PMC:7358770 / 14452-17328
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T167 | 41-56 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T168 | 64-79 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T169 | 482-488 | Body_part | denotes | throat | http://purl.org/sig/ont/fma/fma228738 |
| T170 | 943-966 | Body_part | denotes | upper respiratory tract | http://purl.org/sig/ont/fma/fma45661 |
| T171 | 1859-1863 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T172 | 2109-2124 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T173 | 2309-2324 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T174 | 2502-2506 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T175 | 2606-2612 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T176 | 2748-2752 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T177 | 2789-2797 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 482-488 | Body_part | denotes | throat | http://purl.obolibrary.org/obo/UBERON_0000341 |
| T4 | 943-966 | Body_part | denotes | upper respiratory tract | http://purl.obolibrary.org/obo/UBERON_0001557 |
| T5 | 949-966 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T6 | 1859-1863 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T7 | 2502-2506 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 2606-2612 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T9 | 2748-2752 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 474 | 10-21 | Species | denotes | coronavirus | Tax:11118 |
| 475 | 41-56 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 517 | 244-255 | Species | denotes | coronavirus | Tax:11118 |
| 518 | 321-337 | Species | denotes | human rhinovirus | Tax:169066 |
| 519 | 345-360 | Species | denotes | influenza virus | Tax:11309 |
| 520 | 363-367 | Species | denotes | H1N1 | Tax:114727 |
| 521 | 373-382 | Species | denotes | HCoV OC43 | Tax:31631 |
| 522 | 638-655 | Species | denotes | human coronavirus | Tax:694448 |
| 523 | 656-665 | Species | denotes | HCoV-229E | Tax:11137 |
| 524 | 667-676 | Species | denotes | HCoV-OC43 | Tax:31631 |
| 525 | 678-687 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 526 | 693-702 | Species | denotes | HCoV-HKU1 | Tax:290028 |
| 527 | 787-798 | Species | denotes | coronavirus | Tax:11118 |
| 528 | 799-808 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 529 | 905-910 | Species | denotes | human | Tax:9606 |
| 530 | 911-924 | Species | denotes | coronaviruses | Tax:11118 |
| 531 | 1053-1063 | Species | denotes | rhinovirus | Tax:12059 |
| 532 | 1065-1076 | Species | denotes | coronavirus | Tax:11118 |
| 533 | 1078-1093 | Species | denotes | influenza virus | Tax:11309 |
| 534 | 1328-1345 | Species | denotes | human coronavirus | Tax:694448 |
| 535 | 1351-1368 | Species | denotes | influenza A virus | Tax:11320 |
| 536 | 1422-1427 | Species | denotes | human | Tax:9606 |
| 537 | 1450-1458 | Species | denotes | patients | Tax:9606 |
| 538 | 1597-1609 | Species | denotes | corona-virus | Tax:11118 |
| 539 | 1620-1628 | Species | denotes | patients | Tax:9606 |
| 540 | 1649-1657 | Species | denotes | patients | Tax:9606 |
| 541 | 1025-1036 | Species | denotes | respiratory | Tax:12814 |
| 542 | 339-342 | Species | denotes | HRV | Tax:169066 |
| 543 | 1323-1326 | Species | denotes | HRV | Tax:169066 |
| 544 | 1370-1373 | Species | denotes | IAV | Tax:11320 |
| 545 | 89-100 | Chemical | denotes | carrageenan | MESH:D002351 |
| 546 | 107-115 | Chemical | denotes | chitosan | MESH:D048271 |
| 547 | 257-273 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 548 | 1139-1155 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 549 | 1236-1247 | Chemical | denotes | Carrageenan | MESH:D002351 |
| 550 | 1577-1588 | Chemical | denotes | carrageenan | MESH:D002351 |
| 551 | 462-478 | Disease | denotes | viral infections | MESH:D001102 |
| 552 | 943-976 | Disease | denotes | upper respiratory tract infection | MESH:D012141 |
