PMC:7352545 / 75483-80835
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T215 | 563-566 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T216 | 563-566 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T217 | 1525-1528 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T218 | 1525-1528 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T219 | 2205-2207 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T220 | 2605-2611 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T221 | 2780-2783 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T222 | 2780-2783 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T223 | 2845-2848 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T224 | 2845-2848 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T225 | 2932-2935 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T226 | 2932-2935 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T227 | 3151-3154 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T228 | 3151-3154 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T229 | 3179-3182 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T230 | 3179-3182 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T231 | 3269-3272 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T232 | 3269-3272 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T233 | 4033-4035 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T234 | 4313-4315 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T235 | 4420-4426 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T236 | 4599-4602 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T237 | 4599-4602 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T238 | 4786-4789 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T239 | 4786-4789 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T240 | 4823-4826 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T241 | 4823-4826 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T242 | 4943-4946 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T243 | 4943-4946 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T244 | 5060-5063 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T245 | 5060-5063 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T709 | 29-41 | Body_part | denotes | Gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T710 | 45-50 | Body_part | denotes | Lipid | http://purl.org/sig/ont/fma/fma67264 |
| T711 | 77-82 | Body_part | denotes | Lipid | http://purl.org/sig/ont/fma/fma67264 |
| T712 | 189-192 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T713 | 285-289 | Body_part | denotes | foot | http://purl.org/sig/ont/fma/fma9664 |
| T714 | 294-299 | Body_part | denotes | mouth | http://purl.org/sig/ont/fma/fma49184 |
| T715 | 386-391 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T716 | 470-478 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T717 | 521-526 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T718 | 551-562 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T719 | 662-670 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T720 | 682-687 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T721 | 701-709 | Body_part | denotes | Caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T722 | 815-823 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T723 | 853-860 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T724 | 1222-1230 | Body_part | denotes | clathrin | http://purl.org/sig/ont/fma/fma62262 |
| T725 | 1258-1263 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T726 | 1360-1368 | Body_part | denotes | caveolae | http://purl.org/sig/ont/fma/fma0327007 |
| T727 | 1418-1423 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T728 | 1445-1450 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T729 | 1466-1478 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T730 | 1564-1568 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T731 | 1701-1706 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T732 | 1796-1801 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T733 | 1986-1991 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T734 | 2054-2066 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T735 | 2070-2075 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T736 | 2144-2156 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T737 | 2157-2168 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T738 | 2232-2244 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T739 | 2310-2322 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T740 | 2338-2350 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T741 | 2354-2365 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T742 | 2388-2399 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T743 | 2452-2464 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T744 | 2580-2592 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T745 | 2750-2755 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T746 | 2768-2779 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T747 | 2827-2832 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T748 | 2905-2909 | Body_part | denotes | face | http://purl.org/sig/ont/fma/fma24728 |
