PMC:7361216 / 3086-9159
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T34 | 53-59 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T35 | 71-83 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T36 | 209-212 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T37 | 213-221 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T38 | 284-296 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T39 | 373-392 | Body_part | denotes | natural killer cell | http://purl.org/sig/ont/fma/fma63147 |
T40 | 388-392 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T41 | 453-473 | Body_part | denotes | natural killer cells | http://purl.org/sig/ont/fma/fma63147 |
T42 | 468-473 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T43 | 491-497 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T44 | 499-505 | Body_part | denotes | retina | http://purl.org/sig/ont/fma/fma58301 |
T45 | 507-512 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T46 | 514-522 | Body_part | denotes | prostate | http://purl.org/sig/ont/fma/fma9600 |
T47 | 670-692 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
T48 | 693-699 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T49 | 876-879 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T50 | 904-909 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T51 | 935-938 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T52 | 1075-1078 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T53 | 1186-1189 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T54 | 1207-1220 | Body_part | denotes | sciatic nerve | http://purl.org/sig/ont/fma/fma19034 |
T55 | 1221-1227 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T56 | 1369-1372 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T57 | 1441-1444 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T58 | 1445-1453 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T59 | 1488-1493 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T60 | 1561-1564 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T61 | 1575-1583 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T62 | 1751-1754 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T63 | 1957-1969 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T64 | 2057-2069 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T65 | 2237-2240 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T66 | 2334-2337 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T67 | 2347-2355 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T68 | 2361-2366 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T69 | 2401-2409 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T70 | 2633-2638 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 2656-2659 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T72 | 2671-2676 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T73 | 2714-2729 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T74 | 2724-2729 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T75 | 2872-2875 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T76 | 3010-3023 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T77 | 3284-3297 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T78 | 3371-3384 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T79 | 3499-3502 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T80 | 3586-3599 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T81 | 3613-3620 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T82 | 3640-3648 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T83 | 3774-3781 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T84 | 4032-4039 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T85 | 4112-4119 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T86 | 4296-4309 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T87 | 4345-4352 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T88 | 4455-4467 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T89 | 4611-4623 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T90 | 4762-4777 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
T91 | 4855-4869 | Body_part | denotes | polysaccharide | http://purl.org/sig/ont/fma/fma82746 |
T92 | 4910-4922 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T93 | 5011-5018 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T94 | 5059-5078 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
T95 | 5312-5319 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T96 | 5553-5556 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T97 | 6003-6006 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T15 | 53-59 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T16 | 491-497 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T17 | 499-505 | Body_part | denotes | retina | http://purl.obolibrary.org/obo/UBERON_0000966 |
T18 | 507-512 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T19 | 533-549 | Body_part | denotes | proximal tubules | http://purl.obolibrary.org/obo/UBERON_0004134 |
T20 | 670-692 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
T21 | 678-692 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
T22 | 693-699 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T23 | 904-909 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T24 | 1207-1220 | Body_part | denotes | sciatic nerve | http://purl.obolibrary.org/obo/UBERON_0001322 |
T25 | 1215-1220 | Body_part | denotes | nerve | http://purl.obolibrary.org/obo/UBERON_0001021 |
T26 | 1221-1227 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T27 | 2361-2366 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T28 | 5059-5078 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T9 | 32-42 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T10 | 238-259 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T11 | 939-949 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T12 | 1373-1394 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T13 | 3085-3095 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T14 | 3166-3172 | Disease | denotes | ataxia | http://purl.obolibrary.org/obo/MONDO_0000437 |
T15 | 3440-3448 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T16 | 3503-3513 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T17 | 3624-3632 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T18 | 4526-4534 | Disease | denotes | COViD‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T19 | 5099-5117 | Disease | denotes | multiple sclerosis | http://purl.obolibrary.org/obo/MONDO_0005301 |
T20 | 5237-5257 | Disease | denotes | inflammatory disease | http://purl.obolibrary.org/obo/MONDO_0021166 |
T21 | 5543-5551 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T22 | 5557-5578 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T23 | 5886-5893 | Disease | denotes | COVID19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T24 | 6011-6021 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T38 | 16-17 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T39 | 90-93 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T40 | 235-236 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T41 | 271-272 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T42 | 367-372 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T43 | 373-392 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | natural killer cell |
T44 | 396-401 | http://purl.obolibrary.org/obo/CLO_0003789 | denotes | HNK‐1 |
T45 | 408-413 | http://purl.obolibrary.org/obo/CLO_0003789 | denotes | HNK‐1 |
T46 | 453-473 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | natural killer cells |
T47 | 475-490 | http://purl.obolibrary.org/obo/UBERON_0002346 | denotes | neuroectodermal |
