PMC:7373848 / 10843-11708 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T174","span":{"begin":13,"end":25},"obj":"Body_part"},{"id":"T175","span":{"begin":91,"end":96},"obj":"Body_part"},{"id":"T176","span":{"begin":133,"end":146},"obj":"Body_part"},{"id":"T177","span":{"begin":181,"end":196},"obj":"Body_part"},{"id":"T178","span":{"begin":201,"end":212},"obj":"Body_part"},{"id":"T179","span":{"begin":245,"end":250},"obj":"Body_part"},{"id":"T180","span":{"begin":267,"end":289},"obj":"Body_part"},{"id":"T181","span":{"begin":377,"end":390},"obj":"Body_part"},{"id":"T182","span":{"begin":416,"end":421},"obj":"Body_part"},{"id":"T183","span":{"begin":476,"end":483},"obj":"Body_part"},{"id":"T184","span":{"begin":514,"end":520},"obj":"Body_part"},{"id":"T185","span":{"begin":539,"end":544},"obj":"Body_part"},{"id":"T186","span":{"begin":613,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma85601"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma85601"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma50094"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma3768"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma85601"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma7088"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

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{"project":"LitCovid-PubTator","denotations":[{"id":"129","span":{"begin":777,"end":788},"obj":"Disease"}],"attributes":[{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"MESH:D013610"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

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{"project":"LitCovid-PD-CLO","denotations":[{"id":"T174","span":{"begin":4,"end":12},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T175","span":{"begin":4,"end":12},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T176","span":{"begin":91,"end":96},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T177","span":{"begin":91,"end":96},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T178","span":{"begin":124,"end":132},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T179","span":{"begin":124,"end":132},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T180","span":{"begin":201,"end":207},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T181","span":{"begin":245,"end":250},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T182","span":{"begin":245,"end":250},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T183","span":{"begin":267,"end":289},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T184","span":{"begin":267,"end":289},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T185","span":{"begin":267,"end":289},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T186","span":{"begin":344,"end":352},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T187","span":{"begin":354,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T188","span":{"begin":368,"end":376},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T189","span":{"begin":368,"end":376},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T190","span":{"begin":416,"end":421},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T191","span":{"begin":416,"end":421},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T192","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T193","span":{"begin":488,"end":489},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T194","span":{"begin":539,"end":544},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T195","span":{"begin":539,"end":544},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T196","span":{"begin":539,"end":544},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T197","span":{"begin":539,"end":544},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T198","span":{"begin":599,"end":600},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T199","span":{"begin":613,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T200","span":{"begin":613,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T201","span":{"begin":613,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T202","span":{"begin":613,"end":618},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T203","span":{"begin":711,"end":712},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T204","span":{"begin":737,"end":745},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":406,"end":430},"obj":"Phenotype"},{"id":"T9","span":{"begin":777,"end":788},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0032263"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0001649"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":91,"end":117},"obj":"http://purl.obolibrary.org/obo/GO_0008217"},{"id":"T43","span":{"begin":106,"end":117},"obj":"http://purl.obolibrary.org/obo/GO_0042592"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

{"project":"LitCovid-sentences","denotations":[{"id":"T71","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T72","span":{"begin":124,"end":353},"obj":"Sentence"},{"id":"T73","span":{"begin":354,"end":580},"obj":"Sentence"},{"id":"T74","span":{"begin":581,"end":697},"obj":"Sentence"},{"id":"T75","span":{"begin":698,"end":865},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T379","span":{"begin":4,"end":12},"obj":"UBERON:0018392"},{"id":"T380","span":{"begin":91,"end":96},"obj":"UBERON:0000178;GO:0008217"},{"id":"T381","span":{"begin":97,"end":117},"obj":"GO:0008217"},{"id":"T382","span":{"begin":124,"end":132},"obj":"UBERON:0018392"},{"id":"T383","span":{"begin":181,"end":188},"obj":"UBERON:0005396"},{"id":"T384","span":{"begin":189,"end":196},"obj":"UBERON:0001825"},{"id":"T385","span":{"begin":201,"end":212},"obj":"UBERON:0004363"},{"id":"T386","span":{"begin":245,"end":250},"obj":"UBERON:0000178"},{"id":"T387","span":{"begin":267,"end":289},"obj":"UBERON:0001017"},{"id":"T388","span":{"begin":325,"end":333},"obj":"UBERON:0006798"},{"id":"T389","span":{"begin":368,"end":376},"obj":"UBERON:0018392"},{"id":"T390","span":{"begin":416,"end":421},"obj":"UBERON:0000178"},{"id":"T391","span":{"begin":452,"end":457},"obj":"UBERON:0001638"},{"id":"T392","span":{"begin":476,"end":483},"obj":"CL:0000540"},{"id":"T393","span":{"begin":502,"end":520},"obj":"CL:0011103"},{"id":"T394","span":{"begin":539,"end":544},"obj":"UBERON:0000948"},{"id":"T395","span":{"begin":613,"end":618},"obj":"UBERON:0000948"},{"id":"T396","span":{"begin":625,"end":632},"obj":"UBERON:0000948"},{"id":"T397","span":{"begin":633,"end":646},"obj":"GO:0006936"},{"id":"T398","span":{"begin":683,"end":689},"obj":"UBERON:0001638"},{"id":"T399","span":{"begin":804,"end":811},"obj":"UBERON:0000948"},{"id":"T400","span":{"begin":812,"end":825},"obj":"GO:0006936"},{"id":"T401","span":{"begin":851,"end":857},"obj":"UBERON:0001638"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}

{"project":"2_test","denotations":[{"id":"32700024-25418146-64991457","span":{"begin":119,"end":121},"obj":"25418146"},{"id":"32700024-174143-64991458","span":{"begin":576,"end":578},"obj":"174143"}],"text":"The arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return."}