PMC:7373848 / 13575-14031 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T219","span":{"begin":15,"end":23},"obj":"Body_part"},{"id":"T220","span":{"begin":24,"end":31},"obj":"Body_part"},{"id":"T221","span":{"begin":75,"end":92},"obj":"Body_part"},{"id":"T222","span":{"begin":87,"end":92},"obj":"Body_part"},{"id":"T223","span":{"begin":226,"end":238},"obj":"Body_part"},{"id":"T224","span":{"begin":306,"end":322},"obj":"Body_part"},{"id":"T225","span":{"begin":318,"end":322},"obj":"Body_part"}],"attributes":[{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A221","pred":"fma_id","subj":"T221","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A222","pred":"fma_id","subj":"T222","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A223","pred":"fma_id","subj":"T223","obj":"http://purl.org/sig/ont/fma/fma63183"},{"id":"A224","pred":"fma_id","subj":"T224","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A225","pred":"fma_id","subj":"T225","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T82","span":{"begin":226,"end":238},"obj":"Body_part"},{"id":"T83","span":{"begin":226,"end":231},"obj":"Body_part"},{"id":"T84","span":{"begin":232,"end":238},"obj":"Body_part"}],"attributes":[{"id":"A82","pred":"uberon_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"A83","pred":"uberon_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A84","pred":"uberon_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"185","span":{"begin":0,"end":14},"obj":"Gene"},{"id":"186","span":{"begin":56,"end":61},"obj":"Gene"},{"id":"187","span":{"begin":266,"end":271},"obj":"Gene"},{"id":"188","span":{"begin":297,"end":336},"obj":"Gene"},{"id":"189","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"190","span":{"begin":445,"end":450},"obj":"Gene"},{"id":"191","span":{"begin":389,"end":395},"obj":"Disease"}],"attributes":[{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"Gene:284"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"Gene:7010"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Gene:285"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"Gene:7422"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"Gene:7422"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Gene:285"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"MESH:D009369"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T45","span":{"begin":117,"end":122},"obj":"Disease"},{"id":"T46","span":{"begin":389,"end":395},"obj":"Disease"}],"attributes":[{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T234","span":{"begin":62,"end":71},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T235","span":{"begin":75,"end":92},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T236","span":{"begin":99,"end":100},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T237","span":{"begin":226,"end":238},"obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"T238","span":{"begin":226,"end":238},"obj":"http://www.ebi.ac.uk/efo/EFO_0000817"},{"id":"T239","span":{"begin":306,"end":322},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T240","span":{"begin":449,"end":454},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T90","span":{"begin":15,"end":23},"obj":"Chemical"},{"id":"T91","span":{"begin":24,"end":31},"obj":"Chemical"}],"attributes":[{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":389,"end":395},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T50","span":{"begin":62,"end":71},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T51","span":{"begin":117,"end":130},"obj":"http://purl.obolibrary.org/obo/GO_0042060"},{"id":"T52","span":{"begin":155,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0001525"},{"id":"T53","span":{"begin":239,"end":245},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T54","span":{"begin":318,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T55","span":{"begin":323,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T56","span":{"begin":356,"end":368},"obj":"http://purl.obolibrary.org/obo/GO_0001525"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T88","span":{"begin":0,"end":173},"obj":"Sentence"},{"id":"T89","span":{"begin":174,"end":369},"obj":"Sentence"},{"id":"T90","span":{"begin":370,"end":456},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T460","span":{"begin":0,"end":14},"obj":"PR:000004023"},{"id":"T461","span":{"begin":56,"end":61},"obj":"PR:000002032"},{"id":"T462","span":{"begin":75,"end":86},"obj":"UBERON:0001986;CL:0000115"},{"id":"T463","span":{"begin":87,"end":92},"obj":"CL:0000115"},{"id":"T464","span":{"begin":117,"end":130},"obj":"GO:0042060"},{"id":"T465","span":{"begin":155,"end":167},"obj":"GO:0001525"},{"id":"T466","span":{"begin":202,"end":205},"obj":"PR:000004020"},{"id":"T467","span":{"begin":226,"end":238},"obj":"UBERON:0001981"},{"id":"T468","span":{"begin":266,"end":271},"obj":"PR:000004024"},{"id":"T469","span":{"begin":297,"end":305},"obj":"CL:0002139"},{"id":"T470","span":{"begin":306,"end":317},"obj":"CL:0002139;UBERON:0001986"},{"id":"T471","span":{"begin":318,"end":322},"obj":"CL:0002139"},{"id":"T472","span":{"begin":356,"end":368},"obj":"GO:0001525"},{"id":"T473","span":{"begin":431,"end":441},"obj":"GO:0010467"},{"id":"T474","span":{"begin":445,"end":450},"obj":"PR:000004024"}],"text":"Angiopoietin-1 tyrosine protein kinase receptor related Tie-2 signaling in endothelial cells plays a pivotal role in wound healing, vascular integrity and angiogenesis [25]. Individually, angiopoietin (ANG)-1 is essential for blood vessel growth and maturation, and ANG-2 acts in combination with vascular endothelial cell growth factor (VEGF) to initiate angiogenesis. In conditions like cancer, there is an upregulation and over-expression of ANG-2 [25]."}