PMC:7352545 / 74229-75481
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T211 | 175-177 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T212 | 615-617 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T213 | 769-771 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T214 | 952-954 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T707 | 231-236 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T708 | 887-892 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T286 | 390-393 | Disease | denotes | NDP | http://purl.obolibrary.org/obo/MONDO_0010691 |
| T287 | 715-719 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T288 | 737-745 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T289 | 817-825 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1049 | 100-106 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T1050 | 231-236 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1051 | 508-509 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1052 | 681-689 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T1053 | 828-836 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T1054 | 882-886 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T1055 | 882-886 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T1056 | 887-892 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1057 | 1064-1067 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T1058 | 1205-1208 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T441 | 119-129 | Chemical | denotes | UDP-GlcNAc | http://purl.obolibrary.org/obo/CHEBI_16264 |
| T442 | 119-122 | Chemical | denotes | UDP | http://purl.obolibrary.org/obo/CHEBI_17659|http://purl.obolibrary.org/obo/CHEBI_58223 |
| T444 | 123-129 | Chemical | denotes | GlcNAc | http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685 |
| T3074 | 175-177 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T49127 | 308-317 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T66482 | 390-393 | Chemical | denotes | NDP | http://purl.obolibrary.org/obo/CHEBI_16862 |
| T63999 | 394-404 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T454 | 472-479 | Chemical | denotes | quinone | http://purl.obolibrary.org/obo/CHEBI_36141 |
| T58367 | 554-564 | Chemical | denotes | UDP-GlcNAc | http://purl.obolibrary.org/obo/CHEBI_16264 |
| T69553 | 554-557 | Chemical | denotes | UDP | http://purl.obolibrary.org/obo/CHEBI_17659|http://purl.obolibrary.org/obo/CHEBI_58223 |
| T458 | 558-564 | Chemical | denotes | GlcNAc | http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685 |
| T460 | 615-617 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T465 | 671-680 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T466 | 769-771 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T471 | 952-954 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T476 | 997-1006 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T477 | 1077-1086 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T139 | 178-190 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T140 | 211-222 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialylation |
| T141 | 267-280 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T142 | 618-627 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T143 | 851-864 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T144 | 955-964 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T720 | 0-237 | Sentence | denotes | Using computer simulation techniques, CLQ and CLQ-OH have been suggested to recognize the enzymatic active site of the UDP-GlcNAc 2-epimerase, known as an essential enzyme in SA biosynthesis [144], blocking the sialylation of host cells. |
| T721 | 238-443 | Sentence | denotes | The mechanism underlying the glycosylation inhibition may support the antiviral properties of CLQ and CLQ-OH through interactions of CLQ or CLQ-OH with NDP-saccharide mutases or glycosyltransferases [145]. |
| T722 | 444-588 | Sentence | denotes | CLQ was reported to inhibit quinone reductase 2 [146], known as a catalytic mimetic or structural neighbor of UDP-GlcNAc 2-epimerases [147,148]. |
| T723 | 589-780 | Sentence | denotes | If CLQ or CLQ-OH inhibits SA synthesis, the inhibitory properties may support the antiviral activity of CLQ or CLQ-OH against SARS-CoVs because the SARS-CoV receptor ACE2 contains SA species. |
| T724 | 781-899 | Sentence | denotes | In fact, CLQ exhibits in vitro anti-SARS-CoV-1 activity via defective glycosylation of viral ACE2 in Vero cells [149]. |
| T725 | 900-1093 | Sentence | denotes | In addition. the interference of CLQ or CLQ-OH with SA synthesis may broadly be applicable as an antiviral because the HcoVs or other orthomyxoviruses also utilize SAs as entry molecules [150]. |
| T726 | 1094-1156 | Sentence | denotes | However, the detailed mechanisms should be further elucidated. |
| T727 | 1157-1252 | Sentence | denotes | The CLQ treatment efficacy in Covid-19 patients has, however, not been conclusively determined. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-16439323-51944110 | 192-195 | 16439323 | denotes | 144 |
| 32604730-32171740-51944111 | 438-441 | 32171740 | denotes | 145 |
| 32604730-15078100-51944112 | 493-496 | 15078100 | denotes | 146 |
| 32604730-9068613-51944113 | 583-586 | 9068613 | denotes | 148 |
| 32604730-16115318-51944114 | 894-897 | 16115318 | denotes | 149 |
| 32604730-15766653-51944115 | 1088-1091 | 15766653 | denotes | 150 |
| T27482 | 192-195 | 16439323 | denotes | 144 |
| T60108 | 438-441 | 32171740 | denotes | 145 |
| T75339 | 493-496 | 15078100 | denotes | 146 |
| T38963 | 583-586 | 9068613 | denotes | 148 |
| T54788 | 894-897 | 16115318 | denotes | 149 |
| T38477 | 1088-1091 | 15766653 | denotes | 150 |