PMC:7373848 / 21073-22452
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T373 | 0-8 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T374 | 17-33 | Body_part | denotes | endothelial cell | http://purl.org/sig/ont/fma/fma66772 |
| T375 | 29-33 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T376 | 227-236 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T377 | 266-270 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T378 | 266-268 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T379 | 356-361 | Body_part | denotes | Organ | http://purl.org/sig/ont/fma/fma67498 |
| T380 | 426-430 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T381 | 440-457 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T382 | 452-457 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T383 | 488-494 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T384 | 524-539 | Body_part | denotes | cell components | http://purl.org/sig/ont/fma/fma86454 |
| T385 | 524-528 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T386 | 549-568 | Body_part | denotes | extracellular space | http://purl.org/sig/ont/fma/fma70022 |
| T387 | 614-617 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T388 | 644-651 | Body_part | denotes | Histone | http://purl.org/sig/ont/fma/fma74413 |
| T389 | 755-764 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T390 | 766-775 | Body_part | denotes | Platelets | http://purl.org/sig/ont/fma/fma62851 |
| T391 | 790-801 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
| T392 | 806-810 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T393 | 838-847 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T394 | 989-995 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T395 | 1040-1045 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T396 | 1328-1332 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T94 | 356-361 | Body_part | denotes | Organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T95 | 488-494 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T96 | 790-801 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
| T97 | 989-995 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T98 | 1314-1318 | Body_part | denotes | Silk | http://purl.obolibrary.org/obo/UBERON_0012245 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 349 | 629-634 | Gene | denotes | HMGB1 | Gene:3146 |
| 350 | 806-812 | Gene | denotes | ICAM-1 | Gene:3383 |
| 351 | 817-826 | Gene | denotes | Kindlin-3 | Gene:83706 |
| 352 | 1223-1246 | Chemical | denotes | reactive oxygen species | MESH:D017382 |
| 353 | 1248-1251 | Chemical | denotes | ROS | MESH:D017382 |
| 354 | 1254-1268 | Chemical | denotes | polyphosphates | MESH:D011122 |
| 355 | 1270-1276 | Chemical | denotes | Poly-P | MESH:D011122 |
| 356 | 1279-1288 | Chemical | denotes | adenosine | MESH:D000241 |
| 357 | 1303-1306 | Chemical | denotes | ATP | MESH:D000255 |
| 358 | 479-487 | Disease | denotes | necrotic | MESH:D009336 |
| 359 | 1004-1009 | Disease | denotes | edema | MESH:D004487 |
| 360 | 1014-1026 | Disease | denotes | inflammation | MESH:D007249 |
| 361 | 1102-1114 | Disease | denotes | cytotoxicity | MESH:D064420 |
| 364 | 1321-1323 | Gene | denotes | et | Gene:79157 |
| 365 | 1333-1346 | Disease | denotes | Death Disease | MESH:D003643 |
| 370 | 102-131 | Gene | denotes | Tumor necrosis factor (TNF)-α | Gene:7124 |
| 371 | 255-264 | Gene | denotes | caspase-1 | Gene:834 |
| 372 | 266-271 | Gene | denotes | IL-1β | Gene:3552 |
| 373 | 91-100 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T75 | 34-40 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T76 | 91-100 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T77 | 102-107 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T78 | 185-191 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T79 | 348-355 | Disease | denotes | Sterile | http://purl.obolibrary.org/obo/MONDO_0005047 |
| T80 | 362-368 | Disease | denotes | Injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T81 | 996-1002 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T82 | 1014-1026 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T345 | 17-33 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cell |
| T346 | 51-52 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T347 | 159-161 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T348 | 227-236 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T349 | 356-361 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | Organ |
| T350 | 426-430 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T351 | 440-457 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T352 | 524-528 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T353 | 671-679 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T354 | 790-801 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T355 | 828-837 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activated |
| T356 | 870-879 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T357 | 938-948 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T358 | 1028-1037 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activated |
| T359 | 1038-1045 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T360 | 1328-1332 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T126 | 266-268 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T128 | 636-639 | Chemical | denotes | ATP | http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616 |
| T130 | 644-651 | Chemical | denotes | Histone | http://purl.obolibrary.org/obo/CHEBI_15358 |