T48 | 499-505 | http://purl.obolibrary.org/obo/UBERON_0000966 | denotes | retina |
T49 | 507-512 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T50 | 507-512 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T51 | 533-549 | http://purl.obolibrary.org/obo/UBERON_0004134 | denotes | proximal tubules |
T52 | 583-584 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T53 | 670-692 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
T54 | 670-692 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
T55 | 670-692 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
T56 | 904-909 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T57 | 904-909 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T58 | 913-914 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T59 | 915-920 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T60 | 954-955 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T61 | 1215-1220 | http://purl.obolibrary.org/obo/UBERON_0001021 | denotes | nerve |
T62 | 1235-1240 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T63 | 1241-1249 | http://purl.obolibrary.org/obo/NCBITaxon_9443 | denotes | primates |
T64 | 1261-1267 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T65 | 1486-1493 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T66 | 1907-1908 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T67 | 1919-1920 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T68 | 1949-1950 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T69 | 1985-1990 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T70 | 2038-2039 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T71 | 2055-2056 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T72 | 2076-2082 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T73 | 2112-2113 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T74 | 2153-2158 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T75 | 2361-2366 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T76 | 2361-2366 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T77 | 2374-2379 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T78 | 2617-2627 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T79 | 2631-2638 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T80 | 2650-2655 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T81 | 2669-2676 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
T82 | 2694-2704 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T83 | 2714-2729 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
T84 | 2840-2845 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T85 | 3028-3029 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T86 | 3174-3175 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T87 | 3301-3302 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T88 | 3390-3391 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T89 | 3535-3536 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T90 | 3743-3744 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T91 | 3818-3819 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T92 | 4050-4052 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T93 | 4258-4259 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T94 | 4314-4315 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T95 | 4364-4365 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T96 | 4392-4393 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T97 | 4445-4446 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T98 | 4644-4645 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T99 | 4873-4874 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T100 | 4951-4952 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T101 | 5130-5136 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
T102 | 5310-5311 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T103 | 5379-5385 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
T104 | 5471-5473 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
T105 | 5603-5604 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T106 | 5805-5806 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T107 | 5894-5899 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T108 | 5928-5929 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T109 | 5946-5947 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T27 | 71-83 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T28 | 284-296 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T29 | 331-338 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T30 | 414-421 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T31 | 595-606 | Chemical | denotes | sialic acid | http://purl.obolibrary.org/obo/CHEBI_26667 |
T32 | 602-606 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T33 | 765-771 | Chemical | denotes | phenyl | http://purl.obolibrary.org/obo/CHEBI_30396 |
T34 | 785-790 | Chemical | denotes | sulfo | http://purl.obolibrary.org/obo/CHEBI_29922 |
T35 | 1001-1008 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T36 | 1018-1027 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T37 | 1714-1721 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T38 | 1808-1815 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T39 | 1957-1969 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T40 | 2057-2069 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T41 | 2123-2130 | Chemical | denotes | carrier | http://purl.obolibrary.org/obo/CHEBI_78059 |
T42 | 3010-3023 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T43 | 3040-3047 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T44 | 3284-3297 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T45 | 3371-3384 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T46 | 3586-3599 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T47 | 3613-3620 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T48 | 3640-3648 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T49 | 3696-3703 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T50 | 3774-3781 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T51 | 3870-3877 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T52 | 4032-4039 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T53 | 4112-4119 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T54 | 4145-4152 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T55 | 4296-4309 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T56 | 4345-4352 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T57 | 4366-4373 | Chemical | denotes | carrier | http://purl.obolibrary.org/obo/CHEBI_78059 |
T58 | 4374-4382 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
T59 | 4455-4467 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T60 | 4552-4563 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T61 | 4611-4623 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T62 | 4646-4653 | Chemical | denotes | carrier | http://purl.obolibrary.org/obo/CHEBI_78059 |
T63 | 4762-4777 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
T64 | 4855-4869 | Chemical | denotes | polysaccharide | http://purl.obolibrary.org/obo/CHEBI_18154 |
T65 | 4884-4891 | Chemical | denotes | carrier | http://purl.obolibrary.org/obo/CHEBI_78059 |
T66 | 4910-4922 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T67 | 5011-5018 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T68 | 5030-5037 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T69 | 5205-5212 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T70 | 5291-5298 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T71 | 5312-5319 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T72 | 5320-5327 | Chemical | denotes | carrier | http://purl.obolibrary.org/obo/CHEBI_78059 |
