PMC:7361216 / 5217-6041
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T65 | 106-109 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T66 | 203-206 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T67 | 216-224 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T68 | 230-235 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T69 | 270-278 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T70 | 502-507 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 525-528 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T72 | 540-545 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T73 | 583-598 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T74 | 593-598 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T75 | 741-744 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T27 | 230-235 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T74 | 22-27 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T75 | 230-235 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T76 | 230-235 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T77 | 243-248 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T78 | 486-496 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T79 | 500-507 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T80 | 519-524 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T81 | 538-545 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T82 | 563-573 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T83 | 583-598 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
T84 | 709-714 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22 | 230-235 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T23 | 502-507 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T24 | 540-545 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T25 | 593-598 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T35 | 67-72 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T36 | 466-471 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T37 | 764-769 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T12 | 22-27 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
T14 | 243-248 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
T16 | 519-524 | Species | denotes | human | NCBItxid:9606 |
T17 | 709-714 | Species | denotes | human | NCBItxid:9606 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T32 | 129-255 | Sentence | denotes | Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model. |
T33 | 256-405 | Sentence | denotes | Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach. |
T34 | 406-546 | Sentence | denotes | In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells. |
T35 | 547-612 | Sentence | denotes | In addition, no activation of CD11b dendritic cells was observed. |
T36 | 613-731 | Sentence | denotes | These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials. |
T37 | 732-824 | Sentence | denotes | Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study. |
LitCovid-sample-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T21 | 230-235 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
146 | 22-27 | Species | denotes | mouse | Tax:10090 |
150 | 67-72 | Chemical | denotes | PPSGG | |
145 | 124-127 | Gene | denotes | MAG | Gene:17136 |
144 | 212-215 | Gene | denotes | MAG | Gene:17136 |
147 | 243-248 | Species | denotes | mouse | Tax:10090 |
151 | 466-471 | Chemical | denotes | PPSGG | |
149 | 519-524 | Species | denotes | human | Tax:9606 |
143 | 534-537 | Gene | denotes | MAG | Gene:4099 |
141 | 577-582 | Gene | denotes | CD11b | Gene:3684 |
148 | 709-714 | Species | denotes | human | Tax:9606 |
142 | 755-758 | Gene | denotes | MAG | Gene:4099 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T58 | 124-127 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T59 | 212-215 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T60 | 534-537 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T61 | 577-582 | Protein | denotes | CD11b | https://www.uniprot.org/uniprot/Q8CA73|https://www.uniprot.org/uniprot/Q4VAK2|https://www.uniprot.org/uniprot/Q4VAK1|https://www.uniprot.org/uniprot/Q4VAK0|https://www.uniprot.org/uniprot/P11578|https://www.uniprot.org/uniprot/P11215|https://www.uniprot.org/uniprot/P05555 |
T68 | 755-758 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T65 | 106-109 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T66 | 203-206 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T67 | 216-224 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T68 | 230-235 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T69 | 270-278 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T70 | 502-507 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 525-528 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T72 | 540-545 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T73 | 583-598 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T74 | 593-598 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T75 | 741-744 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
LitCovid-sample-PD-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11 | 230-235 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T12 | 230-235 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T32 | 129-255 | Sentence | denotes | Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model. |
T33 | 256-405 | Sentence | denotes | Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach. |
T34 | 406-546 | Sentence | denotes | In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells. |
T35 | 547-612 | Sentence | denotes | In addition, no activation of CD11b dendritic cells was observed. |
T36 | 613-731 | Sentence | denotes | These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials. |
T37 | 732-824 | Sentence | denotes | Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
141 | 577-582 | Gene | denotes | CD11b | Gene:3684 |
142 | 755-758 | Gene | denotes | MAG | Gene:4099 |
143 | 534-537 | Gene | denotes | MAG | Gene:4099 |
144 | 212-215 | Gene | denotes | MAG | Gene:17136 |
145 | 124-127 | Gene | denotes | MAG | Gene:17136 |
146 | 22-27 | Species | denotes | mouse | Tax:10090 |
147 | 243-248 | Species | denotes | mouse | Tax:10090 |
148 | 709-714 | Species | denotes | human | Tax:9606 |
149 | 519-524 | Species | denotes | human | Tax:9606 |
150 | 67-72 | Chemical | denotes | PPSGG | |
151 | 466-471 | Chemical | denotes | PPSGG |