PMC:7358770 / 33686-37632
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T41 | 2253-2260 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T42 | 2253-2260 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T326 | 51-66 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T327 | 1044-1052 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T328 | 1076-1080 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T329 | 1373-1385 | Body_part | denotes | eosinophilic | http://purl.org/sig/ont/fma/fma62861 |
| T330 | 1576-1583 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T331 | 1652-1655 | Body_part | denotes | IgA | http://purl.org/sig/ont/fma/fma62874 |
| T332 | 1660-1663 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T333 | 1738-1741 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
| T334 | 1753-1758 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T335 | 1812-1819 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T336 | 2253-2260 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T337 | 2404-2411 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T338 | 2582-2589 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T339 | 2618-2625 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T340 | 2738-2746 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T341 | 2791-2799 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T342 | 2881-2889 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T343 | 2918-2922 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T344 | 3346-3361 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T345 | 3404-3419 | Body_part | denotes | oligosaccharide | http://purl.org/sig/ont/fma/fma82742 |
| T346 | 3648-3655 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T347 | 3707-3722 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T348 | 3739-3746 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T349 | 3880-3887 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T350 | 3917-3932 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T22 | 688-693 | Body_part | denotes | venom | http://purl.obolibrary.org/obo/UBERON_0007113 |
| T23 | 1753-1758 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1133 | 51-66 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1148 | 920-925 | Species | denotes | PRRSV | Tax:28344 |
| 1149 | 1094-1098 | Species | denotes | mice | Tax:10090 |
| 1150 | 1116-1124 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1151 | 1165-1173 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1152 | 1196-1201 | Species | denotes | mouse | Tax:10090 |
| 1153 | 1230-1234 | Species | denotes | mice | Tax:10090 |
| 1154 | 1274-1282 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1155 | 1333-1341 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1156 | 1520-1531 | Species | denotes | coronavirus | Tax:11118 |
| 1157 | 1549-1573 | Species | denotes | Bovine coronavirus (BCV) | Tax:11128 |
| 1158 | 1806-1809 | Species | denotes | BCV | Tax:11128 |
| 1159 | 165-184 | Disease | denotes | infectious diseases | MESH:D003141 |
| 1160 | 296-304 | Disease | denotes | toxicity | MESH:D064420 |
| 1161 | 926-935 | Disease | denotes | infection | MESH:D007239 |
| 1165 | 3180-3183 | Species | denotes | COV | Tax:11118 |
| 1166 | 3184-3207 | Disease | denotes | immunosensor array chip | |
| 1167 | 3217-3247 | Disease | denotes | immunosensor fabrication steps | |
| 1177 | 2186-2194 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1178 | 2452-2463 | Species | denotes | coronavirus | Tax:11118 |
| 1179 | 2053-2064 | Species | denotes | coronavirus | Tax:11118 |
| 1180 | 2354-2357 | Species | denotes | HPV | Tax:10566 |
| 1181 | 2359-2362 | Species | denotes | RSV | Tax:12814 |
