
PMC:7352545 / 62119-64185
Annnotations
LitCovid_Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T201 | 1432-1443 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T568 | 7-22 | Body_part | denotes | Heparan Sulfate | http://purl.org/sig/ont/fma/fma63023 |
T569 | 7-14 | Body_part | denotes | Heparan | http://purl.org/sig/ont/fma/fma67110 |
T570 | 24-26 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T571 | 111-140 | Body_part | denotes | heparan sulfate proteoglycans | http://purl.org/sig/ont/fma/fma82834 |
T572 | 111-126 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
T573 | 142-147 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T574 | 201-206 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T575 | 249-256 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T576 | 282-289 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T577 | 301-305 | Body_part | denotes | HSPG | http://purl.org/sig/ont/fma/fma82834 |
T578 | 313-321 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T579 | 384-391 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T580 | 473-480 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T581 | 528-533 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T582 | 547-554 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T583 | 564-568 | Body_part | denotes | HSPG | http://purl.org/sig/ont/fma/fma82834 |
T584 | 613-618 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T585 | 647-655 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T586 | 699-704 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T587 | 712-717 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T588 | 722-739 | Body_part | denotes | glycosaminoglycan | http://purl.org/sig/ont/fma/fma63011 |
T589 | 741-744 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T590 | 755-763 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T591 | 821-826 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T592 | 859-861 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T593 | 874-877 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T594 | 888-890 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T595 | 891-894 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T596 | 980-986 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
T597 | 1021-1023 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T598 | 1024-1027 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T599 | 1137-1152 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
T600 | 1175-1178 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T601 | 1240-1252 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T602 | 1240-1244 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T603 | 1304-1310 | Body_part | denotes | sugars | http://purl.org/sig/ont/fma/fma82737 |
T604 | 1425-1427 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
T605 | 1432-1451 | Body_part | denotes | chondroitin sulfate | http://purl.org/sig/ont/fma/fma82837 |
T606 | 1452-1455 | Body_part | denotes | GAG | http://purl.org/sig/ont/fma/fma63011 |
T607 | 1626-1630 | Body_part | denotes | HSPG | http://purl.org/sig/ont/fma/fma82834 |
T608 | 1732-1736 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T609 | 1902-1913 | Body_part | denotes | Merkel cell | http://purl.org/sig/ont/fma/fma70548 |
T610 | 1909-1913 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T611 | 1942-1947 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
T612 | 1959-1964 | Body_part | denotes | HSPGs | http://purl.org/sig/ont/fma/fma82834 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T31 | 45-60 | Body_part | denotes | Attachment Site | http://purl.obolibrary.org/obo/UBERON_4200047 |
T32 | 509-524 | Body_part | denotes | attachment site | http://purl.obolibrary.org/obo/UBERON_4200047 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T245 | 447-456 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T246 | 1667-1677 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
T247 | 1770-1779 | Disease | denotes | papilloma | http://purl.obolibrary.org/obo/MONDO_0002363 |
T248 | 1806-1817 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
T249 | 1806-1815 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
T250 | 1833-1849 | Disease | denotes | Kaposi’s sarcoma | http://purl.obolibrary.org/obo/MONDO_0005055 |
T251 | 1842-1849 | Disease | denotes | sarcoma | http://purl.obolibrary.org/obo/MONDO_0005089 |
T252 | 1880-1889 | Disease | denotes | papilloma | http://purl.obolibrary.org/obo/MONDO_0002363 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T889 | 111-140 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | heparan sulfate proteoglycans |
T890 | 142-147 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T891 | 183-190 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Viruses |
T892 | 201-206 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T893 | 405-406 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T894 | 464-472 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T895 | 528-533 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T896 | 599-604 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T897 | 613-618 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T898 | 670-675 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T899 | 699-704 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T900 | 712-717 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T901 | 783-784 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T902 | 821-826 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T903 | 872-873 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T904 | 1208-1213 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T905 | 1240-1244 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T906 | 1661-1666 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T907 | 1717-1722 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T908 | 1724-1729 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T909 | 1730-1736 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T910 | 1750-1755 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T911 | 1764-1769 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T912 | 1780-1785 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T913 | 1797-1804 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T914 | 1816-1817 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T915 | 1824-1831 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T916 | 1874-1879 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T917 | 1890-1897 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T918 | 1909-1913 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T919 | 1922-1927 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T920 | 1942-1947 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
T921 | 1959-1964 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | HSPGs |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T241 | 15-22 | Chemical | denotes | Sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
T12264 | 24-26 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056 |
T243 | 111-126 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
T244 | 111-118 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
T245 | 119-126 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
T246 | 127-140 | Chemical | denotes | proteoglycans | http://purl.obolibrary.org/obo/CHEBI_37396 |
T63863 | 221-230 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T35583 | 249-256 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T77933 | 282-289 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T34988 | 313-321 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T251 | 384-391 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T91387 | 473-480 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T253 | 547-554 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T254 | 647-655 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T255 | 722-739 | Chemical | denotes | glycosaminoglycan | http://purl.obolibrary.org/obo/CHEBI_18085 |
T256 | 741-744 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T79623 | 755-763 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T71826 | 859-861 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056 |
T18567 | 874-877 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T80092 | 888-890 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056 |
T27911 | 891-894 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T57873 | 916-931 | Chemical | denotes | tetrasaccharide | http://purl.obolibrary.org/obo/CHEBI_50126 |
T87972 | 949-955 | Chemical | denotes | GlcNAc | http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685 |
T80138 | 959-962 | Chemical | denotes | Gal | http://purl.obolibrary.org/obo/CHEBI_28260 |
T73878 | 966-969 | Chemical | denotes | Gal | http://purl.obolibrary.org/obo/CHEBI_28260 |
T54412 | 973-976 | Chemical | denotes | Xyl | http://purl.obolibrary.org/obo/CHEBI_18222 |
T32519 | 980-986 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
T84324 | 1021-1023 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056 |
T33895 | 1024-1027 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T68117 | 1052-1054 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T13587 | 1093-1095 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T20790 | 1129-1131 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T74944 | 1137-1152 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
T12927 | 1137-1144 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
T280 | 1145-1152 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
T24928 | 1175-1178 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T88817 | 1425-1427 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056 |
T284 | 1432-1451 | Chemical | denotes | chondroitin sulfate | http://purl.obolibrary.org/obo/CHEBI_37397 |
T285 | 1444-1451 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
T5029 | 1452-1455 | Chemical | denotes | GAG | http://purl.obolibrary.org/obo/CHEBI_143889|http://purl.obolibrary.org/obo/CHEBI_18085 |
T13455 | 1573-1580 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
T289 | 1636-1643 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T102 | 1028-1037 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T103 | 1153-1162 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T104 | 1214-1239 | http://purl.obolibrary.org/obo/GO_0051701 | denotes | interaction with the host |
