PMC:7373848 / 23314-25661
Annnotations
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T418","span":{"begin":0,"end":16},"obj":"Body_part"},{"id":"T419","span":{"begin":12,"end":16},"obj":"Body_part"},{"id":"T420","span":{"begin":112,"end":129},"obj":"Body_part"},{"id":"T421","span":{"begin":124,"end":129},"obj":"Body_part"},{"id":"T422","span":{"begin":239,"end":254},"obj":"Body_part"},{"id":"T423","span":{"begin":323,"end":335},"obj":"Body_part"},{"id":"T424","span":{"begin":346,"end":357},"obj":"Body_part"},{"id":"T425","span":{"begin":730,"end":742},"obj":"Body_part"},{"id":"T426","span":{"begin":730,"end":735},"obj":"Body_part"},{"id":"T427","span":{"begin":822,"end":825},"obj":"Body_part"},{"id":"T428","span":{"begin":841,"end":846},"obj":"Body_part"},{"id":"T429","span":{"begin":913,"end":916},"obj":"Body_part"},{"id":"T430","span":{"begin":917,"end":932},"obj":"Body_part"},{"id":"T431","span":{"begin":984,"end":988},"obj":"Body_part"},{"id":"T432","span":{"begin":1007,"end":1011},"obj":"Body_part"},{"id":"T433","span":{"begin":1082,"end":1086},"obj":"Body_part"},{"id":"T434","span":{"begin":1098,"end":1102},"obj":"Body_part"},{"id":"T435","span":{"begin":1111,"end":1118},"obj":"Body_part"},{"id":"T436","span":{"begin":1163,"end":1167},"obj":"Body_part"},{"id":"T437","span":{"begin":1179,"end":1183},"obj":"Body_part"},{"id":"T438","span":{"begin":1251,"end":1254},"obj":"Body_part"},{"id":"T439","span":{"begin":1263,"end":1269},"obj":"Body_part"},{"id":"T440","span":{"begin":1318,"end":1324},"obj":"Body_part"},{"id":"T441","span":{"begin":1325,"end":1330},"obj":"Body_part"},{"id":"T442","span":{"begin":1331,"end":1335},"obj":"Body_part"},{"id":"T443","span":{"begin":1486,"end":1494},"obj":"Body_part"},{"id":"T444","span":{"begin":1501,"end":1505},"obj":"Body_part"},{"id":"T445","span":{"begin":1611,"end":1615},"obj":"Body_part"},{"id":"T446","span":{"begin":1678,"end":1683},"obj":"Body_part"},{"id":"T447","span":{"begin":1690,"end":1694},"obj":"Body_part"},{"id":"T448","span":{"begin":1903,"end":1912},"obj":"Body_part"},{"id":"T449","span":{"begin":1913,"end":1918},"obj":"Body_part"},{"id":"T450","span":{"begin":1925,"end":1929},"obj":"Body_part"},{"id":"T451","span":{"begin":1975,"end":1980},"obj":"Body_part"},{"id":"T452","span":{"begin":2033,"end":2038},"obj":"Body_part"},{"id":"T453","span":{"begin":2045,"end":2049},"obj":"Body_part"},{"id":"T454","span":{"begin":2134,"end":2148},"obj":"Body_part"},{"id":"T455","span":{"begin":2142,"end":2148},"obj":"Body_part"},{"id":"T456","span":{"begin":2277,"end":2291},"obj":"Body_part"}],"attributes":[{"id":"A418","pred":"fma_id","subj":"T418","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A419","pred":"fma_id","subj":"T419","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A420","pred":"fma_id","subj":"T420","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A421","pred":"fma_id","subj":"T421","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A422","pred":"fma_id","subj":"T422","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A423","pred":"fma_id","subj":"T423","obj":"http://purl.org/sig/ont/fma/fma82744"},{"id":"A424","pred":"fma_id","subj":"T424","obj":"http://purl.org/sig/ont/fma/fma82797"},{"id":"A425","pred":"fma_id","subj":"T425","obj":"http://purl.org/sig/ont/fma/fma7149"},{"id":"A426","pred":"fma_id","subj":"T426","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A427","pred":"fma_id","subj":"T427","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A428","pred":"fma_id","subj":"T428","obj":"http://purl.org/sig/ont/fma/fma65132"},{"id":"A429","pred":"fma_id","subj":"T429","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A430","pred":"fma_id","subj":"T430","obj":"http://purl.org/sig/ont/fma/fma86464"},{"id":"A431","pred":"fma_id","subj":"T431","