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PMC:7361216 / 5217-6041 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T65 106-109 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T66 203-206 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T67 216-224 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T68 230-235 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T69 270-278 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T70 502-507 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 525-528 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T72 540-545 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T73 583-598 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T74 593-598 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 741-744 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T27 230-235 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T74 22-27 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T75 230-235 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T76 230-235 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T77 243-248 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T78 486-496 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T79 500-507 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T80 519-524 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T81 538-545 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T82 563-573 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T83 583-598 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T84 709-714 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T22 230-235 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T23 502-507 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T24 540-545 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T25 593-598 http://purl.obolibrary.org/obo/CL_0000000 denotes cells

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T35 67-72 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T36 466-471 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T37 764-769 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T12 22-27 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T14 243-248 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T16 519-524 Species denotes human NCBItxid:9606
T17 709-714 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T32 129-255 Sentence denotes Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model.
T33 256-405 Sentence denotes Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach.
T34 406-546 Sentence denotes In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells.
T35 547-612 Sentence denotes In addition, no activation of CD11b dendritic cells was observed.
T36 613-731 Sentence denotes These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials.
T37 732-824 Sentence denotes Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 230-235 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
146 22-27 Species denotes mouse Tax:10090
150 67-72 Chemical denotes PPSGG
145 124-127 Gene denotes MAG Gene:17136
144 212-215 Gene denotes MAG Gene:17136
147 243-248 Species denotes mouse Tax:10090
151 466-471 Chemical denotes PPSGG
149 519-524 Species denotes human Tax:9606
143 534-537 Gene denotes MAG Gene:4099
141 577-582 Gene denotes CD11b Gene:3684
148 709-714 Species denotes human Tax:9606
142 755-758 Gene denotes MAG Gene:4099

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T58 124-127 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T59 212-215 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T60 534-537 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T61 577-582 Protein denotes CD11b https://www.uniprot.org/uniprot/Q8CA73|https://www.uniprot.org/uniprot/Q4VAK2|https://www.uniprot.org/uniprot/Q4VAK1|https://www.uniprot.org/uniprot/Q4VAK0|https://www.uniprot.org/uniprot/P11578|https://www.uniprot.org/uniprot/P11215|https://www.uniprot.org/uniprot/P05555
T68 755-758 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T65 106-109 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T66 203-206 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T67 216-224 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T68 230-235 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T69 270-278 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T70 502-507 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 525-528 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T72 540-545 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T73 583-598 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T74 593-598 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 741-744 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T11 230-235 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T12 230-235 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T32 129-255 Sentence denotes Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model.
T33 256-405 Sentence denotes Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach.
T34 406-546 Sentence denotes In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells.
T35 547-612 Sentence denotes In addition, no activation of CD11b dendritic cells was observed.
T36 613-731 Sentence denotes These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials.
T37 732-824 Sentence denotes Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
141 577-582 Gene denotes CD11b Gene:3684
142 755-758 Gene denotes MAG Gene:4099
143 534-537 Gene denotes MAG Gene:4099
144 212-215 Gene denotes MAG Gene:17136
145 124-127 Gene denotes MAG Gene:17136
146 22-27 Species denotes mouse Tax:10090
147 243-248 Species denotes mouse Tax:10090
148 709-714 Species denotes human Tax:9606
149 519-524 Species denotes human Tax:9606
150 67-72 Chemical denotes PPSGG
151 466-471 Chemical denotes PPSGG