| 1182 | 2134-2140 | Chemical | denotes | carbon | MESH:D002244 |
| 1183 | 2282-2294 | Disease | denotes | cytotoxicity | MESH:D064420 |
| 1184 | 2945-2954 | Disease | denotes | infection | MESH:D007239 |
| 1185 | 2996-3017 | Disease | denotes | coronavirus infection | MESH:D018352 |
| 1188 | 3893-3904 | Species | denotes | coronavirus | Tax:11118 |
| 1189 | 3917-3932 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1198 | 3453-3458 | Species | denotes | algae | Tax:569578 |
| 1199 | 3661-3672 | Species | denotes | coronavirus | Tax:11118 |
| 1200 | 3768-3779 | Species | denotes | coronavirus | Tax:11118 |
| 1201 | 3346-3361 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1202 | 3392-3419 | Chemical | denotes | carrageenan oligosaccharide | |
| 1203 | 3424-3432 | Chemical | denotes | fucoidan | MESH:C007789 |
| 1204 | 3707-3722 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1205 | 3501-3509 | Disease | denotes | toxicity | MESH:D064420 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T143 | 165-175 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T144 | 695-697 | Disease | denotes | BV | http://purl.obolibrary.org/obo/MONDO_0005316 |
| T145 | 926-935 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T146 | 2364-2370 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T147 | 2945-2954 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T148 | 3008-3017 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T374 | 94-95 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T375 | 193-200 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T376 | 280-288 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T377 | 755-758 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T378 | 901-911 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T379 | 964-965 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T380 | 1074-1080 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T381 | 1114-1115 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T382 | 1163-1164 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T383 | 1196-1201 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T384 | 1311-1312 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T385 | 1886-1887 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T386 | 1925-1930 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | field |
| T387 | 2396-2399 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T388 | 2418-2419 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T389 | 2486-2487 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T390 | 2536-2541 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T391 | 2629-2630 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T392 | 2680-2681 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T393 | 2916-2922 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T394 | 3048-3049 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T395 | 3209-3210 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T396 | 3249-3250 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T397 | 3315-3320 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T505 | 51-66 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T506 | 342-353 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
| T507 | 357-370 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T508 | 452-459 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T509 | 596-605 | Chemical | denotes | adjuvants | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T510 | 640-648 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T512 | 649-657 | Chemical | denotes | alginate | http://purl.obolibrary.org/obo/CHEBI_58187 |
| T513 | 658-670 | Chemical | denotes | nanoparticle | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T514 | 688-693 | Chemical | denotes | venom | http://purl.obolibrary.org/obo/CHEBI_78505 |
| T515 | 972-984 | Chemical | denotes | nanoparticle | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T516 | 1057-1064 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T517 | 1125-1137 | Chemical | denotes | nanoparticle | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T518 | 1255-1267 | Chemical | denotes | nanoparticle | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T519 | 1428-1440 | Chemical | denotes | nanoparticle | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T520 | 1576-1583 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T521 | 1591-1599 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T523 | 1600-1613 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T524 | 1615-1618 | Chemical | denotes | CNP | http://purl.obolibrary.org/obo/CHEBI_80235 |
| T525 | 1727-1732 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T526 | 1812-1819 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T527 | 1827-1830 | Chemical | denotes | CNP | http://purl.obolibrary.org/obo/CHEBI_80235 |
| T528 | 1831-1836 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T529 | 1867-1870 | Chemical | denotes | CNP | http://purl.obolibrary.org/obo/CHEBI_80235 |
| T530 | 1894-1902 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T531 | 1955-1959 | Chemical | denotes | gold | http://purl.obolibrary.org/obo/CHEBI_29287|http://purl.obolibrary.org/obo/CHEBI_30050 |
| T533 | 1960-1973 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T534 | 2017-2028 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
| T535 | 2134-2140 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
| T537 | 2230-2234 | Chemical | denotes | gold | http://purl.obolibrary.org/obo/CHEBI_29287|http://purl.obolibrary.org/obo/CHEBI_30050 |
| T539 | 2235-2248 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T540 | 2253-2260 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T541 | 2404-2411 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T542 | 2582-2589 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T543 | 2590-2596 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T544 | 2618-2625 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T545 | 2637-2644 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T546 | 2682-2690 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T547 | 2738-2746 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T548 | 2791-2799 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T549 | 2854-2861 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T550 | 3095-3103 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T551 | 3119-3132 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T552 | 3154-3165 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
| T553 | 3346-3361 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T554 | 3392-3403 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T555 | 3404-3419 | Chemical | denotes | oligosaccharide | http://purl.obolibrary.org/obo/CHEBI_50699 |
| T556 | 3424-3432 | Chemical | denotes | fucoidan | http://purl.obolibrary.org/obo/CHEBI_5181 |
| T557 | 3540-3550 | Chemical | denotes | reductants | http://purl.obolibrary.org/obo/CHEBI_63247 |
| T558 | 3648-3655 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T559 | 3707-3722 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T560 | 3739-3746 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T561 | 3747-3753 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T562 | 3780-3793 | Chemical | denotes | nanoparticles | http://purl.obolibrary.org/obo/CHEBI_50803 |
| T563 | 3802-3813 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