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A432","pred":"fma_id","subj":"T432","obj":"http://purl.org/sig/ont/fma/fma70664"},{"id":"A433","pred":"fma_id","subj":"T433","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A434","pred":"fma_id","subj":"T434","obj":"http://purl.org/sig/ont/fma/fma70664"},{"id":"A435","pred":"fma_id","subj":"T435","obj":"http://purl.org/sig/ont/fma/fma9666"},{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma70664"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A439","pred":"fma_id","subj":"T439","obj":"http://purl.org/sig/ont/fma/fma264279"},{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A441","pred":"fma_id","subj":"T441","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A442","pred":"fma_id","subj":"T442","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A443","pred":"fma_id","subj":"T443","obj":"http://purl.org/sig/ont/fma/fma63812"},{"id":"A444","pred":"fma_id","subj":"T444","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A445","pred":"fma_id","subj":"T445","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A446","pred":"fma_id","subj":"T446","obj":"http://purl.org/sig/ont/fma/fma3734"},{"id":"A447","pred":"fma_id","subj":"T447","obj":"http://purl.org/sig/ont/fma/fma7182"},{"id":"A448","pred":"fma_id","subj":"T448","obj":"http://purl.org/sig/ont/fma/fma7144"},{"id":"A449","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma3734"},{"id":"A450","pred":"fma_id","subj":"T450","obj":"http://purl.org/sig/ont/fma/fma7182"},{"id":"A451","pred":"fma_id","subj":"T451","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A452","pred":"fma_id","subj":"T452","obj":"http://purl.org/sig/ont/fma/fma3734"},{"id":"A453","pred":"fma_id","subj":"T453","obj":"http://purl.org/sig/ont/fma/fma7182"},{"id":"A454","pred":"fma_id","subj":"T454","obj":"http://purl.org/sig/ont/fma/fma49879"},{"id":"A455","pred":"fma_id","subj":"T455","obj":"http://purl.org/sig/ont/fma/fma50720"},{"id":"A456","pred":"fma_id","subj":"T456","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T101","span":{"begin":730,"end":735},"obj":"Body_part"},{"id":"T102","span":{"begin":841,"end":846},"obj":"Body_part"},{"id":"T103","span":{"begin":917,"end":932},"obj":"Body_part"},{"id":"T104","span":{"begin":984,"end":988},"obj":"Body_part"},{"id":"T105","span":{"begin":1082,"end":1086},"obj":"Body_part"},{"id":"T106","span":{"begin":1111,"end":1118},"obj":"Body_part"},{"id":"T107","span":{"begin":1163,"end":1167},"obj":"Body_part"},{"id":"T108","span":{"begin":1318,"end":1324},"obj":"Body_part"},{"id":"T109","span":{"begin":1325,"end":1330},"obj":"Body_part"},{"id":"T110","span":{"begin":1331,"end":1335},"obj":"Body_part"},{"id":"T111","span":{"begin":1501,"end":1505},"obj":"Body_part"},{"id":"T112","span":{"begin":1611,"end":1615},"obj":"Body_part"},{"id":"T113","span":{"begin":1678,"end":1683},"obj":"Body_part"},{"id":"T114","span":{"begin":1690,"end":1694},"obj":"Body_part"},{"id":"T115","span":{"begin":1903,"end":1912},"obj":"Body_part"},{"id":"T116","span":{"begin":1913,"end":1918},"obj":"Body_part"},{"id":"T117","span":{"begin":1925,"end":1929},"obj":"Body_part"},{"id":"T118","span":{"begin":2033,"end":2038},"obj":"Body_part"},{"id":"T119","span":{"begin":2045,"end":2049},"obj":"Body_part"},{"id":"T120","span":{"begin":2142,"end":2148},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"uberon_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A102","pred":"uberon_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/UBERON_0001021"},{"id":"A103","pred":"uberon_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/UBERON_0002336"},{"id":"A104","pred":"uberon_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A105","pred":"uberon_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A106","pred":"uberon_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/UBERON_0002389"},{"id":"A107","pred":"uberon_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A108","pred":"uberon_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A109","pred":"uberon_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A110","pred":"uberon_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A111","pred":"uberon_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A112","pred":"uberon_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A113","pred":"uberon_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/UBERON_0000947"},{"id":"A114","pred":"uberon_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/UBERON_0002101"},{"id":"A115","pred":"uberon_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/UBERON_0002095"},{"id":"A116","pred":"uberon_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/UBERON_0000947"},{"id":"A117","pred":"uberon_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/UBERON_0002101"},{"id":"A118","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0000947"},{"id":"A119","pred":"uberon_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/UBERON_0002101"},{"id":"A120","pred":"uberon_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/UBERON_0001637"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"408","span":{"begin":698,"end":705},"obj":"Species"},{"id":"409","span":{"begin":2196,"end":2214},"obj":"Chemical"},{"id":"410","span":{"begin":827,"end":830},"obj":"Disease"},{"id":"411","span":{"begin":847,"end":852},"obj":"Disease"},{"id":"412","span":{"begin":933,"end":940},"obj":"Disease"},{"id":"413","span":{"begin":1001,"end":1011},"obj":"Disease"},{"id":"414","span":{"begin":1313,"end":1350},"obj":"Disease"},{"id":"415","span":{"begin":1410,"end":1418},"obj":"Disease"},{"id":"416","span":{"begin":1477,"end":1531},"obj":"Disease"},{"id":"417","span":{"begin":1611,"end":1638},"obj":"Disease"},{"id":"418","span":{"begin":1690,"end":1710},"obj":"Disease"},{"id":"419","span":{"begin":1822,"end":1841},"obj":"Disease"},{"id":"420","span":{"begin":1919,"end":1953},"obj":"Disease"},{"id":"421","span":{"begin":2045,"end":2058},"obj":"Disease"},{"id":"424","span":{"begin":678,"end":686},"obj":"Disease"},{"id":"425","span":{"begin":687,"end":697},"obj":"Disease"},{"id":"427","span":{"begin":2215,"end":2218},"obj":"Disease"},{"id":"437","span":{"begin":66,"end":74},"obj":"Species"},{"id":"438","span":{"begin":239,"end":254},"obj":"Chemical"},{"id":"439","span":{"begin":323,"end":335},"obj":"Chemical"},{"id":"440","span":{"begin":346,"end":357},"obj":"Chemical"},{"id":"441","span":{"begin":362,"end":373},"obj":"Chemical"},{"id":"442","span":{"begin":391,"end":398},"obj":"Chemical"},{"id":"443","span":{"begin":17,"end":29},"obj":"Disease"},{"id":"444","span":{"begin":80,"end":88},"obj":"Disease"},{"id":"445","span":{"begin":628,"end":638},"obj":"Disease"}],"attributes":[{"id":"A408","pred":"tao:has_database_id","subj":"408","obj":"Tax:9606"},{"id":"A410","pred":"tao:has_database_id","subj":"410","obj":"MESH:C567755"},{"id":"A411","pred":"tao:has_database_id","subj":"411","obj":"MESH:D010243"},{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"MESH:D007238"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"MESH:C000657245"},{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"MESH:D008133"},{"id":"A415","pred":"tao:has_database_id","subj":"415","obj":"MESH:D003967"},{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"MESH:D008171"},{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"MESH:D012131"},{"id":"A420","pred":"tao:has_database_id","subj":"420","obj":"MESH:D059787"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"MESH:D007511"},{"id":"A424","pred":"tao:has_database_id","subj":"424","obj":"MESH:C000657245"},{"id":"A425","pred":"tao:has_database_id","subj":"425","