PMC:7358770 / 22137-24963
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 524-531 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | Heparin |
| T38 | 524-531 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | Heparin |
| T39 | 535-542 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T40 | 535-542 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T224 | 37-41 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T225 | 60-72 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T226 | 60-64 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T227 | 125-154 | Body_part | denotes | heparan sulfated proteoglycan | http://purl.org/sig/ont/fma/fma82834 |
| T228 | 142-154 | Body_part | denotes | proteoglycan | http://purl.org/sig/ont/fma/fma63015 |
| T229 | 162-174 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T230 | 162-166 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T231 | 176-191 | Body_part | denotes | Polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T232 | 213-228 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T233 | 307-319 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T234 | 307-311 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T235 | 472-485 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T236 | 472-476 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T237 | 524-531 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
| T238 | 535-542 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T239 | 651-663 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T240 | 651-655 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T241 | 664-677 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
| T242 | 728-730 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
| T243 | 769-783 | Body_part | denotes | polysaccharide | http://purl.org/sig/ont/fma/fma82746 |
| T244 | 951-966 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T245 | 1257-1260 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T246 | 1303-1320 | Body_part | denotes | cellular membrane | http://purl.org/sig/ont/fma/fma63841 |
| T247 | 1448-1464 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T248 | 1459-1464 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T249 | 1590-1595 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T250 | 1881-1886 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T251 | 2013-2018 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T252 | 2146-2153 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T253 | 2196-2200 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T254 | 2349-2356 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T255 | 2361-2365 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T256 | 2413-2418 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 759 | 2817-2820 | Species | denotes | HBV | Tax:10407 |
| 805 | 1627-1640 | Gene | denotes | neuraminidase | Gene:4758 |
| 806 | 1779-1783 | Gene | denotes | EGFR | Gene:1956 |
| 807 | 1785-1789 | Gene | denotes | PKCα | Gene:5578 |
| 808 | 1791-1796 | Gene | denotes | NF-κB | Gene:4790 |
| 809 | 1802-1805 | Gene | denotes | Akt | Gene:207 |
| 810 | 1844-1848 | Gene | denotes | EGFR | Gene:1956 |
| 811 | 2168-2171 | Gene | denotes | Akt | Gene:207 |
| 812 | 2172-2176 | Gene | denotes | mTOR | Gene:2475 |
| 813 | 1007-1019 | Species | denotes | dengue virus | Tax:12637 |
| 814 | 1194-1215 | Species | denotes | human metapneumovirus | Tax:162145 |
| 815 | 1217-1221 | Species | denotes | hMPV | Tax:162145 |
| 816 | 1436-1441 | Species | denotes | human | Tax:9606 |
| 817 | 1980-1986 | Species | denotes | HSV)-2 | Tax:10310 |
| 818 | 2248-2257 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 819 | 2571-2582 | Species | denotes | coronavirus | Tax:11118 |
| 820 | 2583-2592 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 821 | 2682-2695 | Species | denotes | coronaviruses | Tax:11118 |
| 822 | 2738-2751 | Species | denotes | coronaviruses | Tax:11118 |
| 823 | 847-850 | Species | denotes | IAV | Tax:11320 |
| 824 | 1021-1025 | Species | denotes | DENV | Tax:12637 |
| 825 | 1421-1424 | Species | denotes | HRV | Tax:169066 |
| 826 | 1649-1652 | Species | denotes | IAV | Tax:11320 |
| 827 | 1709-1712 | Species | denotes | IAV | Tax:11320 |
| 828 | 1824-1827 | Species | denotes | IAV | Tax:11320 |
| 829 | 2096-2099 | Species | denotes | HPV | Tax:10566 |
| 830 | 125-132 | Chemical | denotes | heparan | |
| 831 | 176-191 | Chemical | denotes | Polysaccharides | MESH:D011134 |
| 832 | 213-228 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 833 | 524-531 | Chemical | denotes | Heparin | MESH:D006493 |
| 834 | 664-677 | Chemical | denotes | carbohydrates | MESH:D002241 |
| 835 | 728-730 | Chemical | denotes | HS | MESH:D006497 |
| 836 | 735-746 | Chemical | denotes | carrageenan | MESH:D002351 |
| 837 | 769-783 | Chemical | denotes | polysaccharide | MESH:D011134 |
| 838 | 951-966 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 839 | 1066-1082 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 840 | 1119-1150 | Chemical | denotes | poly (allylamine) hydrochloride | MESH:C063994 |
| 841 | 1359-1375 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 842 | 1499-1515 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 843 | 1728-1736 | Chemical | denotes | fucoidan | MESH:C007789 |
| 844 | 2484-2525 | Chemical | denotes | N-(2-hydroxypropyl) -3-trimethyl chitosan | |
| 845 | 2716-2721 | Chemical | denotes | water | MESH:D014867 |
| 846 | 851-860 | Disease | denotes | infection | MESH:D007239 |
| 847 | 1234-1256 | Disease | denotes | respiratory infections | MESH:D012141 |
| 848 | 1868-1880 | Disease | denotes | IAV-infected | MESH:D007239 |
| 849 | 2434-2449 | Disease | denotes | virus infection | MESH:D001102 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T91 | 851-860 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T92 | 1007-1013 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T93 | 1234-1256 | Disease | denotes | respiratory infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T94 | 1958-1972 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T95 | 2434-2449 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T96 | 2440-2449 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T97 | 2532-2534 | Disease | denotes | NS | http://purl.obolibrary.org/obo/MONDO_0009735 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T226 | 19-24 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T227 | 35-41 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a cell |
| T228 | 60-64 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T229 | 105-106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T230 | 125-154 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | heparan sulfated proteoglycan |
| T231 | 162-166 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T232 | 307-311 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T233 | 331-336 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T234 | 390-395 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T235 | 440-445 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T236 | 461-466 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T237 | 472-476 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T238 | 477-485 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T239 | 512-517 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T240 | 651-655 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T241 | 1014-1019 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T242 | 1175-1185 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T243 | 1194-1199 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T244 | 1224-1225 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T245 | 1261-1266 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T246 | 1280-1285 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T247 | 1312-1320 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T248 | 1336-1341 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T249 | 1436-1441 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T250 | 1448-1458 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T251 | 1459-1464 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T252 | 1590-1595 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T253 | 1670-1678 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T254 | 1765-1775 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T255 | 1795-1796 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T256 | 1881-1886 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T257 | 1973-1978 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T258 | 2013-2018 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T259 | 2020-2022 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
| T260 | 2100-2110 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T261 | 2196-2200 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T262 | 2261-2262 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T263 | 2361-2365 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T264 | 2413-2418 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T265 | 2434-2439 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T266 | 2535-2537 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
| T267 | 2606-2611 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T351 | 125-132 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T352 | 142-154 | Chemical | denotes | proteoglycan | http://purl.obolibrary.org/obo/CHEBI_37396 |
| T353 | 213-228 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T354 | 524-531 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T355 | 535-542 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T356 | 578-587 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T357 | 664-677 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T358 | 728-730 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815 |
| T360 | 735-746 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T361 | 769-783 | Chemical | denotes | polysaccharide | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T362 | 922-931 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T363 | 951-966 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T364 | 1071-1082 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T365 | 1137-1150 | Chemical | denotes | hydrochloride | http://purl.obolibrary.org/obo/CHEBI_36807 |
| T366 | 1165-1174 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T367 | 1364-1375 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T368 | 1499-1515 | Chemical | denotes | iota-carrageenan | http://purl.obolibrary.org/obo/CHEBI_37168 |
| T369 | 1504-1515 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T370 | 1642-1644 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T371 | 1682-1684 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T372 | 1728-1736 | Chemical | denotes | fucoidan | http://purl.obolibrary.org/obo/CHEBI_5181 |
| T373 | 1791-1793 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T376 | 1897-1906 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T377 | 2060-2068 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T379 | 2146-2153 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T380 | 2308-2315 | Chemical | denotes | polymer | http://purl.obolibrary.org/obo/CHEBI_33839|http://purl.obolibrary.org/obo/CHEBI_60027 |
| T382 | 2349-2356 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T383 | 2517-2525 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T385 | 2532-2534 | Chemical | denotes | NS | http://purl.obolibrary.org/obo/CHEBI_73426 |
| T386 | 2535-2537 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
| T387 | 2716-2721 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T388 | 2797-2805 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 425-436 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T35 | 1779-1783 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T36 | 1828-1839 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T37 | 1844-1848 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T38 | 2163-2167 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T39 | 2201-2210 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T40 | 2201-2210 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32679328-29654857-48281303 | 361-363 | 29654857 | denotes | 12 |
| 32679328-29654857-48281304 | 519-521 | 29654857 | denotes | 12 |
| 32679328-20394070-48281305 | 601-603 | 20394070 | denotes | 87 |
| 32679328-19447134-48281306 | 607-609 | 19447134 | denotes | 88 |
| 32679328-16127029-48281307 | 613-615 | 16127029 | denotes | 89 |
| 32679328-22197247-48281308 | 913-915 | 22197247 | denotes | 91 |
| 32679328-22652218-48281309 | 1061-1063 | 22652218 | denotes | 92 |
| 32679328-18817582-48281310 | 1597-1599 | 18817582 | denotes | 85 |
| 32679328-30093007-48281311 | 2222-2224 | 30093007 | denotes | 95 |
| 32679328-28482585-48281312 | 2753-2755 | 28482585 | denotes | 97 |
| 32679328-30093007-48281313 | 2822-2824 | 30093007 | denotes | 95 |
| T78657 | 361-363 | 29654857 | denotes | 12 |
| T64060 | 519-521 | 29654857 | denotes | 12 |
| T36608 | 601-603 | 20394070 | denotes | 87 |
| T81775 | 607-609 | 19447134 | denotes | 88 |
| T20509 | 613-615 | 16127029 | denotes | 89 |
| T51780 | 913-915 | 22197247 | denotes | 91 |
| T22710 | 1061-1063 | 22652218 | denotes | 92 |
| T43498 | 1597-1599 | 18817582 | denotes | 85 |
| T47034 | 2222-2224 | 30093007 | denotes | 95 |
| T38579 | 2753-2755 | 28482585 | denotes | 97 |
| T64039 | 2822-2824 | 30093007 | denotes | 95 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T138 | 0-175 | Sentence | denotes | The first step for virus to invade a cell is to bind to the cell surface by electrostatic interaction or a receptor, such as heparan sulfated proteoglycan on the cell surface. |
| T139 | 176-365 | Sentence | denotes | Polysaccharides, especially sulfated polysaccharides, have strong polyanionic properties, and can block the positive charge on the cell surface to prevent virus adsorption or invasion [12]. |
| T140 | 366-523 | Sentence | denotes | The invasion process of virus is often associated with the endocytosis of virus, the fusion of virus with cell membrane, and the translocation of virus [12]. |
| T141 | 524-755 | Sentence | denotes | Heparin or heparin-like materials with broad-spectrum antiviral properties [[87], [88], [89]] have been developed to mimic the cell surface carbohydrates responsible for initial viral attachment, such as HS and carrageenan [34,90]. |
| T142 | 756-917 | Sentence | denotes | The sulfated polysaccharide derived from marine microalga showed strong inhibition against IAV infection via the viral adsorption and internalization steps [91]. |
| T143 | 918-1065 | Sentence | denotes | The antiviral effect of sulfated polysaccharides from seaweeds was mainly exerted during dengue virus (DENV)-2 adsorption and internalization [92]. |
| T144 | 1066-1358 | Sentence | denotes | Iota-carrageenan and its N-sulfonated derivatives of poly (allylamine) hydrochloride showed strong antiviral activities against human metapneumovirus (hMPV), a kind of respiratory infections RNA virus, by blocking virus release from the cellular membrane and inhibiting virus adsorption [93]. |
| T145 | 1359-1476 | Sentence | denotes | Iota-carrageenan also effectively prevents the replication of HRV in primary human nasal epithelial cells in culture. |
| T146 | 1477-1601 | Sentence | denotes | The data suggest that iota-carrageenan acts primarily by preventing the binding or the entry of virions into the cells [85]. |
| T147 | 1602-1713 | Sentence | denotes | Fucoidan can bind to the neuraminidase (NA) of IAV, and inhibit the activity of NA to block the release of IAV. |
| T148 | 1714-1892 | Sentence | denotes | Additionally, fucoidan can also interfere with the activation of EGFR, PKCα, NF-κB, and Akt, and inhibit both IAV endocytosis and EGFR internalization in IAV-infected cells [73]. |
| T149 | 1893-2024 | Sentence | denotes | The antiviral mechanism of the fucoidans may be through blocking herpes simplex virus (HSV)-2 virion adsorption to host cells [94]. |
| T150 | 2025-2226 | Sentence | denotes | Our team found that 3,6-O-sulfated chitosan (36S) possessed broad anti-HPV activities by directly targeting viral capsid protein and host PI3K/Akt/mTOR pathway to inhibit cell autophagy (Fig. 6 ) [95]. |
| T151 | 2227-2458 | Sentence | denotes | Interestingly, using HCoV-NL63 as a model system, it can be determined that HTCC polymer blocks the interaction between S protein and cell receptor, consequently blocking its entry into cells and preventing virus infection [68,96]. |
| T152 | 2459-2624 | Sentence | denotes | The nano/microspheres of N-(2-hydroxypropyl) -3-trimethyl chitosan (HTCC-NS/MS) were used for adsorption of the coronavirus HCoV-NL63 from aqueous virus suspensions. |
| T153 | 2625-2757 | Sentence | denotes | This nano/microspheres can be applied for the removal of coronaviruses and purification of water from pathogenic coronaviruses [97]. |
| T154 | 2758-2826 | Sentence | denotes | Fig. 6 The mechanism of 3,6-O-sulfated chitosan inhibiting HBV [95]. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T15 | 728-730 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T10 | 1234-1256 | Phenotype | denotes | respiratory infections | http://purl.obolibrary.org/obo/HP_0011947 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T608 | 19-24 | NCBITaxon:10239 | denotes | virus |
| T609 | 60-72 | GO:0009986 | denotes | cell surface |
| T610 | 125-154 | CHEBI:24499;CHEBI:24499 | denotes | heparan sulfated proteoglycan |
| T611 | 162-174 | GO:0009986 | denotes | cell surface |
| T612 | 176-191 | CHEBI:18154;CHEBI:18154 | denotes | Polysaccharides |
| T613 | 213-228 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T614 | 307-319 | GO:0009986 | denotes | cell surface |
| T615 | 331-336 | NCBITaxon:10239 | denotes | virus |
| T616 | 390-395 | NCBITaxon:10239 | denotes | virus |
| T617 | 425-436 | GO:0006897 | denotes | endocytosis |
| T618 | 440-445 | NCBITaxon:10239 | denotes | virus |
| T619 | 451-457 | GO:0061025 | denotes | fusion |
| T620 | 461-466 | NCBITaxon:10239 | denotes | virus |
| T621 | 472-485 | GO:0005886 | denotes | cell membrane |
| T622 | 512-517 | NCBITaxon:10239 | denotes | virus |
| T623 | 524-531 | CHEBI:24505;CHEBI:24505 | denotes | Heparin |
| T624 | 535-542 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
| T625 | 651-663 | GO:0009986 | denotes | cell surface |
| T626 | 664-677 | CHEBI:16646;CHEBI:16646 | denotes | carbohydrates |
| T627 | 702-707 | NCBITaxon:10239 | denotes | viral |
| T628 | 735-746 | CHEBI:3435;CHEBI:3435 | denotes | carrageenan |
| T629 | 769-783 | CHEBI:65212;CHEBI:65212 | denotes | polysaccharide |
| T630 | 869-874 | NCBITaxon:10239 | denotes | viral |
| T631 | 951-966 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T632 | 1007-1013 | NCBITaxon:9793 | denotes | dengue |
| T633 | 1014-1019 | NCBITaxon:10239 | denotes | virus |
| T634 | 1071-1082 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T635 | 1093-1103 | CHEBI:33543;CHEBI:33543 | denotes | sulfonated |
| T636 | 1137-1150 | CHEBI:36807;CHEBI:36807 | denotes | hydrochloride |
| T637 | 1194-1199 | SP_6;NCBITaxon:9606 | denotes | human |
| T638 | 1217-1221 | NCBITaxon:10359 | denotes | hMPV |
| T639 | 1257-1260 | BV_22 | denotes | RNA |
| T640 | 1261-1266 | BV_22;NCBITaxon:10239 | denotes | virus |
| T641 | 1280-1285 | NCBITaxon:10239 | denotes | virus |
| T642 | 1303-1320 | GO:0005886 | denotes | cellular membrane |
| T643 | 1336-1341 | NCBITaxon:10239 | denotes | virus |
| T644 | 1364-1375 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T645 | 1406-1417 | GO:0006260 | denotes | replication |
| T646 | 1428-1435 | CL:0000001 | denotes | primary |
| T647 | 1436-1441 | SP_6;NCBITaxon:9606 | denotes | human |
| T648 | 1442-1447 | CL:0000082;UBERON:0001823 | denotes | nasal |
| T649 | 1448-1458 | UBERON:0001823;CL:0000066 | denotes | epithelial |
| T650 | 1459-1464 | CL:0000066 | denotes | cells |
| T651 | 1504-1515 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T652 | 1564-1572 | GO:0035376 | denotes | entry of |
| T653 | 1728-1736 | CHEBI:5181;CHEBI:5181 | denotes | fucoidan |
| T654 | 1791-1793 | GO:0005883 | denotes | NF |
| T655 | 1802-1805 | PR:000002190 | denotes | Akt |
| T656 | 1828-1839 | GO:0006897 | denotes | endocytosis |
| T657 | 1958-1978 | NCBITaxon:10376 | denotes | herpes simplex virus |
| T658 | 1980-1983 | NCBITaxon:10298 | denotes | HSV |
| T659 | 2047-2048 | CHEBI:17369;CHEBI:17369 | denotes | 6 |
| T660 | 2051-2059 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T661 | 2060-2068 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T662 | 2096-2099 | NCBITaxon:11886 | denotes | HPV |
| T663 | 2133-2138 | NCBITaxon:10239 | denotes | viral |
| T664 | 2168-2171 | PR:000002190 | denotes | Akt |
| T665 | 2196-2200 | GO:0000422 | denotes | cell |
| T666 | 2201-2210 | GO:0006914 | denotes | autophagy |
| T667 | 2308-2315 | CHEBI:60027;CHEBI:60027 | denotes | polymer |
| T668 | 2347-2356 | PG_1 | denotes | S protein |
| T669 | 2402-2412 | GO:0035376 | denotes | entry into |
| T670 | 2434-2439 | NCBITaxon:10239 | denotes | virus |
| T671 | 2484-2486 | CHEBI:8502;CHEBI:8502 | denotes | N- |
| T672 | 2486-2487 | CHEBI:62946;CHEBI:62946 | denotes | ( |
| T673 | 2487-2488 | CHEBI:17824;CHEBI:17824 | denotes | 2 |
| T674 | 2488-2489 | CHEBI:8502;CHEBI:8502 | denotes | - |
| T675 | 2489-2502 | CHEBI:20067;CHEBI:20067 | denotes | hydroxypropyl |
| T676 | 2505-2506 | CHEBI:53233;CHEBI:53233 | denotes | 3 |
| T677 | 2507-2516 | CHEBI:53233;CHEBI:53233 | denotes | trimethyl |
| T678 | 2517-2525 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T679 | 2571-2582 | NCBITaxon:11118 | denotes | coronavirus |
| T680 | 2598-2605 | CHEBI:15377;CHEBI:15377 | denotes | aqueous |
| T681 | 2606-2611 | NCBITaxon:10239 | denotes | virus |
| T682 | 2682-2695 | NCBITaxon:11118 | denotes | coronaviruses |
| T683 | 2716-2721 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T684 | 2738-2751 | NCBITaxon:11118 | denotes | coronaviruses |
| T685 | 2782-2788 | CHEBI:53233;CHEBI:53233 | denotes | 3,6-O- |
| T686 | 2788-2796 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T687 | 2797-2805 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T688 | 2817-2820 | NCBITaxon:10376 | denotes | HBV |
| T54377 | 6-17 | CHEBI:3435;CHEBI:3435 | denotes | rst step fo |
| T60405 | 40-54 | CHEBI:65212;CHEBI:65212 | denotes | l is to bind t |
| T97116 | 140-145 | NCBITaxon:10239 | denotes | d pro |
| T17827 | 222-237 | CHEBI:18154;CHEBI:18154 | denotes | arides, have st |
| T53742 | 278-284 | NCBITaxon:9793 | denotes | k the |
| T39423 | 285-290 | NCBITaxon:10239 | denotes | ositi |
| T83421 | 339-350 | CHEBI:37168;CHEBI:37168 | denotes | sorption or |
| T36115 | 361-371 | CHEBI:33543;CHEBI:33543 | denotes | 12]. The i |
| T92759 | 405-418 | CHEBI:36807;CHEBI:36807 | denotes | associated wi |
| T32672 | 462-467 | SP_6;NCBITaxon:9606 | denotes | irus |
| T96885 | 483-487 | NCBITaxon:10359 | denotes | ne, |
| T18494 | 522-525 | BV_22 | denotes | . H |
| T90836 | 526-531 | BV_22;NCBITaxon:10239 | denotes | parin |
| T41255 | 545-550 | NCBITaxon:10239 | denotes | ke ma |
| T21887 | 568-585 | GO:0005886 | denotes | -spectrum antivir |
| T58956 | 601-606 | NCBITaxon:10239 | denotes | 87], |
| T30401 | 626-637 | CHEBI:37168;CHEBI:37168 | denotes | n developed |
| T55753 | 668-679 | GO:0006260 | denotes | ohydrates r |
| T42513 | 690-697 | CL:0000001 | denotes | for ini |
| T45720 | 698-703 | SP_6;NCBITaxon:9606 | denotes | ial v |
| T43477 | 704-709 | CL:0000082;UBERON:0001823 | denotes | ral a |
| T78452 | 710-719 | UBERON:0001823;CL:0000066 | denotes | tachment, |
| T90709 | 720-725 | CL:0000066 | denotes | such |
| T17731 | 762-773 | CHEBI:37168;CHEBI:37168 | denotes | lfated poly |
| T21229 | 822-830 | GO:0035376 | denotes | trong in |
| T31244 | 986-994 | CHEBI:5181;CHEBI:5181 | denotes | ainly ex |
| T46328 | 1049-1051 | GO:0005883 | denotes | na |
| T93483 | 1060-1063 | PR:000002190 | denotes | [92 |
| T69930 | 1089-1100 | GO:0006897 | denotes | s N-sulfona |
| T42947 | 1221-1242 | NCBITaxon:10376 | denotes | ), a kind of respirat |
| T16071 | 1244-1247 | NCBITaxon:10298 | denotes | y i |
| T58472 | 1311-1312 | CHEBI:17369;CHEBI:17369 | denotes | |
| T21845 | 1315-1323 | CHEBI:16189;CHEBI:16189 | denotes | brane an |
| T82603 | 1324-1330 | CHEBI:16261;CHEBI:16261 | denotes | inhib |
| T97586 | 1358-1364 | NCBITaxon:11886 | denotes | Iota- |
| T58220 | 1398-1403 | NCBITaxon:10239 | denotes | nts t |
| T99141 | 1431-1434 | PR:000002190 | denotes | mar |
| T24577 | 1460-1464 | GO:0000422 | denotes | ells |
| T69144 | 1465-1474 | GO:0006914 | denotes | in cultur |
| T20448 | 1575-1582 | CHEBI:60027;CHEBI:60027 | denotes | rions i |
| T31179 | 1614-1623 | PG_1 | denotes | bind to |
| T91673 | 1669-1679 | GO:0035376 | denotes | activity |
| T28428 | 1701-1706 | NCBITaxon:10239 | denotes | ease |
| T45439 | 1751-1753 | CHEBI:8502;CHEBI:8502 | denotes | fe |
| T76917 | 1753-1754 | CHEBI:62946;CHEBI:62946 | denotes | r |
| T79671 | 1754-1755 | CHEBI:17824;CHEBI:17824 | denotes | e |
| T40800 | 1755-1756 | CHEBI:8502;CHEBI:8502 | denotes | |
| T31954 | 1756-1769 | CHEBI:20067;CHEBI:20067 | denotes | with the acti |
| T45466 | 1772-1773 | CHEBI:53233;CHEBI:53233 | denotes | i |
| T82199 | 1774-1783 | CHEBI:53233;CHEBI:53233 | denotes | n of EGFR |
| T96261 | 1784-1790 | CHEBI:16261;CHEBI:16261 | denotes | PKCα, |
| T39295 | 1836-1847 | NCBITaxon:11118 | denotes | sis and EGF |
| T83146 | 1863-1870 | CHEBI:15377;CHEBI:15377 | denotes | n in IA |
| T92659 | 1871-1876 | NCBITaxon:10239 | denotes | -infe |
| T64279 | 1947-1960 | NCBITaxon:11118 | denotes | h blocking he |
| T25834 | 1981-1986 | CHEBI:15377;CHEBI:15377 | denotes | SV)-2 |
| T30740 | 2003-2016 | NCBITaxon:11118 | denotes | n to host cel |
| T65995 | 2045-2051 | CHEBI:53233;CHEBI:53233 | denotes | 3,6-O- |
| T67308 | 2051-2059 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T33853 | 2060-2068 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T6480 | 2080-2083 | NCBITaxon:10376 | denotes | sse |
| T689 | 2120-2122 | CHEBI:53233;CHEBI:53233 | denotes | ly |
| T690 | 2122-2123 | CHEBI:17369;CHEBI:17369 | denotes | |
| T691 | 2123-2126 | CHEBI:53233;CHEBI:53233 | denotes | tar |
| T692 | 2126-2134 | CHEBI:16189;CHEBI:16189 | denotes | geting v |
| T693 | 2135-2141 | CHEBI:16261;CHEBI:16261 | denotes | ral ca |
| T694 | 2155-2158 | NCBITaxon:10376 | denotes | nd |
| T3478 | 2180-2185 | NCBITaxon:10239 | denotes | hway |
| T77225 | 2204-2215 | GO:0006260 | denotes | ophagy (Fig |
| T27096 | 2216-2231 | CHEBI:18154;CHEBI:18154 | denotes | 6 ) [95]. Inte |
| T33964 | 2253-2268 | CHEBI:18154;CHEBI:18154 | denotes | NL63 as a model |
| T66240 | 2298-2303 | NCBITaxon:10239;GO:0006260 | denotes | that |
| T82798 | 2304-2315 | GO:0006260 | denotes | TCC polymer |
| T9741 | 2370-2381 | CHEBI:37168;CHEBI:37168 | denotes | ptor, conse |
