PMC:7373848 / 15980-16705 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T258","span":{"begin":34,"end":39},"obj":"Body_part"},{"id":"T259","span":{"begin":159,"end":175},"obj":"Body_part"},{"id":"T260","span":{"begin":171,"end":175},"obj":"Body_part"},{"id":"T261","span":{"begin":310,"end":314},"obj":"Body_part"},{"id":"T262","span":{"begin":390,"end":396},"obj":"Body_part"},{"id":"T263","span":{"begin":437,"end":445},"obj":"Body_part"},{"id":"T264","span":{"begin":459,"end":476},"obj":"Body_part"},{"id":"T265","span":{"begin":471,"end":476},"obj":"Body_part"},{"id":"T266","span":{"begin":500,"end":516},"obj":"Body_part"},{"id":"T267","span":{"begin":512,"end":516},"obj":"Body_part"},{"id":"T268","span":{"begin":540,"end":548},"obj":"Body_part"},{"id":"T269","span":{"begin":677,"end":694},"obj":"Body_part"},{"id":"T270","span":{"begin":689,"end":694},"obj":"Body_part"}],"attributes":[{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A267","pred":"fma_id","subj":"T267","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T86","span":{"begin":310,"end":314},"obj":"Body_part"},{"id":"T87","span":{"begin":390,"end":396},"obj":"Body_part"}],"attributes":[{"id":"A86","pred":"uberon_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A87","pred":"uberon_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PubTator","denotations":[{"id":"256","span":{"begin":256,"end":261},"obj":"Gene"},{"id":"257","span":{"begin":431,"end":436},"obj":"Gene"},{"id":"258","span":{"begin":341,"end":347},"obj":"Species"},{"id":"259","span":{"begin":671,"end":676},"obj":"Species"},{"id":"260","span":{"begin":0,"end":19},"obj":"Disease"},{"id":"261","span":{"begin":65,"end":77},"obj":"Disease"},{"id":"262","span":{"begin":92,"end":104},"obj":"Disease"},{"id":"263","span":{"begin":216,"end":251},"obj":"Disease"},{"id":"264","span":{"begin":310,"end":321},"obj":"Disease"},{"id":"265","span":{"begin":326,"end":335},"obj":"Disease"},{"id":"266","span":{"begin":379,"end":388},"obj":"Disease"},{"id":"267","span":{"begin":650,"end":659},"obj":"Disease"}],"attributes":[{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"Gene:21687"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"Gene:285"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"Tax:10090"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"Tax:9606"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"MESH:D003141"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"MESH:D007249"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"MESH:D007249"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"MESH:D011014"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"MESH:D008171"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"MESH:D003643"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"MESH:D007239"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T54","span":{"begin":0,"end":10},"obj":"Disease"},{"id":"T55","span":{"begin":65,"end":77},"obj":"Disease"},{"id":"T56","span":{"begin":92,"end":104},"obj":"Disease"},{"id":"T57","span":{"begin":239,"end":251},"obj":"Disease"},{"id":"T58","span":{"begin":365,"end":378},"obj":"Disease"},{"id":"T59","span":{"begin":379,"end":388},"obj":"Disease"},{"id":"T60","span":{"begin":650,"end":659},"obj":"Disease"}],"attributes":[{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0019365"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T102","span":{"begin":437,"end":445},"obj":"Chemical"},{"id":"T103","span":{"begin":540,"end":548},"obj":"Chemical"}],"attributes":[{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T19","span":{"begin":270,"end":293},"obj":"Phenotype"}],"attributes":[{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0032654"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T65","span":{"begin":65,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T66","span":{"begin":92,"end":104},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T67","span":{"begin":239,"end":251},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T68","span":{"begin":602,"end":617},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-sentences","denotations":[{"id":"T108","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T109","span":{"begin":79,"end":188},"obj":"Sentence"},{"id":"T110","span":{"begin":189,"end":389},"obj":"Sentence"},{"id":"T111","span":{"begin":390,"end":640},"obj":"Sentence"},{"id":"T112","span":{"begin":641,"end":725},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T542","span":{"begin":34,"end":39},"obj":"UBERON:0000170"},{"id":"T543","span":{"begin":79,"end":91},"obj":"GO:0065007"},{"id":"T544","span":{"begin":159,"end":170},"obj":"UBERON:0001986;CL:0000115"},{"id":"T545","span":{"begin":171,"end":175},"obj":"CL:0000115"},{"id":"T546","span":{"begin":216,"end":228},"obj":"GO:0065007"},{"id":"T547","span":{"begin":229,"end":238},"obj":"UBERON:0002048"},{"id":"T548","span":{"begin":256,"end":261},"obj":"PR:000002032"},{"id":"T549","span":{"begin":270,"end":281},"obj":"UBERON:0001986"},{"id":"T550","span":{"begin":310,"end":314},"obj":"UBERON:0002048"},{"id":"T551","span":{"begin":341,"end":347},"obj":"NCBITaxon:39107"},{"id":"T552","span":{"begin":390,"end":396},"obj":"UBERON:0000479"},{"id":"T553","span":{"begin":431,"end":436},"obj":"PR:000004024"},{"id":"T554","span":{"begin":449,"end":458},"obj":"UBERON:0002048;CL:0000082"},{"id":"T555","span":{"begin":459,"end":470},"obj":"UBERON:0001986;CL:0000115"},{"id":"T556","span":{"begin":471,"end":476},"obj":"CL:0000115"},{"id":"T557","span":{"begin":500,"end":511},"obj":"UBERON:0001986;CL:0000115"},{"id":"T558","span":{"begin":512,"end":516},"obj":"CL:0000115;GO:0044838"},{"id":"T559","span":{"begin":517,"end":526},"obj":"GO:0044838"},{"id":"T560","span":{"begin":580,"end":585},"obj":"PR:000002032"},{"id":"T561","span":{"begin":663,"end":670},"obj":"CL:0000001"},{"id":"T562","span":{"begin":671,"end":676},"obj":"SP_6;NCBITaxon:9606"},{"id":"T563","span":{"begin":677,"end":688},"obj":"UBERON:0001986;CL:0000115"},{"id":"T564","span":{"begin":689,"end":694},"obj":"CL:0000115"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}

{"project":"2_test","denotations":[{"id":"32700024-32119672-64991468","span":{"begin":203,"end":205},"obj":"32119672"}],"text":"Infectious diseases affecting the lungs cause varying degrees of inflammation. Dysregulated inflammation is particularly deleterious and often associated with endothelial cell dysfunction. Trent et al. [31] reported dysregulated pulmonary inflammation and Tie-2-related endothelial dysfunction contributing to lung damage and mortality in a murine model of Orienta Tsutsugamushi infection. Tissue findings included a high level of Ang-2 proteins in pulmonary endothelial cells, a progressive loss of endothelial cell quiescent and junction proteins, and a substantial decrease in Tie-2 receptor at the transcriptional and functional levels. In-vitro infection of primary human endothelial cells demonstrated similar findings."}