| T564 | 3880-3887 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T565 | 3917-3932 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T80 | 2436-2448 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T81 | 2597-2606 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T82 | 3561-3570 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T83 | 3754-3763 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32679328-31647394-48281347 | 519-522 | 31647394 | denotes | 126 |
| 32679328-26154342-48281348 | 630-633 | 26154342 | denotes | 127 |
| 32679328-29776611-48281349 | 937-940 | 29776611 | denotes | 128 |
| 32679328-30847572-48281350 | 2206-2209 | 30847572 | denotes | 131 |
| 32679328-29251725-48281351 | 2396-2399 | 29251725 | denotes | 132 |
| 32679328-19198616-48281352 | 2528-2529 | 19198616 | denotes | 8 |
| 32679328-27552321-48281353 | 2530-2533 | 27552321 | denotes | 133 |
| 32679328-27552321-48281354 | 2748-2751 | 27552321 | denotes | 133 |
| 32679328-27552321-48281355 | 3019-3022 | 27552321 | denotes | 133 |
| 32679328-27552321-48281356 | 3167-3170 | 27552321 | denotes | 133 |
| 32679328-30847572-48281357 | 3326-3329 | 30847572 | denotes | 131 |
| 32679328-31043709-48281358 | 3578-3581 | 31043709 | denotes | 134 |
| 32679328-27267570-48281359 | 3582-3585 | 27267570 | denotes | 135 |
| T91461 | 519-522 | 31647394 | denotes | 126 |
| T4724 | 630-633 | 26154342 | denotes | 127 |
| T23491 | 937-940 | 29776611 | denotes | 128 |
| T17297 | 2206-2209 | 30847572 | denotes | 131 |
| T3277 | 2396-2399 | 29251725 | denotes | 132 |
| T25834 | 2528-2529 | 19198616 | denotes | 8 |
| T61152 | 2530-2533 | 27552321 | denotes | 133 |
| T23570 | 2748-2751 | 27552321 | denotes | 133 |
| T8411 | 3019-3022 | 27552321 | denotes | 133 |
| T19466 | 3167-3170 | 27552321 | denotes | 133 |
| T93799 | 3326-3329 | 30847572 | denotes | 131 |
| T26626 | 3578-3581 | 31043709 | denotes | 134 |
| T38564 | 3582-3585 | 27267570 | denotes | 135 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T208 | 0-66 | Sentence | denotes | 5 Antiviral nanomaterials and delivery systems of polysaccharides |
| T209 | 67-201 | Sentence | denotes | Nanobiotechnology provides a variety of solutions for the prevention, diagnosis, and treatment of infectious diseases such as viruses. |
| T210 | 202-337 | Sentence | denotes | Nanoparticles can be designed as an efficient delivery system to increase the activity of low toxicity vaccines against the host [125]. |
| T211 | 338-524 | Sentence | denotes | The application of nanoparticles in vaccine formulations can not only improve the immunogenicity and stability of antigen, but also achieve targeted delivery and sustained release [126]. |
| T212 | 525-635 | Sentence | denotes | Nanomaterials may have intrinsic immunomodulatory functions, acting as adjuvants or immune potentiators [127]. |
| T213 | 636-942 | Sentence | denotes | The chitosan/alginate nanoparticle encapsulated bee venom (BV) with slow-releasing properties and mucosal adhesiveness has been developed, which can effectively induce non-specific immune stimulation, particularly those related to Th1 responses and viral clearance activities against PRRSV infection [128]. |
| T214 | 943-1156 | Sentence | denotes | The effectiveness of a novel nanoparticle vaccine is supported by stimulating effective neutralizing antibody and antigen-specific T cell responses in mice immunized with a MERS-CoV nanoparticle vaccine candidate. |
| T215 | 1157-1402 | Sentence | denotes | Using a MERS-CoV-permissive transgenic mouse model, it is shown that the mice immunized with this nanoparticle-based MERS-CoV vaccine can protect against a lethal challenge of MERS-CoV without triggering undesirable eosinophilic immunopathology. |
| T216 | 1403-1548 | Sentence | denotes | The biocompatible hollow nanoparticle may accelerate the development of effective and safe vaccines against emerging coronavirus pathogens [129]. |
| T217 | 1549-1733 | Sentence | denotes | Bovine coronavirus (BCV) N protein-loaded chitosan nanoparticles (CNP) can significantly increase both IgA and IgG levels after the second immunization comparable to the control group. |
| T218 | 1734-1837 | Sentence | denotes | The IgM content in serum increased after the second immunization in the BCV N protein-loaded CNP group. |
| T219 | 1838-1937 | Sentence | denotes | These findings indicate that CNP can be used as a novel adjuvant in veterinary vaccine field [130]. |
| T220 | 1938-2065 | Sentence | denotes | In addition, the gold nanoparticles (AuNPs)-based nanomaterials also have good application prospects in anti-novel coronavirus. |
| T221 | 2066-2211 | Sentence | denotes | An electrochemical immunosensor based on an array of AuNPs-modified carbon electrodes was used for the determination of MERS-CoV (Fig. 8 ) [131]. |
| T222 | 2212-2401 | Sentence | denotes | Highly sulfonated gold nanoparticles and heparin coated AuNPs with no cytotoxicity displayed broad-spectrum virucidal properties against HSV, HPV, RSV, dengue and lentivirus in vitro [132]. |
| T223 | 2402-2535 | Sentence | denotes | S protein plays a key role in the pathogenesis of coronavirus, and it is considered a primary target for vaccine preparation [8,133]. |
| T224 | 2536-2753 | Sentence | denotes | Virus like particles (sVLPs) were prepared by protein corona formation with IBV S protein as a model antigen and incubated with 100 nm AuNPs in a solution containing an optimized concentration of viral proteins [133]. |
| T225 | 2754-3024 | Sentence | denotes | As compared to inoculation with free proteins, vaccination with the sVLPs showed enhanced lymphatic antigen delivery, stronger antibody titers, increased splenic T-cell response, and reduced infection-associated symptoms in an avian model of coronavirus infection [133]. |
| T226 | 3025-3172 | Sentence | denotes | The study demonstrates a simple and reliable method in bridging viral antigens with synthetic nanoparticles for improved vaccine application [133]. |
| T227 | 3173-3212 | Sentence | denotes | Fig. 8 COV immunosensor array chip (a). |
| T228 | 3213-3331 | Sentence | denotes | The immunosensor fabrication steps (b), the detection process of the competitive immunosensor for the virus (c) [131]. |
| T229 | 3332-3587 | Sentence | denotes | Additionally, polysaccharides or their derivatives, such as carrageenan oligosaccharide and fucoidan derived from marine algae with biodegradability, abundance, and non-toxicity, can be used as biocompatible reductants for green synthesis AuNPs [134,135]. |
| T230 | 3588-3824 | Sentence | denotes | Based on our previous works, we hypothesize that the S or N protein from coronavirus can be designed to be loaded onto polysaccharides capped AuNPs by protein corona formation for coronavirus nanoparticles vaccine application (Fig. 9 ). |
| T231 | 3825-3946 | Sentence | denotes | Fig. 9 The proposed schematics illustrating the S or N protein from coronavirus loaded onto polysaccharides capped AuNPs. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T962 | 51-66 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T963 | 107-116 | CHEBI:75958;CHEBI:75958 | denotes | solutions |
| T964 | 193-200 | NCBITaxon:10239 | denotes | viruses |
| T965 | 357-370 | GO:0031982 | denotes | nanoparticles |
| T966 | 420-434 | BV_15 | denotes | immunogenicity |
| T967 | 452-459 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T968 | 596-605 | CHEBI:60809;CHEBI:60809 | denotes | adjuvants |
| T969 | 609-615 | UBERON:0002405 | denotes | immune |
| T970 | 640-648 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T971 | 684-687 | NCBITaxon:7460 | denotes | bee |
| T972 | 734-741 | UBERON:0000912 | denotes | mucosal |
| T973 | 817-823 | UBERON:0002405 | denotes | immune |
| T974 | 867-880 | GO:0042110 | denotes | Th1 responses |
| T975 | 885-890 | NCBITaxon:10239 | denotes | viral |
| T976 | 920-925 | NCBITaxon:42413 | denotes | PRRSV |
| T977 | 1044-1052 | GO:0042571 | denotes | antibody |
| T978 | 1057-1064 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T979 | 1074-1075 | CL:0000084 | denotes | T |
| T980 | 1076-1080 | CL:0000084;GO:0042110 | denotes | cell |
| T981 | 1094-1098 | NCBITaxon:10088 | denotes | mice |
| T982 | 1116-1124 | SP_9 | denotes | MERS-CoV |
| T983 | 1165-1173 | SP_9 | denotes | MERS-CoV |
| T984 | 1196-1201 | NCBITaxon:10088 | denotes | mouse |
| T985 | 1230-1234 | NCBITaxon:10088 | denotes | mice |
| T986 | 1255-1267 | CHEBI:50803;CHEBI:50803 | denotes | nanoparticle |
| T987 | 1274-1282 | SP_9 | denotes | MERS-CoV |
| T988 | 1333-1341 | SP_9 | denotes | MERS-CoV |
| T989 | 1373-1385 | CL:0000771 | denotes | eosinophilic |
| T990 | 1520-1531 | NCBITaxon:11118 | denotes | coronavirus |
| T991 | 1549-1555 | NCBITaxon:27592 | denotes | Bovine |
| T992 | 1556-1567 | NCBITaxon:11118 | denotes | coronavirus |
| T993 | 1574-1583 | PG_4 | denotes | N protein |
| T994 | 1591-1599 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T995 | 1652-1655 | GO:0071735 | denotes | IgA |
| T996 | 1660-1663 | GO:0071735 | denotes | IgG |
| T997 | 1738-1741 | GO:0071735 | denotes | IgM |
| T998 | 1753-1758 | UBERON:0001977 | denotes | serum |
| T999 | 1810-1819 | PG_4 | denotes | N protein |
| T1000 | 1894-1902 | CHEBI:60809;CHEBI:60809 | denotes | adjuvant |
| T1001 | 2053-2064 | NCBITaxon:11118 | denotes | coronavirus |
| T1002 | 2186-2194 | SP_9 | denotes | MERS-CoV |
| T1003 | 2219-2229 | CHEBI:33543;CHEBI:33543 | denotes | sulfonated |
| T1004 | 2253-2260 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
| T1005 | 2349-2352 | NCBITaxon:10298 | denotes | HSV |
| T1006 | 2354-2357 | NCBITaxon:11886 | denotes | HPV |
| T1007 | 2359-2362 | NCBITaxon:11886 | denotes | RSV |
| T1008 | 2375-2385 | NCBITaxon:11646 | denotes | lentivirus |
| T1009 | 2402-2411 | PG_1 | denotes | S protein |
| T1010 | 2452-2463 | NCBITaxon:11118 | denotes | coronavirus |
| T1011 | 2612-2615 | NCBITaxon:10376 | denotes | IBV |
| T1012 | 2616-2625 | PG_1 | denotes | S protein |
| T1013 | 2637-2644 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T1014 | 2682-2690 | CHEBI:75958;CHEBI:75958 | denotes | solution |
| T1015 | 2732-2737 | NCBITaxon:10239 | denotes | viral |
| T1016 | 2854-2861 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T1017 | 2881-2889 | GO:0042571 | denotes | antibody |
| T1018 | 2908-2915 | CL:0000214;UBERON:0002106 | denotes | splenic |
| T1019 | 2916-2922 | CL:0000084;GO:0042110 | denotes | T-cell |
| T1020 | 2923-2931 | GO:0042110 | denotes | response |
| T1021 | 2981-2986 | NCBITaxon:8782 | denotes | avian |
| T1022 | 2996-3007 | NCBITaxon:11118 | denotes | coronavirus |
| T1023 | 3080-3088 | GO:0030674 | denotes | bridging |
| T1024 | 3089-3094 | NCBITaxon:10239 | denotes | viral |
| T1025 | 3095-3103 | CHEBI:59132;CHEBI:59132 | denotes | antigens |
| T1026 | 3315-3320 | NCBITaxon:10239 | denotes | virus |
| T1028 | 3346-3361 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T1029 | 3392-3403 | CHEBI:3435;CHEBI:3435 | denotes | carrageenan |
| T1030 | 3404-3419 | CHEBI:50699;CHEBI:50699 | denotes | oligosaccharide |
| T1031 | 3424-3432 | CHEBI:5181;CHEBI:5181 | denotes | fucoidan |
| T1032 | 3646-3655 | PG_4 | denotes | N protein |
| T1033 | 3661-3672 | NCBITaxon:11118 | denotes | coronavirus |
