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PMC:7352545 / 72762-74228 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T701 256-268 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T702 274-286 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T703 704-709 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T704 999-1004 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T705 1200-1212 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T706 1328-1340 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T277 58-66 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T278 417-419 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T280 432-451 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T281 489-496 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T282 1033-1041 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T283 1128-1136 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T284 1155-1164 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T285 1449-1457 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1044 363-368 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1045 687-696 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1046 704-709 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1047 736-745 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T1048 991-1004 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85825 256-268 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T33845 274-286 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T98479 407-412 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T31712 417-419 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T434 509-514 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T30483 529-543 Chemical denotes aminoquinoline http://purl.obolibrary.org/obo/CHEBI_36709
T436 750-752 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T438 855-860 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T439 1200-1212 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T38801 1328-1340 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T133 210-223 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T134 736-745 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T135 750-765 http://purl.obolibrary.org/obo/GO_0032635 denotes IL-6 production
T136 940-962 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T137 949-962 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T138 1364-1377 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T707 0-79 Sentence denotes CLQ and CLQ-OH are under investigation worldwide to treat COVID-19 (Figure 10).
T708 80-224 Sentence denotes CLQ and its derivative CLQ-OH block CoV replication, amplification and spread in in vitro culture via inhibition of ACE2 receptor glycosylation.
T709 225-369 Sentence denotes In HCoVs, interaction of the S glycoprotein with gangliosides initially occur as the first entry step during the replication cycle of the virus.
T710 370-515 Sentence denotes CLQ and CLQ-OH have been alternative drugs for RA and several autoimmune diseases for 70 years, although they are anti-malaria prophylaxis drugs.
T711 516-572 Sentence denotes CLQ-OH is an aminoquinoline with less toxicity than CLQ.
T712 573-669 Sentence denotes CLQ-OH bears an N-hydroxyethyl side chain, which increases its solubility compared to CLQ [141].
T713 670-772 Sentence denotes CLQ-OH modulates activated immune cells via downregulation of TLR signaling and IL-6 production [142].
T714 773-861 Sentence denotes Clinical trials are also under consideration for the efficacy and safety of these drugs.
T715 862-978 Sentence denotes Regarding the action mechanism(s), CLQ and CLQ-OH-mediated inhibition of ACE2 terminal glycosylation was considered.
T716 979-1165 Sentence denotes In in vitro Vero E6 cells, CLQ significantly inhibits SARS-CoV spread by interfering with ACE2 function, acting at the entry and post-entry steps of SARS-CoV-2 replication and infection.
T717 1166-1272 Sentence denotes The binding affinity of ACE2 to S glycoprotein is simulated to be lowered by treatment with CLQ-OH or CLQ.
T718 1273-1394 Sentence denotes CLQ may modify the binding affinity between ACE2 and S glycoprotein by alterations in ACE2 glycosylation or modification.
T719 1395-1466 Sentence denotes CLQ-OH (EC50 0.72 μM) and CLQ (EC50, 5.47 μM) inhibit SARS-CoV-2 [143].

2_test

Id Subject Object Predicate Lexical cue
32604730-32194152-51944108 664-667 32194152 denotes 141
32604730-32150618-51944109 1461-1464 32150618 denotes 143
T93696 664-667 32194152 denotes 141
T42076 1461-1464 32150618 denotes 143

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 432-451 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960