| 553 | 999-1003 | Disease | denotes | cold | MESH:D000067390 |
| 554 | 1230-1234 | Disease | denotes | cold | MESH:D000067390 |
| 555 | 1428-1449 | Disease | denotes | corona virus-infected | MESH:C000657245 |
| 556 | 1611-1619 | Disease | denotes | infected | MESH:D007239 |
| 557 | 749-756 | CellLine | denotes | HM-HTCC | CVCL:1295 |
| 564 | 2494-2498 | Gene | denotes | EGFR | Gene:1956 |
| 565 | 2624-2628 | Gene | denotes | EGFR | Gene:1956 |
| 566 | 2658-2662 | Gene | denotes | EGFR | Gene:1956 |
| 567 | 2502-2515 | Disease | denotes | lung fibrosis | MESH:D005355 |
| 568 | 2526-2532 | Disease | denotes | injury | MESH:D014947 |
| 569 | 2862-2870 | Disease | denotes | fibrosis | MESH:D005355 |
| 588 | 1883-1915 | Gene | denotes | epidermal growth factor receptor | Gene:1956 |
| 589 | 1917-1921 | Gene | denotes | EGFR | Gene:1956 |
| 590 | 1975-1979 | Gene | denotes | EGFR | Gene:1956 |
| 591 | 2222-2226 | Gene | denotes | EGFR | Gene:1956 |
| 592 | 2340-2344 | Gene | denotes | EGFR | Gene:1956 |
| 593 | 1786-1794 | Species | denotes | patients | Tax:9606 |
| 594 | 2036-2044 | Species | denotes | SARS-CoV | Tax:694009 |
| 595 | 2263-2274 | Species | denotes | coronavirus | Tax:11118 |
| 596 | 2133-2141 | Chemical | denotes | fucoidan | MESH:C007789 |
| 597 | 2146-2162 | Chemical | denotes | sulfated rhamnan | |
| 598 | 2309-2324 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 599 | 1734-1752 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 600 | 1796-1814 | Disease | denotes | Pulmonary fibrosis | MESH:D011658 |
| 601 | 1830-1841 | Disease | denotes | hyperactive | MESH:D006948 |
| 602 | 1859-1870 | Disease | denotes | lung injury | MESH:D055370 |
| 603 | 2055-2083 | Disease | denotes | respiratory viral infections | |
| 604 | 2383-2398 | Disease | denotes | viral infection | MESH:D001102 |
| 605 | 2426-2434 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T48 | 102-105 | Disease | denotes | PGS | http://purl.obolibrary.org/obo/MONDO_0010574 |
| T49 | 345-354 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T50 | 462-478 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T51 | 949-976 | Disease | denotes | respiratory tract infection | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T52 | 967-976 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T53 | 992-1003 | Disease | denotes | common cold | http://purl.obolibrary.org/obo/MONDO_0005709 |
| T54 | 1078-1087 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T55 | 1223-1234 | Disease | denotes | common cold | http://purl.obolibrary.org/obo/MONDO_0005709 |
| T56 | 1351-1360 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T57 | 1686-1690 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T58 | 1734-1752 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T59 | 1796-1814 | Disease | denotes | Pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T60 | 1864-1870 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T61 | 2036-2044 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T62 | 2067-2083 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T63 | 2383-2398 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T64 | 2389-2398 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T65 | 2426-2434 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T66 | 2526-2532 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T67 | 2563-2568 | Disease | denotes | wound | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T68 | 2703-2708 | Disease | denotes | wound | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T69 | 2844-2849 | Disease | denotes | wound | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T125 | 22-30 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T126 | 161-169 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T127 | 186-193 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T128 | 210-211 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T129 | 306-312 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T130 | 321-326 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T131 | 355-360 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T132 | 361-362 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T133 | 434-435 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T134 | 638-643 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T135 | 761-762 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T136 | 905-910 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T137 | 1037-1044 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T138 | 1088-1093 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T139 | 1108-1110 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
| T140 | 1205-1206 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T141 | 1207-1212 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T142 | 1306-1311 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T143 | 1328-1333 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T144 | 1361-1362 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T145 | 1363-1368 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T146 | 1422-1427 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T147 | 1435-1440 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T148 | 1604-1609 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T149 | 1828-1829 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T150 | 1859-1863 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T151 | 1859-1863 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T152 | 1923-1932 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T153 | 1936-1942 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T154 | 1980-1989 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T155 | 2208-2218 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T156 | 2330-2331 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T157 | 2502-2506 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T158 | 2502-2506 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T159 | 2536-2537 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T160 | 2643-2653 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T161 | 2737-2738 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T162 | 2748-2752 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T163 | 2748-2752 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T257 | 41-56 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T258 | 64-79 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T259 | 89-100 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T260 | 107-115 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T262 | 262-273 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T263 | 521-529 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T265 | 553-570 | Chemical | denotes | trimethylammonium | http://purl.obolibrary.org/obo/CHEBI_58389 |
| T266 | 571-579 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T268 | 580-588 | Chemical | denotes | chloride | http://purl.obolibrary.org/obo/CHEBI_17996 |
| T269 | 749-751 | Chemical | denotes | HM | http://purl.obolibrary.org/obo/CHEBI_74053 |
| T270 | 770-779 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T271 | 831-839 | Chemical | denotes | polymers | http://purl.obolibrary.org/obo/CHEBI_33839 |
| T272 | 849-857 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T274 | 872-882 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T275 | 1139-1155 | Chemical | denotes | iota-carrageenan | http://purl.obolibrary.org/obo/CHEBI_37168 |
| T276 | 1144-1155 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T277 | 1236-1247 | Chemical | denotes | Carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T278 | 1278-1287 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T279 | 1428-1434 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T280 | 1577-1588 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T281 | 1597-1603 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T282 | 2109-2124 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T283 | 2133-2141 | Chemical | denotes | fucoidan | http://purl.obolibrary.org/obo/CHEBI_5181 |