obj":"MESH:D014657"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"MESH:C567755"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Tax:9606"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"MESH:D006497"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"MESH:D004187"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"MESH:D005944"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"MESH:D014574"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"MESH:D013431"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"MESH:D007249"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"MESH:C000657245"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:D014657"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T90","span":{"begin":17,"end":29},"obj":"Disease"},{"id":"T91","span":{"begin":80,"end":88},"obj":"Disease"},{"id":"T92","span":{"begin":628,"end":638},"obj":"Disease"},{"id":"T93","span":{"begin":678,"end":686},"obj":"Disease"},{"id":"T94","span":{"begin":687,"end":697},"obj":"Disease"},{"id":"T95","span":{"begin":847,"end":852},"obj":"Disease"},{"id":"T96","span":{"begin":1410,"end":1418},"obj":"Disease"},{"id":"T97","span":{"begin":1501,"end":1510},"obj":"Disease"},{"id":"T98","span":{"begin":1511,"end":1519},"obj":"Disease"},{"id":"T99","span":{"begin":1520,"end":1531},"obj":"Disease"},{"id":"T100","span":{"begin":1695,"end":1703},"obj":"Disease"},{"id":"T101","span":{"begin":1704,"end":1710},"obj":"Disease"},{"id":"T103","span":{"begin":1822,"end":1841},"obj":"Disease"},{"id":"T104","span":{"begin":1925,"end":1938},"obj":"Disease"},{"id":"T105","span":{"begin":1930,"end":1938},"obj":"Disease"},{"id":"T106","span":{"begin":2045,"end":2058},"obj":"Disease"},{"id":"T107","span":{"begin":2050,"end":2058},"obj":"Disease"}],"attributes":[{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0006496"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0006547"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005468"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"},{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0005098"},{"id":"A102","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0000491"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0000491"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-CLO
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span":{"begin":1611,"end":1615},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T428","span":{"begin":1678,"end":1683},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T429","span":{"begin":1690,"end":1694},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T430","span":{"begin":1798,"end":1804},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T431","span":{"begin":1842,"end":1850},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T432","span":{"begin":1842,"end":1850},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T433","span":{"begin":1903,"end":1912},"obj":"http://purl.obolibrary.org/obo/UBERON_0002095"},{"id":"T434","span":{"begin":1913,"end":1918},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T435","span":{"begin":1925,"end":1929},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T436","span":{"begin":2017,"end":2019},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T437","span":{"begin":2033,"end":2038},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T438","span":{"begin":2045,"end":2049},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T439","span":{"begin":2063,"end":2071},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T440","span":{"begin":2063,"end":2071},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T441","span":{"begin":2142,"end":2148},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T442","span":{"begin":2142,"end":2148},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T146","span":{"begin":239,"end":254},"obj":"Chemical"},{"id":"T147","span":{"begin":239,"end":246},"obj":"Chemical"},{"id":"T148","span":{"begin":247,"end":254},"obj":"Chemical"},{"id":"T149","span":{"begin":323,"end":335},"obj":"Chemical"},{"id":"T150","span":{"begin":346,"end":357},"obj":"Chemical"},{"id":"T151","span":{"begin":362,"end":373},"obj":"Chemical"},{"id":"T152","span":{"begin":369,"end":373},"obj":"Chemical"},{"id":"T153","span":{"begin":391,"end":398},"obj":"Chemical"},{"id":"T154","span":{"begin":399,"end":404},"obj":"Chemical"},{"id":"T155","span":{"begin":559,"end":566},"obj":"Chemical"},{"id":"T156","span":{"begin":857,"end":859},"obj":"Chemical"},{"id":"T157","span":{"begin":860,"end":862},"obj":"Chemical"},{"id":"T158","span":{"begin":870,"end":880},"obj":"Chemical"},{"id":"T159","span":{"begin":904,"end":906},"obj":"Chemical"},{"id":"T160","span":{"begin":907,"end":909},"obj":"Chemical"},{"id":"T161","span":{"begin":910,"end":912},"obj":"Chemical"},{"id":"T162","span":{"begin":945,"end":947},"obj":"Chemical"},{"id":"T163","span":{"begin":948,"end":950},"obj":"Chemical"},{"id":"T164","span":{"begin":1128,"end":1130},"obj":"Chemical"},{"id":"T165","span":{"begin":1205,"end":1207},"obj":"Chemical"},{"id":"T166","span":{"begin":1296,"end":1298},"obj":"Chemical"},{"id":"T167","span":{"begin":1392,"end":1394},"obj":"Chemical"},{"id":"T168","span":{"begin":1395,"end":1397},"obj":"Chemical"},{"id":"T169","span":{"begin":1398,"end":1400},"obj":"Chemical"},{"id":"T170","span":{"begin":1401,"end":1403},"obj":"Chemical"},{"id":"T171","span":{"begin":1563,"end":1570},"obj":"Chemical"},{"id":"T172","span":{"begin":1596,"end":1598},"obj":"Chemical"},{"id":"T173","span":{"begin":1639,"end":1641},"obj":"Chemical"},{"id":"T174","span":{"begin":1711,"end":1714},"obj":"Chemical"},{"id":"T175","span":{"begin":1954,"end":1957},"obj":"Chemical"},{"id":"T176","span":{"begin":1958,"end":1961},"obj":"Chemical"},{"id":"T177","span":{"begin":2059,"end":2062},"obj":"Chemical"},{"id":"T178","span":{"begin":2122,"end":2124},"obj":"Chemical"},{"id":"T179","span":{"begin":2125,"end":2127},"obj":"Chemical"},{"id":"T180","span":{"begin":2134,"end":2141},"obj":"Chemical"},{"id":"T181","span":{"begin":2243,"end":2245},"obj":"Chemical"},{"id":"T182","span":{"begin":2293,"end":2296},"obj":"Chemical"}],"attributes":[{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_36233"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_5417"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_27252"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_74698"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_8382"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A165","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A168","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A170","pred":"chebi_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/CHEBI_73907"},{"id":"A171","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_15365"},{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A173","pred":"chebi_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_17217"},{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_17217"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_17217"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_17217"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A180","pred":"chebi_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/CHEBI_17898"},{"id":"A181","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_145751"},{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_17217"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T26","span":{"begin":628,"end":638},"obj":"Phenotype"},{"id":"T27","span":{"begin":687,"end":697},"obj":"Phenotype"},{"id":"T28","span":{"begin":989,"end":999},"obj":"Phenotype"},{"id":"T29","span":{"begin":1087,"end":1097},"obj":"Phenotype"},{"id":"T30","span":{"begin":1168,"end":1178},"obj":"Phenotype"},{"id":"T31","span":{"begin":1336,"end":1342},"obj":"Phenotype"},{"id":"T32","span":{"begin":1343,"end":1350},"obj":"Phenotype"},{"id":"T33","span":{"begin":1410,"end":1418},"obj":"Phenotype"},{"id":"T34","span":{"begin":1495,"end":1500},"obj":"Phenotype"},{"id":"T35","span":{"begin":1501,"end":1510},"obj":"Phenotype"},{"id":"T36","span":{"begin":1511,"end":1519},"obj":"Phenotype"},{"id":"T37","span":{"begin":1520,"end":1531},"obj":"Phenotype"},{"id":"T38","span":{"begin":1616,"end":1623},"obj":"Phenotype"},{"id":"T39","span":{"begin":1624,"end":1629},"obj":"Phenotype"},{"id":"T40","span":{"begin":1704,"end":1710},"obj":"Phenotype"},{"id":"T41","span":{"begin":1822,"end":1841},"obj":"Phenotype"},{"id":"T42","span":{"begin":1939,"end":1953},"obj":"Phenotype"}],"attributes":[{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0009710"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0009710"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0009710"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0100806"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0000988"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0002615"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0001297"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0002027"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T108","span":{"begin":17,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T109","span":{"begin":31,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T110","span":{"begin":31,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0006915"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PD-GlycoEpitope
{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T5","span":{"begin":239,"end":254},"obj":"GlycoEpitope"}],"attributes":[{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T168","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"T169","span":{"begin":95,"end":170},"obj":"Sentence"},{"id":"T170","span":{"begin":171,"end":255},"obj":"Sentence"},{"id":"T171","span":{"begin":256,"end":445},"obj":"Sentence"},{"id":"T172","span":{"begin":446,"end":567},"obj":"Sentence"},{"id":"T173","span":{"begin":568,"end":669},"obj":"Sentence"},{"id":"T174","span":{"begin":670,"end":697},"obj":"Sentence"},{"id":"T175","span":{"begin":698,"end":807},"obj":"Sentence"},{"id":"T176","span":{"begin":808,"end":840},"obj":"Sentence"},{"id":"T177","span":{"begin":841,"end":856},"obj":"Sentence"},{"id":"T178","span":{"begin":857,"end":901},"obj":"Sentence"},{"id":"T179","span":{"begin":902,"end":961},"obj":"Sentence"},{"id":"T180","span":{"begin":962,"end":972},"obj":"Sentence"},{"id":"T181","span":{"begin":973,"end":999},"obj":"Sentence"},{"id":"T182","span":{"begin":1000,"end":1040},"obj":"Sentence"},{"id":"T183","span":{"begin":1041,"end":1058},"obj":"Sentence"},{"id":"T184","span":{"begin":1059,"end":1071},"obj":"Sentence"},{"id":"T185","span":{"begin":1072,"end":1097},"obj":"Sentence"},{"id":"T186","span":{"begin":1098,"end":1140},"obj":"Sentence"},{"id":"T187","span":{"begin":1141,"end":1153},"obj":"Sentence"},{"id":"T188","span":{"begin":1154,"end":1178},"obj":"Sentence"},{"id":"T189","span":{"begin":1179,"end":1218},"obj":"Sentence"},{"id":"T190","span":{"begin":1219,"end":1236},"obj":"Sentence"},{"id":"T191","span":{"begin":1237,"end":1280},"obj":"Sentence"},{"id":"T192","span":{"begin":1281,"end":1305},"obj":"Sentence"},{"id":"T193","span":{"begin":1306,"end":1324},"obj":"Sentence"},{"id":"T194","span":{"begin":1325,"end":1330},"obj":"Sentence"},{"id":"T195","span":{"begin":1331,"end":1342},"obj":"Sentence"},{"id":"T196","span":{"begin":1343,"end":1359},"obj":"Sentence"},{"id":"T197","span":{"begin":1360,"end":1389},"obj":"Sentence"},{"id":"T198","span":{"begin":1390,"end":1456},"obj":"Sentence"},{"id":"T199","span":{"begin":1457,"end":1467},"obj":"Sentence"},{"id":"T200","span":{"begin":1468,"end":1485},"obj":"Sentence"},{"id":"T201","span":{"begin":1486,"end":1500},"obj":"Sentence"},{"id":"T202","span":{"begin":1501,"end":1510},"obj":"Sentence"},{"id":"T203","span":{"begin":1511,"end":1519},"obj":"Sentence"},{"id":"T204","span":{"begin":1520,"end":1540},"obj":"Sentence"},{"id":"T205","span":{"begin":1541,"end":1562},"obj":"Sentence"},{"id":"T206","span":{"begin":1563,"end":1588},"obj":"Sentence"},{"id":"T207","span":{"begin":1589,"end":1623},"obj":"Sentence"},{"id":"T208","span":{"begin":1624,"end":1657},"obj":"Sentence"},{"id":"T209","span":{"begin":1658,"end":1668},"obj":"Sentence"},{"id":"T210","span":{"begin":1669,"end":1694},"obj":"Sentence"},{"id":"T211","span":{"begin":1695,"end":1703},"obj":"Sentence"},{"id":"T212","span":{"begin":1704,"end":1727},"obj":"Sentence"},{"id":"T213","span":{"begin":1728,"end":1756},"obj":"Sentence"},{"id":"T214","span":{"begin":1757,"end":1784},"obj":"Sentence"},{"id":"T215","span":{"begin":1785,"end":1888},"obj":"Sentence"},{"id":"T216","span":{"begin":1889,"end":1912},"obj":"Sentence"},{"id":"T217","span":{"begin":1913,"end":1938},"obj":"Sentence"},{"id":"T218","span":{"begin":1939,"end":1957},"obj":"Sentence"},{"id":"T219","span":{"begin":1958,"end":1974},"obj":"Sentence"},{"id":"T220","span":{"begin":1975,"end":2011},"obj":"Sentence"},{"id":"T221","span":{"begin":2012,"end":2062},"obj":"Sentence"},{"id":"T222","span":{"begin":2063,"end":2086},"obj":"Sentence"},{"id":"T223","span":{"begin":2087,"end":2119},"obj":"Sentence"},{"id":"T224","span":{"begin":2120,"end":2214},"obj":"Sentence"},{"id":"T225","span":{"begin":2215,"end":2347},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
LitCovid-PMC-OGER-BB
{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T792","span":{"begin":0,"end":11},"obj":"UBERON:0001986;CL:0000115"},{"id":"T793","span":{"begin":12,"end":16},"obj":"CL:0000115"},{"id":"T794","span":{"begin":31,"end":40},"obj":"GO:0006915"},{"id":"T795","span":{"begin":80,"end":88},"obj":"SP_7"},{"id":"T796","span":{"begin":112,"end":123},"obj":"UBERON:0001986;CL:0000115"},{"id":"T797","span":{"begin":124,"end":129},"obj":"CL:0000115"},{"id":"T798","span":{"begin":134,"end":141},"obj":"NCBITaxon:10239"},{"id":"T799","span":{"begin":192,"end":197},"obj":"NCBITaxon:10239"},{"id":"T800","span":{"begin":198,"end":208},"obj":"SO:0000366"},{"id":"T801","span":{"begin":213,"end":223},"obj":"SO:0000243"},{"id":"T802","span":{"begin":228,"end":235},"obj":"NCBITaxon:10239"},{"id":"T803","span":{"begin":239,"end":254},"obj":"CHEBI:28815;CHEBI:28815"},{"id":"T804","span":{"begin":277,"end":288},"obj":"UBERON:0001986"},{"id":"T805","span":{"begin":323,"end":335},"obj":"CHEBI:36233;CHEBI:36233"},{"id":"T806","span":{"begin":346,"end":357},"obj":"CHEBI:24271;CHEBI:24271"},{"id":"T807","span":{"begin":362,"end":373},"obj":"CHEBI:27252;CHEBI:27252"},{"id":"T808","span":{"begin":391,"end":398},"obj":"CHEBI:16189;CHEBI:16189"},{"id":"T809","span":{"begin":399,"end":404},"obj":"CHEBI:24433;CHEBI:24433"},{"id":"T810","span":{"begin":540,"end":558},"obj":"CHEBI:62643;CHEBI:62643"},{"id":"T811","span":{"begin":676,"end":686},"obj":"SP_7"},{"id":"T824","span":{"begin":1715,"end":1727},"obj":"GO:0007596"},{"id":"T825","span":{"begin":1728,"end":1743},"obj":"GO:0050817"},{"id":"T826","span":{"begin":1903,"end":1912},"obj":"UBERON:0002095"},{"id":"T828","span":{"begin":1925,"end":1929},"obj":"UBERON:0002101"},{"id":"T829","span":{"begin":1962,"end":1974},"obj":"GO:0007596"},{"id":"T830","span":{"begin":2063,"end":2071},"obj":"UBERON:0001637"},{"id":"T831","span":{"begin":2087,"end":2102},"obj":"GO:0050817"},{"id":"T832","span":{"begin":2219,"end":2234},"obj":"UBERON:0002412"},{"id":"T833","span":{"begin":2260,"end":2264},"obj":"CHEBI:42098;CHEBI:42098"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}
2_test
{"project":"2_test","denotations":[{"id":"32700024-32415579-64991488","span":{"begin":90,"end":92},"obj":"32415579"},{"id":"32700024-32274736-64991489","span":{"begin":441,"end":443},"obj":"32274736"},{"id":"32700024-32609196-64991490","span":{"begin":662,"end":664},"obj":"32609196"},{"id":"32700024-32593341-64991490","span":{"begin":662,"end":664},"obj":"32593341"},{"id":"32700024-32562567-64991490","span":{"begin":662,"end":664},"obj":"32562567"},{"id":"32700024-32502585-64991490","span":{"begin":662,"end":664},"obj":"32502585"},{"id":"32700024-32618041-64991490","span":{"begin":662,"end":664},"obj":"32618041"},{"id":"32700024-32075786-64991490","span":{"begin":662,"end":664},"obj":"32075786"},{"id":"32700024-32492199-64991490","span":{"begin":662,"end":664},"obj":"32492199"},{"id":"32700024-32410760-64991490","span":{"begin":662,"end":664},"obj":"32410760"},{"id":"32700024-32474145-64991490","span":{"begin":662,"end":664},"obj":"32474145"},{"id":"32700024-32353183-64991490","span":{"begin":662,"end":664},"obj":"32353183"},{"id":"32700024-32473304-64991490","span":{"begin":662,"end":664},"obj":"32473304"},{"id":"32700024-32360432-64991490","span":{"begin":662,"end":664},"obj":"32360432"},{"id":"32700024-32425264-64991490","span":{"begin":662,"end":664},"obj":"32425264"}],"text":"Endothelial cell inflammation, apoptosis and dysfunction occur in patients with COVID-19 [37]. The interface of endothelial cells and viruses is of longstanding interest. For example, a major viral attachment and entry site for viruses is heparan sulfate. This is found on the endothelial surface and consists of repeating disaccharide unites of glucosamine and uronic acid with interspaced sulfate group attachments (reviewed in Agelidis) [53]. The highly sulfated state results in a negative density and binding capacity for a variety of positively charged ligands. A partial but representative summary of individual sites of vasculitis is provided (Table 1) [54–69].\nTable 1 COVID-19 vasculitis\nPatient (n) Age (Y) Sex Country Organ system Signs and symptoms Diagnostic test Treatment Outcomes References\n1 69 M Brazil CNS (VBS) Trochlea\nNerve palsy MRI\nMR IV Methyl-prednisone Resolved De Oliveira\n1 NR NR NR CNS Corpus Callosum infarct MRI NR NR Varatharaj\n7 11–17 4M\n3F Spanish Skin Chilblains\n“COVID-Toes” Biopsy Observation Resolved\n8 weeks Colmenero\n17 15–63 11M\n6F France Skin Chilblains\nToes, heels, fingers Biopsy N NR Kanitakis\n19 11–17 14M\n5F Italy Skin Chilblains\nToes, heels, soles Biopsy NR Resolution\n\u003e30days El-Hachem\n1 65 M France CNS Altered mental status MRA\nMRI Supportive NR Hanafi\n1 50 M Asia Kidney\nLiver\nLung Sepsis\nHypoxia Necropsy\nBiopsy Supportive Deceased Xu\n1 NR NR NR GI Tract Diarrhea Biopsy Supportive Recovered Carnevale\n10 5–16 7M\n3F Italy Coronary\nArteries Fever\nSkin rash\nDiarrhea\nHypotension Clinical\nEchocardiography IVIG\nAspirin Recovered Verdoni\n1 \u003e 53 NR Switzerland Lung Dyspnea\nFever Necropsy NR Deceased Menter\n4 50–76 3M\n1F Spain Aorta Acute Limb\nIschemia\nStroke CTA Thrombectomy\nAnticoagulation 3 discharged\n1 deceased Gomez Arbelaez -\n1 67 M Italy Aortic Prosthetic graft Respiratory failure Arterial Duplex Supportive Deceased Giacomelli\n2 60, 75 M UK Mesentery\nAorta Acute Limb ischemia\nAbdominal pain CTA\nCTA Thrombectomy\nBowel Resection Discharged Villliany\n5 57–71 3M 2F France Aorta Acute limb ischemia CTA\nArterial Duplex Surgery\nAnticoagulation Amputation Kashi\n1 NR NR Spain Retinal Artery No symptoms Fundoscopy Observation No symptoms Quintana-Castanedo\nVBS vertebrobasilar system, NR not reported, IVIG intravenous immunoglobulin, CTA Computed Tomography Angiography, UK United Kingdom"}