PMC:7360514 / 45278-46630 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7360514","sourcedb":"PMC","sourceid":"7360514","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7360514","text":"Invasive ventilation first requires intubation. During the SARS epidemic in Canada, Fowler et al. [88] described a RR of infection of 13.3 for the intubation procedure. Thompson et al. [90]studied the viral RNA content of aerosols during various procedures in the context of the H1N1 epidemic in England. They found a significantly higher exposure to viral RNA from particles sized \u003c7.3 µm while patients were being intubated. The reach of aerosol contamination in a simulation model was up to 2 m around the patient's head [91]. Wearing appropriate protective equipment is therefore absolutely essential. In addition, this last paper proposed placing a box over the patient's head to prevent aerosol contamination, although this has the downside that hand mobility during manipulation is restricted. The OR of aerosol production during intubation is 2.3. Endotracheal aspiration of a ventilated patient in the same study yielded an OR of 4.11 with respect to the production of virus-laden aerosols. No data on viral transmission in invasively ventilated patients outside of procedures have been published to date. If, for example, a defective or insufficiently blocked cuff can lead to aerosol formation is not known. Furthermore, not all ventilators have a virus filter in their expiratory limb. No data on this are available in published 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