T105 | 1383-1396 | http://purl.obolibrary.org/obo/GO_0009653 | denotes | morphogenesis |
T106 | 1408-1421 | http://purl.obolibrary.org/obo/GO_0009653 | denotes | morphogenesis |
T107 | 1974-1983 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
T108 | 1974-1983 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T597 | 0-6 | Sentence | denotes | 6.3.6. |
T598 | 7-60 | Sentence | denotes | Heparan Sulfate (HS) is the HCoV-NL63 Attachment Site |
T599 | 61-182 | Sentence | denotes | For glycan interaction, HCoV-NL63 and MHV utilize heparan sulfate proteoglycans (HSPGs) as attachment enhancers [87,124]. |
T600 | 183-231 | Sentence | denotes | Viruses recognize HSPGs as attachment molecules. |
T601 | 232-306 | Sentence | denotes | In the spike (S) protein-deficient virions, the M protein recognizes HSPG. |
T602 | 307-368 | Sentence | denotes | The S proteins generally bind to the viral cellular receptor. |
T603 | 369-457 | Sentence | denotes | However, the M protein also acts as a receptor in the early step of HCoV-NL63 infection. |
T604 | 458-534 | Sentence | denotes | The M membrane protein of HCoV-NL63 recognizes the attachment site of HSPGs. |
T605 | 535-711 | Sentence | denotes | HCoV-NL63 M protein binds to HSPG for the initial attachment of virus to host cells and thereafter, the M and S proteins cooperate for virus entrance into the host cells [125]. |
T606 | 712-820 | Sentence | denotes | HSPGs are glycosaminoglycan (GAG)-carrying proteins frequently used as a secondary receptor for viral entry. |
T607 | 821-883 | Sentence | denotes | HSPGs are composed of covalent-bonded HS chains as a GAG form. |
T608 | 884-987 | Sentence | denotes | The HS GAG linkage structure of tetrasaccharide exhibits GluAβ1,3GlcNAcα1,4Galβ1,3Galβ1,4Xylβ-O-serine. |
T609 | 988-1174 | Sentence | denotes | Glycosyltransferases involved in HS GAG synthesis include GlcAT-II (glucuronosyltransferase) and GlcNAcT-II (N-acetylglucosaminyltransferase II) for heparan sulfate synthesis (Figure 9). |
T610 | 1175-1253 | Sentence | denotes | GAG is used as docking sites for virus interaction with the host cell surface. |
T611 | 1254-1317 | Sentence | denotes | GAGs contain negatively charged N- and O-sulfated sugars [126]. |
T612 | 1318-1509 | Sentence | denotes | The biosynthetic pathway and biologic roles in early embryogenic morphogenesis and vulval morphogenesis of HS and chondroitin sulfate GAG have been elucidated in Caenorhabditis elegans [127]. |
T613 | 1510-1610 | Sentence | denotes | The negative charges mediate the interaction of GAGs and their ligands through electrostatic forces. |
T614 | 1611-1685 | Sentence | denotes | Interaction of HSPG with ligands potentiates many virus infectious cycles. |
T615 | 1686-1958 | Sentence | denotes | For examples, adeno-associated virus, human T cell lymphotropic virus type 1, human papilloma virus 16, herpes viruses, hepatitis B and C viruses, Kaposi’s sarcoma-associated herpesvirus, human papilloma viruses and Merkel cell polyoma virus recognize the HSPGs [128,129]. |
T616 | 1959-2066 | Sentence | denotes | HSPGs increase virulence upon interaction with viral factors required for viral attachment and replication. |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T5 | 7-22 | GlycoEpitope | denotes | Heparan Sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
T6 | 24-26 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T7 | 111-126 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
T8 | 859-861 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T9 | 888-890 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T10 | 1021-1023 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T11 | 1137-1152 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
T12 | 1425-1427 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
T13 | 1432-1443 | GlycoEpitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32604730-25187545-51944087 | 174-176 | 25187545 | denotes | 87 |
32604730-17692355-51944088 | 177-180 | 17692355 | denotes | 124 |
32604730-31315999-51944089 | 706-709 | 31315999 | denotes | 125 |
32604730-12369092-51944090 | 1312-1315 | 12369092 | denotes | 126 |
32604730-12761549-51944091 | 1504-1507 | 12761549 | denotes | 127 |
32604730-11507222-51944092 | 1949-1952 | 11507222 | denotes | 128 |
32604730-11518721-51944093 | 1953-1956 | 11518721 | denotes | 129 |
T42843 | 174-176 | 25187545 | denotes | 87 |
T53854 | 177-180 | 17692355 | denotes | 124 |
T94580 | 706-709 | 31315999 | denotes | 125 |
T83893 | 1312-1315 | 12369092 | denotes | 126 |
T73934 | 1504-1507 | 12761549 | denotes | 127 |
T91960 | 1949-1952 | 11507222 | denotes | 128 |
T65288 | 1953-1956 | 11518721 | denotes | 129 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T20 | 1770-1779 | Phenotype | denotes | papilloma | http://purl.obolibrary.org/obo/HP_0012740 |
T21 | 1806-1815 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
T22 | 1833-1849 | Phenotype | denotes | Kaposi’s sarcoma | http://purl.obolibrary.org/obo/HP_0100726 |
T23 | 1880-1889 | Phenotype | denotes | papilloma | http://purl.obolibrary.org/obo/HP_0012740 |