328 13399-13408 Disease denotes infection MESH:D007239
329 13181-13188 CellLine denotes Vero-E6 CVCL:0574
341 14013-14021 Species denotes SARS-CoV Tax:694009
342 14025-14035 Species denotes SARS-CoV-2 Tax:2697049
343 14092-14097 Species denotes human Tax:9606
344 14110-14123 Species denotes coronaviruses Tax:11118
345 14455-14463 Species denotes SARS-CoV Tax:694009
346 14124-14128 Species denotes 229E Tax:11137
347 14130-14134 Species denotes NL63 Tax:277944
348 14136-14140 Species denotes OC43 Tax:31631
349 14145-14149 Species denotes HKU1 Tax:290028
350 14048-14080 Disease denotes Middle East respiratory syndrome MESH:D018352
351 14082-14086 Disease denotes MERS MESH:D018352
354 14852-14862 Species denotes SARS-CoV-2 Tax:2697049
355 14932-14937 Species denotes human Tax:9606
360 15611-15619 Species denotes SARS-CoV Tax:694009
361 15645-15655 Species denotes SARS-CoV-2 Tax:2697049
362 15667-15671 Disease denotes MERS MESH:D018352
363 15676-15692 Disease denotes common cold HCoV MESH:D003139
378 15874-15882 Species denotes SARS-CoV Tax:694009
379 15889-15899 Species denotes SARS-CoV-2 Tax:2697049
380 16012-16017 Species denotes human Tax:9606
381 16030-16043 Species denotes coronaviruses Tax:11118
382 16139-16149 Species denotes SARS-CoV-2 Tax:2697049
383 16154-16162 Species denotes SARS-CoV Tax:694009
384 16347-16360 Species denotes coronaviruses Tax:11118
385 16371-16377 Species denotes humans Tax:9606
386 16044-16048 Species denotes 229E Tax:11137
387 16050-16054 Species denotes NL63 Tax:277944
388 16056-16060 Species denotes OC43 Tax:31631
389 16065-16069 Species denotes HKU1 Tax:290028
390 16003-16007 Disease denotes MERS MESH:D018352
391 16328-16332 Disease denotes MERS MESH:D018352
393 16458-16466 Species denotes SARS-CoV Tax:694009
399 16593-16604 Species denotes coronavirus Tax:11118
400 16608-16618 Species denotes SARS-CoV-2 Tax:2697049
401 16645-16658 Species denotes coronavirus 2 Tax:2697049
402 16522-16526 Disease denotes MERS MESH:D018352
403 16528-16560 Disease denotes Middle East respiratory syndrome MESH:D018352
406 16987-16995 Chemical denotes glycines MESH:D005998
407 17004-17013 Chemical denotes cysteines MESH:D003545
430 17861-17866 Gene denotes spike Gene:43740568
431 17424-17429 Gene denotes spike Gene:43740568
432 17341-17351 Species denotes SARS-CoV-2 Tax:2697049
433 17364-17372 Species denotes SARS-CoV Tax:694009
434 17433-17443 Species denotes SARS-Co-V2 Tax:2697049
435 17875-17885 Species denotes SARS-CoV-2 Tax:2697049
436 17971-17979 Species denotes SARS-CoV Tax:694009
437 17382-17386 Species denotes OC43 Tax:31631
438 17388-17392 Species denotes HKU1 Tax:290028
439 17394-17398 Species denotes 229E Tax:11137
440 17400-17404 Species denotes NL63 Tax:277944
441 17626-17630 Species denotes OC43 Tax:31631
442 17679-17683 Species denotes HKU1 Tax:290028
443 17735-17739 Species denotes 229E Tax:11137
444 17794-17798 Species denotes NL63 Tax:277944
445 18074-18078 Species denotes OC43 Tax:31631
446 18127-18131 Species denotes HKU1 Tax:290028
447 18183-18187 Species denotes 229E Tax:11137
448 18242-18246 Species denotes NL63 Tax:277944
449 17376-17380 Disease denotes MERS MESH:D018352
450 17576-17580 Disease denotes MERS MESH:D018352
451 18024-18028 Disease denotes MERS MESH:D018352
454 17272-17277 Gene denotes spike Gene:43740568
455 17130-17143 Species denotes coronaviruses Tax:11118
462 18344-18352 Species denotes SARS-CoV Tax:694009
463 18381-18392 Species denotes coronavirus Tax:11118
464 18394-18404 Species denotes SARS-CoV-2 Tax:2697049
465 18431-18442 Species denotes coronavirus Tax:11118
466 18304-18308 Disease denotes MERS MESH:D018352
467 18310-18342 Disease denotes Middle East respiratory syndrome MESH:D018352
470 18916-18917 Gene denotes S Gene:43740568
471 18905-18915 Species denotes SARS-CoV-2 Tax:2697049
474 19362-19367 Gene denotes spike Gene:43740568
475 19307-19313 Species denotes murine Tax:10090
486 19434-19442 Species denotes SARS-CoV Tax:694009
487 19571-19581 Species denotes SARS-CoV-2 Tax:2697049
488 19630-19640 Species denotes SARS-CoV-2 Tax:2697049
489 19853-19863 Species denotes SARS-CoV-2 Tax:2697049
490 20142-20152 Species denotes SARS-CoV-2 Tax:2697049
491 20211-20221 Species denotes SARS-COV-2 Tax:2697049
492 19668-19673 CellLine denotes 293FT CVCL:6911
493 19962-19967 CellLine denotes 293FT CVCL:6911
494 19975-19980 CellLine denotes COS-7 CVCL:0224
495 20068-20073 CellLine denotes COS-7 CVCL:0224
497 20375-20385 Species denotes SARS-CoV-2 Tax:2697049
505 20731-20734 Gene denotes Myc Gene:4609
506 20705-20710 Gene denotes spike Gene:43740568
507 20633-20643 Species denotes SARS-CoV-2 Tax:2697049
508 20645-20692 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
509 20596-20600 Chemical denotes DAPI MESH:C007293
510 20602-20631 Chemical denotes 4′,6-diamidino-2-phenylindole MESH:C007293
511 20564-20573 Disease denotes hepatitis MESH:D056486
522 20870-20873 Gene denotes Myc Gene:17869
523 20875-20883 Gene denotes 2B2, 1A9 Gene:628883
524 21023-21026 Gene denotes Myc Gene:4609
525 21104-21107 Gene denotes Myc Gene:4609
526 21161-21162 Gene denotes S Gene:43740568
527 21034-21044 Species denotes SARS-CoV-2 Tax:2697049
528 21079-21089 Species denotes SARS-CoV-2 Tax:2697049
529 21214-21225 Species denotes horseradish Tax:3704
530 20926-20931 CellLine denotes 293FT CVCL:6911
531 21000-21005 CellLine denotes 293FT CVCL:6911
540 21554-21557 Gene denotes Myc Gene:4609
541 21559-21567 Gene denotes 2B2, 1A9 Gene:628883
542 21643-21646 Gene denotes Myc Gene:4609
543 21678-21681 Gene denotes Myc Gene:4609
544 21715-21725 Species denotes SARS-CoV-2 Tax:2697049
545 21804-21819 Chemical denotes Alexa Fluor 488
546 21906-21910 Chemical denotes DAPI MESH:C007293
547 21621-21625 CellLine denotes COS7 CVCL:0224
549 21944-21950 Species denotes murine Tax:10090
556 22043-22044 Gene denotes S Gene:43740568
557 22232-22233 Gene denotes S Gene:43740568
558 22056-22066 Species denotes SARS-CoV-2 Tax:2697049
559 22245-22255 Species denotes SARS-CoV-2 Tax:2697049
560 22088-22093 CellLine denotes 293FT CVCL:6911
561 22098-22103 CellLine denotes COS-7 CVCL:0224
563 22309-22319 Species denotes SARS-CoV-2 Tax:2697049
570 22680-22683 Gene denotes Myc Gene:4609
571 22654-22659 Gene denotes spike Gene:43740568
572 22582-22592 Species denotes SARS-CoV-2 Tax:2697049
573 22594-22641 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
574 22498-22502 Chemical denotes DAPI MESH:C007293
575 22504-22533 Chemical denotes 4′,6-diamidino-2-phenylindole MESH:C007293
583 22819-22827 Gene denotes 2B2, 1A9 Gene:628883
584 23038-23039 Gene denotes S Gene:43740568
585 22979-22989 Species denotes SARS-CoV-2 Tax:2697049
586 23027-23037 Species denotes SARS-CoV-2 Tax:2697049
587 23080-23091 Species denotes horseradish Tax:3704
588 22870-22875 CellLine denotes 293FT CVCL:6911
589 22944-22949 CellLine denotes 293FT CVCL:6911
593 23312-23320 Gene denotes 2B2, 1A9 Gene:628883
594 23369-23379 Species denotes SARS-CoV-2 Tax:2697049
595 23458-23468 Species denotes SARS-CoV-2 Tax:2697049
602 23844-23847 Gene denotes Myc Gene:4609
603 23849-23857 Gene denotes 2B2, 1A9 Gene:628883
604 24003-24013 Species denotes SARS-CoV-2 Tax:2697049
605 24096-24111 Chemical denotes Alexa Fluor 488
606 24188-24192 Chemical denotes DAPI MESH:C007293
607 23945-23950 CellLine denotes COS-7 CVCL:0224
610 24543-24544 Gene denotes S Gene:43740568
611 24556-24566 Species denotes SARS-CoV-2 Tax:2697049
614 24786-24795 Gene denotes S protein
615 24830-24849 Disease denotes SARS-CoV-2 infected MESH:C000657245
621 25054-25059 Species denotes human Tax:9606
622 25115-25125 Species denotes SARS-CoV-2 Tax:2697049
623 25373-25390 Species denotes influenza A virus Tax:11320
624 25064-25070 Chemical denotes CR3022
625 25253-25259 Chemical denotes CR3022
627 25715-25734 Disease denotes SARS-CoV-2 infected MESH:C000657245
634 25761-25765 Species denotes H7N7 Tax:119218
635 25866-25876 Species denotes SARS-CoV-2 Tax:2697049
636 25878-25925 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
637 25767-25776 Species denotes influenza Tax:11320
638 25780-25784 Species denotes H7N7 Tax:119218
639 25834-25843 Disease denotes infection MESH:D007239
648 25997-26002 Species denotes human Tax:9606
649 26048-26058 Species denotes SARS-CoV-2 Tax:2697049
650 26186-26190 Species denotes H7N7 Tax:119218
651 26455-26465 Species denotes SARS-CoV-2 Tax:2697049
652 26501-26505 Species denotes H7N7 Tax:119218
653 26173-26182 Species denotes influenza Tax:11320
654 26488-26497 Species denotes influenza Tax:11320
655 26007-26013 Chemical denotes CR3022
663 26589-26599 Species denotes SARS-CoV-2 Tax:2697049
664 26710-26725 Chemical denotes Alexa Fluor 488
665 26797-26826 Chemical denotes 4′,6-diamidino-2-phenylindole MESH:C007293
666 26828-26832 Chemical denotes DAPI MESH:C007293
667 26550-26558 Disease denotes infected MESH:D007239
668 26575-26583 Disease denotes infected MESH:D007239
669 26641-26650 Disease denotes infection MESH:D007239
675 26870-26884 Disease denotes CoV-2-infected MESH:C000657245
676 26964-26983 Disease denotes SARS-CoV-2-infected MESH:C000657245
677 27007-27016 Disease denotes infection MESH:D007239
678 27098-27107 Disease denotes infection MESH:D007239
679 26885-26892 CellLine denotes Vero-E6 CVCL:0574
686 27160-27168 Species denotes SARS-CoV Tax:694009
687 27301-27311 Species denotes SARS-CoV-2 Tax:2697049
688 27442-27450 Species denotes SARS-CoV Tax:694009
689 27509-27519 Species denotes SARS-CoV-2 Tax:2697049
690 27628-27636 Species denotes SARS-CoV Tax:694009
691 27691-27701 Species denotes SARS-CoV-2 Tax:2697049
711 27891-27895 Gene denotes ACE2 Gene:59272
712 28200-28204 Gene denotes ACE2 Gene:59272
713 27768-27776 Species denotes SARS-CoV Tax:694009
714 27861-27869 Species denotes SARS-CoV Tax:694009
715 27876-27886 Species denotes SARS-CoV-2 Tax:2697049
716 27942-27950 Species denotes SARS-CoV Tax:694009
717 27996-28006 Species denotes SARS-CoV-2 Tax:2697049
718 28087-28094 Species denotes patient Tax:9606
719 28128-28138 Species denotes SARS-CoV-2 Tax:2697049
720 28333-28343 Species denotes SARS-CoV-2 Tax:2697049
721 28901-28911 Species denotes SARS-CoV-2 Tax:2697049
722 29115-29123 Species denotes SARS-CoV Tax:694009
723 29348-29356 Species denotes SARS-CoV Tax:694009
724 29363-29373 Species denotes SARS-CoV-2 Tax:2697049
725 28035-28041 Chemical denotes CR3022
726 28685-28704 Disease denotes SARS-CoV-2-infected MESH:C000657245
727 28728-28737 Disease denotes infection MESH:D007239
728 28819-28828 Disease denotes infection MESH:D007239
729 28974-28982 Disease denotes COVID-19 MESH:C000657245
737 29462-29470 Species denotes SARS-CoV Tax:694009
738 29494-29504 Species denotes SARS-CoV-2 Tax:2697049
739 29656-29666 Species denotes SARS-CoV-2 Tax:2697049
740 30287-30295 Species denotes SARS-CoV Tax:694009
741 30387-30397 Species denotes SARS-CoV-2 Tax:2697049
742 29752-29773 Disease denotes SARS-CoV-2 infections MESH:C000657245
743 29900-29921 Disease denotes SARS-CoV-2 infections MESH:C000657245
745 30815-30827 Gene denotes 4B12 and 2B2
747 31209-31210 Gene denotes S Gene:43740568

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 53-61 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 53-57 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T3 99-107 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 99-103 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 152-160 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 152-156 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 208-216 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 250-260 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T9 290-298 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 290-294 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T11 356-389 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T12 391-395 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T13 451-459 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 451-455 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T15 526-534 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 526-530 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T17 616-624 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 616-620 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 659-667 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 659-663 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T21 748-756 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 748-752 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 786-794 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 786-790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T25 840-848 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 840-844 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T27 896-907 Disease denotes common-cold http://purl.obolibrary.org/obo/MONDO_0005709
T28 959-967 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 959-963 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T30 988-996 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 988-992 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T32 1033-1041 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 1033-1037 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T34 1294-1302 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 1294-1298 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T36 1338-1346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 1338-1342 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T38 1375-1386 Disease denotes common-cold http://purl.obolibrary.org/obo/MONDO_0005709
T39 1476-1484 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 1476-1480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T41 1595-1603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 1595-1599 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T43 1739-1747 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 1739-1743 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T45 1808-1816 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T46 1836-1869 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T47 1883-1891 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 1883-1887 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T49 1976-1994 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T50 1996-2000 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 2090-2098 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 2090-2094 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 2137-2145 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 2447-2455 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 2447-2451 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T56 2539-2547 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 2648-2656 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 2648-2652 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 2705-2714 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 3180-3188 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 3180-3184 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T62 3207-3211 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T63 3242-3250 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 3242-3246 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T65 3345-3353 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 3345-3349 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 3378-3386 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T68 3561-3569 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 3561-3565 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T70 3586-3594 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 3586-3590 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T72 3748-3756 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 3748-3752 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T74 3953-3968 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T75 3959-3968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 4002-4010 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 4002-4006 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 4117-4125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 4117-4121 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T80 4149-4157 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 4149-4153 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T82 4179-4187 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 4179-4183 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T84 4267-4275 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 4267-4271 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T86 4354-4362 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 4354-4358 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T88 4567-4575 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 4567-4571 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T90 4680-4688 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 4680-4684 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T92 4746-4754 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 4746-4750 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T94 5156-5164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 5156-5160 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T96 5174-5182 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 5174-5178 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T98 5415-5423 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 5415-5419 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T100 5541-5549 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 5541-5545 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T102 5675-5683 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 5675-5679 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T104 6918-6926 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 6918-6922 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 7260-7268 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 7260-7264 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 7401-7412 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T109 7401-7410 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T110 9974-9982 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 9974-9978 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 11396-11398 Disease denotes VL http://purl.obolibrary.org/obo/MONDO_0024555
T113 12167-12175 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T114 12167-12171 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T115 13023-13038 Disease denotes Virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T116 13029-13038 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T117 13214-13222 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 13214-13218 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 13226-13234 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 13226-13230 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T121 13317-13326 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T122 13399-13408 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T123 14013-14021 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 14013-14017 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T125 14025-14033 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T126 14025-14029 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T127 14098-14109 Disease denotes common-cold http://purl.obolibrary.org/obo/MONDO_0005709