| T1034 | 3707-3722 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T1035 | 3768-3779 | NCBITaxon:11118 | denotes | coronavirus |
| T1036 | 3878-3887 | PG_4 | denotes | N protein |
| T1037 | 3893-3904 | NCBITaxon:11118 | denotes | coronavirus |
| T1038 | 3917-3932 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T50281 | 76-89 | GO:0031982 | denotes | chnology prov |
| T79323 | 138-151 | BV_15 | denotes | iagnosis, and |
| T87731 | 169-176 | CHEBI:59132;CHEBI:59132 | denotes | ctious |
| T93585 | 311-320 | CHEBI:60809;CHEBI:60809 | denotes | es agains |
| T74571 | 324-329 | UBERON:0002405 | denotes | e hos |
| T83905 | 354-360 | CHEBI:16261;CHEBI:16261 | denotes | of nan |
| T60667 | 397-400 | NCBITaxon:7460 | denotes | n n |
| T82055 | 448-454 | UBERON:0000912 | denotes | of an |
| T34262 | 532-537 | UBERON:0002405 | denotes | erial |
| T56816 | 581-594 | GO:0042110 | denotes | ons, acting a |
| T10408 | 599-604 | NCBITaxon:10239 | denotes | uvant |
| T21597 | 635-640 | NCBITaxon:42413 | denotes | The |
| T89685 | 761-769 | GO:0042571 | denotes | en devel |
| T54248 | 774-781 | CHEBI:59132;CHEBI:59132 | denotes | which |
| T75414 | 791-792 | CL:0000084 | denotes | i |
| T38436 | 793-797 | CL:0000084;GO:0042110 | denotes | ely |
| T88531 | 811-815 | NCBITaxon:10088 | denotes | cifi |
| T10095 | 834-842 | SP_9 | denotes | n, parti |
| T43562 | 883-891 | SP_9 | denotes | d viral |
| T4048 | 914-919 | NCBITaxon:10088 | denotes | ainst |
| T43378 | 948-952 | NCBITaxon:10088 | denotes | ffec |
| T54097 | 972-984 | CHEBI:50803;CHEBI:50803 | denotes | nanoparticle |
| T48256 | 991-999 | SP_9 | denotes | e is sup |
| T69198 | 1051-1059 | SP_9 | denotes | y and an |
| T80961 | 1091-1101 | CL:0000771 | denotes | in mice im |
| T73673 | 1236-1248 | NCBITaxon:11118 | denotes | mmunized wit |
| T13292 | 1266-1272 | NCBITaxon:27592 | denotes | e-base |
| T10371 | 1273-1284 | NCBITaxon:11118 | denotes | MERS-CoV v |
| T92482 | 1291-1300 | PG_4 | denotes | can prote |
| T60172 | 1308-1314 | CHEBI:16261;CHEBI:16261 | denotes | st a l |
| T68568 | 1367-1370 | GO:0071735 | denotes | rab |
| T86288 | 1375-1378 | GO:0071735 | denotes | sin |
| T7719 | 1455-1458 | GO:0071735 | denotes | th |
| T41043 | 1470-1475 | UBERON:0001977 | denotes | t of |
| T91616 | 1526-1535 | PG_4 | denotes | virus pat |
| T37714 | 1612-1620 | CHEBI:60809;CHEBI:60809 | denotes | s (CNP) |
| T30064 | 1772-1783 | NCBITaxon:11118 | denotes | er the seco |
| T35628 | 1905-1913 | SP_9 | denotes | veterin |
| T30531 | 1938-1948 | CHEBI:33543;CHEBI:33543 | denotes | In additio |
| T77881 | 1972-1979 | CHEBI:24505;CHEBI:24505 | denotes | s (AuNP |
| T31076 | 2067-2070 | NCBITaxon:10298 | denotes | n e |
| T51451 | 2072-2075 | NCBITaxon:11886 | denotes | ctr |
| T92713 | 2077-2080 | NCBITaxon:11886 | denotes | hem |
| T25633 | 2094-2104 | NCBITaxon:11646 | denotes | sor based |
| T55159 | 2121-2130 | PG_1 | denotes | NPs-modif |
| T46374 | 2171-2182 | NCBITaxon:11118 | denotes | termination |
| T57126 | 2332-2335 | NCBITaxon:10376 | denotes | ope |
| T19185 | 2336-2345 | PG_1 | denotes | ties agai |
| T57125 | 2357-2364 | CHEBI:59132;CHEBI:59132 | denotes | , RSV, |
| T85049 | 2402-2410 | CHEBI:75958;CHEBI:75958 | denotes | S protei |
| T62091 | 2452-2457 | NCBITaxon:10239 | denotes | coron |
| T56876 | 2574-2581 | CHEBI:59132;CHEBI:59132 | denotes | ared by |
| T56434 | 2601-2609 | GO:0042571 | denotes | ation wi |
| T60371 | 2628-2635 | CL:0000214;UBERON:0002106 | denotes | a mode |
| T45199 | 2636-2642 | CL:0000084;GO:0042110 | denotes | antig |
| T21004 | 2643-2651 | GO:0042110 | denotes | n and in |
| T15497 | 2701-2706 | NCBITaxon:8782 | denotes | an o |
| T7796 | 2716-2727 | NCBITaxon:11118 | denotes | oncentratio |
| T31634 | 2800-2808 | GO:0030674 | denotes | vaccina |