T73 | 5460-5467 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T74 | 5471-5473 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 175-182 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T13 | 192-202 | http://purl.obolibrary.org/obo/IDO_0000607 | denotes | production |
T14 | 388-392 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T15 | 468-473 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T16 | 904-909 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T17 | 1488-1493 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T18 | 1532-1539 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T19 | 1740-1750 | http://purl.obolibrary.org/obo/IDO_0000450 | denotes | pathogenic |
T20 | 1763-1770 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T21 | 1985-1990 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T22 | 2361-2366 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T23 | 2633-2638 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T24 | 2671-2676 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T25 | 2724-2729 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T26 | 3303-3310 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T27 | 3348-3356 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | diseases |
T28 | 4068-4073 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | sites |
T29 | 4180-4185 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | sites |
T30 | 4981-4988 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T31 | 5250-5257 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T32 | 5610-5617 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T33 | 5637-5645 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | diseases |
T34 | 5713-5720 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T35 | 5894-5899 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T24 | 71-83 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T25 | 284-296 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T26 | 595-606 | Chemical | denotes | sialic acid | http://purl.obolibrary.org/obo/CHEBI_26667 |
T27 | 765-771 | Chemical | denotes | phenyl | http://purl.obolibrary.org/obo/CHEBI_30396 |
T28 | 785-790 | Chemical | denotes | sulfo | http://purl.obolibrary.org/obo/CHEBI_29922 |
T29 | 852-857 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T30 | 1145-1150 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T31 | 1330-1335 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T32 | 1689-1694 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T33 | 1957-1969 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T34 | 2057-2069 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T35 | 2198-2203 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T36 | 2597-2602 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T37 | 2895-2900 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T38 | 3010-3023 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T39 | 3284-3297 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T40 | 3371-3384 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T41 | 3586-3599 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T42 | 3613-3620 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T43 | 3640-3648 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T44 | 3696-3703 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T45 | 3774-3781 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T46 | 3870-3877 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T47 | 4032-4039 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T48 | 4112-4119 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T49 | 4145-4152 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T50 | 4296-4309 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
T51 | 4345-4352 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T52 | 4417-4422 | Chemical | denotes | PPSGG | http://purl.obolibrary.org/obo/CHEBI_137080 |
T53 | 4455-4467 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T54 | 4552-4563 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T55 | 4611-4623 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T56 | 4762-4777 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
T57 | 4855-4869 | Chemical | denotes | polysaccharide | http://purl.obolibrary.org/obo/CHEBI_18154 |
T58 | 4910-4922 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
T59 | 5011-5018 | Chemical | denotes | mannose | http://purl.obolibrary.org/obo/CHEBI_37684 |
T60 | 5030-5037 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T61 | 5291-5298 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
T62 | 5312-5319 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T63 | 5460-5467 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T7 | 367-372 | Species | denotes | human | NCBItxid:9606 |
T8 | 915-920 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
T10 | 1235-1240 | Species | denotes | human | NCBItxid:9606 |
T11 | 1241-1249 | Species | denotes | primates | NCBItxid:9443 |
T12 | 2153-2158 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
T14 | 2374-2379 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
T16 | 2650-2655 | Species | denotes | human | NCBItxid:9606 |
T17 | 2840-2845 | Species | denotes | human | NCBItxid:9606 |
T18 | 3440-3448 | Species | denotes | COVID‐19 | NCBItxid:2697049 |
T19 | 3624-3632 | Species | denotes | COVID‐19 | NCBItxid:2697049 |
T20 | 3745-3763 | Species | denotes | feline coronavirus | NCBItxid:12663 |
T21 | 4526-4534 | Species | denotes | COViD‐19 | NCBItxid:2697049 |
T22 | 5543-5551 | Species | denotes | COVID‐19 | NCBItxid:2697049 |
T23 | 5886-5893 | Species | denotes | COVID19 | NCBItxid:2697049 |
T24 | 6055-6063 | Species | denotes | CoVID‐19 | NCBItxid:2697049 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T18 | 0-15 | Sentence | denotes | 1 INTRODUCTION |
T19 | 16-166 | Sentence | denotes | A demyelinating neuropathy targeting myelin‐associated glycoprotein (MAG) has an incidence of approximately one per 100,000 (Mygland & Monstad, 2001). |
T20 | 167-403 | Sentence | denotes | In this disease there is production of an IgM antibody resulting in a “monoclonal gammopathy” targeting a particular carbohydrate known as Cellular Differentiation antigen 57 (CD57) and also known as human natural killer cell‐1 (HNK‐1). |
T21 | 404-566 | Sentence | denotes | The HNK‐1 antigen is found on MAG, as well as on natural killer cells, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules (Pernick, 2019). |
T22 | 567-700 | Sentence | denotes | CD57 belongs to a family of sialic acid‐binding Ig‐like lectins (siglecs) found on both peripheral and central nervous system myelin. |
T23 | 701-950 | Sentence | denotes | In this issue investigators (Aliu et al, 2020) showed that poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood in a mouse model of this IgM neuropathy. |
T24 | 951-1106 | Sentence | denotes | In a previous study these investigators developed antigen‐specific molecules with nanomolar inhibitory potency for anti‐MAG IgM (Herrendorff et al., 2017). |
T25 | 1107-1250 | Sentence | denotes | Here the investigators also show that PPSGG blocked the binding of an anti‐MAG IgM from patients to sciatic nerve myelin of non‐human primates. |
T26 | 1251-1336 | Sentence | denotes | They also tested some of the pharmacokinetic and pharmacodynamic properties of PPSGG. |
T27 | 1337-1509 | Sentence | denotes | In patients suffering from this IgM monoclonal gammopathy, non‐specific strategies are used to diminish IgM antibody including targeting of all CD20 B cells with Rituximab. |
T28 | 1510-1661 | Sentence | denotes | On occasion flares of disease occur with increased IgM levels of antibody targeting MAG have followed therapy with Rituximab (Broglio and Luria, 2005). |
