PMC:7352545 / 65825-67654
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T202 | 240-242 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T203 | 287-289 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T204 | 616-618 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T205 | 810-812 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T206 | 845-847 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T207 | 870-872 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T208 | 883-885 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T209 | 1016-1018 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T634 | 94-99 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T635 | 448-460 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T636 | 472-487 | Body_part | denotes | oligosaccharide | http://purl.org/sig/ont/fma/fma82742 |
| T637 | 553-565 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T638 | 622-634 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T639 | 696-701 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T640 | 713-721 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T641 | 804-809 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T642 | 918-930 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T643 | 1152-1164 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T644 | 1248-1253 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T645 | 1365-1377 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T646 | 1407-1419 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T255 | 1192-1200 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T256 | 1354-1362 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T257 | 1714-1718 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T948 | 0-3 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T949 | 94-99 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T950 | 123-133 | http://purl.obolibrary.org/obo/NCBITaxon_7742 | denotes | vertebrate |
| T951 | 134-139 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T952 | 157-160 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T953 | 229-234 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T954 | 281-286 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T955 | 343-350 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Viruses |
| T956 | 616-621 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SA, S |
| T957 | 663-668 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T958 | 696-701 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T959 | 765-768 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T960 | 912-917 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T961 | 918-930 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T962 | 1203-1208 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T963 | 1232-1242 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T964 | 1248-1253 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T965 | 1429-1437 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T966 | 1502-1507 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T967 | 1508-1515 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T968 | 1594-1599 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T969 | 1822-1828 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T15460 | 240-242 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T56686 | 254-261 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T34664 | 287-289 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T82447 | 443-445 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T19608 | 448-460 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T5761 | 472-487 | Chemical | denotes | oligosaccharide | http://purl.obolibrary.org/obo/CHEBI_50699 |
| T6280 | 510-512 | Chemical | denotes | EM | http://purl.obolibrary.org/obo/CHEBI_73507 |
| T60563 | 553-565 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T82160 | 616-618 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T59100 | 622-634 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T13995 | 713-721 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T83883 | 758-764 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T50854 | 797-803 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
| T43350 | 810-812 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T93757 | 845-847 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T35064 | 870-872 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T41394 | 883-885 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T58977 | 1016-1018 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T17884 | 1039-1044 | Chemical | denotes | NeuGc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T8946 | 1056-1061 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T93873 | 1152-1164 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T74696 | 1295-1304 | Chemical | denotes | N-glycans | http://purl.obolibrary.org/obo/CHEBI_59520 |
| T25458 | 1297-1304 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T17555 | 1365-1377 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T34749 | 1407-1419 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T46074 | 1600-1607 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T117 | 80-93 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry to host |
| T118 | 682-695 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry to host |
| T119 | 1117-1130 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T120 | 1429-1444 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T121 | 1542-1553 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T637 | 0-100 | Sentence | denotes | SAs are predominant surface determinants for pathogen attachment, adherence and entry to host cells. |
| T638 | 101-213 | Sentence | denotes | Eleven representative vertebrate virus families utilize SAs as initial entry receptors or as attachment factors. |
| T639 | 214-342 | Sentence | denotes | Interaction of virus with SA-containing glycans is complex because virus SA-binding lectins are inherently of very low affinity. |
| T640 | 343-442 | Sentence | denotes | Viruses acquire enzymes to catalyze virion elution by regional depletion of binding receptors [56]. |
| T641 | 443-498 | Sentence | denotes | TM S glycoprotein recognizes oligosaccharide receptors. |
| T642 | 499-702 | Sentence | denotes | Using cryo-EM technology and observed structures of S glycoprotein trimers of CoV OC43 complexed with 9-O-acetylated SA, S glycoprotein was demonstrated to mediate virus adhesion and entry to host cells. |
| T643 | 703-769 | Sentence | denotes | All CoV S proteins show conservation in binding to 9-O-acetyl-SAs. |
| T644 | 770-821 | Sentence | denotes | MERS-CoV also recognizes 9-carbon sugar SA species. |
| T645 | 822-856 | Sentence | denotes | MERS-CoV S-1A binds to SA species. |
| T646 | 857-987 | Sentence | denotes | For example, SAα2,3- over SAα2,6-linkages expressed in human erythrocytes and mucins are preferentially targeted by MERS-CoV S-1A. |
| T647 | 988-1075 | Sentence | denotes | Binding is hence blocked by SA modification to 5-N-NeuGc and 7, 9-O-NeuAc species [73]. |
| T648 | 1076-1278 | Sentence | denotes | For example, impairment of ACE2 receptor glycosylation does not influence S-glycoprotein-ACE2 interaction, however, SARS-CoV-2 virus entry into respiratory epithelial host cells was downregulated [133]. |
| T649 | 1279-1445 | Sentence | denotes | Changes in ACE2 N-glycans do not apparently influence interaction with the SARS-CoV S glycoprotein, but instead, impair viral S glycoprotein-mediated membrane fusion. |
| T650 | 1446-1516 | Sentence | denotes | The receptor glycan structures decide the entry of some human viruses. |
| T651 | 1517-1626 | Sentence | denotes | Changes in ACE2 receptor sialylation influences interaction affinity between virus ligands and host receptor. |
| T652 | 1627-1724 | Sentence | denotes | Inter-species or individual genetic variations such as drift and mutation may occur in SARS-CoVs. |
| T653 | 1725-1829 | Sentence | denotes | This explains currently emerging differences in CoV responses within the same population such as humans. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-27185912-51944098 | 438-440 | 27185912 | denotes | 56 |
| 32604730-23615615-51944099 | 1071-1073 | 23615615 | denotes | 73 |
| 32604730-25348530-51944100 | 1273-1276 | 25348530 | denotes | 133 |
| T24249 | 438-440 | 27185912 | denotes | 56 |
| T62960 | 1071-1073 | 23615615 | denotes | 73 |
| T11948 | 1273-1276 | 25348530 | denotes | 133 |