PMC:7354481 / 41697-43278
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T285 | 372-376 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T286 | 499-505 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T287 | 761-779 | Body_part | denotes | regulatory T cells | http://purl.org/sig/ont/fma/fma84070 |
| T288 | 774-779 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T289 | 980-984 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T290 | 1119-1125 | Body_part | denotes | Genome | http://purl.org/sig/ont/fma/fma84116 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T59 | 499-505 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T252 | 0-20 | Disease | denotes | Sudden cardiac death | http://purl.obolibrary.org/obo/MONDO_0007264 |
| T253 | 74-82 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T254 | 473-481 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T255 | 814-834 | Disease | denotes | autoimmune disorders | http://purl.obolibrary.org/obo/MONDO_0007179 |
| T256 | 858-875 | Disease | denotes | allergic diseases | http://purl.obolibrary.org/obo/MONDO_0005271 |
| T257 | 858-866 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
| T258 | 881-887 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T259 | 943-949 | Disease | denotes | glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
| T260 | 1112-1118 | Disease | denotes | Glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
| T261 | 1180-1204 | Disease | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T262 | 1195-1204 | Disease | denotes | carcinoma | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T263 | 1230-1249 | Disease | denotes | Alzheimer’s disease | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T264 | 1504-1519 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T265 | 1510-1519 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T476 | 24-25 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T477 | 91-94 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T478 | 278-279 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T479 | 372-376 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T480 | 526-527 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T481 | 624-633 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T482 | 665-675 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T483 | 725-728 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T484 | 761-779 | http://purl.obolibrary.org/obo/CL_0000815 | denotes | regulatory T cells |
| T485 | 792-793 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T486 | 889-892 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
| T487 | 907-910 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T488 | 980-984 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T489 | 1055-1057 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
| T490 | 1055-1057 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
| T491 | 1075-1076 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T492 | 1263-1266 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T493 | 1349-1352 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T494 | 1384-1385 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T161 | 325-334 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
| T162 | 1016-1030 | Chemical | denotes | ribonucleotide | http://purl.obolibrary.org/obo/CHEBI_26561 |
| T163 | 1055-1057 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
| T167 | 1386-1395 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T78 | 0-20 | Phenotype | denotes | Sudden cardiac death | http://purl.obolibrary.org/obo/HP_0001645 |
| T79 | 161-180 | Phenotype | denotes | myocardial fibrosis | http://purl.obolibrary.org/obo/HP_0001685 |
| T80 | 814-834 | Phenotype | denotes | autoimmune disorders | http://purl.obolibrary.org/obo/HP_0002960 |
| T81 | 881-887 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T82 | 943-949 | Phenotype | denotes | glioma | http://purl.obolibrary.org/obo/HP_0009733 |
| T83 | 1112-1118 | Phenotype | denotes | Glioma | http://purl.obolibrary.org/obo/HP_0009733 |
| T84 | 1180-1204 | Phenotype | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/HP_0001402 |
| T85 | 1230-1249 | Phenotype | denotes | Alzheimer’s disease | http://purl.obolibrary.org/obo/HP_0002511 |
| T86 | 1404-1411 | Phenotype | denotes | seizure | http://purl.obolibrary.org/obo/HP_0001250 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T154 | 665-684 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathways |
| T155 | 665-675 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T156 | 960-975 | http://purl.obolibrary.org/obo/GO_0045926 | denotes | inhibits growth |
| T157 | 969-975 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T158 | 980-990 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T159 | 1504-1519 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T275 | 0-216 | Sentence | denotes | Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. |
| T276 | 217-512 | Sentence | denotes | Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. |
| T277 | 513-691 | Sentence | denotes | TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. |
| T278 | 692-1211 | Sentence | denotes | Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. |
| T279 | 1212-1345 | Sentence | denotes | Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. |
| T280 | 1346-1472 | Sentence | denotes | It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. |
| T281 | 1473-1581 | Sentence | denotes | The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32512929-29515035-144200781 | 507-510 | 29515035 | denotes | 101 |
| 32512929-29515035-144200782 | 686-689 | 29515035 | denotes | 101 |
| 32512929-32348937-144200783 | 889-892 | 32348937 | denotes | 102 |
| 32512929-28239651-144200784 | 1133-1136 | 28239651 | denotes | 103 |
| 32512929-28469953-144200785 | 1206-1209 | 28469953 | denotes | 104 |
| 32512929-31949677-144200786 | 1340-1343 | 31949677 | denotes | 105 |
| 32512929-18055455-144200787 | 1468-1470 | 18055455 | denotes | 49 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1049 | 444-452 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1050 | 513-519 | Gene | denotes | TGF-β1 | Gene:7040 |
| 1051 | 615-623 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1052 | 648-654 | Gene | denotes | TGF-β1 | Gene:7040 |
| 1053 | 702-710 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1054 | 895-903 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1055 | 1059-1063 | Gene | denotes | RRM1 | Gene:6240 |
| 1056 | 1490-1498 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1057 | 1251-1259 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1058 | 1139-1147 | Gene | denotes | miR-1468 | Gene:100302115 |
| 1059 | 130-138 | Species | denotes | patients | Tax:9606 |
| 1060 | 1086-1094 | Species | denotes | patients | Tax:9606 |
| 1061 | 1415-1423 | Species | denotes | patients | Tax:9606 |
| 1062 | 7-20 | Disease | denotes | cardiac death | MESH:D003643 |
| 1063 | 64-70 | Disease | denotes | deaths | MESH:D003643 |
| 1064 | 74-82 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1065 | 161-180 | Disease | denotes | myocardial fibrosis | MESH:D005355 |
| 1066 | 359-367 | Disease | denotes | fibrosis | MESH:D005355 |
| 1067 | 473-490 | Disease | denotes | COVID-19-diseased | MESH:C000657245 |
| 1068 | 540-548 | Disease | denotes | fibrosis | MESH:D005355 |
| 1069 | 587-595 | Disease | denotes | fibrosis | MESH:D005355 |
| 1070 | 814-834 | Disease | denotes | autoimmune disorders | MESH:D001327 |
| 1071 | 858-875 | Disease | denotes | allergic diseases | MESH:D004342 |
| 1072 | 881-887 | Disease | denotes | asthma | MESH:D001249 |
| 1073 | 943-949 | Disease | denotes | glioma | MESH:D005910 |
| 1074 | 1112-1118 | Disease | denotes | Glioma | MESH:D005910 |
| 1075 | 1180-1204 | Disease | denotes | hepatocellular carcinoma | MESH:D006528 |
| 1076 | 1230-1249 | Disease | denotes | Alzheimer’s disease | MESH:D000544 |
| 1077 | 1404-1411 | Disease | denotes | seizure | MESH:D012640 |
| 1078 | 1441-1466 | Disease | denotes | intracerebral haemorrhage | MESH:D002543 |
| 1079 | 1504-1519 | Disease | denotes | viral infection | MESH:D001102 |