| T749 | 2987-2992 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T750 | 3019-3024 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T751 | 3043-3053 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T752 | 3072-3079 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T753 | 3139-3150 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T754 | 3162-3174 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T755 | 3257-3268 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T756 | 3298-3305 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T757 | 3409-3421 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T758 | 3431-3438 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T759 | 3512-3523 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T760 | 3597-3608 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T761 | 3627-3638 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T762 | 3803-3808 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T763 | 3852-3859 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T764 | 4124-4136 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T765 | 4152-4164 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T766 | 4275-4287 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T767 | 4291-4303 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T768 | 4603-4608 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T769 | 4646-4653 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T770 | 4693-4697 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T771 | 4721-4728 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T772 | 4844-4851 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T773 | 5172-5184 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T774 | 5189-5201 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T775 | 5210-5223 | Body_part | denotes | cell surfaces | http://purl.org/sig/ont/fma/fma67653 |
| T776 | 5210-5214 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T777 | 5229-5234 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T778 | 5255-5259 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T39 | 104-120 | Body_part | denotes | attachment sites | http://purl.obolibrary.org/obo/UBERON_4200047 |
| T40 | 285-289 | Body_part | denotes | foot | http://purl.obolibrary.org/obo/UBERON_0002387 |
| T41 | 294-299 | Body_part | denotes | mouth | http://purl.obolibrary.org/obo/UBERON_0000165 |
| T42 | 2816-2819 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
| T43 | 2905-2909 | Body_part | denotes | face | http://purl.obolibrary.org/obo/UBERON_0001456 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T290 | 143-149 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T291 | 157-162 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T292 | 170-181 | Disease | denotes | hepatitis C | http://purl.obolibrary.org/obo/MONDO_0005231 |
| T293 | 170-179 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T294 | 216-223 | Disease | denotes | measles | http://purl.obolibrary.org/obo/MONDO_0004619 |
| T295 | 231-248 | Disease | denotes | Newcastle disease | http://purl.obolibrary.org/obo/MONDO_0005875 |
| T296 | 285-307 | Disease | denotes | foot-and-mouth disease | http://purl.obolibrary.org/obo/MONDO_0005765 |
| T297 | 294-307 | Disease | denotes | mouth disease | http://purl.obolibrary.org/obo/MONDO_0006858 |
| T298 | 343-352 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T299 | 1057-1072 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T300 | 1063-1072 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T301 | 1184-1193 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T302 | 1379-1387 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T303 | 1661-1669 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T304 | 1715-1723 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T305 | 1822-1830 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T306 | 1929-1937 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T307 | 2297-2305 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T308 | 2380-2383 | Disease | denotes | GBS | http://purl.obolibrary.org/obo/MONDO_0016218 |
| T309 | 2439-2442 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T311 | 2468-2476 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T312 | 3080-3083 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T314 | 3175-3178 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T316 | 3289-3292 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T318 | 3365-3368 | Disease | denotes | GBS | http://purl.obolibrary.org/obo/MONDO_0016218 |
| T319 | 3422-3425 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T321 | 3475-3478 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T323 | 3616-3619 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T325 | 3723-3731 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T326 | 4729-4732 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T328 | 4895-4898 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T330 | 5159-5167 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1059 | 20-28 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | Membrane |
| T1060 | 122-129 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Viruses |
| T1061 | 150-155 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1062 | 163-168 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1063 | 182-187 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1064 | 194-199 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T1065 | 207-212 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1066 | 224-229 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1067 | 249-254 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1068 | 278-283 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1069 | 294-299 | http://www.ebi.ac.uk/efo/EFO_0000825 | denotes | mouth |
