PMC:7358770 / 28551-28918 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T287","span":{"begin":153,"end":166},"obj":"Body_part"},{"id":"T288","span":{"begin":233,"end":238},"obj":"Body_part"}],"attributes":[{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":153,"end":166},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"959","span":{"begin":67,"end":72},"obj":"Gene"},{"id":"960","span":{"begin":77,"end":80},"obj":"Gene"},{"id":"961","span":{"begin":81,"end":84},"obj":"Gene"},{"id":"962","span":{"begin":85,"end":88},"obj":"Gene"},{"id":"963","span":{"begin":255,"end":260},"obj":"Gene"},{"id":"964","span":{"begin":265,"end":268},"obj":"Gene"},{"id":"965","span":{"begin":269,"end":272},"obj":"Gene"},{"id":"966","span":{"begin":273,"end":276},"obj":"Gene"},{"id":"967","span":{"begin":41,"end":44},"obj":"Species"},{"id":"968","span":{"begin":344,"end":347},"obj":"Species"},{"id":"969","span":{"begin":222,"end":232},"obj":"CellLine"}],"attributes":[{"id":"A959","pred":"tao:has_database_id","subj":"959","obj":"Gene:4790"},{"id":"A960","pred":"tao:has_database_id","subj":"960","obj":"Gene:22882"},{"id":"A961","pred":"tao:has_database_id","subj":"961","obj":"Gene:5609"},{"id":"A962","pred":"tao:has_database_id","subj":"962","obj":"Gene:2048"},{"id":"A963","pred":"tao:has_database_id","subj":"963","obj":"Gene:4790"},{"id":"A964","pred":"tao:has_database_id","subj":"964","obj":"Gene:22882"},{"id":"A965","pred":"tao:has_database_id","subj":"965","obj":"Gene:5609"},{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Gene:2048"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"Tax:10407"},{"id":"A968","pred":"tao:has_database_id","subj":"968","obj":"Tax:10407"},{"id":"A969","pred":"tao:has_database_id","subj":"969","obj":"CVCL:L855"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T114","span":{"begin":28,"end":31},"obj":"Disease"},{"id":"T115","span":{"begin":194,"end":197},"obj":"Disease"}],"attributes":[{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0010574"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0010574"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T315","span":{"begin":71,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T316","span":{"begin":89,"end":98},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T317","span":{"begin":132,"end":142},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T318","span":{"begin":153,"end":166},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T319","span":{"begin":233,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T320","span":{"begin":242,"end":250},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T321","span":{"begin":259,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T423","span":{"begin":67,"end":69},"obj":"Chemical"},{"id":"T426","span":{"begin":81,"end":84},"obj":"Chemical"},{"id":"T427","span":{"begin":175,"end":185},"obj":"Chemical"},{"id":"T428","span":{"begin":255,"end":257},"obj":"Chemical"},{"id":"T431","span":{"begin":269,"end":272},"obj":"Chemical"},{"id":"T432","span":{"begin":301,"end":311},"obj":"Chemical"}],"attributes":[{"id":"A423","pred":"chebi_id","subj":"T423","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A424","pred":"chebi_id","subj":"T423","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A425","pred":"chebi_id","subj":"T423","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A426","pred":"chebi_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/CHEBI_28398"},{"id":"A427","pred":"chebi_id","subj":"T427","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A428","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A429","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A430","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A431","pred":"chebi_id","subj":"T431","obj":"http://purl.obolibrary.org/obo/CHEBI_28398"},{"id":"A432","pred":"chebi_id","subj":"T432","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T67","span":{"begin":89,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T68","span":{"begin":89,"end":98},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T69","span":{"begin":146,"end":159},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T70","span":{"begin":348,"end":361},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"2_test","denotations":[{"id":"32679328-27083353-48281324","span":{"begin":363,"end":365},"obj":"27083353"},{"id":"T80216","span":{"begin":363,"end":365},"obj":"27083353"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T177","span":{"begin":58,"end":193},"obj":"Sentence"},{"id":"T178","span":{"begin":194,"end":367},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T816","span":{"begin":41,"end":44},"obj":"NCBITaxon:10376"},{"id":"T817","span":{"begin":45,"end":56},"obj":"GO:0006260"},{"id":"T818","span":{"begin":67,"end":69},"obj":"GO:0005883"},{"id":"T819","span":{"begin":77,"end":80},"obj":"PR:P11345"},{"id":"T820","span":{"begin":81,"end":84},"obj":"GO:0000165"},{"id":"T821","span":{"begin":89,"end":98},"obj":"GO:0000165"},{"id":"T822","span":{"begin":153,"end":166},"obj":"UBERON:0002405"},{"id":"T823","span":{"begin":255,"end":257},"obj":"GO:0005883"},{"id":"T824","span":{"begin":265,"end":268},"obj":"PR:P11345"},{"id":"T825","span":{"begin":344,"end":347},"obj":"NCBITaxon:10376"},{"id":"T835","span":{"begin":63,"end":66},"obj":"NCBITaxon:10376"},{"id":"T63551","span":{"begin":89,"end":103},"obj":"CHEBI:18154;CHEBI:18154"},{"id":"T22250","span":{"begin":104,"end":112},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T24115","span":{"begin":274,"end":278},"obj":"UBERON:0000104"},{"id":"T95811","span":{"begin":313,"end":317},"obj":"UBERON:0000104"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}

{"project":"MyTest","denotations":[{"id":"959","span":{"begin":67,"end":72},"obj":"Gene"},{"id":"960","span":{"begin":77,"end":80},"obj":"Gene"},{"id":"961","span":{"begin":81,"end":84},"obj":"Gene"},{"id":"962","span":{"begin":85,"end":88},"obj":"Gene"},{"id":"963","span":{"begin":255,"end":260},"obj":"Gene"},{"id":"964","span":{"begin":265,"end":268},"obj":"Gene"},{"id":"965","span":{"begin":269,"end":272},"obj":"Gene"},{"id":"966","span":{"begin":273,"end":276},"obj":"Gene"},{"id":"967","span":{"begin":41,"end":44},"obj":"Species"},{"id":"968","span":{"begin":344,"end":347},"obj":"Species"},{"id":"969","span":{"begin":222,"end":232},"obj":"CellLine"}],"attributes":[{"id":"A961","pred":"tao:has_database_id","subj":"961","obj":"Gene:5609"},{"id":"A959","pred":"tao:has_database_id","subj":"959","obj":"Gene:4790"},{"id":"A963","pred":"tao:has_database_id","subj":"963","obj":"Gene:4790"},{"id":"A968","pred":"tao:has_database_id","subj":"968","obj":"Tax:10407"},{"id":"A962","pred":"tao:has_database_id","subj":"962","obj":"Gene:2048"},{"id":"A965","pred":"tao:has_database_id","subj":"965","obj":"Gene:5609"},{"id":"A969","pred":"tao:has_database_id","subj":"969","obj":"CVCL:L855"},{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Gene:2048"},{"id":"A964","pred":"tao:has_database_id","subj":"964","obj":"Gene:22882"},{"id":"A960","pred":"tao:has_database_id","subj":"960","obj":"Gene:22882"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"Tax:10407"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The molecular mechanisms of PGS inhibits HBV replication. Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]."}