T128 14455-14463 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 14455-14459 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 14852-14860 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 14852-14856 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 15611-15619 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 15611-15615 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 15645-15653 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 15645-15649 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 15676-15687 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T137 15874-15882 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T138 15874-15878 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T139 15889-15897 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 15889-15893 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T141 16018-16029 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T142 16139-16147 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 16139-16143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T144 16154-16162 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 16154-16158 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 16458-16466 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 16458-16462 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T148 16562-16566 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T149 16608-16616 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T150 16608-16612 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T151 17341-17349 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T152 17341-17345 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T153 17364-17372 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 17364-17368 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T155 17433-17437 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 17529-17533 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 17875-17883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T158 17875-17879 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T159 17971-17979 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T160 17971-17975 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T161 18344-18352 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T162 18344-18348 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T163 18394-18402 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 18394-18398 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T165 18905-18913 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T166 18905-18909 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T167 19379-19387 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T168 19379-19383 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T169 19434-19442 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T170 19434-19438 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T171 19571-19579 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 19571-19575 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 19630-19638 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 19630-19634 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T175 19853-19861 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T176 19853-19857 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T177 20142-20150 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T178 20142-20146 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T179 20211-20215 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T180 20375-20383 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T181 20375-20379 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T182 20564-20575 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T183 20564-20573 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T184 20633-20641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T185 20633-20637 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 20645-20692 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T187 20645-20678 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T188 21034-21042 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T189 21034-21038 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 21079-21087 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 21079-21083 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T192 21715-21723 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 21715-21719 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 22010-22018 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 22010-22014 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T196 22056-22064 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T197 22056-22060 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T198 22245-22253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T199 22245-22249 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T200 22309-22317 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 22309-22313 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 22561-22563 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T203 22582-22590 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T204 22582-22586 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T205 22594-22641 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T206 22594-22627 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T207 22979-22987 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T208 22979-22983 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 23027-23035 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T210 23027-23031 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 23369-23377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T212 23369-23373 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 23458-23466 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T214 23458-23462 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 24003-24011 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T216 24003-24007 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 24556-24564 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 24556-24560 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 24830-24838 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T220 24830-24834 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 25115-25123 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T222 25115-25119 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 25373-25382 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T224 25715-25723 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T225 25715-25719 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T226 25767-25776 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T227 25834-25843 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T228 25845-25847 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T229 25866-25874 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T230 25866-25870 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T231 25878-25925 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T232 25878-25911 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T233 26048-26056 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T234 26048-26052 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T235 26173-26182 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T236 26455-26463 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T237 26455-26459 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 26488-26497 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T239 26589-26597 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T240 26589-26593 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T241 26641-26650 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T242 26865-26873 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T243 26865-26869 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T244 26964-26972 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T245 26964-26968 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 27007-27016 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T247 27098-27107 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T248 27160-27168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T249 27160-27164 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T250 27301-27309 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T251 27301-27305 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T252 27442-27450 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 27442-27446 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 27509-27517 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T255 27509-27513 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T256 27628-27636 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T257 27628-27632 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 27691-27699 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T259 27691-27695 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 27768-27776 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T261 27768-27772 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 27861-27869 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T263 27861-27865 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 27876-27884 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T265 27876-27880 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T266 27942-27950 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T267 27942-27946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T268 27996-28004 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T269 27996-28000 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T270 28069-28073 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T271 28128-28136 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T272 28128-28132 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T273 28333-28341 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T274 28333-28337 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T275 28685-28693 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T276 28685-28689 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T277 28728-28737 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T278 28819-28828 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T279 28901-28909 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T280 28901-28905 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T281 28974-28982 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T282 29115-29123 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T283 29115-29119 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T284 29348-29356 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T285 29348-29352 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T286 29363-29371 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T287 29363-29367 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T288 29462-29470 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T289 29462-29466 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T290 29494-29502 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T291 29494-29498 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T292 29656-29664 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T293 29656-29660 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T294 29752-29760 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T295 29752-29756 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T296 29763-29776 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T297 29900-29908 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T298 29900-29904 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T299 29911-29924 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T300 30287-30295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T301 30287-30291 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T302 30387-30395 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T303 30387-30391 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T304 30546-30549 Disease denotes WBS http://purl.obolibrary.org/obo/MONDO_0008678
T305 30629-30633 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 30-32 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T2 30-32 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T3 131-132 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T4 218-221 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 244-249 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6 434-438 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 629-632 http://purl.obolibrary.org/obo/PR_000001343 denotes Aim
T8 1021-1027 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T9 1053-1058 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1070-1075 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 1121-1122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1139-1141 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T13 1139-1141 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T14 1280-1282 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T15 1280-1282 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T16 1369-1374 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 1520-1530 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T18 1615-1620 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19 1648-1649 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 1896-1897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1898-1903 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T22 1923-1924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 2200-2206 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T24 2302-2305 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3-5
T25 2313-2318 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 2375-2387 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T27 2405-2406 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 2419-2421 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T29 2476-2477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 2805-2808 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31 2852-2856 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T32 2948-2950 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T33 3037-3042 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T34 3052-3054 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T35 3052-3054 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T36 3103-3112 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T37 3126-3128 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T38 3126-3128 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T39 3195-3198 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T40 3272-3273 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T41 3310-3311 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T42 3464-3465 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 3493-3498 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T44 3508-3513 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T45 3544-3550 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T46 3653-3657 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T47 3659-3661 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T48 3700-3702 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T49 3711-3714 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T50 3900-3902 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T51 3900-3902 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T52 3953-3958 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T53 4063-4066 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T54 4082-4085 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T55 4387-4389 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T56 4411-4416 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T57 4438-4441 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T58 4609-4610 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T59 4666-4668 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T60 4666-4668 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T61 4811-4812 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 4979-4980 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 5020-5022 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T64 5020-5022 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T65 5057-5060 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T66 5114-5121 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T67 5150-5155 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T68 5187-5190 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T69 5230-5233 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T70 5449-5459 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T71 5561-5566 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T72 5593-5594 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 5661-5663 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T74 5697-5702 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T75 5703-5707 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T76 5703-5707 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T77 5715-5726 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T78 5715-5726 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T79 5715-5726 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T80 5715-5720 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T81 5715-5720 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T82 6093-6098 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T83 6305-6310 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T84 6394-6403 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridoma
T85 6475-6479 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T86 6524-6526 http://purl.obolibrary.org/obo/CLO_0003797 denotes HP
T87 6524-6526 http://purl.obolibrary.org/obo/PR_000008725 denotes HP
T88 6997-7001 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T89 7194-7195 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 7411-7412 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T91 7413-7418 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T92 7452-7453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 7528-7533 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T94 7620-7622 http://purl.obolibrary.org/obo/CLO_0003797 denotes HP
T95 7620-7622 http://purl.obolibrary.org/obo/PR_000008725 denotes HP
T96 7749-7754 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T97 7859-7864 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T98 8029-8033 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T99 8058-8062 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 °C
T100 8077-8081 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T101 8164-8168 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T102 8286-8294 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T103 8339-8347 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T104 8507-8511 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 °C
T105 8533-8541 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T106 8586-8587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 8696-8704 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T108 8976-8987 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T109 8976-8987 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T110 8976-8987 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T111 8976-8981 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T112 8976-8981 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T113 9182-9184 http://purl.obolibrary.org/obo/CLO_0009141 denotes St
T114 9182-9184 http://purl.obolibrary.org/obo/CLO_0050980 denotes St
T115 9193-9195 http://purl.obolibrary.org/obo/CLO_0007815 denotes MO
T116 9229-9234 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T117 9299-9304 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T118 9376-9378 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T119 9415-9419 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T120 9425-9430 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T121 9791-9794 http://purl.obolibrary.org/obo/CL_0000784 denotes iPC
T122 9795-9804 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T123 9805-9809 http://purl.obolibrary.org/obo/UBERON_0005389 denotes lens
T124 10125-10127 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T125 10143-10144 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 10207-10208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 10282-10286 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 °C
T128 10611-10615 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T129 10621-10626 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T130 11028-11029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 11235-11240 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T132 11269-11270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 11311-11313 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T134 11436-11441 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T135 11470-11474 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T136 11675-11678 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T137 11675-11678 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T138 11675-11678 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T139 11675-11678 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T140 11675-11678 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T141 11675-11678 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T142 11675-11678 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T143 11679-11684 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T144 11896-11898 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T145 11969-11970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 12018-12022 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4 °C
T147 12455-12456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 12568-12572 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T149 12578-12587 http://purl.obolibrary.org/obo/CLO_0053695 denotes human IgG
T150 12802-12803 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T151 12892-12898 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tailed
T152 12911-12915 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T153 13023-13028 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T154 13082-13087 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T155 13181-13194 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero-E6 cells
T156 13244-13249 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T157 13299-13300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 13410-13415 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T159 13465-13470 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T160 13502-13507 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T161 13633-13638 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T162 13732-13736 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T163 13742-13747 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T164 13843-13848 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T165 14092-14097 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T166 14229-14230 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T167 14932-14937 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T168 15443-15444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T169 15597-15599 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T170 15597-15599 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T171 15719-15721 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T172 15719-15721 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T173 15967-15970 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T174 15987-15990 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T175 16012-16017 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T176 16371-16377 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T177 16435-16437 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T178 16435-16437 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T179 16676-16683 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T180 17195-17197 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T181 17195-17197 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T182 17430-17432 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T183 17430-17432 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T184 18826-18827 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 18836-18840 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T186 18985-18987 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T187 19205-19206 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 19344-19345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T189 19525-19532 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T190 19583-19584 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T191 19674-19679 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T192 19784-19788 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T193 19809-19811 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T194 19968-19973 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T195 19975-19986 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T196 19975-19986 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T197 19975-19986 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T198 19975-19980 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T199 19975-19980 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T200 20068-20079 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T201 20068-20079 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T202 20068-20079 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T203 20068-20073 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T204 20068-20073 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T205 20373-20374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T206 20396-20398 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T207 20396-20398 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T208 20410-20411 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T209 20430-20437 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T210 20468-20469 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T211 20481-20486 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T212 20502-20509 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T213 20541-20543 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T214 20574-20575 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T215 20576-20581 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T216 20786-20787 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T217 20808-20809 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 20894-20898 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T219 20932-20936 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T220 20963-20971 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T221 21006-21011 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T222 21065-21067 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T223 21151-21159 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T224 21200-21208 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T225 21270-21271 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T226 21426-21427 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T227 21578-21582 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T228 21621-21631 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS7 cells
T229 21621-21631 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS7 cells
T230 21621-21631 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS7 cells
T231 21621-21625 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS7
T232 21621-21625 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS7
T233 21676-21677 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 21869-21873 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T235 22098-22109 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T236 22098-22109 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T237 22098-22109 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T238 22098-22103 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T239 22098-22103 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T240 22332-22333 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T241 22388-22389 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T242 22438-22443 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T243 22735-22736 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T244 22757-22758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 22838-22842 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T246 22876-22880 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T247 22907-22915 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T248 22950-22955 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T249 23017-23025 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T250 23066-23074 http://purl.obolibrary.org/obo/CLO_0007225 denotes labelled
T251 23136-23137 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T252 23292-23293 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T253 23331-23335 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T254 23534-23535 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T255 23868-23872 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T256 23945-23956 http://purl.obolibrary.org/obo/CLO_0051656 denotes COS-7 cells
T257 23945-23956 http://purl.obolibrary.org/obo/CLO_0051657 denotes COS-7 cells
T258 23945-23956 http://purl.obolibrary.org/obo/CLO_0051658 denotes COS-7 cells
T259 23945-23950 http://purl.obolibrary.org/obo/CLO_0002597 denotes COS-7
T260 23945-23950 http://purl.obolibrary.org/obo/CLO_0050508 denotes COS-7
T261 23974-23979 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T262 24151-24155 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T263 24572-24578 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T264 24799-24800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T265 24850-24855 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T266 24894-24897 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T267 24981-24982 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 25054-25059 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T269 25101-25103 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T270 25230-25231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 25272-25273 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 25329-25330 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T273 25383-25384 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T274 25385-25390 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T275 25667-25668 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T276 25683-25684 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 25712-25713 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T278 25735-25740 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T279 25777-25778 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T280 25927-25928 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T281 25997-26002 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T282 26035-26036 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 26183-26184 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T284 26192-26197 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T285 26210-26211 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T286 26498-26499 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T287 26523-26524 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T288 26526-26539 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T289 26656-26661 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T290 26855-26861 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T291 26885-26898 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero-E6 cells
T292 26939-26940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T293 26984-26989 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T294 27369-27374 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 27428-27430 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T296 27428-27430 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T297 27835-27837 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T298 27899-27900 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T299 28067-28068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 28096-28098 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T301 28244-28250 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T302 28417-28418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 28480-28482 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T304 28480-28482 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T305 28513-28515 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T306 28660-28661 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 28705-28710 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T308 29101-29103 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T309 29101-29103 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T310 29235-29237 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T311 29235-29237 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T312 29317-29321 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T313 29449-29451 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T314 29449-29451 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T315 29583-29585 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T316 29583-29585 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T317 29777-29778 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T318 29925-29926 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 30071-30072 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 30115-30116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T321 30273-30275 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T322 30273-30275 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T323 30627-30628 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T324 30668-30669 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T325 30809-30813 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T326 31047-31056 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T327 31157-31166 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T328 31271-31280 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T329 31493-31502 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T330 31632-31641 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T331 31671-31680 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T332 31696-31697 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T333 31757-31766 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T334 31817-31826 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised
T335 31899-31908 http://purl.obolibrary.org/obo/OBI_0000245 denotes organised

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 30-32 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T2 473-484 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T3 543-555 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T4 559-566 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5 737-744 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 799-806 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7 972-979 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T8 1008-1015 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 1110-1117 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 1139-1141 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T11 1233-1240 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 1280-1282 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T13 1307-1314 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1489-1496 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 1584-1591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T16 2780-2792 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T17 2796-2803 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 2888-2895 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 3052-3054 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T20 3126-3128 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T21 3232-3234 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T22 3633-3635 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T23 3687-3689 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T24 3847-3857 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T25 3847-3852 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T26 3853-3857 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T27 3900-3902 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T28 4067-4069 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T29 4086-4088 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T30 4311-4322 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T31 4430-4437 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 4580-4587 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 4666-4668 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T34 4963-4970 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 5001-5008 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T36 5020-5022 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T37 5034-5045 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T38 5034-5039 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T39 5040-5045 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T40 5139-5146 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 5191-5193 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T42 5267-5276 Chemical denotes immunogen http://purl.obolibrary.org/obo/CHEBI_60816
T43 5404-5411 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 5530-5537 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 5582-5589 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 5795-5797 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T47 5906-5908 Chemical denotes MA http://purl.obolibrary.org/obo/CHEBI_474859|http://purl.obolibrary.org/obo/CHEBI_73610|http://purl.obolibrary.org/obo/CHEBI_90325
T50 6021-6031 Chemical denotes penicillin http://purl.obolibrary.org/obo/CHEBI_17334|http://purl.obolibrary.org/obo/CHEBI_51356
T52 6046-6058 Chemical denotes streptomycin http://purl.obolibrary.org/obo/CHEBI_17076|http://purl.obolibrary.org/obo/CHEBI_58007
T54 6218-6228 Chemical denotes penicillin http://purl.obolibrary.org/obo/CHEBI_17334|http://purl.obolibrary.org/obo/CHEBI_51356
T56 6240-6252 Chemical denotes streptomycin http://purl.obolibrary.org/obo/CHEBI_17076|http://purl.obolibrary.org/obo/CHEBI_58007
T58 6267-6276 Chemical denotes geneticin http://purl.obolibrary.org/obo/CHEBI_42768
T59 6344-6347 Chemical denotes CO2 http://purl.obolibrary.org/obo/CHEBI_16526
T60 6514-6521 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 6524-6526 Chemical denotes HP http://purl.obolibrary.org/obo/CHEBI_74055
T62 6545-6547 Chemical denotes GE http://purl.obolibrary.org/obo/CHEBI_73801
T63 6569-6571 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T65 6649-6672 Chemical denotes sodium dodecyl sulphate http://purl.obolibrary.org/obo/CHEBI_8984
T66 6649-6655 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T67 6656-6663 Chemical denotes dodecyl http://purl.obolibrary.org/obo/CHEBI_23870
T68 6664-6672 Chemical denotes sulphate http://purl.obolibrary.org/obo/CHEBI_16189
T69 6673-6687 Chemical denotes polyacrylamide http://purl.obolibrary.org/obo/CHEBI_51135|http://purl.obolibrary.org/obo/CHEBI_53656|http://purl.obolibrary.org/obo/CHEBI_60766
T72 6709-6712 Chemical denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T73 6807-6814 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74 6821-6828 Chemical denotes reagent http://purl.obolibrary.org/obo/CHEBI_33893
T75 6896-6903 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 6931-6938 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 7152-7159 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T78 7209-7216 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 7424-7431 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T80 7620-7622 Chemical denotes HP http://purl.obolibrary.org/obo/CHEBI_74055
T81 7623-7626 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T82 7640-7647 Chemical denotes reagent http://purl.obolibrary.org/obo/CHEBI_33893
T83 7820-7829 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T87 7908-7914 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T88 7975-7982 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 8236-8239 Chemical denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T90 8271-8285 Chemical denotes nitrocellulose http://purl.obolibrary.org/obo/CHEBI_53325
T91 8382-8386 Chemical denotes Tris http://purl.obolibrary.org/obo/CHEBI_9754
T92 8853-8855 Chemical denotes MP http://purl.obolibrary.org/obo/CHEBI_73612
T93 9153-9165 Chemical denotes Triton X-100 http://purl.obolibrary.org/obo/CHEBI_9750
T94 9388-9403 Chemical denotes Alexa Fluor 488 http://purl.obolibrary.org/obo/CHEBI_52661
T95 9394-9399 Chemical denotes Fluor http://purl.obolibrary.org/obo/CHEBI_24061
T96 9562-9574 Chemical denotes phenylindole http://purl.obolibrary.org/obo/CHEBI_48559
T97 9576-9580 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T98 9624-9628 Chemical denotes Gold http://purl.obolibrary.org/obo/CHEBI_29287
T99 9987-9994 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 10103-10109 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T101 10117-10123 Chemical denotes NaHCO3 http://purl.obolibrary.org/obo/CHEBI_32139
T102 10131-10137 Chemical denotes Na2CO3 http://purl.obolibrary.org/obo/CHEBI_29377
T103 10163-10170 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T104 10476-10482 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T105 10699-10705 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T106 10958-10972 Chemical denotes sulphuric acid http://purl.obolibrary.org/obo/CHEBI_26836
T107 10968-10972 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T108 11336-11338 Chemical denotes VH http://purl.obolibrary.org/obo/CHEBI_73700
T109 11396-11398 Chemical denotes VL http://purl.obolibrary.org/obo/CHEBI_75013
T110 11751-11758 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T111 11874-11880 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T112 11888-11894 Chemical denotes NaHCO3 http://purl.obolibrary.org/obo/CHEBI_32139
T113 11902-11908 Chemical denotes Na2CO3 http://purl.obolibrary.org/obo/CHEBI_29377
T114 12180-12187 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 12262-12264 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T116 12756-12770 Chemical denotes sulphuric acid http://purl.obolibrary.org/obo/CHEBI_26836
T117 12766-12770 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T118 13440-13448 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T119 13449-13456 Chemical denotes acetone http://purl.obolibrary.org/obo/CHEBI_15347
T120 13577-13583 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T121 13705-13720 Chemical denotes Alexa Fluor 488 http://purl.obolibrary.org/obo/CHEBI_52661
T122 13711-13716 Chemical denotes Fluor http://purl.obolibrary.org/obo/CHEBI_24061
T123 13794-13800 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T124 13812-13816 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T125 13981-13988 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T126 14561-14565 Chemical denotes MEGA http://purl.obolibrary.org/obo/CHEBI_6617
T127 14601-14606 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T128 14607-14611 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T129 14704-14711 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T130 14789-14796 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T131 14816-14826 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T132 14816-14821 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T133 14822-14826 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T134 14891-14898 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 15326-15333 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 15377-15384 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 15389-15394 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T138 15395-15399 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T139 15597-15599 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T140 15719-15721 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T141 16111-16116 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T142 16117-16121 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T143 16227-16234 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T144 16435-16437 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T145 16475-16487 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T146 16886-16897 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T147 16886-16891 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T148 16892-16897 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T149 16951-16958 Chemical denotes magenta http://purl.obolibrary.org/obo/CHEBI_87661
T150 17094-17099 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T151 17100-17104 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T152 17182-17194 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T153 17195-17197 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T154 17278-17290 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T155 17317-17322 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T156 17323-17327 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T157 17430-17432 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T158 17438-17440 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T159 17867-17874 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 18482-18487 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T161 18488-18492 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T162 18774-18779 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T163 18780-18784 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T164 18918-18926 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T165 19000-19005 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T166 19006-19010 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T167 19124-19131 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T168 19175-19180 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T169 19181-19185 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T170 19294-19299 Chemical denotes bases http://purl.obolibrary.org/obo/CHEBI_22695
T171 19368-19375 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T172 19643-19650 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T173 20122-20129 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T174 20224-20231 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T175 20388-20395 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T176 20396-20398 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T177 20430-20437 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T178 20502-20509 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T179 20545-20555 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T180 20545-20550 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T181 20551-20555 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T182 20587-20594 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T183 20596-20600 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T184 20619-20631 Chemical denotes phenylindole http://purl.obolibrary.org/obo/CHEBI_48559
T185 20696-20703 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T186 20711-20718 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T187 21047-21054 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T188 21328-21336 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T189 21728-21735 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T190 21804-21819 Chemical denotes Alexa Fluor 488 http://purl.obolibrary.org/obo/CHEBI_52661
T191 21810-21815 Chemical denotes Fluor http://purl.obolibrary.org/obo/CHEBI_24061
T192 21874-21880 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T193 21906-21910 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T194 21999-22006 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T195 22045-22052 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 22234-22241 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 22322-22329 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T198 22362-22369 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T199 22403-22410 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T200 22459-22466 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T201 22498-22502 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T202 22521-22533 Chemical denotes phenylindole http://purl.obolibrary.org/obo/CHEBI_48559
T203 22645-22652 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T204 22660-22667 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T205 22992-22999 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T206 23194-23202 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T207 23382-23389 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T208 23471-23478 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T209 24016-24023 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T210 24096-24111 Chemical denotes Alexa Fluor 488 http://purl.obolibrary.org/obo/CHEBI_52661
T211 24102-24107 Chemical denotes Fluor http://purl.obolibrary.org/obo/CHEBI_24061
T212 24156-24162 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T213 24188-24192 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T214 24272-24279 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T215 24402-24409 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T216 24545-24552 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T217 24685-24692 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T218 24788-24795 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T219 24925-24932 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 25164-25171 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T221 25305-25312 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T222 25358-25360 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T223 25362-25369 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T224 25482-25489 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T225 25545-25547 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T226 25552-25559 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T227 25672-25679 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T228 25741-25743 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T229 26065-26072 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T230 26159-26161 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T231 26162-26169 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T232 26468-26475 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T233 26507-26509 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T234 26710-26725 Chemical denotes Alexa Fluor 488 http://purl.obolibrary.org/obo/CHEBI_52661
T235 26716-26721 Chemical denotes Fluor http://purl.obolibrary.org/obo/CHEBI_24061
T236 26814-26826 Chemical denotes phenylindole http://purl.obolibrary.org/obo/CHEBI_48559
T237 26828-26832 Chemical denotes DAPI http://purl.obolibrary.org/obo/CHEBI_51231
T238 27083-27090 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T239 27149-27156 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T240 27290-27297 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T241 27428-27430 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T242 27680-27687 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T243 28161-28168 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T244 28322-28329 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T245 28406-28413 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T246 28480-28482 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T247 28594-28601 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T248 28804-28811 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T249 29101-29103 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T250 29162-29169 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T251 29188-29195 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T252 29235-29237 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T253 29272-29279 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T254 29449-29451 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T255 29583-29585 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T256 29669-29676 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T257 30273-30275 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T258 30878-30886 Chemical denotes reagents http://purl.obolibrary.org/obo/CHEBI_33893
T259 31094-31096 Chemical denotes VM http://purl.obolibrary.org/obo/CHEBI_75015
T260 31648-31651 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 7002-7011 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2 8588-8616 http://purl.obolibrary.org/obo/GO_0004601 denotes horseradish peroxidase (HRP)
T3 11475-11484 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 29317-29339 http://purl.obolibrary.org/obo/GO_0002456 denotes cell-mediated immunity
T5 29317-29339 http://purl.obolibrary.org/obo/GO_0002449 denotes cell-mediated immunity

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 19784-19788 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T2 20894-20898 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T3 21578-21582 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T4 22838-22842 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T5 23331-23335 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T6 23868-23872 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438
T7 30809-30813 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2
T2 111-119 Sentence denotes Abstract
T3 120-130 Sentence denotes Background
T4 131-261 Sentence denotes A novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide human infections.
T5 262-512 Sentence denotes While genetically distinct, SARS-CoV-1, the aetiological agent responsible for an outbreak of severe acute respiratory syndrome (SARS) in 2002–2003, utilises the same host cell receptor as SARS-CoV-2 for entry: angiotensin-converting enzyme 2 (ACE2).
T6 513-627 Sentence denotes Parts of the SARS-CoV-1 spike glycoprotein (S protein), which interacts with ACE2, appear conserved in SARS-CoV-2.
T7 629-632 Sentence denotes Aim
T8 633-772 Sentence denotes The cross-reactivity with SARS-CoV-2 of monoclonal antibodies (mAbs) previously generated against the S protein of SARS-CoV-1 was assessed.
T9 774-781 Sentence denotes Methods
T10 782-922 Sentence denotes The SARS-CoV-2 S protein sequence was aligned to those of SARS-CoV-1, Middle East respiratory syndrome (MERS) and common-cold coronaviruses.
T11 923-1150 Sentence denotes Abilities of mAbs generated against SARS-CoV-1 S protein to bind SARS-CoV-2 or its S protein were tested with SARS-CoV-2 infected cells as well as cells expressing either the full length protein or a fragment of its S2 subunit.
T12 1151-1241 Sentence denotes Quantitative ELISA was also performed to compare binding of mAbs to recombinant S protein.
T13 1243-1250 Sentence denotes Results
T14 1251-1401 Sentence denotes An immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses.
T15 1402-1531 Sentence denotes Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines.
T16 1532-1672 Sentence denotes In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format.
T17 1674-1684 Sentence denotes Conclusion
T18 1685-1817 Sentence denotes The cross-reactive mAbs may serve as useful tools for SARS-CoV-2 research and for the development of diagnostic assays for COVID-19.
T19 1819-1831 Sentence denotes Introduction
T20 1832-2041 Sentence denotes The severe acute respiratory syndrome coronavirus (SARS-CoV-1), a virus considered to have a zoonotic origin, is the aetiological agent for the infectious disease, SARS, which first emerged in 2002–2003 [1,2].
T21 2042-2307 Sentence denotes In December of 2019, another novel coronavirus (SARS-CoV-2), which causes coronavirus disease (COVID-19), appeared to have crossed species barriers to infect humans and was effectively transmitted from person to person, leading to an outbreak in Wuhan, China [3-5].
T22 2308-2437 Sentence denotes This virus subsequently spread worldwide, leading the World Health Organization (WHO) to declare a pandemic on 11 March 2020 [6].
