PMC:7352545 / 75560-77514
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T215 | 486-489 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T216 | 486-489 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T217 | 1448-1451 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T218 | 1448-1451 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T711 | 0-5 | Body_part | denotes | Lipid | http://purl.org/sig/ont/fma/fma67264 |
| T712 | 112-115 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T713 | 208-212 | Body_part | denotes | foot | http://purl.org/sig/ont/fma/fma9664 |
| T714 | 217-222 | Body_part | denotes | mouth | http://purl.org/sig/ont/fma/fma49184 |
| T715 | 309-314 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T716 | 393-401 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T717 | 444-449 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T718 | 474-485 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T719 | 585-593 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T720 | 605-610 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T721 | 624-632 | Body_part | denotes | Caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T722 | 738-746 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T723 | 776-783 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T724 | 1145-1153 | Body_part | denotes | clathrin | http://purl.org/sig/ont/fma/fma62262 |
| T725 | 1181-1186 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T726 | 1283-1291 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T727 | 1341-1346 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T728 | 1368-1373 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T729 | 1389-1401 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T730 | 1487-1491 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T731 | 1624-1629 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T732 | 1719-1724 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T733 | 1909-1914 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T39 | 27-43 | Body_part | denotes | attachment sites | http://purl.obolibrary.org/obo/UBERON_4200047 |
| T40 | 208-212 | Body_part | denotes | foot | http://purl.obolibrary.org/obo/UBERON_0002387 |
| T41 | 217-222 | Body_part | denotes | mouth | http://purl.obolibrary.org/obo/UBERON_0000165 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T290 | 66-72 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T291 | 80-85 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T292 | 93-104 | Disease | denotes | hepatitis C | http://purl.obolibrary.org/obo/MONDO_0005231 |
| T293 | 93-102 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T294 | 139-146 | Disease | denotes | measles | http://purl.obolibrary.org/obo/MONDO_0004619 |
| T295 | 154-171 | Disease | denotes | Newcastle disease | http://purl.obolibrary.org/obo/MONDO_0005875 |
| T296 | 208-230 | Disease | denotes | foot-and-mouth disease | http://purl.obolibrary.org/obo/MONDO_0005765 |
| T297 | 217-230 | Disease | denotes | mouth disease | http://purl.obolibrary.org/obo/MONDO_0006858 |
| T298 | 266-275 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T299 | 980-995 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T300 | 986-995 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T301 | 1107-1116 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T302 | 1302-1310 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T303 | 1584-1592 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T304 | 1638-1646 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T305 | 1745-1753 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T306 | 1852-1860 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1060 | 45-52 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Viruses |
| T1061 | 73-78 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1062 | 86-91 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1063 | 105-110 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1064 | 117-122 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T1065 | 130-135 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1066 | 147-152 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1067 | 172-177 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1068 | 201-206 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1069 | 217-222 | http://www.ebi.ac.uk/efo/EFO_0000825 | denotes | mouth |
| T1070 | 231-236 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1071 | 245-250 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1072 | 276-281 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1073 | 294-299 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1074 | 325-330 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1075 | 413-418 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1076 | 750-751 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1077 | 882-883 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1078 | 980-985 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1079 | 1143-1144 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1080 | 1176-1180 | http://purl.obolibrary.org/obo/CLO_0007646 | denotes | MDCK |
| T1081 | 1176-1180 | http://purl.obolibrary.org/obo/CLO_0050861 | denotes | MDCK |
| T1082 | 1181-1186 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1083 | 1200-1207 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T1084 | 1341-1346 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1085 | 1455-1463 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T1086 | 1487-1496 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell-type |
| T1087 | 1616-1629 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
| T1088 | 1743-1744 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1089 | 1764-1767 | http://purl.obolibrary.org/obo/CLO_0001002 | denotes | 162 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T93448 | 0-5 | Chemical | denotes | Lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T480 | 309-314 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T80566 | 393-401 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T482 | 441-443 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T485 | 444-449 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T59892 | 474-489 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T12984 | 474-485 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T98801 | 486-489 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T490 | 523-534 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T36640 | 605-610 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T91320 | 776-783 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1202 | 1368-1373 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T9370 | 1389-1401 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T51169 | 1448-1451 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T498 | 1546-1557 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T6978 | 1719-1724 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T14452 | 1871-1876 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T48427 | 1909-1914 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T145 | 830-842 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestering |
| T146 | 1038-1049 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T147 | 1506-1518 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T148 | 1909-1932 | http://purl.obolibrary.org/obo/GO_0051665 | denotes | lipid-raft localization |
| T149 | 1920-1932 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T730 | 0-44 | Sentence | denotes | Lipid rafts are also viral attachment sites. |
| T731 | 45-363 | Sentence | denotes | Viruses such as IBV, dengue virus, Ebola virus, hepatitis C virus, HIV, human herpes virus 6, measles virus, Newcastle disease virus, poliovirus, West Nile virus, foot-and-mouth disease virus, simian virus 40, rotavirus, influenza virus and Marburg virus also use lipid rafts for virus entry [151,152,153,154,155,156]. |
| T732 | 364-490 | Sentence | denotes | In avian CoV IBV, structural proteins of the IBV virus are co-localized with PM lipid rafts embedded with the ganglioside GM1. |
| T733 | 491-623 | Sentence | denotes | HCoV-229E entry is prevented by cholesterol depleted conditions because HCoV-229E clusters in caveolae-associated lipid rafts [157]. |
| T734 | 624-773 | Sentence | denotes | Caveolae of caveolin-1, -2 and -3 are cross-linked [158] and control the molecular distribution between rafts and caveolae in a regulatory mechanism. |
| T735 | 774-843 | Sentence | denotes | S protein-CD13 cross-linking occurs via CD13-caveolin-1 sequestering. |
| T736 | 844-919 | Sentence | denotes | HCoV-229E particles similarly exhibit a longitudinal distribution property. |
| T737 | 920-996 | Sentence | denotes | HCoV-229E-colocalized caveolin-1 undergoes the next step of virus infection. |
| T738 | 997-1117 | Sentence | denotes | Caveolin-1 knockdown inhibited HCoV-229E endocytosis and entry and thus caveolin-1 is essential for HCoV-229E infection. |
| T739 | 1118-1193 | Sentence | denotes | TGEV also endocytoses by a clathrin-mediated mechanism in MDCK cells [159]. |
| T740 | 1194-1298 | Sentence | denotes | Other viruses including HCoV-OC43 also use an entry receptor sequestered to cross-linked caveolae [160]. |
| T741 | 1299-1408 | Sentence | denotes | In SARS-CoV, the first entry step to host cells needs ACE2 in intact lipid rafts by the S glycoprotein [151]. |
| T742 | 1409-1525 | Sentence | denotes | ACE2 is associated with caveolin-1 and GM1 in membrane rafts depending on its cell-type specific localization [161]. |
| T743 | 1526-1671 | Sentence | denotes | Raft integrity with cholesterol and ACE2 is necessary for SARS-CoV pseudovirus entry into Vero E6 cells and for SARS-CoV-microdomain-based entry. |
| T744 | 1672-1769 | Sentence | denotes | C-type lectin, CD209 L (L-SIGN), can also form lipid rafts and acts as a SARS-CoV receptor [162]. |
| T745 | 1770-1954 | Sentence | denotes | Information of the CoV entry pathways is important for therapeutic designation of SARS-CoV-targeting drugs, for example, if agents disrupt lipid-raft localization of the ACE2 receptor. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T14 | 486-489 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T15 | 1448-1451 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-18279660-51944116 | 338-341 | 18279660 | denotes | 151 |
| 32604730-28081264-51944117 | 342-345 | 28081264 | denotes | 152 |
| 32604730-12876558-51944118 | 346-349 | 12876558 | denotes | 153 |
| 32604730-16139599-51944119 | 350-353 | 16139599 | denotes | 154 |
| 32604730-16126288-51944120 | 354-357 | 16126288 | denotes | 155 |
| 32604730-1350662-51944121 | 618-621 | 1350662 | denotes | 157 |
| 32604730-12748632-51944122 | 676-679 | 12748632 | denotes | 158 |
| 32604730-9420255-51944123 | 1188-1191 | 9420255 | denotes | 159 |
| 32604730-8505072-51944124 | 1293-1296 | 8505072 | denotes | 160 |
| 32604730-18279660-51944125 | 1403-1406 | 18279660 | denotes | 151 |
| 32604730-15496474-51944126 | 1764-1767 | 15496474 | denotes | 162 |
| T80212 | 338-341 | 18279660 | denotes | 151 |
| T52763 | 342-345 | 28081264 | denotes | 152 |
| T4649 | 346-349 | 12876558 | denotes | 153 |
| T47495 | 350-353 | 16139599 | denotes | 154 |
| T88062 | 354-357 | 16126288 | denotes | 155 |
| T59666 | 618-621 | 1350662 | denotes | 157 |
| T69792 | 676-679 | 12748632 | denotes | 158 |
| T50168 | 1188-1191 | 9420255 | denotes | 159 |
| T58602 | 1293-1296 | 8505072 | denotes | 160 |
| T36192 | 1403-1406 | 18279660 | denotes | 151 |
| T84413 | 1764-1767 | 15496474 | denotes | 162 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 93-102 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |