PMC:7373848 / 16706-17109 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T271","span":{"begin":164,"end":184},"obj":"Body_part"},{"id":"T272","span":{"begin":238,"end":255},"obj":"Body_part"},{"id":"T273","span":{"begin":270,"end":278},"obj":"Body_part"},{"id":"T274","span":{"begin":323,"end":328},"obj":"Body_part"},{"id":"T275","span":{"begin":352,"end":368},"obj":"Body_part"},{"id":"T276","span":{"begin":364,"end":368},"obj":"Body_part"}],"attributes":[{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma63011"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma63891"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T88","span":{"begin":323,"end":328},"obj":"Body_part"}],"attributes":[{"id":"A88","pred":"uberon_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PubTator","denotations":[{"id":"272","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"273","span":{"begin":125,"end":130},"obj":"Gene"},{"id":"274","span":{"begin":369,"end":373},"obj":"Gene"},{"id":"275","span":{"begin":143,"end":147},"obj":"Species"}],"attributes":[{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"Gene:7075"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"Gene:21846"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"Gene:7075"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"Tax:10090"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T279","span":{"begin":81,"end":82},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T280","span":{"begin":270,"end":278},"obj":"http://purl.obolibrary.org/obo/CHEBI_3815"},{"id":"T281","span":{"begin":323,"end":328},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T282","span":{"begin":323,"end":328},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T283","span":{"begin":337,"end":338},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T284","span":{"begin":352,"end":368},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T285","span":{"begin":393,"end":402},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T104","span":{"begin":238,"end":255},"obj":"Chemical"}],"attributes":[{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T69","span":{"begin":383,"end":402},"obj":"http://purl.obolibrary.org/obo/GO_0038001"},{"id":"T70","span":{"begin":393,"end":402},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-sentences","denotations":[{"id":"T113","span":{"begin":0,"end":124},"obj":"Sentence"},{"id":"T114","span":{"begin":125,"end":287},"obj":"Sentence"},{"id":"T115","span":{"begin":288,"end":403},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T565","span":{"begin":0,"end":5},"obj":"PR:000016330"},{"id":"T566","span":{"begin":68,"end":77},"obj":"GO:0010467"},{"id":"T567","span":{"begin":125,"end":130},"obj":"PR:000016330"},{"id":"T568","span":{"begin":143,"end":147},"obj":"NCBITaxon:10088"},{"id":"T569","span":{"begin":164,"end":184},"obj":"GO:0031012"},{"id":"T570","span":{"begin":238,"end":255},"obj":"CHEBI:18085;CHEBI:18085"},{"id":"T571","span":{"begin":323,"end":328},"obj":"UBERON:0000178"},{"id":"T572","span":{"begin":352,"end":363},"obj":"UBERON:0001986;CL:0000115"},{"id":"T573","span":{"begin":364,"end":368},"obj":"CL:0000115"},{"id":"T574","span":{"begin":369,"end":373},"obj":"PR:000016330"},{"id":"T575","span":{"begin":383,"end":392},"obj":"GO:0038001"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}

{"project":"2_test","denotations":[{"id":"32700024-31319059-64991469","span":{"begin":120,"end":122},"obj":"31319059"}],"text":"Tie-1 is upregulated by oscillating shear stress and differentially expressed in a dynamic pattern with disturbed flow [32]. Tie-1 deletion in mice causes abnormal extracellular matrix deposition and remodeling characterized by increased glycosaminoglycan and decreased collagen content. The findings suggest that abnormal blood flow is a stimulus for endothelial cell Tie1-mediated paracrine signaling."}