T23 2438-2614 Sentence denotes To date, SARS-CoV-2 continues to pose a high global health and economy burden, and as at 3 May 2020, COVID-19 had affected 215 countries with over 3.35 million confirmed cases.
T24 2615-2738 Sentence denotes To tackle the problems caused by SARS-CoV-2, improving its detection and knowledge of its infection mechanism is important.
T25 2739-2881 Sentence denotes In this respect, the viral surface spike glycoprotein (S protein) has been demonstrated to play key role in host cell selectivity and binding.
T26 2882-3138 Sentence denotes The S protein is functionally divided into two subunits, with the S1 subunit containing the receptor binding domain (RBD), which allows attachment to host cells, and the S2 subunit mediating fusion between viral and host membranes (reviewed by Li, F.) [7].
T27 3139-3309 Sentence denotes Phylogenetic analysis revealed that like SARS-CoV-1 and bat-derived SARS-like coronaviruses (SL-CoVs), SARS-CoV-2 belongs to lineage B of the betacoronavirus genus [8,9].
T28 3310-3530 Sentence denotes A study of 56 complete and partial SARS-CoV-2 genomes isolated from COVID-19 patients showed very high sequence conservation of more than 99%, indicating a recent introduction of the virus into the human population [10].
T29 3531-3666 Sentence denotes Although the animal source of SARS-CoV-2 is not clear, SARS-CoV-1 is believed to have originated from SL-CoVs residing in bats [11-14].
T30 3667-3818 Sentence denotes For the majority of SL-CoVs, the S1 subunit has low sequence identity to that of SARS-CoV-1, which suggests species-dependent receptor binding [14,15].
T31 3819-3995 Sentence denotes On the other hand, the high amino acid sequence identity of more than 90% in the S2 subunit suggests that the fusion mechanism during virus infection is well-conserved [14,15].
T32 3996-4200 Sentence denotes While SARS-CoV-2 shares higher whole-genome sequence identity with bat-SL-CoVZC45 and bat-SL-CoVZXC21 (88–89%) than with SARS-CoV-1 (79–82%), the RBD of SARS-CoV-2 is more similar to SARS-CoV-1 RBD [8,9].
T33 4201-4391 Sentence denotes In line with this, several research groups have demonstrated that SARS-CoV-2 utilises the same host receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV-1 for viral entry [3,16-18].
T34 4392-4508 Sentence denotes Due to its role in virus entry, the S protein has been the target for the generation of monoclonal antibodies (mAb).
T35 4509-4608 Sentence denotes In our previous work, we used five different fragments of SARS-CoV-1 S protein to immunise rabbits.
T36 4609-4762 Sentence denotes A fragment corresponding to residues 1029 to 1192 in the S2 subunit of SARS-CoV-1 was found to stimulate neutralising antibodies against SARS-CoV-1 [19].
T37 4763-4919 Sentence denotes This fragment was subsequently used to generate a panel of murine mAbs with their respective binding domains characterised and described in Lip et al. [20].
T38 4920-5211 Sentence denotes One of them, mAb 1A9, which binds to the S protein through a recently identified epitope within the S2 subunit at amino acids 1111–1130, has the ability to bind and cross-neutralise pseudotyped viruses expressing the S protein of human SARS-CoV-1, civet SARS-CoV and bat SL-CoV strains [21].
T39 5212-5460 Sentence denotes In this study, we aim to verify if the sequence of the immunogen used to generate mAb 1A9, as well as three other mAbs, is conserved in different coronaviruses and if these mAbs bind to the S protein of SARS-CoV-2 expressed in mammalian cell lines.
T40 5461-5686 Sentence denotes Importantly, mAb 1A9 is investigated for its ability to detect the S protein in SARS-CoV-2 infected cells and purified S protein in a sandwich ELISA format when paired with another mAb binding to the S1 subunit of SARS-CoV-2.
T41 5688-5695 Sentence denotes Methods
T42 5697-5702 Sentence denotes Cells
T43 5703-6086 Sentence denotes Vero E6 and COS-7 cells were purchased from the American Type Culture Collection (Manassas, VA, United States) and cultured in Dulbecco’s Modified Eagle’s Medium (DMEM; Thermo Fisher Scientific, Waltham MA, United States) supplemented with 10% fetal bovine serum (FBS; HyClone, Logan, UT, United States), 100 units/mL penicillin and 100 µg/mL streptomycin (Thermo Fisher Scientific).
T44 6087-6304 Sentence denotes 293FT cells were purchased from Invitrogen (Carlsbad, CA, United States) and grown in DMEM supplemented with 10% FBS, 100 units/mL penicillin, 100 µg/mL streptomycin and 500 µg/mL geneticin (Thermo Fisher Scientific).
T45 6305-6348 Sentence denotes Cells were maintained at 37 °C with 5% CO2.
T46 6350-6389 Sentence denotes Purification of monoclonal antibody 1A9
T47 6390-6446 Sentence denotes The hybridoma for mAb 1A9 was previously generated [20].
T48 6447-6609 Sentence denotes All mAbs were purified from cell culture supernatants using HiTrap protein G HP affinity columns (GE Healthcare, Chicago, IL, United States) and stored at −80 °C.
T49 6610-6728 Sentence denotes The purity of the mAb was confirmed by sodium dodecyl sulphate-polyacrylamide gel electrophoretic (SDS-PAGE) analysis.
T50 6729-6856 Sentence denotes The concentration of the purified mAb was determined using the Coomassie Plus protein assay reagent (Thermo Fisher Scientific).
T51 6858-6917 Sentence denotes Plasmids for expression of full spike protein and fragments
T52 6918-7098 Sentence denotes SARS-CoV-2 S-protein-expressing plasmids were codon-optimised and generated by gene synthesis (Bio Basic Asia Pacific, Singapore) according to GenBank accession number: QHD43416.1.
T53 7099-7282 Sentence denotes One plasmid is for expressing untagged full-length S protein while the other is for expressing a Myc-tagged S-protein fragment consisting of residues 1048–1206 (SARS-CoV-2 numbering).
T54 7283-7471 Sentence denotes The pXJ40-Myc expression vector was used as an empty vector control and pXJ40-Myc-HBcAg plasmid expressing Myc-tagged hepatitis B virus core antigen (HBcAg) was used as a negative control.
T55 7473-7521 Sentence denotes Transient transfection and western blot analysis
T56 7522-7717 Sentence denotes 293FT cells were seeded onto 6-cm dishes 24 hours before transient transfection using X-tremeGENE HP DNA transfection reagent (Roche, Basel, Switzerland) according to the manufacturer’s protocol.
T57 7718-7858 Sentence denotes At 24 hours post-transfection, cells were harvested, spun down by centrifugation and washed with cold phosphate buffered saline (PBS) twice.
T58 7859-7937 Sentence denotes Cells were then resuspended in 2× Laemmli sample buffer, boiled and sonicated.
T59 7938-8140 Sentence denotes Clarified supernatant containing the protein of interest was obtained by spinning down the cell lysate at 13,000 rpm at 4 °C to remove the cell debris and further analysed by western blot (WB) analysis.
T60 8141-8334 Sentence denotes Equal amounts of total cell lysates were loaded per lane and resolved using electrophoresis on SDS-PAGE gels and transferred onto nitrocellulose membrane (Bio-Rad, Hercules, CA, United States).
T61 8335-8522 Sentence denotes The membrane was blocked in 5% skimmed milk in Tris-buffered saline with 0.05% Tween 20 (TBST) for 1 hour at room temperature (RT) and incubated with primary antibodies at 4 °C overnight.
T62 8523-8691 Sentence denotes After the membrane was washed with TBST, it was incubated with a horseradish peroxidase (HRP)-conjugated secondary antibody (Thermo Fisher Scientific) at RT for 1 hour.
T63 8692-8881 Sentence denotes The membrane was then washed with TBST again and bound antibodies visualised with enhanced chemiluminescence substrate (Thermo Fisher Scientific) using ChemiDoc MP Imaging System (Bio-Rad).
T64 8883-8937 Sentence denotes Transient transfection and immunofluorescence analysis
T65 8938-9222 Sentence denotes For immunofluorescence (IF) analysis, COS-7 cells on glass coverslips were transfected as above and fixed at 24 hours post-transfection in 4% paraformaldehyde for 10 min at RT followed by permeabilisation with 0.2% Triton X-100 (Sigma-Aldrich, St. Louis, MO, United States) for 5 min.
T66 9223-9298 Sentence denotes Fixed cells were then blocked with PBS containing 10% FBS for 30 min at RT.
T67 9299-9493 Sentence denotes Cells were immunolabelled for 1 hour at RT with the indicated murine mAb and 45 min with Alexa Fluor 488-conjugated goat anti-mouse IgG antibody (Life Technologies, Carlsbad, CA, United States).
T68 9494-9693 Sentence denotes Immunolabelled coverslips were counterstained with 4′,6-diamidino-2-phenylindole (DAPI; Sigma-Aldrich), and mounted using ProLong Gold Antifade Mountant (Molecular Probes, Eugene, OR, United States).
T69 9694-9872 Sentence denotes Images were acquired with Olympus CKX53 microscope using Olympus (Tokyo, Japan) LCAch N 20×/0.40 iPC objective lens and Olympus DP27 colour camera with Olympus cellSens software.
T70 9873-9946 Sentence denotes Each channel was collected separately, with images at 1024 × 1024 pixels.
T71 9948-9953 Sentence denotes ELISA
T72 9954-10064 Sentence denotes Whole ectodomain of SARS-CoV-2 S protein with His Tag (Sino Biological Inc., Beijing, China; catalogue number:
T73 10065-10287 Sentence denotes 40589-B08V1) was diluted with coating buffer (0.1 M NaHCO3, 34 mM Na2CO3) and a total of 20 ng of protein was loaded into individual wells of a 96 well plate (Nunc, Roskilde, Denmark) and allowed to coat overnight at 4 °C.
T74 10288-10522 Sentence denotes Plates were then washed four times with 0.05% Tween 20 in PBS (PBST) and blocked with 5% bovine serum albumin (BSA)/PBST for 30 min before murine antibodies serially diluted with blocking buffer were added to desired wells for 1 hour.
T75 10523-10739 Sentence denotes Plate were washed four times with PBST before incubation for 1 hour with HRP-conjugated goat anti-mouse IgG (Thermo Fisher Scientific) secondary antibodies diluted in blocking buffer, and washed four times with PBST.
T76 10740-10973 Sentence denotes Visualisation of bound secondary antibodies was done by the addition of 3,3',5,5'-tetramethylbenzidine (TMB) substrate (Thermo Fisher Scientific) for 5 min in the absence of light and the reaction was stopped with 2 M sulphuric acid.
T77 10974-11188 Sentence denotes Optical density at 450 nm (OD450nm) was determined by a Tecan (Männedorf, Switzerland) Infinite M1000 reader and normalised OD450nm was obtained by subtracting background absorbances determined in BSA coated wells.
T78 11190-11230 Sentence denotes Production of monoclonal antibody CR3022
T79 11231-11315 Sentence denotes The human mAb CR3022 was expressed in a similar manner as previously described [22].