| T284 | 2155-2162 | Chemical | denotes | rhamnan | http://purl.obolibrary.org/obo/CHEBI_84684 |
| T285 | 2309-2324 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T286 | 2629-2636 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T287 | 2773-2783 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T288 | 2789-2797 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 462-478 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T13 | 1893-1899 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T14 | 1917-1921 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T15 | 1923-1932 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T16 | 1975-1979 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T17 | 1980-1989 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T18 | 2067-2083 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T19 | 2222-2226 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T20 | 2340-2344 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T21 | 2383-2398 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T22 | 2494-2498 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T23 | 2563-2576 | http://purl.obolibrary.org/obo/GO_0042060 | denotes | wound healing |
| T24 | 2624-2628 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T25 | 2658-2662 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T26 | 2703-2716 | http://purl.obolibrary.org/obo/GO_0042060 | denotes | wound healing |
| T27 | 2844-2857 | http://purl.obolibrary.org/obo/GO_0042060 | denotes | wound healing |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32679328-28280379-48281282 | 490-492 | 28280379 | denotes | 67 |
| 32679328-24219370-48281283 | 1096-1098 | 24219370 | denotes | 69 |
| 32679328-11726001-48281284 | 1108-1110 | 11726001 | denotes | 71 |
| 32679328-28390872-48281285 | 2085-2087 | 28390872 | denotes | 72 |
| 32679328-30177184-48281286 | 2279-2281 | 30177184 | denotes | 74 |
| 32679328-28390872-48281287 | 2872-2874 | 28390872 | denotes | 72 |
| T66604 | 490-492 | 28280379 | denotes | 67 |
| T22725 | 1096-1098 | 24219370 | denotes | 69 |
| T1961 | 1108-1110 | 11726001 | denotes | 71 |
| T58628 | 2085-2087 | 28390872 | denotes | 72 |
| T31607 | 2279-2281 | 30177184 | denotes | 74 |
| T95227 | 2872-2874 | 28390872 | denotes | 72 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T91 | 0-56 | Sentence | denotes | 2.3 Anti-coronavirus activity of marine polysaccharides |
| T92 | 57-256 | Sentence | denotes | Marine polysaccharides, such as carrageenan, PGS, chitosan, and their derivatives, show good inhibitory activity against various viruses, which provides a reference for their research on coronavirus. |
| T93 | 257-494 | Sentence | denotes | Iota-carrageenan containing lozenges show highly active against human rhinovirus (HRV), influenza virus A H1N1, and HCoV OC43 throughout the entire dissolution process, and are a promising therapy against viral infections of throat [67]. |
| T94 | 495-930 | Sentence | denotes | The cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), shows significant inhibition against the human coronavirus HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, and its hydrophobically modified derivative (HM-HTCC) is a potent inhibitor of the coronavirus HCoV-NL63, indicating that HTCC polymers based on chitosan are effective inhibitors of all low-pathogenic human coronaviruses [68]. |
| T95 | 931-1113 | Sentence | denotes | Acute viral upper respiratory tract infection, also known as common cold, is mainly caused by respiratory viruses such as rhinovirus, coronavirus, influenza virus [[69], [70], [71]]. |
| T96 | 1114-1235 | Sentence | denotes | Clinical trials applying iota-carrageenan nasal spray have shown to reduce the duration of a virus-confirmed common cold. |
| T97 | 1236-1459 | Sentence | denotes | Carrageenan nasal spray shows significant antiviral efficacy in three virus subgroups, HRV, human coronavirus, and influenza A virus (IAV), and the highest effectiveness was observed in human corona virus-infected patients. |
| T98 | 1460-1663 | Sentence | denotes | The reduced duration of disease was 3 days (p < 0.01), and the number of relapses was three times less (p < 0.01) in carrageenan treated corona-virus -infected patients compared to control patients [70]. |
| T99 | 1664-1795 | Sentence | denotes | After the outbreak of SARS in 2003, many survivors developed residual pulmonary fibrosis with increased severity in older patients. |
| T100 | 1796-1960 | Sentence | denotes | Pulmonary fibrosis is caused by a hyperactive host response to lung injury mediated by epidermal growth factor receptor (EGFR) signaling in animal models (Fig. 5 ). |
| T101 | 1961-2089 | Sentence | denotes | Inhibition of EGFR signaling can prevent an excessive fibrotic response to SARS-CoV and other respiratory viral infections [72]. |
| T102 | 2090-2283 | Sentence | denotes | Moreover, sulfated polysaccharides such as fucoidan and sulfated rhamnan, can interfere or inhibit the expression and activation of EGFR pathway, which may help to suppress coronavirus [73,74]. |
| T103 | 2284-2445 | Sentence | denotes | The understanding of how polysaccharides play a role in EGFR and other pro-fibrotic pathways after viral infection will provide new ideas for COVID-19 treatment. |
| T104 | 2446-2516 | Sentence | denotes | Fig. 5 The illustration about potential role of EGFR in lung fibrosis. |
| T105 | 2517-2671 | Sentence | denotes | Physical injury or a pathogen ① initiates the wound healing response by damaging healthy tissue, releasing EGFR ligands ② and activating the EGFR pathway. |
| T106 | 2672-2755 | Sentence | denotes | This results in an exaggerated wound healing response leading to a fibrotic lung ③. |
| T107 | 2756-2876 | Sentence | denotes | The early use of inhibitors like tyrosine kinase ④ could prevent the normal progress of wound healing and fibrosis [72]. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T3 | 943-976 | Phenotype | denotes | upper respiratory tract infection | http://purl.obolibrary.org/obo/HP_0002788 |
| T4 | 1734-1752 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T5 | 1796-1814 | Phenotype | denotes | Pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T386 | 10-21 | NCBITaxon:11118 | denotes | coronavirus |
| T387 | 41-56 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T388 | 64-79 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T389 | 89-100 | CHEBI:3435;CHEBI:3435 | denotes | carrageenan |
| T390 | 107-115 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T391 | 186-193 | NCBITaxon:10239 | denotes | viruses |
| T392 | 244-255 | NCBITaxon:11118 | denotes | coronavirus |
| T393 | 262-273 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T394 | 321-326 | SP_6;NCBITaxon:9606 | denotes | human |
| T395 | 327-337 | NCBITaxon:7729 | denotes | rhinovirus |
| T396 | 339-342 | NCBITaxon:10298 | denotes | HRV |
| T397 | 345-354 | NCBITaxon:7719 | denotes | influenza |
| T398 | 355-360 | NCBITaxon:10239 | denotes | virus |
| T399 | 462-467 | NCBITaxon:10239 | denotes | viral |
| T400 | 482-488 | UBERON:0000341 | denotes | throat |
| T401 | 499-511 | CHEBI:36916;CHEBI:36916 | denotes | cationically |
| T402 | 521-529 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T403 | 531-533 | CHEBI:8502;CHEBI:8502 | denotes | N- |
| T404 | 533-534 | CHEBI:62946;CHEBI:62946 | denotes | ( |
| T405 | 534-535 | CHEBI:86228;CHEBI:86228 | denotes | 2 |
| T406 | 535-549 | CHEBI:20067;CHEBI:20067 | denotes | -hydroxypropyl |
| T407 | 551-553 | CHEBI:53233;CHEBI:53233 | denotes | 3- |
| T408 | 553-570 | CHEBI:58389;CHEBI:58389 | denotes | trimethylammonium |
| T409 | 571-579 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T410 | 580-588 | CHEBI:17996;CHEBI:17996 | denotes | chloride |
| T411 | 638-643 | SP_6;NCBITaxon:9606 | denotes | human |
| T412 | 644-655 | NCBITaxon:11118 | denotes | coronavirus |
| T413 | 770-779 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T414 | 787-798 | NCBITaxon:11118 | denotes | coronavirus |
| T415 | 831-839 | CHEBI:60027;CHEBI:60027 | denotes | polymers |
| T416 | 849-857 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T417 | 872-882 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T418 | 905-910 | SP_6;NCBITaxon:9606 | denotes | human |
| T419 | 911-924 | NCBITaxon:11118 | denotes | coronaviruses |
| T420 | 937-942 | NCBITaxon:10239 | denotes | viral |
| T421 | 943-966 | UBERON:0001557 | denotes | upper respiratory tract |
| T422 | 1025-1036 | NCBITaxon:11886;UBERON:0001004 | denotes | respiratory |
| T423 | 1037-1044 | NCBITaxon:10239 | denotes | viruses |
| T424 | 1053-1063 | NCBITaxon:11632 | denotes | rhinovirus |
| T425 | 1065-1076 | NCBITaxon:11118 | denotes | coronavirus |
| T426 | 1078-1087 | NCBITaxon:7719 | denotes | influenza |
| T427 | 1088-1093 | NCBITaxon:10239 | denotes | virus |
| T428 | 1156-1161 | UBERON:0000004 | denotes | nasal |
| T429 | 1207-1212 | NCBITaxon:10239 | denotes | virus |
| T430 | 1236-1247 | CHEBI:3435;CHEBI:3435 | denotes | Carrageenan |
| T431 | 1248-1253 | UBERON:0000004 | denotes | nasal |
| T432 | 1306-1311 | NCBITaxon:10239 | denotes | virus |
| T433 | 1323-1326 | NCBITaxon:10298 | denotes | HRV |
| T434 | 1328-1333 | SP_6;NCBITaxon:9606 | denotes | human |
| T435 | 1334-1345 | NCBITaxon:11118 | denotes | coronavirus |
| T436 | 1351-1360 | NCBITaxon:7719 | denotes | influenza |
| T437 | 1361-1362 | NCBITaxon:11118 | denotes | A |
| T438 | 1363-1368 | NCBITaxon:10239 | denotes | virus |
| T439 | 1370-1373 | NCBITaxon:10090 | denotes | IAV |
| T440 | 1422-1427 | SP_6;NCBITaxon:9606 | denotes | human |
| T441 | 1428-1440 | NCBITaxon:11118 | denotes | corona virus |
| T442 | 1577-1588 | CHEBI:3435;CHEBI:3435 | denotes | carrageenan |
| T443 | 1604-1609 | NCBITaxon:10239 | denotes | virus |
| T444 | 1686-1690 | SP_10 | denotes | SARS |
| T445 | 1734-1743 | UBERON:0002048 | denotes | pulmonary |
| T446 | 1796-1805 | UBERON:0002048 | denotes | Pulmonary |
| T447 | 1859-1863 | UBERON:0002048 | denotes | lung |
| T448 | 1883-1892 | UBERON:0007376 | denotes | epidermal |
| T449 | 1936-1942 | NCBITaxon:33208 | denotes | animal |
| T450 | 2036-2044 | SP_10 | denotes | SARS-CoV |
| T451 | 2055-2066 | UBERON:0001004 | denotes | respiratory |
| T452 | 2067-2072 | NCBITaxon:10239 | denotes | viral |
| T453 | 2109-2124 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T454 | 2133-2141 | CHEBI:5181;CHEBI:5181 | denotes | fucoidan |
| T455 | 2193-2203 | GO:0010467 | denotes | expression |
| T456 | 2263-2274 | NCBITaxon:11118 | denotes | coronavirus |
| T457 | 2309-2324 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T458 | 2383-2388 | NCBITaxon:10239 | denotes | viral |
| T459 | 2426-2434 | SP_7 | denotes | COVID-19 |
| T460 | 2502-2506 | UBERON:0002048 | denotes | lung |
| T461 | 2563-2576 | GO:0042060 | denotes | wound healing |
| T462 | 2606-2612 | UBERON:0000479 | denotes | tissue |
| T463 | 2703-2716 | GO:0042060 | denotes | wound healing |
| T464 | 2748-2752 | UBERON:0002048 | denotes | lung |
| T465 | 2773-2783 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T466 | 2844-2857 | GO:0042060 | denotes | wound healing |
| T14564 | 27-32 | NCBITaxon:10239 | denotes | ity o |
| T78644 | 56-67 | CHEBI:3435;CHEBI:3435 | denotes | Marine pol |
| T61009 | 68-73 | UBERON:0000004 | denotes | sacch |
| T26450 | 128-133 | NCBITaxon:10239 | denotes | eriva |
| T44330 | 145-148 | NCBITaxon:10298 | denotes | goo |
| T91750 | 150-155 | SP_6;NCBITaxon:9606 | denotes | inhib |
| T28706 | 156-167 | NCBITaxon:11118 | denotes | tory activi |
| T62224 | 173-182 | NCBITaxon:7719 | denotes | inst vari |
| T52975 | 183-184 | NCBITaxon:11118 | denotes | u |
| T56824 | 185-190 | NCBITaxon:10239 | denotes | viru |
| T6464 | 192-195 | NCBITaxon:10090 | denotes | s, |
| T63501 | 244-249 | SP_6;NCBITaxon:9606 | denotes | coron |
| T92240 | 250-265 | NCBITaxon:11118 | denotes | virus. Iota-car |
| T36860 | 401-412 | CHEBI:3435;CHEBI:3435 | denotes | ire dissolu |
| T22385 | 428-433 | NCBITaxon:10239 | denotes | d are |
| T29049 | 510-514 | SP_10 | denotes | y mo |
| T9086 | 560-569 | UBERON:0002048 | denotes | ylammoniu |
| T98204 | 624-633 | UBERON:0002048 | denotes | n against |
| T97201 | 687-691 | UBERON:0002048 | denotes | , an |
| T11579 | 711-719 | UBERON:0007376 | denotes | hydroph |
| T66143 | 763-769 | NCBITaxon:33208 | denotes | potent |
| T25205 | 865-873 | SP_10 | denotes | ective i |
| T42644 | 884-894 | UBERON:0001004 | denotes | f all low- |
| T73955 | 895-900 | NCBITaxon:10239 | denotes | athog |
| T15745 | 937-952 | CHEBI:18154;CHEBI:18154 | denotes | viral upper res |
| T67895 | 962-970 | CHEBI:5181;CHEBI:5181 | denotes | ract inf |
| T80518 | 1022-1033 | GO:0010467 | denotes | by respirat |
| T76611 | 1093-1104 | NCBITaxon:11118 | denotes | [[69], [70 |
| T23665 | 1139-1157 | CHEBI:18154;CHEBI:18154 | denotes | iota-carrageenan n |
| T43103 | 1216-1221 | NCBITaxon:10239 | denotes | firme |
| T9923 | 1259-1267 | SP_7 | denotes | shows s |
| T76859 | 1333-1337 | UBERON:0002048 | denotes | cor |
| T63113 | 1394-1407 | GO:0042060 | denotes | fectiveness w |
| T60497 | 1437-1443 | UBERON:0000479 | denotes | rus-in |
| T86318 | 1535-1548 | GO:0042060 | denotes | lapses was th |
| T65457 | 1580-1584 | UBERON:0002048 | denotes | rage |
| T57985 | 1605-1615 | CHEBI:35222;CHEBI:35222 | denotes | irus -infe |
| T23270 | 1676-1689 | GO:0042060 | denotes | tbreak of SAR |
| T467 | 1771-1775 | UBERON:0002048 | denotes | erit |
| T468 | 1832-1845 | GO:0042060 | denotes | peractive hos |
| T469 | 1875-1881 | UBERON:0000479 | denotes | ated b |
| T470 | 1973-1986 | GO:0042060 | denotes | f EGFR signal |
| T471 | 2018-2022 | UBERON:0002048 | denotes | roti |
| T472 | 2043-2053 | CHEBI:35222;CHEBI:35222 | denotes | V and othe |
| T473 | 2115-2128 | GO:0042060 | denotes | ccharides suc |
| T40773 | 2157-2168 | NCBITaxon:11118 | denotes | amnan, can |
| T10595 | 2208-2223 | CHEBI:18154;CHEBI:18154 | denotes | activation of E |
| T39528 | 2308-2313 | NCBITaxon:10239 | denotes | poly |
| T45767 | 2387-2397 | SP_7 | denotes | l infectio |
| T71246 | 2405-2414 | CHEBI:36357;CHEBI:36357 | denotes | rovide ne |
| T62167 | 2427-2436 | NCBITaxon:47034 | denotes | OVID-19 t |
| T56183 | 2535-2540 | NCBITaxon:10239 | denotes | a pa |
| T66872 | 2541-2551 | UBERON:0001004 | denotes | hogen ① in |
| T14904 | 2641-2656 | CHEBI:18154;CHEBI:18154 | denotes | d activating th |
| T54314 | 2660-2671 | NCBITaxon:11118 | denotes | FR pathway. |
| T98755 | 2677-2682 | NCBITaxon:8782 | denotes | resul |
| T82764 | 2683-2694 | NCBITaxon:11118 | denotes | s in an exa |
| T30287 | 2784-2789 | NCBITaxon:8782 | denotes | like |
| T88059 | 2810-2813 | PR:000003015 | denotes | ld |
| T70997 | 2843-2854 | GO:0006260 | denotes | wound heal |
| T63381 | 2858-2861 | NCBITaxon:10376 | denotes | and |
MyTest
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 474 | 10-21 | Species | denotes | coronavirus | Tax:11118 |
| 475 | 41-56 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 517 | 244-255 | Species | denotes | coronavirus | Tax:11118 |
| 518 | 321-337 | Species | denotes | human rhinovirus | Tax:169066 |
| 519 | 345-360 | Species | denotes | influenza virus | Tax:11309 |
| 520 | 363-367 | Species | denotes | H1N1 | Tax:114727 |
| 521 | 373-382 | Species | denotes | HCoV OC43 | Tax:31631 |
| 522 | 638-655 | Species | denotes | human coronavirus | Tax:694448 |
| 523 | 656-665 | Species | denotes | HCoV-229E | Tax:11137 |
| 524 | 667-676 | Species | denotes | HCoV-OC43 | Tax:31631 |
| 525 | 678-687 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 526 | 693-702 | Species | denotes | HCoV-HKU1 | Tax:290028 |
| 527 | 787-798 | Species | denotes | coronavirus | Tax:11118 |
| 528 | 799-808 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 529 | 905-910 | Species | denotes | human | Tax:9606 |
| 530 | 911-924 | Species | denotes | coronaviruses | Tax:11118 |
| 531 | 1053-1063 | Species | denotes | rhinovirus | Tax:12059 |
| 532 | 1065-1076 | Species | denotes | coronavirus | Tax:11118 |
| 533 | 1078-1093 | Species | denotes | influenza virus | Tax:11309 |
| 534 | 1328-1345 | Species | denotes | human coronavirus | Tax:694448 |
| 535 | 1351-1368 | Species | denotes | influenza A virus | Tax:11320 |
| 536 | 1422-1427 | Species | denotes | human | Tax:9606 |
| 537 | 1450-1458 | Species | denotes | patients | Tax:9606 |
| 538 | 1597-1609 | Species | denotes | corona-virus | Tax:11118 |
| 539 | 1620-1628 | Species | denotes | patients | Tax:9606 |
| 540 | 1649-1657 | Species | denotes | patients | Tax:9606 |
| 541 | 1025-1036 | Species | denotes | respiratory | Tax:12814 |
| 542 | 339-342 | Species | denotes | HRV | Tax:169066 |
| 543 | 1323-1326 | Species | denotes | HRV | Tax:169066 |
| 544 | 1370-1373 | Species | denotes | IAV | Tax:11320 |
| 545 | 89-100 | Chemical | denotes | carrageenan | MESH:D002351 |
| 546 | 107-115 | Chemical | denotes | chitosan | MESH:D048271 |
| 547 | 257-273 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 548 | 1139-1155 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 549 | 1236-1247 | Chemical | denotes | Carrageenan | MESH:D002351 |
| 550 | 1577-1588 | Chemical | denotes | carrageenan | MESH:D002351 |
| 551 | 462-478 | Disease | denotes | viral infections | MESH:D001102 |
| 552 | 943-976 | Disease | denotes | upper respiratory tract infection | MESH:D012141 |
| 553 | 999-1003 | Disease | denotes | cold | MESH:D000067390 |
| 554 | 1230-1234 | Disease | denotes | cold | MESH:D000067390 |
| 555 | 1428-1449 | Disease | denotes | corona virus-infected | MESH:C000657245 |
| 556 | 1611-1619 | Disease | denotes | infected | MESH:D007239 |
| 557 | 749-756 | CellLine | denotes | HM-HTCC | CVCL:1295 |
| 564 | 2494-2498 | Gene | denotes | EGFR | Gene:1956 |
| 565 | 2624-2628 | Gene | denotes | EGFR | Gene:1956 |
| 566 | 2658-2662 | Gene | denotes | EGFR | Gene:1956 |
| 567 | 2502-2515 | Disease | denotes | lung fibrosis | MESH:D005355 |
| 568 | 2526-2532 | Disease | denotes | injury | MESH:D014947 |
| 569 | 2862-2870 | Disease | denotes | fibrosis | MESH:D005355 |
| 588 | 1883-1915 | Gene | denotes | epidermal growth factor receptor | Gene:1956 |
| 589 | 1917-1921 | Gene | denotes | EGFR | Gene:1956 |
| 590 | 1975-1979 | Gene | denotes | EGFR | Gene:1956 |
| 591 | 2222-2226 | Gene | denotes | EGFR | Gene:1956 |
| 592 | 2340-2344 | Gene | denotes | EGFR | Gene:1956 |
| 593 | 1786-1794 | Species | denotes | patients | Tax:9606 |
| 594 | 2036-2044 | Species | denotes | SARS-CoV | Tax:694009 |
| 595 | 2263-2274 | Species | denotes | coronavirus | Tax:11118 |
| 596 | 2133-2141 | Chemical | denotes | fucoidan | MESH:C007789 |
| 597 | 2146-2162 | Chemical | denotes | sulfated rhamnan | |
| 598 | 2309-2324 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 599 | 1734-1752 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 600 | 1796-1814 | Disease | denotes | Pulmonary fibrosis | MESH:D011658 |
| 601 | 1830-1841 | Disease | denotes | hyperactive | MESH:D006948 |
| 602 | 1859-1870 | Disease | denotes | lung injury | MESH:D055370 |
| 603 | 2055-2083 | Disease | denotes | respiratory viral infections | |
| 604 | 2383-2398 | Disease | denotes | viral infection | MESH:D001102 |
| 605 | 2426-2434 | Disease | denotes | COVID-19 | MESH:C000657245 |