PMC:7354481 / 39608-40965 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":52,"end":56},"obj":"Body_part"},{"id":"T269","span":{"begin":57,"end":63},"obj":"Body_part"},{"id":"T270","span":{"begin":139,"end":143},"obj":"Body_part"},{"id":"T271","span":{"begin":311,"end":333},"obj":"Body_part"},{"id":"T272","span":{"begin":328,"end":333},"obj":"Body_part"},{"id":"T273","span":{"begin":543,"end":547},"obj":"Body_part"},{"id":"T274","span":{"begin":1020,"end":1024},"obj":"Body_part"},{"id":"T275","span":{"begin":1100,"end":1104},"obj":"Body_part"},{"id":"T276","span":{"begin":1174,"end":1194},"obj":"Body_part"},{"id":"T277","span":{"begin":1211,"end":1217},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma0326143"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T49","span":{"begin":52,"end":56},"obj":"Body_part"},{"id":"T50","span":{"begin":57,"end":63},"obj":"Body_part"},{"id":"T51","span":{"begin":139,"end":143},"obj":"Body_part"},{"id":"T52","span":{"begin":543,"end":547},"obj":"Body_part"},{"id":"T53","span":{"begin":1020,"end":1024},"obj":"Body_part"},{"id":"T54","span":{"begin":1100,"end":1104},"obj":"Body_part"},{"id":"T55","span":{"begin":1211,"end":1217},"obj":"Body_part"}],"attributes":[{"id":"A49","pred":"uberon_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A50","pred":"uberon_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T237","span":{"begin":663,"end":685},"obj":"Disease"},{"id":"T238","span":{"begin":673,"end":685},"obj":"Disease"},{"id":"T239","span":{"begin":689,"end":709},"obj":"Disease"},{"id":"T240","span":{"begin":698,"end":709},"obj":"Disease"},{"id":"T241","span":{"begin":741,"end":749},"obj":"Disease"},{"id":"T242","span":{"begin":892,"end":902},"obj":"Disease"},{"id":"T243","span":{"begin":985,"end":1007},"obj":"Disease"},{"id":"T244","span":{"begin":995,"end":1007},"obj":"Disease"},{"id":"T245","span":{"begin":1020,"end":1033},"obj":"Disease"},{"id":"T246","span":{"begin":1322,"end":1345},"obj":"Disease"}],"attributes":[{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005149"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A239","pred":"mondo_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/MONDO_0005100"},{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0019340"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0005149"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T440","span":{"begin":9,"end":12},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T441","span":{"begin":52,"end":56},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T442","span":{"begin":52,"end":56},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T443","span":{"begin":81,"end":83},"obj":"http://purl.obolibrary.org/obo/CLO_0001527"},{"id":"T444","span":{"begin":139,"end":143},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T445","span":{"begin":139,"end":143},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T446","span":{"begin":195,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T447","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T448","span":{"begin":299,"end":302},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T449","span":{"begin":311,"end":333},"obj":"http://purl.obolibrary.org/obo/CL_0000134"},{"id":"T450","span":{"begin":449,"end":459},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T451","span":{"begin":543,"end":547},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T452","span":{"begin":543,"end":547},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T453","span":{"begin":622,"end":625},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T454","span":{"begin":1020,"end":1024},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T455","span":{"begin":1020,"end":1024},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T456","span":{"begin":1100,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T457","span":{"begin":1100,"end":1104},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T458","span":{"begin":1260,"end":1270},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T159","span":{"begin":226,"end":230},"obj":"Chemical"},{"id":"T160","span":{"begin":779,"end":785},"obj":"Chemical"}],"attributes":[{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T66","span":{"begin":673,"end":685},"obj":"Phenotype"},{"id":"T67","span":{"begin":698,"end":709},"obj":"Phenotype"},{"id":"T68","span":{"begin":849,"end":857},"obj":"Phenotype"},{"id":"T69","span":{"begin":882,"end":902},"obj":"Phenotype"},{"id":"T70","span":{"begin":995,"end":1007},"obj":"Phenotype"},{"id":"T71","span":{"begin":1012,"end":1033},"obj":"Phenotype"},{"id":"T72","span":{"begin":1322,"end":1345},"obj":"Phenotype"}],"attributes":[{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0100324"},{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0030828"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0006532"},{"id":"A70","pred":"hp_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0006528"},{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0001626"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T141","span":{"begin":139,"end":155},"obj":"http://purl.obolibrary.org/obo/GO_0030324"},{"id":"T142","span":{"begin":231,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T143","span":{"begin":449,"end":459},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T144","span":{"begin":472,"end":494},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T145","span":{"begin":543,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0060425"},{"id":"T146","span":{"begin":548,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0009653"},{"id":"T147","span":{"begin":1100,"end":1116},"obj":"http://purl.obolibrary.org/obo/GO_0030324"},{"id":"T148","span":{"begin":1211,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0001894"},{"id":"T149","span":{"begin":1218,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T150","span":{"begin":1260,"end":1270},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T262","span":{"begin":0,"end":168},"obj":"Sentence"},{"id":"T263","span":{"begin":169,"end":346},"obj":"Sentence"},{"id":"T264","span":{"begin":347,"end":597},"obj":"Sentence"},{"id":"T265","span":{"begin":598,"end":715},"obj":"Sentence"},{"id":"T266","span":{"begin":716,"end":1034},"obj":"Sentence"},{"id":"T267","span":{"begin":1035,"end":1253},"obj":"Sentence"},{"id":"T268","span":{"begin":1254,"end":1357},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"2_test","denotations":[{"id":"32512929-32205856-144200774","span":{"begin":81,"end":83},"obj":"32205856"},{"id":"32512929-30013141-144200775","span":{"begin":342,"end":344},"obj":"30013141"},{"id":"32512929-32044414-144200776","span":{"begin":711,"end":713},"obj":"32044414"},{"id":"32512929-23739951-144200777","span":{"begin":1347,"end":1349},"obj":"23739951"},{"id":"32512929-18095342-144200778","span":{"begin":1350,"end":1352},"obj":"18095342"},{"id":"32512929-18313409-144200779","span":{"begin":1353,"end":1355},"obj":"18313409"}],"text":"miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

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