T80 11316-11637 Sentence denotes The variable heavy (VH; GenBank accession number: DQ168569) and variable light (VL; GenBank accession number: DQ168570) genes of CR3022 were generated by gene synthesis (Bio Basic Asia Pacific) and cloned into pFUSEss-CHIg-hIgG1 and pFUSE2ss-CLIg-hK cloning vectors (InvivoGen, San Diego, CA, United States) respectively.
T81 11638-11824 Sentence denotes Transfection of suspension FreeStyle 293 cells (Thermo Fisher Scientific) and purification of antibodies by fast protein liquid chromatography is as described in our previous study [23].
T82 11826-11840 Sentence denotes Sandwich ELISA
T83 11841-12023 Sentence denotes Mab 1A9 was diluted with coating buffer (0.1 M NaHCO3, 34 mM Na2CO3) and 0.1 µg of antibody was coated onto individual wells of a Maxisorp flat-bottom plate (Nunc) overnight at 4 °C.
T84 12024-12130 Sentence denotes The plate was washed three times with PBST before blocking was done using 5% BSA/PBST at 37 °C for 60 min.
T85 12131-12228 Sentence denotes Dilutions of His-tagged full length SARS-CoV-2 S protein (Sino Biological Inc., catalogue number:
T86 12229-12305 Sentence denotes 40589-B08V1) and His-tagged H7N7-HA (Sino Biological Inc., catalogue number:
T87 12306-12415 Sentence denotes 11082-V08B) were added to desired wells and incubated at 37 °C for 90 min followed by three washes with PBST.
T88 12416-12645 Sentence denotes 100 µL of CR3022 antibody was added at a concentration of 1 µg/mL and incubated at 37 °C for 60 min followed by three PBST washes before HRP-conjugated goat anti-human IgG (Thermo Fisher Scientific) was added for 60 min at 37 °C.
T89 12646-12771 Sentence denotes Finally, after three PBST washes, TMB (Sigma-Aldrich) was added for 5 min and the reaction was stopped by 2 M sulphuric acid.
T90 12772-12832 Sentence denotes The OD450nm was determined by a Tecan Infinite M1000 reader.
T91 12833-13021 Sentence denotes Statistical analyses were performed using an unpaired, one-tailed Student’s t-test with Welch’s correction for unequal variances. p values < 0.05 were considered statistically significant.
T92 13023-13061 Sentence denotes Virus infection and immunofluorescence
T93 13062-13180 Sentence denotes All works with live virus were performed in the biosafety level (BSL)3 facility at the Public Health Agency of Sweden.
T94 13181-13382 Sentence denotes Vero-E6 cells were infected with SARS-CoV-2 (SARS-CoV-2-Iso/01/human/2020/SWE; GenBank accession number: MT093571) at a multiplicity of infection (MOI) of one in DMEM 2% FBS (Thermo Fisher Scientific).
T95 13383-13501 Sentence denotes At 24 hour post-infection, cells were fixed with chilled methanol/acetone and the cells were kept at −20 °C overnight.
T96 13502-13628 Sentence denotes Cells were then stained using mAb 1A9 at 5 µg/mL at 37 °C for 30 min in IF buffer (BSA 0.2%, Triton ×100 0.1% in PBS, pH 7.4).
T97 13629-13842 Sentence denotes The cells were washed three times with PBS and incubated, subsequently with Alexa Fluor 488-conjugated goat anti-mouse IgG antibody (Thermo Fisher Scientific) in IF buffer containing DAPI for an additional 30 min.
T98 13843-13953 Sentence denotes Cells were washed three times with PBS before visualisation and image acquisition with fluorescent microscopy.
T99 13955-13978 Sentence denotes Bioinformatics analysis
T100 13979-14228 Sentence denotes S protein reference sequences for SARS-CoV-1, SARS-CoV-2, batRaTG13, Middle East respiratory syndrome (MERS) and human common-cold coronaviruses 229E, NL63, OC43 and HKU1 were downloaded from the National Center for Biotechnology Information (NCBI).
T101 14229-14510 Sentence denotes A multiple sequence alignment was created with multiple alignment using fast Fourier transform (MAFFT) using the slow but accurate L-INS-I parameter settings [24] and the alignment curated, cut to the target region 1029–1192 (SARS-CoV-1 numbering) and visualised with Jalview [25].
T102 14511-14838 Sentence denotes We used Molecular Evolutionary Genetics Analysis (MEGA) X [26] to calculate the number of amino-acid differences for all sequence pairs in the alignment of the mAb target region and the full S protein normalised by the length of the aligned sequence of the respective reference protein to obtain per cent amino acid identities.
T103 14839-15034 Sentence denotes To determine SARS-CoV-2 sequence diversity in the S protein within the current pandemic, 230 human and environmental viral sequences were downloaded from GISAID’s EpiCoV database on 1 March 2020.
T104 15035-15175 Sentence denotes We gratefully acknowledge the authors, originating and submitting laboratories of the sequences on which this part of the research is based.
T105 15176-15222 Sentence denotes The list is detailed in Supplementary Table 1.
T106 15223-15334 Sentence denotes The nt sequences were searched with basic local alignment search tool (BLAST)X against the reference S protein.
T107 15335-15488 Sentence denotes 174 hits covered the full length of the S protein and amino-acid mutations were counted and tabulated using a custom Perl script (Supplementary Table 2).
T108 15490-15507 Sentence denotes Ethical statement
T109 15508-15557 Sentence denotes Ethical approval was not required for this study.
T110 15559-15566 Sentence denotes Results
T111 15568-15692 Sentence denotes An immunogenic domain in the S2 subunit of SARS-CoV-1 is highly conserved in SARS-CoV-2 but not in MERS and common cold HCoV
T112 15693-15911 Sentence denotes Sequence alignment of the S2 fragment corresponding to residues 1029 to 1192 shows that this fragment, which encompasses the heptad repeat (HR)2 but not HR1, is highly conserved in SARS-CoV-1 and SARS-CoV-2 (Figure 1).
T113 15912-16388 Sentence denotes When compared with additional reference sequences from bat RaTG13 (closest bat precursor), MERS and human common cold coronaviruses 229E, NL63, OC43 and HKU1 (Figure 1), it becomes apparent that the amino-acid identity between SARS-CoV-2 and SARS-CoV-1 is much higher in this region (93%, Table) than over the full protein length (78%, Table) and the similarity drops sharply (< 40% in this region) when considering MERS and the other coronaviruses infecting humans regularly.
T114 16389-16521 Sentence denotes Figure 1 Multiple sequence alignment for the S2 subunit fragment of SARS-CoV-1 spike glycoprotein with other relevant coronaviruses
T115 16522-16527 Sentence denotes MERS:
T116 16528-16659 Sentence denotes Middle East respiratory syndrome; SARS: severe acute respiratory coronavirus 1; SARS-CoV-2: severe acute respiratory coronavirus 2.
T117 16660-16832 Sentence denotes The name of the viruses, for which sequences are being compared figure on the left side of the alignment, together with the respective sequences’ GenBank accession numbers.
T118 16833-17077 Sentence denotes Colour schemes represent the following categories of amino acids: blue – hydrophobic, cyan – aromatic, green – polar, magenta – negative charge, orange – glycines, pink – cysteines, red – positive charge, yellow – prolines, white – unconserved.
T119 17078-17290 Sentence denotes Table Pairwise amino-acid identity across relevant coronaviruses in the sequence fragment of the spike glycoprotein S2 subunit recognised by monoclonal antibody 1A9 or the sequence of the full spike glycoprotein
T120 17291-17340 Sentence denotes Query/reference Pairwise amino-acid identity (%)
T121 17341-17404 Sentence denotes SARS-CoV-2 BatRaTG13 SARS-CoV-1 MERS OC43 HKU1 229E NL63
T122 17405-17432 Sentence denotes Fragment region of spike S2
T123 17433-17479 Sentence denotes SARS-Co-V2 100.00 SB SB SB SB SB SB SB
T124 17480-17528 Sentence denotes BatRaTG13 99.40 100.00 SB SB SB SB SB SB
T125 17529-17575 Sentence denotes SARS 93.10 92.50 100.00 SB SB SB SB SB
T126 17576-17625 Sentence denotes MERS 39.00 39.00 39.00 100.00 SB SB SB SB
T127 17626-17678 Sentence denotes OC43 39.00 39.00 38.40 51.20 100.00 SB SB SB
T128 17679-17734 Sentence denotes HKU1 32.70 32.70 30.80 50.60 68.40 100.00 SB SB
T129 17735-17793 Sentence denotes 229E 30.80 30.20 32.10 31.50 29.70 30.40 100.00 SB
T130 17794-17855 Sentence denotes NL63 30.80 30.20 30.20 32.10 31.60 33.50 64.20 100.00
T131 17856-17874 Sentence denotes Full spike protein
T132 17875-17921 Sentence denotes SARS-CoV-2 100.00 SB SB SB SB SB SB SB
T133 17922-17970 Sentence denotes BatRaTG13 97.70 100.00 SB SB SB SB SB SB
T134 17971-18023 Sentence denotes SARS-CoV-1 77.80 78.20 100.00 SB SB SB SB SB
T135 18024-18073 Sentence denotes MERS 35.40 35.40 35.20 100.00 SB SB SB SB
T136 18074-18126 Sentence denotes OC43 37.30 37.10 36.90 39.50 100.00 SB SB SB
T137 18127-18182 Sentence denotes HKU1 35.20 35.30 35.00 39.00 67.00 100.00 SB SB
T138 18183-18241 Sentence denotes 229E 41.70 41.50 41.80 41.80 43.50 43.50 100.00 SB
T139 18242-18303 Sentence denotes NL63 36.30 36.20 36.20 35.40 39.70 37.80 64.70 100.00
T140 18304-18309 Sentence denotes MERS:
T141 18310-18460 Sentence denotes Middle East respiratory syndrome; SARS-CoV-1: severe acute respiratory coronavirus; SARS-CoV-2: severe acute respiratory coronavirus; SB: shown below.
T142 18461-18574 Sentence denotes High to low pairwise amino-acid identity are coloured coded respectively by contrasting green to red backgrounds.
T143 18575-18854 Sentence denotes The sequence identity is not affected by the order in which paired sequences are compared so only one-way comparisons are shown to avoid redundancies; the abbreviation ‘SB’ is used when the pairwise amino-acid identity in question is already shown in a further cell of the table.
T144 18855-18989 Sentence denotes We also studied the sequence diversity across 174 SARS-CoV-2 S proteins derived from nt sequences shared via the GISAID platform [27].
T145 18990-19156 Sentence denotes Only four amino-acid mutations were found within the putative antibody-binding region compared with 30 mutations over the full length protein (Supplementary Table 2).
T146 19157-19300 Sentence denotes Two of these four amino-acid mutations are from a sequence flagged in GISAID’s EpiCoV database as lower quality due to many undetermined bases.
T147 19302-19389 Sentence denotes Four murine monoclonal antibodies bind to a fragment of the spike protein of SARS-CoV-2
T148 19390-19582 Sentence denotes Four mAbs with distinct binding profiles to SARS-CoV-1, as previously mapped by internal deletion mutagenesis study, were selected for testing to determine if they cross-react with SARS-CoV-2.
T149 19583-19789 Sentence denotes A fragment containing residues 1048 to 1206 of SARS-CoV-2 S protein was expressed in 293FT cells via transient transfection and WB analysis was performed using the four mAbs, namely 2B2, 1A9, 4B12 and 1G10.
T150 19790-19931 Sentence denotes As shown in Figure 2A, all four mAbs detected this fragment of SARS-CoV-2, which is consistent with the sequence alignment shown in Figure 1.
T151 19932-20018 Sentence denotes Due to the easy detachment of 293FT cells, COS-7 cells were used for IF assay instead.
T152 20019-20165 Sentence denotes IF analysis performed on transiently transfected COS-7 cells showed binding of the four mAbs to this S protein fragment of SARS-CoV-2 (Figure 2B).
T153 20166-20321 Sentence denotes These interactions are also specific for the SARS-COV-2 S protein (1048–1206) fragment as all four mAbs did not show binding to the negative control HBcAg.
T154 20322-20540 Sentence denotes Figure 2 Monoclonal antibodies expected to target a SARS-CoV-2 S protein S2 fragment, (A) hybridise to the peptide fragment in western blot and (B) recognise cells expressing the peptide as shown by immunofluorescence
T155 20541-20601 Sentence denotes aa: amino acid; HBcAg: hepatitis B virus core antigen; DAPI:
T156 20602-20785 Sentence denotes 4′,6-diamidino-2-phenylindole; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; S protein: spike protein; vec: pXJ40-Myc expression vector used as an empty vector control.
T157 20786-20788 Sentence denotes A.
T158 20789-20900 Sentence denotes Each photo depicts a western blot using the primary antibody indicated below it (Myc, 2B2, 1A9, 4B12, or 1G10).
T159 20901-21175 Sentence denotes Empty vector-transfected 293FT cell products are on the lanes labelled as ‘Vec’, while products of 293FT cells expressing Myc-tagged SARS-CoV-2 S protein fragment (aa 1048–1206; SARS-CoV-2 numbering) or Myc-tagged HBcAg are on the lanes respectively labelled ‘S’ or ‘HBcAg’.
T160 21176-21269 Sentence denotes Primary antibodies were labelled with horseradish peroxidase-conjugated secondary antibodies.
T161 21270-21425 Sentence denotes A ladder indicative of the molecular weights in kD of the proteins relative to their vertical position on the blots, is indicated on the left of the panel.
T162 21426-21428 Sentence denotes B.
T163 21429-21584 Sentence denotes Each photo depicts an immunofluorescence assay using either no primary antibody, or the primary antibody indicated below it (Myc, 2B2, 1A9, 4B12, or 1G10).
T164 21585-21868 Sentence denotes Immunofluorescence assay results of COS7 cells expressing Myc-tagged HBcAg (top photos) or a Myc-tagged fragment (aa1048–1206) of SARS-CoV-2 S protein (bottom photos) using the indicated primary antibodies, followed by Alexa Fluor 488-conjugated secondary antibody (green) are shown.
T165 21869-21918 Sentence denotes Cell nuclei were counterstained with DAPI (blue).
T166 21919-21937 Sentence denotes Scale bar = 50 µm.
T167 21939-22020 Sentence denotes Four murine monoclonal antibodies bind to the full-length S protein of SARS-CoV-2
T168 22021-22170 Sentence denotes Next, the full-length S protein of SARS-CoV-2 was overexpressed in 293FT and COS-7 cells and detected with each of the mAbs using WB and IF analyses.
T169 22171-22268 Sentence denotes As shown in Figure 3, all four mAbs bound to the full-length S protein of SARS-CoV-2 (Figure 3A).
T170 22269-22497 Sentence denotes Figure 3 Antibodies expected to target SARS-CoV-2 S protein, (A) hybridise to the denatured protein in western blot, (B) bind to the protein in ELISA and (C) recognise cells expressing the protein as shown by immunofluorescence
T171 22498-22503 Sentence denotes DAPI:
T172 22504-22734 Sentence denotes 4′,6-diamidino-2-phenylindole; mAb: monoclonal antibody: OD: optical density; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; S protein: spike protein; vec: pXJ40-Myc expression vector used as an empty vector control.
T173 22735-22737 Sentence denotes A.
T174 22738-22844 Sentence denotes Each photo depicts a western blot using the primary antibody indicated below it (2B2, 1A9, 4B12, or 1G10).
T175 22845-23041 Sentence denotes Empty vector-transfected 293FT cell products are on the lanes labelled as ‘Vec’, while products of 293FT cells expressing full-length SARS-CoV-2 S protein are on the lanes labelled ‘SARS-CoV-2 S’.
T176 23042-23135 Sentence denotes Primary antibodies were labelled with horseradish peroxidase-conjugated secondary antibodies.
T177 23136-23291 Sentence denotes A ladder indicative of the molecular weights in kD of the proteins relative to their vertical position on the blots, is indicated on the left of the panel.
T178 23292-23294 Sentence denotes B.
T179 23295-23414 Sentence denotes The abilities of 2B2, 1A9, 4B12 and 1G10 monoclonal antibodies to bind to SARS-CoV-2 S protein was determined by ELISA.
T180 23415-23533 Sentence denotes Individual wells were coated with 20 ng of SARS-CoV-2 S protein and incubated with serially diluted mAbs as indicated.
T181 23534-23715 Sentence denotes A representative plot from three independent experiment is show for each antibody and error bars correspond to standard deviations of each mAb experiment carried out in triplicates.
T182 23716-23718 Sentence denotes C.
T183 23719-23874 Sentence denotes Each photo depicts an immunofluorescence assay using either no primary antibody, or the primary antibody indicated below it (Myc, 2B2, 1A9, 4B12, or 1G10).
T184 23875-24040 Sentence denotes Immunofluorescence analysis was performed on empty vector-transfected COS-7 cells (top photos) and cells expressing full-length SARS-CoV-2 S protein (bottom photos).
T185 24041-24150 Sentence denotes The indicated primary antibodies were used followed by Alexa Fluor 488-conjugated secondary antibody (green).
T186 24151-24200 Sentence denotes Cell nuclei were counterstained with DAPI (blue).
T187 24201-24219 Sentence denotes Scale bar = 50 µm.
T188 24220-24388 Sentence denotes The binding of these mAbs to recombinant purified S protein was also determined using indirect ELISA where different concentrations of antibodies were used for binding.
T189 24389-24492 Sentence denotes Binding to S protein was observed for all four mAbs with 1A9 showing the strongest binding (Figure 3B).
T190 24493-24598 Sentence denotes Similarly, all four mAbs bound to the full-length S protein of SARS-CoV-2 when tested via IF (Figure 3C).
T191 24599-24732 Sentence denotes Collectively our data demonstrates the ability of all four mAbs to bind full-length S protein in both its native and denatured forms.
T192 24734-24855 Sentence denotes Utility of monoclonal antibody 1A9 for detection of S protein in a sandwich ELISA format and in SARS-CoV-2 infected cells
T193 24856-24973 Sentence denotes Based on indirect ELISA data, mAb 1A9 has the strongest binding to S protein when compared with the other three mAbs.
T194 24974-25126 Sentence denotes Hence, a sandwich ELISA was performed to determine if it can be paired with the human mAb CR3022 which is known to bind to the S1 subunit of SARS-CoV-2.
T195 25127-25292 Sentence denotes As shown in Figure 4A, recombinant S protein was detected at 15.6 ng/mL and above when 1A9 was used as a capture antibody and CR3022 was used as a detector antibody.
T196 25293-25436 Sentence denotes Since the S protein was His-tagged, a His-tagged haemagglutinin (HA) protein of influenza A virus was used to check for specificity of binding.
T197 25437-25599 Sentence denotes The absorbance readings in the presence of S protein were significantly higher than that in the presence of HA for protein concentrations of 15.6 ng/mL and above.
T198 25600-25740 Sentence denotes Figure 4 Performance of monoclonal antibody 1A9 for detection of (A) S protein in a sandwich ELISA format and (B) SARS-CoV-2 infected cells
T199 25741-25926 Sentence denotes HA: haemagglutinin; H7N7: influenza A (H7N7); mAb: monoclonal antibody; MOI: multiplicity of infection; OD: optical density; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.
T200 25927-25929 Sentence denotes A.
T201 25930-26073 Sentence denotes Sandwich ELISA assay to determine mAb 1A9 ability to pair with the human mAb CR3022 for the detection of a His-tagged SARS-CoV-2 spike protein.
T202 26074-26147 Sentence denotes 1A9 and CR3022 were used as capture and detector antibodies respectively.
T203 26148-26229 Sentence denotes His-tagged HA protein of influenza A (H7N7) virus was used as a negative control.
T204 26230-26297 Sentence denotes Averaged readings across three replicate experiments are presented.
T205 26298-26378 Sentence denotes Error bars represent standard deviations across the three replicate experiments.
T206 26379-26522 Sentence denotes Asterisks indicate significantly increased binding of the antibody pairs to SARS-CoV-2 S protein compared to influenza A (H7N7) HA at p < 0.05.
T207 26523-26525 Sentence denotes B.
T208 26526-26624 Sentence denotes Vero E6 cells were mock-infected (left panel) or infected with SARS-CoV-2 (right panel; MOI of 1).
T209 26625-26764 Sentence denotes At 24 hour post infection, the cells were stained with mAb 1A9 (5 µg/mL) followed by Alexa Fluor 488-conjugated secondary antibody (green).
T210 26765-26840 Sentence denotes Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI; blue).
T211 26841-26899 Sentence denotes Next, 1A9 was tested on SARS-CoV-2-infected Vero-E6 cells.
T212 26900-27108 Sentence denotes As shown in Figure 4B, mAb 1A9 stained a considerable number of SARS-CoV-2-infected cells at 24 hours post-infection showing that it is sensitive enough to detect the expression of S protein during infection.
T213 27110-27120 Sentence denotes Discussion
T214 27121-27237 Sentence denotes Numerous mAbs against the S protein of SARS-CoV-1 have been generated for research and diagnostic assay development.
T215 27238-27375 Sentence denotes Some of these may be able to cross-react with the S protein of SARS-CoV-2 and serve as tools to aid research on this newly emerged virus.
T216 27376-27541 Sentence denotes In this current study, an immunogenic domain in the S2 subunit of SARS-CoV-1 was found to be highly conserved in multiple strains of SARS-CoV-2 (Figure 1 and Table).
T217 27542-27720 Sentence denotes Consistently, WB and IF analyses showed that four different mAbs generated using this SARS-CoV-1 domain were cross-reactive against the S protein of SARS-CoV-2 (Figures 2 and 3).
T218 27721-27846 Sentence denotes Recent cross-reactivity studies have evaluated SARS-CoV-1 neutralising antibodies that bind to the RBD-containing S1 subunit.
T219 27847-28019 Sentence denotes Although both SARS-CoV-1 and SARS-CoV-2 use ACE2 as a receptor for viral entry [3,16], several SARS-CoV-1 RBD-directed mAbs did not cross-react with SARS-CoV-2 RBD [28,29].
