PMC:7373848 / 8734-9340
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7373848","sourcedb":"PMC","sourceid":"7373848","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7373848","text":"The luminal surface of endothelial cells within arteries, veins and microvessels is coated with a thin (~ 500 nm) glycocalyx layer of plasma proteins, sulfated proteoglycans, glycoproteins and hyaluronan (reviewed in Weinbaum) [10]. Endothelial cell glycocalyx has several recognized functions, including maintaining vascular integrity, permeability, shear stress, mechanosensing and inflammatory responses. Leukocytes traversing a small-caliber capillary actually crush the glycocalyx. The transient deformation quickly corrects due to the elasticity of core proteins that behave like elastic fibers [11].","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":193,"end":203},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T137","span":{"begin":23,"end":40},"obj":"Body_part"},{"id":"T138","span":{"begin":35,"end":40},"obj":"Body_part"},{"id":"T139","span":{"begin":48,"end":56},"obj":"Body_part"},{"id":"T140","span":{"begin":58,"end":63},"obj":"Body_part"},{"id":"T141","span":{"begin":114,"end":124},"obj":"Body_part"},{"id":"T142","span":{"begin":134,"end":140},"obj":"Body_part"},{"id":"T143","span":{"begin":141,"end":149},"obj":"Body_part"},{"id":"T144","span":{"begin":160,"end":173},"obj":"Body_part"},{"id":"T145","span":{"begin":175,"end":188},"obj":"Body_part"},{"id":"T146","span":{"begin":193,"end":203},"obj":"Body_part"},{"id":"T147","span":{"begin":233,"end":249},"obj":"Body_part"},{"id":"T148","span":{"begin":245,"end":249},"obj":"Body_part"},{"id":"T149","span":{"begin":250,"end":260},"obj":"Body_part"},{"id":"T150","span":{"begin":408,"end":418},"obj":"Body_part"},{"id":"T151","span":{"begin":446,"end":455},"obj":"Body_part"},{"id":"T152","span":{"begin":475,"end":485},"obj":"Body_part"},{"id":"T153","span":{"begin":560,"end":568},"obj":"Body_part"},{"id":"T154","span":{"begin":586,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma63812"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma63814"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma66838"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma63015"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma63014"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma66838"},{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma66838"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma63868"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":446,"end":455},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"99","span":{"begin":4,"end":11},"obj":"Chemical"}],"attributes":[{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D010634"},{"subj":"99","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T155","span":{"begin":23,"end":40},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T156","span":{"begin":48,"end":56},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T157","span":{"begin":48,"end":56},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T158","span":{"begin":58,"end":63},"obj":"http://purl.obolibrary.org/obo/UBERON_0001638"},{"id":"T159","span":{"begin":58,"end":63},"obj":"http://www.ebi.ac.uk/efo/EFO_0000816"},{"id":"T160","span":{"begin":96,"end":97},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T161","span":{"begin":134,"end":140},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T162","span":{"begin":233,"end":249},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T163","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T164","span":{"begin":430,"end":431},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T165","span":{"begin":602,"end":604},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"attributes":[{"subj":"T155","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T39","span":{"begin":141,"end":149},"obj":"Chemical"},{"id":"T40","span":{"begin":160,"end":173},"obj":"Chemical"},{"id":"T41","span":{"begin":175,"end":188},"obj":"Chemical"},{"id":"T42","span":{"begin":193,"end":203},"obj":"Chemical"},{"id":"T44","span":{"begin":560,"end":568},"obj":"Chemical"}],"attributes":[{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A43","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_16336"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T37","span":{"begin":384,"end":406},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T37","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T55","span":{"begin":0,"end":232},"obj":"Sentence"},{"id":"T56","span":{"begin":233,"end":407},"obj":"Sentence"},{"id":"T57","span":{"begin":408,"end":486},"obj":"Sentence"},{"id":"T58","span":{"begin":487,"end":606},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T311","span":{"begin":23,"end":34},"obj":"UBERON:0001986;CL:0000115"},{"id":"T312","span":{"begin":35,"end":40},"obj":"CL:0000115"},{"id":"T313","span":{"begin":48,"end":56},"obj":"UBERON:0001637"},{"id":"T314","span":{"begin":58,"end":63},"obj":"UBERON:0001638"},{"id":"T315","span":{"begin":114,"end":124},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T316","span":{"begin":134,"end":140},"obj":"UBERON:0001969"},{"id":"T317","span":{"begin":160,"end":173},"obj":"CHEBI:37396;CHEBI:37396"},{"id":"T318","span":{"begin":175,"end":188},"obj":"CHEBI:17089;CHEBI:17089;BV_11"},{"id":"T319","span":{"begin":233,"end":244},"obj":"UBERON:0001986;CL:0000115"},{"id":"T320","span":{"begin":245,"end":249},"obj":"CL:0000115"},{"id":"T321","span":{"begin":250,"end":260},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T322","span":{"begin":408,"end":418},"obj":"CL:0000738"},{"id":"T323","span":{"begin":446,"end":455},"obj":"UBERON:0001982"},{"id":"T324","span":{"begin":475,"end":485},"obj":"CHEBI:17089;CHEBI:17089"}],"attributes":[{"subj":"T311","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T312","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T313","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T314","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T315","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T316","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T317","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T318","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T319","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T320","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T321","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T322","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T323","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T324","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"2_test","denotations":[{"id":"32700024-17373886-64991451","span":{"begin":228,"end":230},"obj":"17373886"},{"id":"32700024-15545600-64991452","span":{"begin":602,"end":604},"obj":"15545600"}],"attributes":[{"subj":"32700024-17373886-64991451","pred":"source","obj":"2_test"},{"subj":"32700024-15545600-64991452","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#93bcec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d6ec93"},{"id":"LitCovid-PD-UBERON","color":"#e793ec"},{"id":"LitCovid-PubTator","color":"#93eccd"},{"id":"LitCovid-PD-CLO","color":"#ecb393"},{"id":"LitCovid-PD-CHEBI","color":"#9993ec"},{"id":"LitCovid-PD-GO-BP","color":"#a6ec93"},{"id":"LitCovid-sentences","color":"#ec93c0"},{"id":"LitCovid-PMC-OGER-BB","color":"#93daec"},{"id":"2_test","color":"#ece493"}]}]}}