| T57542 | 2414-2426 | NCBITaxon:28344;GO:0000003 | denotes | ells and pre |
| T48832 | 2431-2441 | GO:0045333;NCBITaxon:11886 | denotes | ng virus i |
| T67598 | 2442-2450 | NCBITaxon:11886 | denotes | fection |
| T72988 | 2451-2456 | NCBITaxon:10239 | denotes | 68,96 |
| T89206 | 2541-2549 | UBERON:0003215 | denotes | re used |
| T8863 | 2550-2561 | CL:0000583 | denotes | or adsorpti |
| T71781 | 2568-2579 | CHEBI:3435;CHEBI:3435 | denotes | he coronavi |
| T57562 | 2580-2595 | CHEBI:50699;CHEBI:50699 | denotes | us HCoV-NL63 fr |
| T39851 | 2661-2672 | GO:0006260 | denotes | d for the r |
| T91626 | 2762-2770 | CHEBI:35195;CHEBI:35195 | denotes | 6 The m |
| T67343 | 2771-2785 | CHEBI:18154;CHEBI:18154 | denotes | chanism of 3,6 |
| T78083 | 2791-2803 | NCBITaxon:61463 | denotes | fated chitos |
| T83884 | 2804-2817 | NCBITaxon:2778 | denotes | n inhibiting |
MyTest
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 759 | 2817-2820 | Species | denotes | HBV | Tax:10407 |
| 805 | 1627-1640 | Gene | denotes | neuraminidase | Gene:4758 |
| 806 | 1779-1783 | Gene | denotes | EGFR | Gene:1956 |
| 807 | 1785-1789 | Gene | denotes | PKCα | Gene:5578 |
| 808 | 1791-1796 | Gene | denotes | NF-κB | Gene:4790 |
| 809 | 1802-1805 | Gene | denotes | Akt | Gene:207 |
| 810 | 1844-1848 | Gene | denotes | EGFR | Gene:1956 |
| 811 | 2168-2171 | Gene | denotes | Akt | Gene:207 |
| 812 | 2172-2176 | Gene | denotes | mTOR | Gene:2475 |
| 813 | 1007-1019 | Species | denotes | dengue virus | Tax:12637 |
| 814 | 1194-1215 | Species | denotes | human metapneumovirus | Tax:162145 |
| 815 | 1217-1221 | Species | denotes | hMPV | Tax:162145 |
| 816 | 1436-1441 | Species | denotes | human | Tax:9606 |
| 817 | 1980-1986 | Species | denotes | HSV)-2 | Tax:10310 |
| 818 | 2248-2257 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 819 | 2571-2582 | Species | denotes | coronavirus | Tax:11118 |
| 820 | 2583-2592 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 821 | 2682-2695 | Species | denotes | coronaviruses | Tax:11118 |
| 822 | 2738-2751 | Species | denotes | coronaviruses | Tax:11118 |
| 823 | 847-850 | Species | denotes | IAV | Tax:11320 |
| 824 | 1021-1025 | Species | denotes | DENV | Tax:12637 |
| 825 | 1421-1424 | Species | denotes | HRV | Tax:169066 |
| 826 | 1649-1652 | Species | denotes | IAV | Tax:11320 |
| 827 | 1709-1712 | Species | denotes | IAV | Tax:11320 |
| 828 | 1824-1827 | Species | denotes | IAV | Tax:11320 |
| 829 | 2096-2099 | Species | denotes | HPV | Tax:10566 |
| 830 | 125-132 | Chemical | denotes | heparan | |
| 831 | 176-191 | Chemical | denotes | Polysaccharides | MESH:D011134 |
| 832 | 213-228 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 833 | 524-531 | Chemical | denotes | Heparin | MESH:D006493 |
| 834 | 664-677 | Chemical | denotes | carbohydrates | MESH:D002241 |
| 835 | 728-730 | Chemical | denotes | HS | MESH:D006497 |
| 836 | 735-746 | Chemical | denotes | carrageenan | MESH:D002351 |
| 837 | 769-783 | Chemical | denotes | polysaccharide | MESH:D011134 |
| 838 | 951-966 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 839 | 1066-1082 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 840 | 1119-1150 | Chemical | denotes | poly (allylamine) hydrochloride | MESH:C063994 |
| 841 | 1359-1375 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 842 | 1499-1515 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 843 | 1728-1736 | Chemical | denotes | fucoidan | MESH:C007789 |
| 844 | 2484-2525 | Chemical | denotes | N-(2-hydroxypropyl) -3-trimethyl chitosan | |
| 845 | 2716-2721 | Chemical | denotes | water | MESH:D014867 |
| 846 | 851-860 | Disease | denotes | infection | MESH:D007239 |
| 847 | 1234-1256 | Disease | denotes | respiratory infections | MESH:D012141 |
| 848 | 1868-1880 | Disease | denotes | IAV-infected | MESH:D007239 |
| 849 | 2434-2449 | Disease | denotes | virus infection | MESH:D001102 |