| T82150 | 2809-2814 | NCBITaxon:10239 | denotes | ion w |
| T7983 | 2815-2823 | CHEBI:59132;CHEBI:59132 | denotes | th the s |
| T40309 | 3028-3033 | NCBITaxon:10239 | denotes | stud |
| T1027 | 3186-3192 | NCBITaxon:10239 | denotes | munose |
| T66392 | 3218-3234 | CHEBI:18154;CHEBI:18154 | denotes | mmunosensor fabr |
| T95404 | 3265-3276 | CHEBI:3435;CHEBI:3435 | denotes | n process o |
| T65376 | 3277-3292 | CHEBI:50699;CHEBI:50699 | denotes | the competitiv |
| T70876 | 3298-3306 | CHEBI:5181;CHEBI:5181 | denotes | nosensor |
| T22289 | 3522-3531 | PG_4 | denotes | as bioco |
| T87816 | 3537-3548 | NCBITaxon:11118 | denotes | le reductan |
| T59261 | 3583-3598 | CHEBI:18154;CHEBI:18154 | denotes | 35]. Based on o |
| T42889 | 3644-3655 | NCBITaxon:11118 | denotes | r N protein |
| T71749 | 3752-3761 | PG_4 | denotes | a formati |
| T19010 | 3767-3778 | NCBITaxon:11118 | denotes | coronaviru |
| T37619 | 3791-3806 | CHEBI:18154;CHEBI:18154 | denotes | es vaccine appl |
| T1039 | 3880-3889 | PG_4 | denotes | protein f |
| T1040 | 3895-3906 | NCBITaxon:11118 | denotes | ronavirus l |
| T1041 | 3919-3934 | CHEBI:18154;CHEBI:18154 | denotes | lysaccharides c |
MyTest
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1133 | 51-66 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1148 | 920-925 | Species | denotes | PRRSV | Tax:28344 |
| 1149 | 1094-1098 | Species | denotes | mice | Tax:10090 |
| 1150 | 1116-1124 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1151 | 1165-1173 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1152 | 1196-1201 | Species | denotes | mouse | Tax:10090 |
| 1153 | 1230-1234 | Species | denotes | mice | Tax:10090 |
| 1154 | 1274-1282 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1155 | 1333-1341 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1156 | 1520-1531 | Species | denotes | coronavirus | Tax:11118 |
| 1157 | 1549-1573 | Species | denotes | Bovine coronavirus (BCV) | Tax:11128 |
| 1158 | 1806-1809 | Species | denotes | BCV | Tax:11128 |
| 1159 | 165-184 | Disease | denotes | infectious diseases | MESH:D003141 |
| 1160 | 296-304 | Disease | denotes | toxicity | MESH:D064420 |
| 1161 | 926-935 | Disease | denotes | infection | MESH:D007239 |
| 1165 | 3180-3183 | Species | denotes | COV | Tax:11118 |
| 1166 | 3184-3207 | Disease | denotes | immunosensor array chip | |
| 1167 | 3217-3247 | Disease | denotes | immunosensor fabrication steps | |
| 1177 | 2186-2194 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1178 | 2452-2463 | Species | denotes | coronavirus | Tax:11118 |
| 1179 | 2053-2064 | Species | denotes | coronavirus | Tax:11118 |
| 1180 | 2354-2357 | Species | denotes | HPV | Tax:10566 |
| 1181 | 2359-2362 | Species | denotes | RSV | Tax:12814 |
| 1182 | 2134-2140 | Chemical | denotes | carbon | MESH:D002244 |
| 1183 | 2282-2294 | Disease | denotes | cytotoxicity | MESH:D064420 |
| 1184 | 2945-2954 | Disease | denotes | infection | MESH:D007239 |
| 1185 | 2996-3017 | Disease | denotes | coronavirus infection | MESH:D018352 |
| 1188 | 3893-3904 | Species | denotes | coronavirus | Tax:11118 |
| 1189 | 3917-3932 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1198 | 3453-3458 | Species | denotes | algae | Tax:569578 |
| 1199 | 3661-3672 | Species | denotes | coronavirus | Tax:11118 |
| 1200 | 3768-3779 | Species | denotes | coronavirus | Tax:11118 |
| 1201 | 3346-3361 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1202 | 3392-3419 | Chemical | denotes | carrageenan oligosaccharide | |
| 1203 | 3424-3432 | Chemical | denotes | fucoidan | MESH:C007789 |
| 1204 | 3707-3722 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 1205 | 3501-3509 | Disease | denotes | toxicity | MESH:D064420 |