| T131 | 1130-1135 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T132 | 1223-1246 | Chemical | denotes | reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T133 | 1232-1238 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T134 | 1248-1251 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T135 | 1254-1268 | Chemical | denotes | polyphosphates | http://purl.obolibrary.org/obo/CHEBI_26197 |
| T136 | 1279-1301 | Chemical | denotes | adenosine triphosphate | http://purl.obolibrary.org/obo/CHEBI_15422 |
| T137 | 1279-1288 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T138 | 1289-1301 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T139 | 1303-1306 | Chemical | denotes | ATP | http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T22 | 102-107 | Phenotype | denotes | Tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T23 | 1004-1009 | Phenotype | denotes | edema | http://purl.obolibrary.org/obo/HP_0000969 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T88 | 108-116 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T89 | 108-116 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T90 | 108-116 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T91 | 108-116 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T92 | 241-251 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T93 | 290-300 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
| T94 | 426-436 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T95 | 721-734 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T96 | 938-967 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | activation of the coagulation |
| T97 | 956-967 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T98 | 1014-1026 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T99 | 1328-1338 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | Cell Death |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T147 | 0-101 | Sentence | denotes | Cytokine-induced endothelial cell injury occurs in a variety of conditions including acute infection. |
| T148 | 102-163 | Sentence | denotes | Tumor necrosis factor (TNF)-α is particularly cytotoxic [48]. |
| T149 | 164-326 | Sentence | denotes | The mechanism(s) for injury include recruitment and binding of monocytes, up-regulation of caspase-1, IL-1β and expression of pyroptosis-related factors (Fig. 6). |
| T150 | 327-369 | Sentence | denotes | Fig. 6 Mechanisms of Sterile Organ Injury. |
| T151 | 370-569 | Sentence | denotes | Toxic insults initiate both controlled and uncontrolled cell death in endothelial cells leading to apoptotic/necrotic tissue and release of intracellular cell components into the extracellular space. |
| T152 | 570-765 | Sentence | denotes | These include immunogenic compounds such as RNA and DAMPs (HMGB1, ATP and Histone) which bind to and activate specific TLRs, driving the NFkB-mediated transcription of pro-inflammatory cytokines. |
| T153 | 766-827 | Sentence | denotes | Platelets adhere to the endothelium via ICAM-1 and Kindlin-3. |
| T154 | 828-921 | Sentence | denotes | Activated platelets release Poly P, which activates Factor XII, and subsequently, complement. |
| T155 | 922-1027 | Sentence | denotes | This results in activation of the coagulation pathways and further tissue injury, edema and inflammation. |
| T156 | 1028-1115 | Sentence | denotes | Activated T cells release pro-inflammatory mediators and can cause direct cytotoxicity. |
| T157 | 1116-1307 | Sentence | denotes | High mobility group box (HMGB)-1, damage associated molecular patterns (DAMPS), toll-like receptors (TLR), reactive oxygen species (ROS), polyphosphates (Poly-P), adenosine triphosphate (ATP) |
| T158 | 1308-1327 | Sentence | denotes | (From Silk E et al. |
| T159 | 1328-1362 | Sentence | denotes | Cell Death Disease 2017; 8: e2812. |
| T160 | 1363-1379 | Sentence | denotes | With permission) |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T710 | 17-28 | UBERON:0001986;CL:0000115 | denotes | endothelial |
| T711 | 29-33 | CL:0000115 | denotes | cell |
| T712 | 125-128 | PR:000000134 | denotes | TNF |
| T713 | 227-236 | CL:0000576 | denotes | monocytes |
| T714 | 255-264 | PR:000002309 | denotes | caspase-1 |
| T715 | 266-271 | PR:000001136 | denotes | IL-1β |
| T716 | 276-286 | GO:0010467 | denotes | expression |
| T717 | 356-361 | UBERON:0000062 | denotes | Organ |
| T718 | 398-408 | GO:0065007 | denotes | controlled |
| T719 | 426-436 | GO:0008219 | denotes | cell death |
| T720 | 440-451 | UBERON:0001986;CL:0000115 | denotes | endothelial |
| T721 | 452-457 | CL:0000115 | denotes | cells |
| T722 | 488-494 | UBERON:0000479 | denotes | tissue |
| T723 | 510-523 | GO:0005622 | denotes | intracellular |
| T724 | 549-568 | GO:0005615 | denotes | extracellular space |
| T725 | 584-595 | CHEBI:60816;CHEBI:60816 | denotes | immunogenic |
| T726 | 596-605 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T727 | 629-634 | PR:000008630 | denotes | HMGB1 |
| T728 | 644-651 | CHEBI:15358;CHEBI:15358;PR:000041244 | denotes | Histone |
| T729 | 766-775 | CL:0000233 | denotes | Platelets |
| T730 | 790-801 | UBERON:0001986 | denotes | endothelium |
| T731 | 806-812 | PR:000001467 | denotes | ICAM-1 |
| T732 | 817-826 | PR:000029845 | denotes | Kindlin-3 |
| T733 | 838-847 | CL:0000233 | denotes | platelets |
| T734 | 956-967 | GO:0050817 | denotes | coagulation |
| T735 | 989-995 | UBERON:0000479 | denotes | tissue |
| T736 | 1038-1045 | CL:0000084 | denotes | T cells |
| T737 | 1054-1080 | CHEBI:67079;CHEBI:67079 | denotes | pro-inflammatory mediators |
| T738 | 1188-1193 | CHEBI:51231;CHEBI:51231 | denotes | DAMPS |
| T739 | 1223-1246 | CHEBI:26523;CHEBI:26523 | denotes | reactive oxygen species |
| T740 | 1328-1338 | GO:0008219 | denotes | Cell Death |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32700024-3458948-64991484 | 159-161 | 3458948 | denotes | 48 |