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PMC:7354481 / 197-2628 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 327-335 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T3 357-361 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T4 1349-1355 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 357-361 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 0-47 Disease denotes Severe acute respiratory syndrome coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 0-33 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T4 49-57 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 117-125 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 135-143 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 459-467 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 530-534 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T9 709-717 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 807-815 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 891-895 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T12 1257-1265 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1607-1615 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 1856-1864 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2388-2396 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T3 64-65 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 163-169 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T5 357-361 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T6 357-361 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T7 400-401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 554-561 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T9 755-762 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T10 1038-1039 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1082-1087 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T12 1156-1163 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T13 1466-1471 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T14 1472-1479 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T15 2137-2138 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 2259-2264 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 327-341 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 289-311 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T2 1002-1025 http://purl.obolibrary.org/obo/GO_0006355 denotes transcriptional control

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-134 Sentence denotes Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the betacoronavirus family, which causes COVID-19 disease.
T4 135-426 Sentence denotes SARS-CoV-2 pathogenicity in humans leads to increased mortality rates due to alterations of significant pathways, including some resulting in exacerbated inflammatory responses linked to the “cytokine storm” and extensive lung pathology, as well as being linked to a number of comorbidities.
T5 427-625 Sentence denotes Our current study compared five SARS-CoV-2 sequences from different geographical regions to those from SARS, MERS and two cold viruses, OC43 and 229E, to identify the presence of miR-like sequences.
T6 626-763 Sentence denotes We identified seven key miRs, which highlight considerable differences between the SARS-CoV-2 sequences, compared with the other viruses.
T7 764-939 Sentence denotes The level of conservation between the five SARS-CoV-2 sequences was identical but poor compared with the other sequences, with SARS showing the highest degree of conservation.
T8 940-1127 Sentence denotes This decrease in similarity could result in reduced levels of transcriptional control, as well as a change in the physiological effect of the virus and associated host-pathogen responses.
T9 1128-1226 Sentence denotes MERS and the milder symptom viruses showed greater differences and even significant sequence gaps.
T10 1227-1367 Sentence denotes This divergence away from the SARS-CoV-2 sequences broadly mirrors the phylogenetic relationships obtained from the whole-genome alignments.
T11 1368-1618 Sentence denotes Therefore, patterns of mutation, occurring during sequence divergence from the longer established human viruses to the more recent ones, may have led to the emergence of sequence motifs that can be related directly to the pathogenicity of SARS-CoV-2.
T12 1619-1811 Sentence denotes Importantly, we identified 7 key-microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) with significant links to KEGG pathways linked to viral pathogenicity and host responses.
T13 1812-1986 Sentence denotes According to Bioproject data (PRJNA615032), SARS-CoV-2 mediated transcriptomic alterations were similar to the target pathways of the selected 7 miRs identified in our study.
T14 1987-2105 Sentence denotes This mechanism could have considerable significance in determining the symptom spectrum of future potential pandemics.
T15 2106-2283 Sentence denotes KEGG pathway analysis revealed a number of critical pathways linked to the seven identified miRs that may provide insight into the interplay between the virus and comorbidities.
T16 2284-2431 Sentence denotes Based on our reported findings, miRNAs may constitute potential and effective therapeutic approaches in COVID-19 and its pathological consequences.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
21 0-47 Species denotes Severe acute respiratory syndrome coronavirus-2 Tax:2697049
22 49-59 Species denotes SARS-CoV-2 Tax:2697049
23 80-95 Species denotes betacoronavirus Tax:694002
24 135-145 Species denotes SARS-CoV-2 Tax:2697049
25 163-169 Species denotes humans Tax:9606
26 459-469 Species denotes SARS-CoV-2 Tax:2697049
27 709-719 Species denotes SARS-CoV-2 Tax:2697049
28 807-817 Species denotes SARS-CoV-2 Tax:2697049
29 1257-1267 Species denotes SARS-CoV-2 Tax:2697049
30 1466-1471 Species denotes human Tax:9606
31 1607-1617 Species denotes SARS-CoV-2 Tax:2697049
32 1856-1866 Species denotes SARS-CoV-2 Tax:2697049
33 563-567 Species denotes OC43 Tax:31631
34 572-576 Species denotes 229E Tax:11137
35 117-125 Disease denotes COVID-19 MESH:C000657245
36 189-198 Disease denotes mortality MESH:D003643
37 536-540 Disease denotes MERS MESH:D018352
38 1128-1132 Disease denotes MERS MESH:D018352
39 2388-2396 Disease denotes COVID-19 MESH:C000657245