| T1070 | 308-313 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1071 | 322-327 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1072 | 353-358 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1073 | 371-376 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1074 | 402-407 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1075 | 490-495 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1076 | 827-828 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1077 | 959-960 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1078 | 1057-1062 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1079 | 1220-1221 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1080 | 1253-1257 | http://purl.obolibrary.org/obo/CLO_0007646 | denotes | MDCK |
| T1081 | 1253-1257 | http://purl.obolibrary.org/obo/CLO_0050861 | denotes | MDCK |
| T1082 | 1258-1263 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1083 | 1277-1284 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T1084 | 1418-1423 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1085 | 1532-1540 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T1086 | 1564-1573 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell-type |
| T1087 | 1693-1706 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
| T1088 | 1820-1821 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1089 | 1841-1844 | http://purl.obolibrary.org/obo/CLO_0001002 | denotes | 162 |
| T1090 | 2046-2049 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T1091 | 2087-2088 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1092 | 2352-2353 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T1093 | 2536-2539 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T1094 | 2572-2575 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T1095 | 2594-2599 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T1096 | 2643-2646 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T1097 | 2905-2909 | http://purl.obolibrary.org/obo/UBERON_0001456 | denotes | face |
| T1098 | 2965-2966 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1099 | 3002-3010 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
| T1100 | 3043-3062 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T1101 | 3043-3062 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T1102 | 3212-3213 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1103 | 3307-3310 | http://purl.obolibrary.org/obo/CLO_0001003 | denotes | 163 |
| T1104 | 3353-3354 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1105 | 3380-3381 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1106 | 4040-4041 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1107 | 4057-4060 | http://purl.obolibrary.org/obo/CLO_0001003 | denotes | 163 |
| T1108 | 4337-4338 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1109 | 4471-4474 | http://purl.obolibrary.org/obo/CLO_0001003 | denotes | 163 |
| T1110 | 4693-4697 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1111 | 4962-4963 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1112 | 5090-5100 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T1113 | 5210-5214 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1114 | 5255-5259 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1115 | 5275-5276 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1116 | 5344-5351 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T478 | 45-50 | Chemical | denotes | Lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T93448 | 77-82 | Chemical | denotes | Lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T480 | 386-391 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T80566 | 470-478 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T482 | 518-520 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T485 | 521-526 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T59892 | 551-566 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T12984 | 551-562 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T98801 | 563-566 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T490 | 600-611 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T36640 | 682-687 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T91320 | 853-860 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1202 | 1445-1450 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T9370 | 1466-1478 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T51169 | 1525-1528 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T498 | 1623-1634 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T6978 | 1796-1801 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T14452 | 1948-1953 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T48427 | 1986-1991 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T502 | 2054-2066 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T43884 | 2070-2075 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T78952 | 2144-2156 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T505 | 2157-2168 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T506 | 2205-2207 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T511 | 2232-2244 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T512 | 2310-2322 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T513 | 2338-2350 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T47698 | 2354-2365 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T17261 | 2388-2399 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T70796 | 2452-2464 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T517 | 2580-2592 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T21270 | 2605-2611 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T27149 | 2768-2783 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T50306 | 2768-2779 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T27834 | 2780-2783 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T524 | 2845-2848 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T527 | 2914-2920 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T529 | 2932-2935 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T532 | 2993-3001 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
| T534 | 3043-3053 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T11500 | 3043-3048 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T536 | 3049-3053 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T83159 | 3072-3079 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T538 | 3095-3098 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T540 | 3104-3107 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T543 | 3116-3119 | Chemical | denotes | Arg | http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952 |
| T545 | 3139-3154 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T547 | 3139-3150 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T548 | 3151-3154 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T51486 | 3162-3174 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T550 | 3179-3182 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T45335 | 3244-3253 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T98318 | 3257-3272 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T55541 | 3257-3268 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T56997 | 3269-3272 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T35428 | 3298-3305 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T559 | 3409-3421 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T15401 | 3431-3438 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T561 | 3512-3523 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T15638 | 3512-3517 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T563 | 3518-3523 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T45964 | 3524-3527 | Chemical | denotes | Gly | http://purl.obolibrary.org/obo/CHEBI_15428 |
| T565 | 3529-3532 | Chemical | denotes | Pro | http://purl.obolibrary.org/obo/CHEBI_50342 |
| T63446 | 3540-3543 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T568 | 3597-3608 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T84843 | 3597-3602 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T570 | 3603-3608 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T40788 | 3627-3638 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T572 | 3800-3802 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T26574 | 3803-3808 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T576 | 3852-3859 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T24019 | 3906-3912 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T579 | 3913-3918 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T581 | 3946-3952 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T583 | 3953-3958 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T585 | 3990-3995 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T7706 | 4033-4035 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T58089 | 4042-4050 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T592 | 4124-4136 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T593 | 4152-4164 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T594 | 4275-4287 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T595 | 4291-4303 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T23800 | 4313-4315 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T3322 | 4411-4416 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T39211 | 4420-4426 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T70554 | 4509-4515 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T18624 | 4516-4521 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T95244 | 4599-4602 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T91399 | 4646-4653 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T75759 | 4721-4728 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T66644 | 4786-4789 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T616 | 4823-4826 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T69799 | 4844-4851 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T620 | 4860-4864 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T621 | 4943-4946 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T75682 | 4948-4951 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T45327 | 4964-4972 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T94022 | 4987-4993 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T14276 | 5023-5026 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T99238 | 5045-5048 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T633 | 5060-5063 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T31697 | 5080-5089 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T48080 | 5172-5184 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T638 | 5189-5201 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T639 | 5229-5234 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T640 | 5260-5262 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T643 | 5325-5330 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T145 | 907-919 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestering |
| T146 | 1115-1126 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T147 | 1583-1595 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T148 | 1986-2009 | http://purl.obolibrary.org/obo/GO_0051665 | denotes | lipid-raft localization |
| T149 | 1997-2009 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T728 | 0-4 | Sentence | denotes | 7.2. |
| T729 | 5-76 | Sentence | denotes | Interaction of Membrane Gangliosides in Lipid Rafts with CLQ and CLQ-OH |
| T730 | 77-121 | Sentence | denotes | Lipid rafts are also viral attachment sites. |
| T731 | 122-440 | Sentence | denotes | Viruses such as IBV, dengue virus, Ebola virus, hepatitis C virus, HIV, human herpes virus 6, measles virus, Newcastle disease virus, poliovirus, West Nile virus, foot-and-mouth disease virus, simian virus 40, rotavirus, influenza virus and Marburg virus also use lipid rafts for virus entry [151,152,153,154,155,156]. |
| T732 | 441-567 | Sentence | denotes | In avian CoV IBV, structural proteins of the IBV virus are co-localized with PM lipid rafts embedded with the ganglioside GM1. |
| T733 | 568-700 | Sentence | denotes | HCoV-229E entry is prevented by cholesterol depleted conditions because HCoV-229E clusters in caveolae-associated lipid rafts [157]. |
| T734 | 701-850 | Sentence | denotes | Caveolae of caveolin-1, -2 and -3 are cross-linked [158] and control the molecular distribution between rafts and caveolae in a regulatory mechanism. |
| T735 | 851-920 | Sentence | denotes | S protein-CD13 cross-linking occurs via CD13-caveolin-1 sequestering. |
| T736 | 921-996 | Sentence | denotes | HCoV-229E particles similarly exhibit a longitudinal distribution property. |
| T737 | 997-1073 | Sentence | denotes | HCoV-229E-colocalized caveolin-1 undergoes the next step of virus infection. |
| T738 | 1074-1194 | Sentence | denotes | Caveolin-1 knockdown inhibited HCoV-229E endocytosis and entry and thus caveolin-1 is essential for HCoV-229E infection. |
| T739 | 1195-1270 | Sentence | denotes | TGEV also endocytoses by a clathrin-mediated mechanism in MDCK cells [159]. |
| T740 | 1271-1375 | Sentence | denotes | Other viruses including HCoV-OC43 also use an entry receptor sequestered to cross-linked caveolae [160]. |
| T741 | 1376-1485 | Sentence | denotes | In SARS-CoV, the first entry step to host cells needs ACE2 in intact lipid rafts by the S glycoprotein [151]. |
| T742 | 1486-1602 | Sentence | denotes | ACE2 is associated with caveolin-1 and GM1 in membrane rafts depending on its cell-type specific localization [161]. |
| T743 | 1603-1748 | Sentence | denotes | Raft integrity with cholesterol and ACE2 is necessary for SARS-CoV pseudovirus entry into Vero E6 cells and for SARS-CoV-microdomain-based entry. |
| T744 | 1749-1846 | Sentence | denotes | C-type lectin, CD209 L (L-SIGN), can also form lipid rafts and acts as a SARS-CoV receptor [162]. |
| T745 | 1847-2031 | Sentence | denotes | Information of the CoV entry pathways is important for therapeutic designation of SARS-CoV-targeting drugs, for example, if agents disrupt lipid-raft localization of the ACE2 receptor. |
| T746 | 2032-2103 | Sentence | denotes | CLQ binds the SAs and gangliosides in lipid rafts with a high affinity. |
| T747 | 2104-2177 | Sentence | denotes | Therefore, CLQ or CLQ-OH prevents the S glycoprotein–ganglioside binding. |
| T748 | 2178-2271 | Sentence | denotes | CLQ (or CLQ-OH) binding to SA consequently prevents S glycoprotein binding to host receptors. |
| T749 | 2272-2351 | Sentence | denotes | The N-terminal region of SARS-CoV-2 S glycoprotein interacts with gangliosides. |
| T750 | 2352-2479 | Sentence | denotes | A ganglioside-binding site (GBS) or ganglioside-binding domain (GBD) is present in the NTD of the S glycoprotein of SARS-CoV-2. |
| T751 | 2480-2593 | Sentence | denotes | Using molecular modeling and simulation technology, CLQ has been suggested to recognize the SAs and gangliosides. |
| T752 | 2594-2636 | Sentence | denotes | Human type Neu5Ac binds to CLQ and CLQ-OH. |
| T753 | 2637-2685 | Sentence | denotes | Thus, SAs are binding targets of CLQ and CLQ-OH. |
| T754 | 2686-2784 | Sentence | denotes | CLQ and CLQ-OH have two specific recognition sites in the polar sugar residues of ganglioside GM1. |
| T755 | 2785-2890 | Sentence | denotes | The first site is found at the tip of the sugar residues of GM1 with an interaction energy of −47 kJ/mol. |
| T756 | 2891-3034 | Sentence | denotes | The CLQ rings face the GalNAc residue of GM1, while the second site is in a large region of the sugar-ceramide junction and the sugar residues. |
| T757 | 3035-3155 | Sentence | denotes | Several amino acid residues of the S protein NTD, which are Phe-135, Asn-137 and Arg-158, recognize the ganglioside GM1. |
| T758 | 3156-3312 | Sentence | denotes | The S glycoprotein NTD-GM1 complex is suggested to form a trimolecular complex with two molecules of ganglioside GM1 anchored to the NTD of S protein [163]. |
| T759 | 3313-3426 | Sentence | denotes | The ACE2-binding RBD is suggested to be a potential GBS located on a differential site of the S glycoprotein NTD. |
| T760 | 3427-3507 | Sentence | denotes | The protein sequence interfacing surface of the NTD is the consensus GBDs [164]. |
| T761 | 3508-3660 | Sentence | denotes | The amino acids Gly, Pro and/or Ser residues found in GBD motifs are in the same 111–158 amino acids of the NTD as the ganglioside-attachment interface. |
| T762 | 3661-3741 | Sentence | denotes | The GBD is conserved throughout viral isolates from worldwide COVID-19 patients. |
| T763 | 3742-3866 | Sentence | denotes | The GBD potentially increases viral attachment ability to PM lipid rafts and contact between host ACE-2 and S protein [165]. |
| T764 | 3867-3975 | Sentence | denotes | The interaction between CLQ-OH and 9-O-acetyl-NeuAc is also similar to the 9-O-acetyl-NeuAc-CLQ interaction. |
| T765 | 3976-4062 | Sentence | denotes | The CLQ-OH OH group enhances the interaction of CLQ with SA via a hydrogen bond [163]. |
| T766 | 4063-4234 | Sentence | denotes | In conditions with CLQ or CLQ-OH derivative treatment, the S glycoprotein cannot bind to gangliosides in in silico studies, which are used to uncover the action mechanism. |
| T767 | 4235-4304 | Sentence | denotes | CLQ and CLQ-OH prevent the binding of S glycoprotein to gangliosides. |
| T768 | 4305-4476 | Sentence | denotes | The CLQ-SA complex is formed in a mixed surface and balls by the positioning of the negative charged COOH group of Neu5Ac and one of the two cationic charges of CLQ [163]. |
| T769 | 4477-4572 | Sentence | denotes | CoVs preferentially bind to 9-O-acetyl-NeuAc [60], differentiating with other viral properties. |
| T770 | 4573-4714 | Sentence | denotes | As CLQ interacts with the GM1 sugar part, the N-terminal domain of the S protein loses viral attachment capacity to the cell receptors [166]. |
| T771 | 4715-4947 | Sentence | denotes | The S protein NTD and the CLQ/CLQ-OH maintain the same position during GM1 binding, consequently preventing GM1 binding to the S protein and the drug at the same time, because the NTD and the CLQ/CLQ-OH simultaneously recognize GM1. |
| T772 | 4948-5064 | Sentence | denotes | Asn-167 forms a hydrogen bond with the GalNAc residue, whereas an aromatic Phe-135 stacks to the Glc residue of GM1. |
| T773 | 5065-5224 | Sentence | denotes | Therefore, the antiviral activities of CLQ and CLQ-OH is to block the interaction between the SARS-CoV-2 S glycoprotein and gangliosides on host cell surfaces. |
| T774 | 5225-5352 | Sentence | denotes | The lipid composition of host cell PM can also be a potential target for preventive and therapeutic drugs against such viruses. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T14 | 563-566 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T15 | 1525-1528 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T16 | 2780-2783 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T17 | 2845-2848 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T18 | 2932-2935 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T19 | 3151-3154 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T20 | 3179-3182 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T21 | 3269-3272 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T22 | 4599-4602 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T23 | 4786-4789 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T24 | 4823-4826 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T25 | 4943-4946 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T26 | 5060-5063 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-18279660-51944116 | 415-418 | 18279660 | denotes | 151 |
| 32604730-28081264-51944117 | 419-422 | 28081264 | denotes | 152 |
| 32604730-12876558-51944118 | 423-426 | 12876558 | denotes | 153 |
| 32604730-16139599-51944119 | 427-430 | 16139599 | denotes | 154 |
| 32604730-16126288-51944120 | 431-434 | 16126288 | denotes | 155 |
| 32604730-1350662-51944121 | 695-698 | 1350662 | denotes | 157 |
| 32604730-12748632-51944122 | 753-756 | 12748632 | denotes | 158 |
| 32604730-9420255-51944123 | 1265-1268 | 9420255 | denotes | 159 |
| 32604730-8505072-51944124 | 1370-1373 | 8505072 | denotes | 160 |
| 32604730-18279660-51944125 | 1480-1483 | 18279660 | denotes | 151 |
| 32604730-15496474-51944126 | 1841-1844 | 15496474 | denotes | 162 |
| 32604730-32251731-51944127 | 3307-3310 | 32251731 | denotes | 163 |
| 32604730-25140899-51944128 | 3502-3505 | 25140899 | denotes | 164 |
| 32604730-32251731-51944129 | 4057-4060 | 32251731 | denotes | 163 |
| 32604730-32251731-51944130 | 4471-4474 | 32251731 | denotes | 163 |
| 32604730-32293710-51944131 | 4709-4712 | 32293710 | denotes | 166 |
| T80212 | 415-418 | 18279660 | denotes | 151 |
| T52763 | 419-422 | 28081264 | denotes | 152 |
| T4649 | 423-426 | 12876558 | denotes | 153 |
| T47495 | 427-430 | 16139599 | denotes | 154 |
| T88062 | 431-434 | 16126288 | denotes | 155 |
| T59666 | 695-698 | 1350662 | denotes | 157 |
| T69792 | 753-756 | 12748632 | denotes | 158 |
| T50168 | 1265-1268 | 9420255 | denotes | 159 |
| T58602 | 1370-1373 | 8505072 | denotes | 160 |
| T36192 | 1480-1483 | 18279660 | denotes | 151 |
| T84413 | 1841-1844 | 15496474 | denotes | 162 |
| T25798 | 3307-3310 | 32251731 | denotes | 163 |
| T45602 | 3502-3505 | 25140899 | denotes | 164 |
| T55235 | 4057-4060 | 32251731 | denotes | 163 |
| T50194 | 4471-4474 | 32251731 | denotes | 163 |
| T9412 | 4709-4712 | 32293710 | denotes | 166 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 170-179 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |