PMC:7354481 / 29758-32634
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T185 | 96-99 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T186 | 396-399 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T187 | 578-581 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T188 | 1062-1066 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T189 | 1067-1071 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T190 | 1380-1384 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T191 | 1484-1497 | Body_part | denotes | lymphoblastic | http://purl.org/sig/ont/fma/fma83030 |
| T192 | 1568-1572 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T193 | 1718-1728 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T194 | 1993-2000 | Body_part | denotes | genomes | http://purl.org/sig/ont/fma/fma84116 |
| T195 | 2142-2146 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T196 | 2150-2154 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T197 | 2179-2183 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T198 | 2251-2255 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T199 | 2273-2276 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T200 | 2294-2299 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T201 | 2358-2370 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T202 | 2358-2362 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T203 | 2371-2384 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T26 | 1067-1071 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T27 | 1380-1384 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T28 | 1568-1572 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T112 | 103-111 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T113 | 126-134 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T114 | 379-387 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T115 | 585-593 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T116 | 760-771 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T117 | 760-769 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T118 | 772-782 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T119 | 899-913 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T120 | 1052-1078 | Disease | denotes | non-small cell lung cancer | http://purl.obolibrary.org/obo/MONDO_0005233 |
| T121 | 1056-1078 | Disease | denotes | small cell lung cancer | http://purl.obolibrary.org/obo/MONDO_0008433 |
| T122 | 1067-1078 | Disease | denotes | lung cancer | http://purl.obolibrary.org/obo/MONDO_0008903 |
| T123 | 1072-1078 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T124 | 1080-1085 | Disease | denotes | NSCLC | http://purl.obolibrary.org/obo/MONDO_0005233 |
| T125 | 1380-1391 | Disease | denotes | lung cancer | http://purl.obolibrary.org/obo/MONDO_0008903 |
| T126 | 1385-1391 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T127 | 1478-1506 | Disease | denotes | acute lymphoblastic leukemia | http://purl.obolibrary.org/obo/MONDO_0004967 |
| T128 | 1484-1506 | Disease | denotes | lymphoblastic leukemia | http://purl.obolibrary.org/obo/MONDO_0001018 |
| T129 | 1498-1506 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T130 | 1508-1511 | Disease | denotes | ALL | http://purl.obolibrary.org/obo/MONDO_0004967 |
| T131 | 1568-1579 | Disease | denotes | lung cancer | http://purl.obolibrary.org/obo/MONDO_0008903 |
| T132 | 1573-1579 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T133 | 1982-1990 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T134 | 2177-2192 | Disease | denotes | T cell leukemia | http://purl.obolibrary.org/obo/MONDO_0005525 |
| T135 | 2184-2192 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T136 | 2207-2213 | Disease | denotes | HTLV-1 | http://purl.obolibrary.org/obo/MONDO_0005801 |
| T137 | 2239-2244 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T138 | 2279-2288 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T139 | 2420-2435 | Disease | denotes | avian influenza | http://purl.obolibrary.org/obo/MONDO_0018695 |
| T140 | 2426-2435 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T141 | 2499-2513 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T142 | 2522-2531 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T143 | 2636-2650 | Disease | denotes | Avian leukosis | http://purl.obolibrary.org/obo/MONDO_0025381 |
| T144 | 2758-2774 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T145 | 2855-2863 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T146 | 2866-2875 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T298 | 154-155 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T299 | 313-314 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T300 | 500-501 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T301 | 625-630 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T302 | 631-636 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T303 | 663-666 | http://purl.obolibrary.org/obo/PR_000001932 | denotes | hsa |
| T304 | 770-771 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T305 | 914-919 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T306 | 999-1002 | http://purl.obolibrary.org/obo/PR_000001932 | denotes | hsa |