T29 | 1662-1771 | Sentence | denotes | The strategy employed with PPSGG is specific to the antigen that triggers the pathogenic IgM in this disease. |
T30 | 1772-1851 | Sentence | denotes | One can refer to such treatment as “antigen‐specific” immunotherapy (Figure 1). |
T31 | 1852-2259 | Sentence | denotes | FIGURE 1 The strategy employed by Aliu et al, provide a basis for a passive immune therapy with a decoy carbohydrate preventing the virus from docking on its receptor, and also provide a foundation for a carbohydrate‐based active immunization when coupled to a suitable carrier Investigations in the mouse model revealed that practical doses of PPSGG were able to sufficiently reduce IgM that binds to MAG. |
T32 | 2260-2386 | Sentence | denotes | Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model. |
T33 | 2387-2536 | Sentence | denotes | Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach. |
T34 | 2537-2677 | Sentence | denotes | In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells. |
T35 | 2678-2743 | Sentence | denotes | In addition, no activation of CD11b dendritic cells was observed. |
T36 | 2744-2862 | Sentence | denotes | These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials. |
T37 | 2863-2955 | Sentence | denotes | Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study. |
T38 | 2956-3240 | Sentence | denotes | Writing about these exquisite approaches to targeting carbohydrates for a potential antigen‐specific therapy for an inflammatory neuropathy characterized by sensory impairment, disturbance in gait, tremor, and ataxia (a form of incoordination following sensory loss) makes one wonder: |
T39 | 3241-3418 | Sentence | denotes | Could such an approach, targeting critical carbohydrates in a disease, have broader applicability to other diseases where complex carbohydrates play a key pathophysiologic role? |
T40 | 3419-3633 | Sentence | denotes | In these days of the COVID‐19 pandemic, the experiments described on monoclonal IgM neuropathy raise the issue that a similar strategy might be deployed to target the carbohydrates in the spike protein of COVID‐19. |
T41 | 3634-3704 | Sentence | denotes | Spike proteins in coronviruses are known to be camouflaged by glycans: |
T42 | 3705-3853 | Sentence | denotes | Mass spectrometry studies revealed in a feline coronavirus that high mannose and complex N‐Glycans accounted for a quarter of the mass of the spike. |
T43 | 3854-3977 | Sentence | denotes | Moreover, the N‐glycans are critical for providing the propeller like conformation of these structures (Yang et al., 2020). |
T44 | 3978-4099 | Sentence | denotes | In the so‐called receptor‐binding domain of the spike protein there are 22 glycan‐binding sites (Shahajan, Supekar et al. |
T45 | 4100-4106 | Sentence | denotes | 2020). |
T46 | 4107-4230 | Sentence | denotes | High mannose, hybrid and complex‐type glycans across the N‐glycosylation sites have been identified with mass spectrometry. |
T47 | 4231-4439 | Sentence | denotes | One could imagine building a therapeutic which might contain the carbohydrates, or a suitable mimic, of the spike protein coupled to a carrier molecule, much in a similar fashion to how PPSGG was constructed. |
T48 | 4440-4591 | Sentence | denotes | Such a “decoy” carbohydrate could block the binding and subsequent internalization of COViD‐19 to its receptor, angiotensin converting enzyme‐2 (ACE2). |
T49 | 4592-4693 | Sentence | denotes | In addition, spike carbohydrate clusters coupled to a carrier might proof to be an effective vaccine. |
T50 | 4694-4826 | Sentence | denotes | Both the pneumococcal vaccine and the meningococcal vaccines target polysaccharides in pneumococcus and meningococcus, respectively. |
T51 | 4827-4947 | Sentence | denotes | They couple the appropriate polysaccharide to a suitable carrier to achieve potent carbohydrate‐specific immunogenicity. |
T52 | 4948-5167 | Sentence | denotes | In a different neuroinflammatory disease antibodies to cryptic mannose containing glycans were observed in the cerebrospinal fluid of individuals with multiple sclerosis, and in its animal model EAE (Wang et al., 2014). |
T53 | 5168-5258 | Sentence | denotes | There again is some precedent for an antigen‐specific therapy for an inflammatory disease. |
T54 | 5259-5410 | Sentence | denotes | Injection of these oligomannose glycans coupled to a protein carrier reduced the clinical severity of paralysis in this animal model (Wang, Bhat et al. |
T55 | 5411-5417 | Sentence | denotes | 2014). |
T56 | 5418-5552 | Sentence | denotes | The success in parlaying the oligomannose glycans in MS and in its EAE model, could be emulated in strategies for therapy of COVID‐19. |
T57 | 5553-5618 | Sentence | denotes | IgM monoclonal gammopathy targeting MAG is indeed a rare disease. |
T58 | 5619-5721 | Sentence | denotes | Lessons from rare diseases often inform us of bold approaches for the treatment of widespread disease. |
T59 | 5722-5900 | Sentence | denotes | The pioneering work of Aliu and colleagues described in this issue, might serve as a guidepost for designing effective therapeutics to the glycan components of the COVID19 virus. |
T60 | 5901-6073 | Sentence | denotes | Such endeavors may produce a sweet ending to a tragedy including both the harsh clinical realities of IgM MAG neuropathy and to the horrors of the deadly CoVID‐19 pandemic. |
LitCovid-sample-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T11 | 53-59 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T12 | 491-497 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T13 | 499-505 | Body_part | denotes | retina | http://purl.obolibrary.org/obo/UBERON_0000966 |
T14 | 507-512 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T15 | 533-549 | Body_part | denotes | proximal tubules | http://purl.obolibrary.org/obo/UBERON_0004134 |
T16 | 670-692 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
T17 | 693-699 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T18 | 904-909 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T19 | 1207-1220 | Body_part | denotes | sciatic nerve | http://purl.obolibrary.org/obo/UBERON_0001322 |
T20 | 1221-1227 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
T21 | 2361-2366 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T22 | 5059-5078 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
90 | 18-42 | Disease | denotes | demyelinating neuropathy | MESH:D003711 |
82 | 53-83 | Gene | denotes | myelin‐associated glycoprotein | Gene:4099 |
85 | 85-88 | Gene | denotes | MAG | Gene:4099 |
88 | 284-296 | Chemical | denotes | carbohydrate | MESH:D002241 |
87 | 367-372 | Species | denotes | human | Tax:9606 |
83 | 396-401 | Gene | denotes | HNK‐1 | Gene:27087 |
84 | 408-413 | Gene | denotes | HNK‐1 | Gene:27087 |
86 | 434-437 | Gene | denotes | MAG | Gene:4099 |
89 | 595-606 | Chemical | denotes | sialic acid | MESH:D019158 |
91 | 670-699 | Disease | denotes | central nervous system myelin | MESH:D020278 |
110 | 760-813 | Chemical | denotes | poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate) | |
111 | 814-841 | Chemical | denotes | (1→3)‐β‐d‐galactopyranoside | |
112 | 852-857 | Chemical | denotes | PPSGG | |
106 | 872-875 | Gene | denotes | MAG | Gene:17136 |
107 | 915-920 | Species | denotes | mouse | Tax:10090 |
115 | 935-949 | Disease | denotes | IgM neuropathy | MESH:D053306 |
105 | 1071-1074 | Gene | denotes | MAG | Gene:17136 |
113 | 1145-1150 | Chemical | denotes | PPSGG | |
104 | 1182-1185 | Gene | denotes | MAG | Gene:4099 |
108 | 1195-1203 | Species | denotes | patients | Tax:9606 |
109 | 1235-1240 | Species | denotes | human | Tax:9606 |
114 | 1330-1335 | Chemical | denotes | PPSGG | |
122 | 1340-1348 | Species | denotes | patients | Tax:9606 |
123 | 1499-1508 | Chemical | denotes | Rituximab | MESH:D000069283 |
121 | 1594-1597 | Gene | denotes | MAG | Gene:4099 |
124 | 1625-1634 | Chemical | denotes | Rituximab | MESH:D000069283 |
125 | 1689-1694 | Chemical | denotes | PPSGG | |
128 | 1951-1969 | Chemical | denotes | decoy carbohydrate | |
129 | 2057-2069 | Chemical | denotes | carbohydrate | MESH:D002241 |
146 | 2153-2158 | Species | denotes | mouse | Tax:10090 |
150 | 2198-2203 | Chemical | denotes | PPSGG | |
145 | 2255-2258 | Gene | denotes | MAG | Gene:17136 |
144 | 2343-2346 | Gene | denotes | MAG | Gene:17136 |
147 | 2374-2379 | Species | denotes | mouse | Tax:10090 |
151 | 2597-2602 | Chemical | denotes | PPSGG | |
149 | 2650-2655 | Species | denotes | human | Tax:9606 |
143 | 2665-2668 | Gene | denotes | MAG | Gene:4099 |
141 | 2708-2713 | Gene | denotes | CD11b | Gene:3684 |
148 | 2840-2845 | Species | denotes | human | Tax:9606 |
142 | 2886-2889 | Gene | denotes | MAG | Gene:4099 |
166 | 3010-3023 | Chemical | denotes | carbohydrates | MESH:D002241 |
170 | 3085-3095 | Disease | denotes | neuropathy | MESH:D009422 |
171 | 3113-3131 | Disease | denotes | sensory impairment | MESH:D012678 |
172 | 3154-3160 | Disease | denotes | tremor | MESH:D014202 |
173 | 3166-3172 | Disease | denotes | ataxia | MESH:D001259 |
174 | 3184-3198 | Disease | denotes | incoordination | MESH:D001259 |
167 | 3284-3297 | Chemical | denotes | carbohydrates | MESH:D002241 |
168 | 3371-3384 | Chemical | denotes | carbohydrates | MESH:D002241 |
175 | 3440-3448 | Disease | denotes | COVID‐19 | MESH:C000657245 |
176 | 3499-3513 | Disease | denotes | IgM neuropathy | MESH:D053306 |
169 | 3586-3599 | Chemical | denotes | carbohydrates | MESH:D002241 |
165 | 3607-3612 | Gene | denotes | spike | Gene:43740568 |
177 | 3624-3632 | Disease | denotes | COVID‐19 | MESH:C000657245 |
185 | 3634-3639 | Gene | denotes | Spike | Gene:43740568 |
188 | 3696-3703 | Chemical | denotes | glycans | MESH:D011134 |
187 | 3745-3763 | Species | denotes | feline coronavirus | Tax:12663 |
189 | 3774-3781 | Chemical | denotes | mannose | MESH:D008358 |
190 | 3794-3803 | Chemical | denotes | N‐Glycans | |
186 | 3847-3852 | Gene | denotes | spike | Gene:43740568 |
191 | 3868-3877 | Chemical | denotes | N‐glycans | |
212 | 4026-4031 | Gene | denotes | spike | Gene:43740568 |
217 | 4053-4059 | Chemical | denotes | glycan | MESH:D011134 |
218 | 4112-4119 | Chemical | denotes | mannose | MESH:D008358 |
219 | 4145-4152 | Chemical | denotes | glycans | MESH:D011134 |
220 | 4164-4165 | Chemical | denotes | N | MESH:D009584 |
221 | 4296-4309 | Chemical | denotes | carbohydrates | MESH:D002241 |
213 | 4339-4344 | Gene | denotes | spike | Gene:43740568 |
222 | 4417-4422 | Chemical | denotes | PPSGG | |
223 | 4448-4467 | Chemical | denotes | decoy” carbohydrate | |
228 | 4526-4534 | Disease | denotes | COViD‐19 | MESH:C000657245 |
214 | 4552-4583 | Gene | denotes | angiotensin converting enzyme‐2 | Gene:59272 |
215 | 4585-4589 | Gene | denotes | ACE2 | Gene:59272 |
216 | 4605-4610 | Gene | denotes | spike | Gene:43740568 |
224 | 4611-4623 | Chemical | denotes | carbohydrate | MESH:D002241 |
229 | 4703-4715 | Disease | denotes | pneumococcal | MESH:D011008 |
230 | 4732-4745 | Disease | denotes | meningococcal | MESH:D008589 |
225 | 4762-4777 | Chemical | denotes | polysaccharides | MESH:D011134 |
231 | 4781-4811 | Disease | denotes | pneumococcus and meningococcus | |
226 | 4855-4869 | Chemical | denotes | polysaccharide | MESH:D011134 |
227 | 4910-4922 | Chemical | denotes | carbohydrate | MESH:D002241 |
246 | 4963-4988 | Disease | denotes | neuroinflammatory disease | MESH:D003141 |
241 | 5003-5010 | Gene | denotes | cryptic | Gene:55997 |
242 | 5011-5018 | Chemical | denotes | mannose | MESH:D008358 |
243 | 5030-5037 | Chemical | denotes | glycans | MESH:D011134 |
247 | 5099-5117 | Disease | denotes | multiple sclerosis | MESH:D009103 |
244 | 5278-5298 | Chemical | denotes | oligomannose glycans | |
248 | 5361-5370 | Disease | denotes | paralysis | MESH:D010243 |
245 | 5447-5467 | Chemical | denotes | oligomannose glycans | |
249 | 5543-5551 | Disease | denotes | COVID‐19 | MESH:C000657245 |
256 | 5589-5592 | Gene | denotes | MAG | Gene:4099 |
258 | 5745-5749 | Chemical | denotes | Aliu | |
259 | 5861-5867 | Chemical | denotes | glycan | MESH:D011134 |
257 | 5886-5899 | Species | denotes | COVID19 virus | Tax:2697049 |
260 | 6003-6021 | Disease | denotes | IgM MAG neuropathy | MESH:D053306 |
261 | 6055-6063 | Disease | denotes | CoVID‐19 | MESH:C000657245 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T34 | 53-83 | Protein | denotes | myelin‐associated glycoprotein | https://www.uniprot.org/uniprot/Q567S4|https://www.uniprot.org/uniprot/Q15489|https://www.uniprot.org/uniprot/P20917|https://www.uniprot.org/uniprot/P20916|https://www.uniprot.org/uniprot/P16880|https://www.uniprot.org/uniprot/P07723|https://www.uniprot.org/uniprot/P07722|https://www.uniprot.org/uniprot/P02685|https://www.uniprot.org/uniprot/F5GYC0|https://www.uniprot.org/uniprot/B7Z2E5|https://www.uniprot.org/uniprot/A0A087WPR1 |
T45 | 85-88 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T46 | 434-437 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T47 | 872-875 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T48 | 1071-1074 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T49 | 1182-1185 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T50 | 1481-1485 | Protein | denotes | CD20 | https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4 |
T57 | 1594-1597 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T58 | 2255-2258 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T59 | 2343-2346 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T60 | 2665-2668 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T61 | 2708-2713 | Protein | denotes | CD11b | https://www.uniprot.org/uniprot/Q8CA73|https://www.uniprot.org/uniprot/Q4VAK2|https://www.uniprot.org/uniprot/Q4VAK1|https://www.uniprot.org/uniprot/Q4VAK0|https://www.uniprot.org/uniprot/P11578|https://www.uniprot.org/uniprot/P11215|https://www.uniprot.org/uniprot/P05555 |
T68 | 2886-2889 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T69 | 3607-3620 | Protein | denotes | spike protein | https://www.uniprot.org/uniprot/P31340 |
T70 | 3634-3648 | Protein | denotes | Spike proteins | https://www.uniprot.org/uniprot/P31340 |
T71 | 4026-4039 | Protein | denotes | spike protein | https://www.uniprot.org/uniprot/P31340 |
T72 | 4339-4352 | Protein | denotes | spike protein | https://www.uniprot.org/uniprot/P31340 |
T73 | 4552-4583 | Protein | denotes | angiotensin converting enzyme‐2 | https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1 |
T88 | 4585-4589 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T89 | 5310-5319 | Protein | denotes | a protein | https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306 |
T98 | 5589-5592 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
T99 | 6007-6010 | Protein | denotes | MAG | https://www.uniprot.org/uniprot/Q567S4 |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T34 | 53-59 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T35 | 71-83 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T36 | 209-212 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T37 | 213-221 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T38 | 284-296 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T39 | 373-392 | Body_part | denotes | natural killer cell | http://purl.org/sig/ont/fma/fma63147 |
T40 | 388-392 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T41 | 453-473 | Body_part | denotes | natural killer cells | http://purl.org/sig/ont/fma/fma63147 |
T42 | 468-473 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T43 | 491-497 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T44 | 499-505 | Body_part | denotes | retina | http://purl.org/sig/ont/fma/fma58301 |
T45 | 507-512 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T46 | 514-522 | Body_part | denotes | prostate | http://purl.org/sig/ont/fma/fma9600 |
T47 | 670-692 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
T48 | 693-699 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T49 | 876-879 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T50 | 904-909 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T51 | 935-938 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T52 | 1075-1078 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T53 | 1186-1189 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T54 | 1207-1220 | Body_part | denotes | sciatic nerve | http://purl.org/sig/ont/fma/fma19034 |
T55 | 1221-1227 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
T56 | 1369-1372 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T57 | 1441-1444 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T58 | 1445-1453 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T59 | 1488-1493 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T60 | 1561-1564 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T61 | 1575-1583 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T62 | 1751-1754 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T63 | 1957-1969 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T64 | 2057-2069 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T65 | 2237-2240 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T66 | 2334-2337 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T67 | 2347-2355 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T68 | 2361-2366 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T69 | 2401-2409 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T70 | 2633-2638 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 2656-2659 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T72 | 2671-2676 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T73 | 2714-2729 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T74 | 2724-2729 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T75 | 2872-2875 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T76 | 3010-3023 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T77 | 3284-3297 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T78 | 3371-3384 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T79 | 3499-3502 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T80 | 3586-3599 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T81 | 3613-3620 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T82 | 3640-3648 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T83 | 3774-3781 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T84 | 4032-4039 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T85 | 4112-4119 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T86 | 4296-4309 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
T87 | 4345-4352 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T88 | 4455-4467 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T89 | 4611-4623 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T90 | 4762-4777 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
T91 | 4855-4869 | Body_part | denotes | polysaccharide | http://purl.org/sig/ont/fma/fma82746 |
T92 | 4910-4922 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
T93 | 5011-5018 | Body_part | denotes | mannose | http://purl.org/sig/ont/fma/fma82801 |
T94 | 5059-5078 | Body_part | denotes | cerebrospinal fluid | http://purl.org/sig/ont/fma/fma20935 |
T95 | 5312-5319 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T96 | 5553-5556 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
T97 | 6003-6006 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
LitCovid-sample-PD-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 499-505 | http://purl.obolibrary.org/obo/MAT_0000142 | denotes | retina |
T4 | 507-512 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
T5 | 514-522 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
T6 | 533-541 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximal |
T7 | 670-692 | http://purl.obolibrary.org/obo/MAT_0000457 | denotes | central nervous system |
T8 | 678-692 | http://purl.obolibrary.org/obo/MAT_0000026 | denotes | nervous system |
T9 | 904-909 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T10 | 904-909 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T11 | 2361-2366 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T12 | 2361-2366 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T13 | 5059-5078 | http://purl.obolibrary.org/obo/MAT_0000499 | denotes | cerebrospinal fluid |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 670-699 | http://purl.obolibrary.org/obo/GO_0022010 | denotes | central nervous system myelin |
T5 | 4166-4179 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T12 | 32-42 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T13 | 238-259 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T14 | 939-949 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T15 | 1373-1394 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T16 | 3085-3095 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T17 | 3166-3172 | Disease | denotes | ataxia | http://purl.obolibrary.org/obo/MONDO_0000437 |
T18 | 3440-3448 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T19 | 3503-3513 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T20 | 3624-3632 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T21 | 4526-4534 | Disease | denotes | COViD‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T22 | 5099-5117 | Disease | denotes | multiple sclerosis | http://purl.obolibrary.org/obo/MONDO_0005301 |
T23 | 5237-5257 | Disease | denotes | inflammatory disease | http://purl.obolibrary.org/obo/MONDO_0021166 |
T24 | 5543-5551 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T25 | 5557-5578 | Disease | denotes | monoclonal gammopathy | http://purl.obolibrary.org/obo/MONDO_0004960 |
T26 | 5886-5893 | Disease | denotes | COVID19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T27 | 6011-6021 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
T28 | 6055-6063 | Disease | denotes | CoVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 18-31 | Phenotype | denotes | demyelinating | http://purl.obolibrary.org/obo/HP_0011096 |
T3 | 32-42 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T4 | 939-949 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T5 | 1551-1571 | Phenotype | denotes | increased IgM levels | http://purl.obolibrary.org/obo/HP_0003496 |
T6 | 3085-3095 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T7 | 3113-3131 | Phenotype | denotes | sensory impairment | http://purl.obolibrary.org/obo/HP_0003474 |
T8 | 3133-3152 | Phenotype | denotes | disturbance in gait | http://purl.obolibrary.org/obo/HP_0001288 |
T9 | 3154-3160 | Phenotype | denotes | tremor | http://purl.obolibrary.org/obo/HP_0001337 |
T10 | 3166-3172 | Phenotype | denotes | ataxia | http://purl.obolibrary.org/obo/HP_0001251 |
T11 | 3184-3198 | Phenotype | denotes | incoordination | http://purl.obolibrary.org/obo/HP_0002311 |
T12 | 3209-3221 | Phenotype | denotes | sensory loss | http://purl.obolibrary.org/obo/HP_0003474 |
T13 | 3503-3513 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T14 | 5361-5370 | Phenotype | denotes | paralysis | http://purl.obolibrary.org/obo/HP_0003470 |
T15 | 6011-6021 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 18-31 | Phenotype | denotes | demyelinating | http://purl.obolibrary.org/obo/HP_0011096 |
T3 | 32-42 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T4 | 939-949 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T5 | 1551-1571 | Phenotype | denotes | increased IgM levels | http://purl.obolibrary.org/obo/HP_0003496 |
T6 | 3085-3095 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T7 | 3113-3131 | Phenotype | denotes | sensory impairment | http://purl.obolibrary.org/obo/HP_0003474 |
T8 | 3133-3152 | Phenotype | denotes | disturbance in gait | http://purl.obolibrary.org/obo/HP_0001288 |
T9 | 3154-3160 | Phenotype | denotes | tremor | http://purl.obolibrary.org/obo/HP_0001337 |
T10 | 3166-3172 | Phenotype | denotes | ataxia | http://purl.obolibrary.org/obo/HP_0001251 |
T11 | 3184-3198 | Phenotype | denotes | incoordination | http://purl.obolibrary.org/obo/HP_0002311 |
T12 | 3209-3221 | Phenotype | denotes | sensory loss | http://purl.obolibrary.org/obo/HP_0003474 |
T13 | 3503-3513 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
T14 | 5361-5370 | Phenotype | denotes | paralysis | http://purl.obolibrary.org/obo/HP_0003470 |
T15 | 6011-6021 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5 | 670-699 | http://purl.obolibrary.org/obo/GO_0022010 | denotes | central nervous system myelin |
T6 | 4166-4179 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5 | 670-699 | http://purl.obolibrary.org/obo/GO_0022010 | denotes | central nervous system myelin |
T6 | 4164-4179 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N‐glycosylation |
T7 | 4166-4179 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T18 | 0-15 | Sentence | denotes | 1 INTRODUCTION |
T19 | 16-166 | Sentence | denotes | A demyelinating neuropathy targeting myelin‐associated glycoprotein (MAG) has an incidence of approximately one per 100,000 (Mygland & Monstad, 2001). |
T20 | 167-403 | Sentence | denotes | In this disease there is production of an IgM antibody resulting in a “monoclonal gammopathy” targeting a particular carbohydrate known as Cellular Differentiation antigen 57 (CD57) and also known as human natural killer cell‐1 (HNK‐1). |
T21 | 404-566 | Sentence | denotes | The HNK‐1 antigen is found on MAG, as well as on natural killer cells, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules (Pernick, 2019). |
T22 | 567-700 | Sentence | denotes | CD57 belongs to a family of sialic acid‐binding Ig‐like lectins (siglecs) found on both peripheral and central nervous system myelin. |
T23 | 701-950 | Sentence | denotes | In this issue investigators (Aliu et al, 2020) showed that poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood in a mouse model of this IgM neuropathy. |
T24 | 951-1106 | Sentence | denotes | In a previous study these investigators developed antigen‐specific molecules with nanomolar inhibitory potency for anti‐MAG IgM (Herrendorff et al., 2017). |
T25 | 1107-1250 | Sentence | denotes | Here the investigators also show that PPSGG blocked the binding of an anti‐MAG IgM from patients to sciatic nerve myelin of non‐human primates. |
T26 | 1251-1336 | Sentence | denotes | They also tested some of the pharmacokinetic and pharmacodynamic properties of PPSGG. |
T27 | 1337-1509 | Sentence | denotes | In patients suffering from this IgM monoclonal gammopathy, non‐specific strategies are used to diminish IgM antibody including targeting of all CD20 B cells with Rituximab. |
T28 | 1510-1661 | Sentence | denotes | On occasion flares of disease occur with increased IgM levels of antibody targeting MAG have followed therapy with Rituximab (Broglio and Luria, 2005). |
T29 | 1662-1771 | Sentence | denotes | The strategy employed with PPSGG is specific to the antigen that triggers the pathogenic IgM in this disease. |
T30 | 1772-1851 | Sentence | denotes | One can refer to such treatment as “antigen‐specific” immunotherapy (Figure 1). |
T31 | 1852-2259 | Sentence | denotes | FIGURE 1 The strategy employed by Aliu et al, provide a basis for a passive immune therapy with a decoy carbohydrate preventing the virus from docking on its receptor, and also provide a foundation for a carbohydrate‐based active immunization when coupled to a suitable carrier Investigations in the mouse model revealed that practical doses of PPSGG were able to sufficiently reduce IgM that binds to MAG. |
T32 | 2260-2386 | Sentence | denotes | Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model. |
T33 | 2387-2536 | Sentence | denotes | Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach. |
T34 | 2537-2677 | Sentence | denotes | In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells. |
T35 | 2678-2743 | Sentence | denotes | In addition, no activation of CD11b dendritic cells was observed. |
T36 | 2744-2862 | Sentence | denotes | These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials. |
T37 | 2863-2955 | Sentence | denotes | Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study. |
T38 | 2956-3240 | Sentence | denotes | Writing about these exquisite approaches to targeting carbohydrates for a potential antigen‐specific therapy for an inflammatory neuropathy characterized by sensory impairment, disturbance in gait, tremor, and ataxia (a form of incoordination following sensory loss) makes one wonder: |
T39 | 3241-3418 | Sentence | denotes | Could such an approach, targeting critical carbohydrates in a disease, have broader applicability to other diseases where complex carbohydrates play a key pathophysiologic role? |
T40 | 3419-3633 | Sentence | denotes | In these days of the COVID‐19 pandemic, the experiments described on monoclonal IgM neuropathy raise the issue that a similar strategy might be deployed to target the carbohydrates in the spike protein of COVID‐19. |
T41 | 3634-3704 | Sentence | denotes | Spike proteins in coronviruses are known to be camouflaged by glycans: |
T42 | 3705-3853 | Sentence | denotes | Mass spectrometry studies revealed in a feline coronavirus that high mannose and complex N‐Glycans accounted for a quarter of the mass of the spike. |
T43 | 3854-3977 | Sentence | denotes | Moreover, the N‐glycans are critical for providing the propeller like conformation of these structures (Yang et al., 2020). |
T44 | 3978-4099 | Sentence | denotes | In the so‐called receptor‐binding domain of the spike protein there are 22 glycan‐binding sites (Shahajan, Supekar et al. |
T45 | 4100-4106 | Sentence | denotes | 2020). |
T46 | 4107-4230 | Sentence | denotes | High mannose, hybrid and complex‐type glycans across the N‐glycosylation sites have been identified with mass spectrometry. |
T47 | 4231-4439 | Sentence | denotes | One could imagine building a therapeutic which might contain the carbohydrates, or a suitable mimic, of the spike protein coupled to a carrier molecule, much in a similar fashion to how PPSGG was constructed. |
T48 | 4440-4591 | Sentence | denotes | Such a “decoy” carbohydrate could block the binding and subsequent internalization of COViD‐19 to its receptor, angiotensin converting enzyme‐2 (ACE2). |
T49 | 4592-4693 | Sentence | denotes | In addition, spike carbohydrate clusters coupled to a carrier might proof to be an effective vaccine. |
T50 | 4694-4826 | Sentence | denotes | Both the pneumococcal vaccine and the meningococcal vaccines target polysaccharides in pneumococcus and meningococcus, respectively. |
T51 | 4827-4947 | Sentence | denotes | They couple the appropriate polysaccharide to a suitable carrier to achieve potent carbohydrate‐specific immunogenicity. |
T52 | 4948-5167 | Sentence | denotes | In a different neuroinflammatory disease antibodies to cryptic mannose containing glycans were observed in the cerebrospinal fluid of individuals with multiple sclerosis, and in its animal model EAE (Wang et al., 2014). |
T53 | 5168-5258 | Sentence | denotes | There again is some precedent for an antigen‐specific therapy for an inflammatory disease. |
T54 | 5259-5410 | Sentence | denotes | Injection of these oligomannose glycans coupled to a protein carrier reduced the clinical severity of paralysis in this animal model (Wang, Bhat et al. |
T55 | 5411-5417 | Sentence | denotes | 2014). |
T56 | 5418-5552 | Sentence | denotes | The success in parlaying the oligomannose glycans in MS and in its EAE model, could be emulated in strategies for therapy of COVID‐19. |
T57 | 5553-5618 | Sentence | denotes | IgM monoclonal gammopathy targeting MAG is indeed a rare disease. |
T58 | 5619-5721 | Sentence | denotes | Lessons from rare diseases often inform us of bold approaches for the treatment of widespread disease. |
T59 | 5722-5900 | Sentence | denotes | The pioneering work of Aliu and colleagues described in this issue, might serve as a guidepost for designing effective therapeutics to the glycan components of the COVID19 virus. |
T60 | 5901-6073 | Sentence | denotes | Such endeavors may produce a sweet ending to a tragedy including both the harsh clinical realities of IgM MAG neuropathy and to the horrors of the deadly CoVID‐19 pandemic. |
LitCovid-sample-Glycan
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 3774-3781 | http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname | denotes | mannose |
T2 | 4112-4119 | http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname | denotes | mannose |
T3 | 5011-5018 | http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname | denotes | mannose |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
82 | 53-83 | Gene | denotes | myelin‐associated glycoprotein | Gene:4099 |
83 | 396-401 | Gene | denotes | HNK‐1 | Gene:27087 |
84 | 408-413 | Gene | denotes | HNK‐1 | Gene:27087 |
85 | 85-88 | Gene | denotes | MAG | Gene:4099 |
86 | 434-437 | Gene | denotes | MAG | Gene:4099 |
87 | 367-372 | Species | denotes | human | Tax:9606 |
88 | 284-296 | Chemical | denotes | carbohydrate | MESH:D002241 |
89 | 595-606 | Chemical | denotes | sialic acid | MESH:D019158 |
90 | 18-42 | Disease | denotes | demyelinating neuropathy | MESH:D003711 |
91 | 670-699 | Disease | denotes | central nervous system myelin | MESH:D020278 |
104 | 1182-1185 | Gene | denotes | MAG | Gene:4099 |
105 | 1071-1074 | Gene | denotes | MAG | Gene:17136 |
106 | 872-875 | Gene | denotes | MAG | Gene:17136 |
107 | 915-920 | Species | denotes | mouse | Tax:10090 |
108 | 1195-1203 | Species | denotes | patients | Tax:9606 |
109 | 1235-1240 | Species | denotes | human | Tax:9606 |
110 | 760-813 | Chemical | denotes | poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate) | |
111 | 814-841 | Chemical | denotes | (1→3)‐β‐d‐galactopyranoside | |
112 | 852-857 | Chemical | denotes | PPSGG | |
113 | 1145-1150 | Chemical | denotes | PPSGG | |
114 | 1330-1335 | Chemical | denotes | PPSGG | |
115 | 935-949 | Disease | denotes | IgM neuropathy | MESH:D053306 |
121 | 1594-1597 | Gene | denotes | MAG | Gene:4099 |
122 | 1340-1348 | Species | denotes | patients | Tax:9606 |
123 | 1499-1508 | Chemical | denotes | Rituximab | MESH:D000069283 |
124 | 1625-1634 | Chemical | denotes | Rituximab | MESH:D000069283 |
125 | 1689-1694 | Chemical | denotes | PPSGG | |
128 | 1951-1969 | Chemical | denotes | decoy carbohydrate | |
129 | 2057-2069 | Chemical | denotes | carbohydrate | MESH:D002241 |
141 | 2708-2713 | Gene | denotes | CD11b | Gene:3684 |
142 | 2886-2889 | Gene | denotes | MAG | Gene:4099 |
143 | 2665-2668 | Gene | denotes | MAG | Gene:4099 |
144 | 2343-2346 | Gene | denotes | MAG | Gene:17136 |
145 | 2255-2258 | Gene | denotes | MAG | Gene:17136 |
146 | 2153-2158 | Species | denotes | mouse | Tax:10090 |
147 | 2374-2379 | Species | denotes | mouse | Tax:10090 |
148 | 2840-2845 | Species | denotes | human | Tax:9606 |
149 | 2650-2655 | Species | denotes | human | Tax:9606 |
150 | 2198-2203 | Chemical | denotes | PPSGG | |
151 | 2597-2602 | Chemical | denotes | PPSGG | |
165 | 3607-3612 | Gene | denotes | spike | Gene:43740568 |
166 | 3010-3023 | Chemical | denotes | carbohydrates | MESH:D002241 |
167 | 3284-3297 | Chemical | denotes | carbohydrates | MESH:D002241 |
168 | 3371-3384 | Chemical | denotes | carbohydrates | MESH:D002241 |
169 | 3586-3599 | Chemical | denotes | carbohydrates | MESH:D002241 |
170 | 3085-3095 | Disease | denotes | neuropathy | MESH:D009422 |
171 | 3113-3131 | Disease | denotes | sensory impairment | MESH:D012678 |
172 | 3154-3160 | Disease | denotes | tremor | MESH:D014202 |
173 | 3166-3172 | Disease | denotes | ataxia | MESH:D001259 |
174 | 3184-3198 | Disease | denotes | incoordination | MESH:D001259 |
175 | 3440-3448 | Disease | denotes | COVID‐19 | MESH:C000657245 |
176 | 3499-3513 | Disease | denotes | IgM neuropathy | MESH:D053306 |
177 | 3624-3632 | Disease | denotes | COVID‐19 | MESH:C000657245 |
185 | 3634-3639 | Gene | denotes | Spike | Gene:43740568 |
186 | 3847-3852 | Gene | denotes | spike | Gene:43740568 |
187 | 3745-3763 | Species | denotes | feline coronavirus | Tax:12663 |
188 | 3696-3703 | Chemical | denotes | glycans | MESH:D011134 |
189 | 3774-3781 | Chemical | denotes | mannose | MESH:D008358 |
190 | 3794-3803 | Chemical | denotes | N‐Glycans | |
191 | 3868-3877 | Chemical | denotes | N‐glycans | |
212 | 4026-4031 | Gene | denotes | spike | Gene:43740568 |
213 | 4339-4344 | Gene | denotes | spike | Gene:43740568 |
214 | 4552-4583 | Gene | denotes | angiotensin converting enzyme‐2 | Gene:59272 |
215 | 4585-4589 | Gene | denotes | ACE2 | Gene:59272 |
216 | 4605-4610 | Gene | denotes | spike | Gene:43740568 |
217 | 4053-4059 | Chemical | denotes | glycan | MESH:D011134 |
218 | 4112-4119 | Chemical | denotes | mannose | MESH:D008358 |
219 | 4145-4152 | Chemical | denotes | glycans | MESH:D011134 |
220 | 4164-4165 | Chemical | denotes | N | MESH:D009584 |
221 | 4296-4309 | Chemical | denotes | carbohydrates | MESH:D002241 |
222 | 4417-4422 | Chemical | denotes | PPSGG | |
223 | 4448-4467 | Chemical | denotes | decoy” carbohydrate | |
224 | 4611-4623 | Chemical | denotes | carbohydrate | MESH:D002241 |
225 | 4762-4777 | Chemical | denotes | polysaccharides | MESH:D011134 |
226 | 4855-4869 | Chemical | denotes | polysaccharide | MESH:D011134 |
227 | 4910-4922 | Chemical | denotes | carbohydrate | MESH:D002241 |
228 | 4526-4534 | Disease | denotes | COViD‐19 | MESH:C000657245 |
229 | 4703-4715 | Disease | denotes | pneumococcal | MESH:D011008 |
230 | 4732-4745 | Disease | denotes | meningococcal | MESH:D008589 |
231 | 4781-4811 | Disease | denotes | pneumococcus and meningococcus | |
241 | 5003-5010 | Gene | denotes | cryptic | Gene:55997 |
242 | 5011-5018 | Chemical | denotes | mannose | MESH:D008358 |
243 | 5030-5037 | Chemical | denotes | glycans | MESH:D011134 |
244 | 5278-5298 | Chemical | denotes | oligomannose glycans | |
245 | 5447-5467 | Chemical | denotes | oligomannose glycans | |
246 | 4963-4988 | Disease | denotes | neuroinflammatory disease | MESH:D003141 |
247 | 5099-5117 | Disease | denotes | multiple sclerosis | MESH:D009103 |
248 | 5361-5370 | Disease | denotes | paralysis | MESH:D010243 |
249 | 5543-5551 | Disease | denotes | COVID‐19 | MESH:C000657245 |
256 | 5589-5592 | Gene | denotes | MAG | Gene:4099 |
257 | 5886-5899 | Species | denotes | COVID19 virus | Tax:2697049 |
258 | 5745-5749 | Chemical | denotes | Aliu | |
259 | 5861-5867 | Chemical | denotes | glycan | MESH:D011134 |
260 | 6003-6021 | Disease | denotes | IgM MAG neuropathy | MESH:D053306 |
261 | 6055-6063 | Disease | denotes | CoVID‐19 | MESH:C000657245 |