PMC:7371427 / 16862-17500 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T168","span":{"begin":47,"end":55},"obj":"Body_part"},{"id":"T169","span":{"begin":60,"end":65},"obj":"Body_part"},{"id":"T170","span":{"begin":89,"end":96},"obj":"Body_part"},{"id":"T171","span":{"begin":140,"end":162},"obj":"Body_part"},{"id":"T172","span":{"begin":163,"end":179},"obj":"Body_part"},{"id":"T173","span":{"begin":174,"end":179},"obj":"Body_part"},{"id":"T174","span":{"begin":198,"end":222},"obj":"Body_part"},{"id":"T175","span":{"begin":214,"end":222},"obj":"Body_part"},{"id":"T176","span":{"begin":295,"end":300},"obj":"Body_part"},{"id":"T177","span":{"begin":371,"end":376},"obj":"Body_part"},{"id":"T178","span":{"begin":414,"end":422},"obj":"Body_part"},{"id":"T179","span":{"begin":504,"end":509},"obj":"Body_part"},{"id":"T180","span":{"begin":543,"end":548},"obj":"Body_part"},{"id":"T181","span":{"begin":632,"end":637},"obj":"Body_part"}],"attributes":[{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma7198"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma17562"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma14521"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma7198"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma71493"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma71493"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma7198"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma7197"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T54","span":{"begin":47,"end":55},"obj":"Body_part"},{"id":"T55","span":{"begin":60,"end":65},"obj":"Body_part"},{"id":"T56","span":{"begin":214,"end":222},"obj":"Body_part"},{"id":"T57","span":{"begin":414,"end":422},"obj":"Body_part"},{"id":"T58","span":{"begin":504,"end":509},"obj":"Body_part"},{"id":"T59","span":{"begin":543,"end":548},"obj":"Body_part"},{"id":"T60","span":{"begin":632,"end":637},"obj":"Body_part"}],"attributes":[{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A60","pred":"uberon_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-PubTator","denotations":[{"id":"54","span":{"begin":382,"end":386},"obj":"Chemical"},{"id":"55","span":{"begin":477,"end":481},"obj":"Chemical"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T36","span":{"begin":47,"end":55},"obj":"Disease"},{"id":"T37","span":{"begin":214,"end":222},"obj":"Disease"},{"id":"T38","span":{"begin":414,"end":422},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0021040"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0021040"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0021040"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T292","span":{"begin":47,"end":55},"obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"T293","span":{"begin":60,"end":65},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T294","span":{"begin":60,"end":65},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T295","span":{"begin":83,"end":96},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T296","span":{"begin":105,"end":106},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T297","span":{"begin":107,"end":108},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T298","span":{"begin":163,"end":173},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T299","span":{"begin":174,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T300","span":{"begin":181,"end":182},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T301","span":{"begin":214,"end":222},"obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"T302","span":{"begin":224,"end":225},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T303","span":{"begin":261,"end":270},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T304","span":{"begin":295,"end":300},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"T305","span":{"begin":295,"end":300},"obj":"http://purl.obolibrary.org/obo/UBERON_0000058"},{"id":"T306","span":{"begin":337,"end":346},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T307","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"T308","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/UBERON_0000058"},{"id":"T309","span":{"begin":414,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"T310","span":{"begin":504,"end":509},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T311","span":{"begin":504,"end":509},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T312","span":{"begin":543,"end":548},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T313","span":{"begin":543,"end":548},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T314","span":{"begin":626,"end":631},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T315","span":{"begin":632,"end":637},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T316","span":{"begin":632,"end":637},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T28","span":{"begin":89,"end":96},"obj":"Chemical"},{"id":"T29","span":{"begin":455,"end":464},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_16541"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}

{"project":"LitCovid-sentences","denotations":[{"id":"T99","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T100","span":{"begin":104,"end":638},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IHC images of coronavirus receptors in healthy pancreas and liver samples from the Human Protein Atlas.\n(A–B) ACE2 expression on the apical surface of gallbladder epithelial cells (A) and on ductal surfaces in the pancreas (B). (C) ANPEP is expressed on apical membranes in pancreatic acini and ducts. (D) TMPRSS2 is expressed on apical membranes in pancreatic acini and ducts. (E) DPP4 is expressed weakly in the pancreas, both on ductal surfaces and in endocrine islets. (F) DPP4 expression in healthy liver. (G) ANPEP expression in healthy liver; ANPEP appears to be the most strongly expressed coronavirus receptor in the human liver."}