PMC:7373848 / 10829-12212 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7373848","sourcedb":"PMC","sourceid":"7373848","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7373848","text":"Baroreceptors\nThe arterial baroreceptor system is intimately involved with maintaining vascular tone and blood pressure homeostasis [16]. Arterial baroreceptors (stretch receptors located in the carotid sinuses and aortic arch) provide continuous feedback on blood pressure to the central nervous system, which responds with physiological efferent autonomic activity. Activation of arterial baroreceptors in response to increased blood pressure causes activation of vagal cardio-inhibitory neurons and a decrease of sympathetic neuron discharges to the heart and peripheral resistance bed [17]. The end-result is a decrease in heart rate, cardiac contractility, peripheral vascular resistance and venous return. By contrast, a decrease in sympathetic activity and vagal inhibition, leads to tachycardia and heightened cardiac contractility, vascular resistance and venous return.\nBaroreflex activity responds to the influence of many factors, including respiratory, behavioral and environmental factors. Common cardiovascular diseases, ranging from coronary artery disease, myocardial infarction, essential hypertension and heart failure are associated with baroreceptor reflex abnormalities, primarily chronic adrenergic activation [18].\nWhether or not COVID-19 associated vascular injury causes baroreceptor reflex abnormalities is a question under investigation in our 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