| T307 | 1062-1066 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T308 | 1067-1071 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T309 | 1067-1071 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T310 | 1122-1124 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T311 | 1245-1246 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T312 | 1357-1358 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T313 | 1380-1384 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T314 | 1380-1384 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T315 | 1441-1442 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T316 | 1568-1572 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T317 | 1568-1572 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T318 | 1687-1689 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T319 | 1695-1698 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T320 | 2117-2120 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T321 | 2142-2146 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T322 | 2150-2154 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T323 | 2171-2176 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T324 | 2177-2183 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T325 | 2193-2198 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T326 | 2245-2250 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T327 | 2251-2255 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T328 | 2292-2299 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T329 | 2300-2303 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T330 | 2358-2362 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T331 | 2514-2519 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T332 | 2651-2656 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T333 | 2730-2738 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human as |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T79 | 698-702 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T80 | 1122-1124 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T81 | 1718-1728 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T82 | 2035-2043 | Chemical | denotes | O-glycan | http://purl.obolibrary.org/obo/CHEBI_59521 |
| T83 | 2371-2384 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T84 | 2391-2400 | Chemical | denotes | O-glycans | http://purl.obolibrary.org/obo/CHEBI_59521 |
| T85 | 2393-2400 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T86 | 2459-2466 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T87 | 2549-2557 | Chemical | denotes | O-glycan | http://purl.obolibrary.org/obo/CHEBI_59521 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T28 | 760-769 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T29 | 1052-1078 | Phenotype | denotes | non-small cell lung cancer | http://purl.obolibrary.org/obo/HP_0030358 |
| T30 | 1080-1085 | Phenotype | denotes | NSCLC | http://purl.obolibrary.org/obo/HP_0030358 |
| T31 | 1380-1391 | Phenotype | denotes | lung cancer | http://purl.obolibrary.org/obo/HP_0100526 |
| T32 | 1478-1506 | Phenotype | denotes | acute lymphoblastic leukemia | http://purl.obolibrary.org/obo/HP_0006721 |
| T33 | 1508-1511 | Phenotype | denotes | ALL | http://purl.obolibrary.org/obo/HP_0006721 |
| T34 | 1568-1579 | Phenotype | denotes | lung cancer | http://purl.obolibrary.org/obo/HP_0100526 |
| T35 | 2184-2192 | Phenotype | denotes | leukemia | http://purl.obolibrary.org/obo/HP_0001909 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T99 | 2037-2056 | http://purl.obolibrary.org/obo/GO_0000271 | denotes | glycan biosynthesis |
| T100 | 2044-2056 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T101 | 2341-2354 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T102 | 2551-2570 | http://purl.obolibrary.org/obo/GO_0000271 | denotes | glycan biosynthesis |
| T103 | 2558-2570 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T104 | 2758-2774 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T195 | 0-15 | Sentence | denotes | 4.1.2. miR-5197 |
| T196 | 16-140 | Sentence | denotes | miR-5197-3p was identified as the most effective miR to interact with the guide RNA of SARS-CoV, MERS-CoV and COVID-19 [49]. |
| T197 | 141-400 | Sentence | denotes | According to a recent study, out of 2565 miRNAs, only three critical miRs, 5197-3p, 4778-3p and 6864-5p could interact with complete complementary miR (cc-miR) and possess a critical therapeutic potential due to their binding affinity on SARS-CoV-2 guide RNA. |
| T198 | 401-642 | Sentence | denotes | It was suggested that the generation of miR-5197-3p-based complete complementary miRNA may possess a significant therapeutic response, owing to its structural affinity to guide RNA of SARS-CoV-2, without any side effects on human genes [49]. |
| T199 | 643-800 | Sentence | denotes | Previous patents on hsa-miR-5197-5p indicated that any drug targeting this miR might be critical in the treatment of hepatitis B infections (WO2018193902A1). |
| T200 | 801-959 | Sentence | denotes | Similar to this finding, it was shown that miR-5197-3p might be used in vaccine strategies in the herpes simplex virus (HSV-1) (WO2013109604A1WO2013109604A1). |
| T201 | 960-1092 | Sentence | denotes | In another study, allelic variances of hsa-miR-5197 were found to be highly associated with non-small cell lung cancer (NSCLC) [50]. |
| T202 | 1093-1292 | Sentence | denotes | According to the Harvard and MD Anderson databases, miR-5197 shows significant differences between Caucasians and Chinese populations (data gained from a Han Chinese cohort from Nanjing, China) [50]. |
| T203 | 1293-1401 | Sentence | denotes | The rs2042253 polymorphism (T>C variation) of miR-5197 provided a protective effect on lung cancer survival. |
| T204 | 1402-1535 | Sentence | denotes | Moreover, this SNP is reported to have a high read frequency for paediatric acute lymphoblastic leukemia (ALL) in the UK cohort [51]. |
| T205 | 1536-1691 | Sentence | denotes | High throughput analysis of 408 lung cancer patients showed that miR-5197 polymorphism is highly correlated with chemotherapy-induced severe toxicity [52]. |
| T206 | 1692-1883 | Sentence | denotes | It has been accepted that nucleotide variations in pre-miRNAs may have contributed to the stability of stem-loop structure and may affect recognition sites for Drosha and Dicer cleavage [53]. |
| T207 | 1884-2098 | Sentence | denotes | In our current study, we did not find any mutations in miR-5197 sequences obtained from different SARS-CoV-2 genomes, however we found that mucin type O-glycan biosynthesis was related to both miRs 5197-3 and 8066. |
| T208 | 2099-2272 | Sentence | denotes | This KEGG pathway has been involved in the cell-to-cell transmission of human T cell leukemia virus type 1 (HTLV-1) [54] and plays roles in Ebola virus cell attachment [55]. |
| T209 | 2273-2390 | Sentence | denotes | HIV-1 infection of T cells has also been shown to result in altered glycosylation of cell surface glycoproteins [56]. |
| T210 | 2391-2441 | Sentence | denotes | O-glycans are also linked to avian influenza [57]. |
| T211 | 2442-2537 | Sentence | denotes | Mucosal O-linked glycans are furthermore associated with herpes simplex virus 1 infection [58]. |
| T212 | 2538-2682 | Sentence | denotes | Mucin type O-glycan biosynthesis miR pathways have been identified in avian oncogenic retrovirus (Avian leukosis virus subgroup J (ALV-J)) [59]. |
| T213 | 2683-2876 | Sentence | denotes | This KEGG pathway is therefore related both to human as well as veterinary viral infections and further studies will be needed to establish the function of miR-5197 during SARS-CoV-2 infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32512929-18055455-144200730 | 136-138 | 18055455 | denotes | 49 |
| 32512929-18055455-144200731 | 638-640 | 18055455 | denotes | 49 |
| 32512929-21606961-144200732 | 1687-1689 | 21606961 | denotes | 52 |
| 32512929-30333195-144200733 | 2216-2218 | 30333195 | denotes | 54 |
| 32512929-22171268-144200734 | 2268-2270 | 22171268 | denotes | 55 |
| 32512929-30389789-144200735 | 2386-2388 | 30389789 | denotes | 56 |
| 32512929-12925577-144200736 | 2437-2439 | 12925577 | denotes | 57 |
| 32512929-24233973-144200737 | 2533-2535 | 24233973 | denotes | 58 |
| 32512929-23030500-144200738 | 2678-2680 | 23030500 | denotes | 59 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
|---|---|---|---|---|---|---|
| 561 | 7-15 | Chemical | denotes | miR-5197 | ||
| 572 | 441-449 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 573 | 663-675 | Gene | denotes | hsa-miR-5197 | Gene:100846991 | |
| 574 | 103-111 | Species | denotes | SARS-CoV | Tax:694009 | |
| 575 | 113-121 | Species | denotes | MERS-CoV | Tax:1335626 | |
| 576 | 379-389 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
| 577 | 585-595 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
| 578 | 625-630 | Species | denotes | human | Tax:9606 | |
| 579 | 899-927 | Species | denotes | herpes simplex virus (HSV-1) | Tax:10298 | |
| 580 | 126-134 | Disease | denotes | COVID-19 | MESH:C000657245 | |
| 581 | 760-782 | Disease | denotes | hepatitis B infections | MESH:D006509 | |
| 604 | 999-1011 | Gene | denotes | hsa-miR-5197 | Gene:100846991 | |
| 605 | 1145-1153 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 606 | 1339-1347 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 607 | 1601-1609 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 608 | 1852-1858 | Gene | denotes | Drosha | Gene:29102 | |
| 609 | 1863-1868 | Gene | denotes | Dicer | Gene:23405 | |
| 610 | 1939-1947 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 611 | 2024-2029 | Gene | denotes | mucin | Gene:100508689 | |
| 612 | 1580-1588 | Species | denotes | patients | Tax:9606 | |
| 613 | 1982-1992 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
| 614 | 2171-2205 | Species | denotes | human T cell leukemia virus type 1 | Tax:11908 | |
| 615 | 2207-2213 | Species | denotes | HTLV-1 | Tax:11908 | |
| 616 | 2239-2250 | Species | denotes | Ebola virus | Tax:205488 | |
| 617 | 2035-2043 | Chemical | denotes | O-glycan | ||
| 618 | 1052-1078 | Disease | denotes | non-small cell lung cancer | MESH:D002289 | |
| 619 | 1080-1085 | Disease | denotes | NSCLC | MESH:D002289 | |
| 620 | 1380-1391 | Disease | denotes | lung cancer | MESH:D008175 | |
| 621 | 1478-1506 | Disease | denotes | acute lymphoblastic leukemia | MESH:D054198 | |
| 622 | 1568-1579 | Disease | denotes | lung cancer | MESH:D008175 | |
| 623 | 1677-1685 | Disease | denotes | toxicity | MESH:D064420 | |
| 624 | 2273-2288 | Disease | denotes | HIV-1 infection | MESH:D015658 | |
| 625 | 1297-1306 | Mutation | denotes | rs2042253 | rs2042253 | |
| 639 | 2538-2543 | Gene | denotes | Mucin | Gene:100508689 | |
| 640 | 2839-2847 | Gene | denotes | miR-5197 | Gene:100846991 | |
| 641 | 2499-2521 | Species | denotes | herpes simplex virus 1 | Tax:10298 | |
| 642 | 2636-2667 | Species | denotes | Avian leukosis virus subgroup J | Tax:1401444 | |
| 643 | 2669-2674 | Species | denotes | ALV-J | Tax:1401444 | |
| 644 | 2730-2735 | Species | denotes | human | Tax:9606 | |
| 645 | 2426-2435 | Species | denotes | influenza | Tax:11309 | |
| 646 | 2391-2400 | Chemical | denotes | O-glycans | ||
| 647 | 2450-2466 | Chemical | denotes | O-linked glycans | ||
| 648 | 2549-2557 | Chemical | denotes | O-glycan | ||
| 649 | 2522-2531 | Disease | denotes | infection | MESH:D007239 | |
| 650 | 2758-2774 | Disease | denotes | viral infections | MESH:D001102 | |
| 651 | 2855-2875 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |