PMC:7371427 / 45855-47191 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T588","span":{"begin":82,"end":88},"obj":"Body_part"},{"id":"T589","span":{"begin":453,"end":458},"obj":"Body_part"},{"id":"T590","span":{"begin":627,"end":636},"obj":"Body_part"},{"id":"T591","span":{"begin":638,"end":663},"obj":"Body_part"},{"id":"T592","span":{"begin":986,"end":991},"obj":"Body_part"}],"attributes":[{"id":"A588","pred":"fma_id","subj":"T588","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A589","pred":"fma_id","subj":"T589","obj":"http://purl.org/sig/ont/fma/fma14543"},{"id":"A590","pred":"fma_id","subj":"T590","obj":"http://purl.org/sig/ont/fma/fma7131"},{"id":"A591","pred":"fma_id","subj":"T591","obj":"http://purl.org/sig/ont/fma/fma9434"},{"id":"A592","pred":"fma_id","subj":"T592","obj":"http://purl.org/sig/ont/fma/fma14543"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T248","span":{"begin":82,"end":88},"obj":"Body_part"},{"id":"T249","span":{"begin":453,"end":458},"obj":"Body_part"},{"id":"T250","span":{"begin":627,"end":636},"obj":"Body_part"},{"id":"T251","span":{"begin":986,"end":991},"obj":"Body_part"}],"attributes":[{"id":"A248","pred":"uberon_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A249","pred":"uberon_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A250","pred":"uberon_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/UBERON_0001043"},{"id":"A251","pred":"uberon_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"126","span":{"begin":1206,"end":1231},"obj":"Disease"},{"id":"127","span":{"begin":1292,"end":1300},"obj":"Disease"}],"attributes":[{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"MESH:D012131"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T82","span":{"begin":1082,"end":1090},"obj":"Disease"},{"id":"T83","span":{"begin":1082,"end":1086},"obj":"Disease"},{"id":"T84","span":{"begin":1292,"end":1300},"obj":"Disease"}],"attributes":[{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T865","span":{"begin":453,"end":458},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T866","span":{"begin":627,"end":636},"obj":"http://purl.obolibrary.org/obo/UBERON_0001043"},{"id":"T867","span":{"begin":655,"end":663},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T868","span":{"begin":813,"end":819},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T869","span":{"begin":986,"end":991},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T87","span":{"begin":1112,"end":1114},"obj":"Chemical"}],"attributes":[{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_42820"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T263","span":{"begin":0,"end":293},"obj":"Sentence"},{"id":"T264","span":{"begin":294,"end":411},"obj":"Sentence"},{"id":"T265","span":{"begin":412,"end":583},"obj":"Sentence"},{"id":"T266","span":{"begin":584,"end":767},"obj":"Sentence"},{"id":"T267","span":{"begin":768,"end":924},"obj":"Sentence"},{"id":"T268","span":{"begin":925,"end":1336},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"MyTest","denotations":[{"id":"32463365-32142785-27519129","span":{"begin":1123,"end":1127},"obj":"32142785"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}

{"project":"2_test","denotations":[{"id":"32463365-32142785-27519129","span":{"begin":1123,"end":1127},"obj":"32142785"}],"text":"While our study profiles the expression of the coronavirus receptors from various tissue samples, whether and how much receptor expression varies among individuals across various factors like age, disease states, genetic diversity, lifestyle, and environmental factors are not well understood. For instance, in order to understand variation of expression with age we explored ACE2 expression using GTEx samples. Interestingly, ACE2 expression levels in colon (transverse) samples were higher in younger individuals in comparison to older individuals (Figure 2—figure supplement 19A). In contrast, ACE2 expression levels in the esophagus (gastroesophageal junction) were lower in younger individuals in comparison to older individuals (Figure 2—figure supplement 19B). These patterns of ACE2 expression need to be tested more rigorously on larger sample sizes across diverse ethnicities to establish statistical significance. If ACE2 were found to be expressed more significantly in the colon of younger individuals, taken together with recent reports of sustained fecal shedding of SARS-CoV-2 (Xu et al., 2020a; Gu et al., 2020), the emerging epidemiological hypothesis of younger individuals having fewer respiratory complications in general and serving as facile vectors in transmission of COVID-19 requires more deeper investigation."}