T220 28020-28223 Sentence denotes Interestingly, CR3022, which was isolated from a SARS convalescent patient [22], showed cross-reactivity to SARS-CoV-2 RBD and recognises an epitope that does not overlap with the ACE2 binding site [28].
T221 28224-28356 Sentence denotes Among the four mAbs tested in this study, indirect ELISA showed that 1A9 binds strongest to the S protein of SARS-CoV-2 (Figure 3B).
T222 28357-28524 Sentence denotes To determine if 1A9 is useful for detection of S protein in a sandwich ELISA, it was paired with CR3022 since 1A9 binds to S2 subunit while CR3022 binds to S1 subunit.
T223 28525-28630 Sentence denotes As would be expected, these two antibodies can be paired to detect S protein from 15.6 ng/mL (Figure 4A).
T224 28631-28841 Sentence denotes In addition, mAb 1A9 stained a considerable number of SARS-CoV-2-infected cells at 24 hours post-infection showing that it is sensitive enough to detect the expression of S protein during infection (Figure 4B).
T225 28842-28983 Sentence denotes Thus, mAbs 1A9 will be useful for studying the kinetics of SARS-CoV-2 replication in vitro and development of diagnostic assays for COVID-19.
T226 28984-29131 Sentence denotes It is noteworthy that cytotoxic T-lymphocyte (CTL) epitopes also reside at residues 884–891 and 1116–1123 within the S2 subunit of SARS-CoV-1 [30].
T227 29132-29223 Sentence denotes Interestingly, the latter CTL epitope overlaps with the epitope recognised by mAb 1A9 [21].
T228 29224-29374 Sentence denotes Hence, the S2 subunit may serve as an important antigen for inducing both humoral as well as cell-mediated immunity against SARS-CoV-1 and SARS-CoV-2.
T229 29375-29594 Sentence denotes To our knowledge, this is the first study showing that mAbs targeting the S2 domain of SARS-CoV-1 can cross-react with SARS-CoV-2 and this observation is consistent with the high sequence conservation in the S2 subunit.
T230 29595-29801 Sentence denotes The ability of these antibodies, particularly 1A9, to detect SARS-CoV-2 S protein in indirect and sandwich ELISAs demonstrate their utility for detection of SARS-CoV-2 infections in a public health setting.
T231 29802-30022 Sentence denotes Whether or not the current sensitivity of these antibodies are sufficient for robust detection of SARS-CoV-2 infections in a clinical setting and how they compare to existing PCR-based detection remains to be determined.
T232 30023-30170 Sentence denotes Successful development of these antibodies into a point of care diagnostic kit will provide a complementary approach to existing detection methods.
T233 30171-30306 Sentence denotes Besides the mAbs characterised here, several other mAbs have been reported to bind to epitopes in the S2 subunit of SARS-CoV-1 [31-33].
T234 30307-30398 Sentence denotes Thus, it will be important to determine if these mAbs can also cross-react with SARS-CoV-2.
T235 30400-30416 Sentence denotes Acknowledgements
T236 30417-30569 Sentence denotes The work performed in NUS/NUHS was supported by NUHS Research Office under Project Number NUHSRO/2020/033/RO5+5/CORONAVIRUS/LOA (WBS R-571-000-071-733).
T237 30570-30712 Sentence denotes The work performed in IMCB and BII was also supported by A*STAR through intramural funding and an A*CRUSE gap funding (ACCL/19-GAP064-R20H-F).
T238 30714-30887 Sentence denotes Conflict of interest: WJH and YJT declare that they are involved in the licensing of mAbs 1A9, 1G10, 4B12 and 2B2 to commercial companies as research or diagnostic reagents.
T239 30888-30954 Sentence denotes The other authors have declared that no competing interests exist.
T240 30955-30978 Sentence denotes Authors’ contributions:
T241 30979-31084 Sentence denotes Zheng Z – Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T242 31085-31194 Sentence denotes Monteil, VM - Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T243 31195-31308 Sentence denotes Maurer-Stroh, S - Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T244 31309-31362 Sentence denotes Yew CW - Designed experiments, performed experiments.
T245 31363-31417 Sentence denotes Leong C - Designed experiments, performed experiments.
T246 31418-31530 Sentence denotes Mohd-Ismail NK - Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T247 31531-31607 Sentence denotes Cheyyatraivendran Arularasu S - Designed experiments, performed experiments.
T248 31608-31647 Sentence denotes Chow VTK – Analysed and organised data.
T249 31648-31686 Sentence denotes Lin RTP – Analysed and organised data.
T250 31687-31794 Sentence denotes Mirazimi A– Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T251 31795-31832 Sentence denotes Hong WJ- Analysed and organised data.
T252 31833-31936 Sentence denotes Tan YJ- Designed experiments, performed experiments, analysed and organised data, wrote the manuscript.
T253 31938-31956 Sentence denotes Supplementary Data
T254 31957-31978 Sentence denotes Supplementary Table 1
T255 31979-32015 Sentence denotes Click here for additional data file.
T256 32017-32035 Sentence denotes Supplementary Data
T257 32036-32057 Sentence denotes Supplementary Table 2
T258 32058-32094 Sentence denotes Click here for additional data file.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 7401-7410 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T2 20564-20573 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32700671-12690091-29327457 2036-2037 12690091 denotes 1
32700671-12690092-29327458 2038-2039 12690092 denotes 2
32700671-32015507-29327459 2302-2303 32015507 denotes 3
32700671-32005086-29327459 2302-2303 32005086 denotes 3
32700671-31995857-29327459 2302-2303 31995857 denotes 3
32700671-27578435-29327460 3135-3136 27578435 denotes 7
32700671-31987001-29327461 3304-3305 31987001 denotes 8
32700671-32007145-29327462 3306-3307 32007145 denotes 9
32700671-32027036-29327463 3526-3528 32027036 denotes 10
32700671-16169905-29327464 3659-3661 16169905 denotes 11
32700671-24172901-29327464 3659-3661 24172901 denotes 11
32700671-29190287-29327464 3659-3661 29190287 denotes 11
32700671-26719272-29327464 3659-3661 26719272 denotes 11
32700671-26719272-29327465 3811-3813 26719272 denotes 14
32700671-19906932-29327466 3814-3816 19906932 denotes 15
32700671-26719272-29327467 3988-3990 26719272 denotes 14
32700671-19906932-29327468 3991-3993 19906932 denotes 15
32700671-31987001-29327469 4195-4196 31987001 denotes 8
32700671-32007145-29327470 4197-4198 32007145 denotes 9
32700671-32015507-29327471 4382-4383 32015507 denotes 3
32700671-14647384-29327472 4384-4386 14647384 denotes 16
32700671-31996437-29327472 4384-4386 31996437 denotes 16
32700671-32094589-29327472 4384-4386 32094589 denotes 16
32700671-15731223-29327473 4758-4760 15731223 denotes 19
32700671-16378996-29327474 4915-4917 16378996 denotes 20
32700671-25019613-29327475 5207-5209 25019613 denotes 21
32700671-16378996-29327476 6442-6444 16378996 denotes 20
32700671-16796401-29327477 11311-11313 16796401 denotes 22
32700671-31906790-29327478 11820-11822 31906790 denotes 23
32700671-29506019-29327479 14388-14390 29506019 denotes 24
32700671-19151095-29327480 14506-14508 19151095 denotes 25
32700671-29722887-29327481 14570-14572 29722887 denotes 26
32700671-31565258-29327482 18985-18987 31565258 denotes 27
32700671-32015507-29327483 27927-27928 32015507 denotes 3
32700671-14647384-29327484 27929-27931 14647384 denotes 16
32700671-32065055-29327485 28012-28014 32065055 denotes 28
32700671-32075877-29327486 28015-28017 32075877 denotes 29
32700671-16796401-29327487 28096-28098 16796401 denotes 22
32700671-32065055-29327488 28219-28221 32065055 denotes 28
32700671-19475608-29327489 29127-29129 19475608 denotes 30
32700671-25019613-29327490 29219-29221 25019613 denotes 21
32700671-21592986-29327491 30299-30301 21592986 denotes 31
32700671-15731234-29327491 30299-30301 15731234 denotes 31
32700671-15939399-29327491 30299-30301 15939399 denotes 31

MyTest

Id Subject Object Predicate Lexical cue
32700671-12690091-29327457 2036-2037 12690091 denotes 1
32700671-12690092-29327458 2038-2039 12690092 denotes 2
32700671-32015507-29327459 2302-2303 32015507 denotes 3
32700671-32005086-29327459 2302-2303 32005086 denotes 3
32700671-31995857-29327459 2302-2303 31995857 denotes 3
32700671-27578435-29327460 3135-3136 27578435 denotes 7
32700671-31987001-29327461 3304-3305 31987001 denotes 8
32700671-32007145-29327462 3306-3307 32007145 denotes 9
32700671-32027036-29327463 3526-3528 32027036 denotes 10
32700671-16169905-29327464 3659-3661 16169905 denotes 11
32700671-24172901-29327464 3659-3661 24172901 denotes 11
32700671-29190287-29327464 3659-3661 29190287 denotes 11
32700671-26719272-29327464 3659-3661 26719272 denotes 11
32700671-26719272-29327465 3811-3813 26719272 denotes 14
32700671-19906932-29327466 3814-3816 19906932 denotes 15
32700671-26719272-29327467 3988-3990 26719272 denotes 14
32700671-19906932-29327468 3991-3993 19906932 denotes 15
32700671-31987001-29327469 4195-4196 31987001 denotes 8
32700671-32007145-29327470 4197-4198 32007145 denotes 9
32700671-32015507-29327471 4382-4383 32015507 denotes 3
32700671-14647384-29327472 4384-4386 14647384 denotes 16
32700671-31996437-29327472 4384-4386 31996437 denotes 16
32700671-32094589-29327472 4384-4386 32094589 denotes 16
32700671-15731223-29327473 4758-4760 15731223 denotes 19
32700671-16378996-29327474 4915-4917 16378996 denotes 20
32700671-25019613-29327475 5207-5209 25019613 denotes 21
32700671-16378996-29327476 6442-6444 16378996 denotes 20
32700671-16796401-29327477 11311-11313 16796401 denotes 22
32700671-31906790-29327478 11820-11822 31906790 denotes 23
32700671-29506019-29327479 14388-14390 29506019 denotes 24
32700671-19151095-29327480 14506-14508 19151095 denotes 25
32700671-29722887-29327481 14570-14572 29722887 denotes 26
32700671-31565258-29327482 18985-18987 31565258 denotes 27
32700671-32015507-29327483 27927-27928 32015507 denotes 3
32700671-14647384-29327484 27929-27931 14647384 denotes 16
32700671-32065055-29327485 28012-28014 32065055 denotes 28
32700671-32075877-29327486 28015-28017 32075877 denotes 29
32700671-16796401-29327487 28096-28098 16796401 denotes 22
32700671-32065055-29327488 28219-28221 32065055 denotes 28
32700671-19475608-29327489 29127-29129 19475608 denotes 30
32700671-25019613-29327490 29219-29221 25019613 denotes 21
32700671-21592986-29327491 30299-30301 21592986 denotes 31
32700671-15731234-29327491 30299-30301 15731234 denotes 31
32700671-15939399-29327491 30299-30301 15939399 denotes 31