
PMC:7352545 / 55083-56695
Annnotations
LitCovid_Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T193 | 742-751 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
T194 | 742-751 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
T195 | 1529-1531 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T476 | 14-19 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T477 | 39-52 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
T478 | 87-94 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T479 | 136-148 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T480 | 257-261 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T481 | 349-354 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
T482 | 397-404 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T483 | 538-543 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T484 | 551-555 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T485 | 742-751 | Body_part | denotes | galactose | http://purl.org/sig/ont/fma/fma82794 |
T486 | 830-835 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
T487 | 863-867 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T488 | 877-884 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T489 | 886-889 | Body_part | denotes | CAM | http://purl.org/sig/ont/fma/fma67214 |
T490 | 899-903 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
T491 | 1056-1060 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T492 | 1084-1096 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T493 | 1097-1101 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T494 | 1117-1124 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T495 | 1149-1153 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T496 | 1185-1190 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
T497 | 1227-1234 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T498 | 1540-1548 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T499 | 1606-1611 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T221 | 570-573 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
T223 | 696-699 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
T225 | 782-785 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
T227 | 820-823 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
T229 | 1482-1492 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T776 | 14-19 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T777 | 104-112 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T778 | 161-163 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T779 | 173-178 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | heads |
T780 | 173-178 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | heads |
T781 | 190-192 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T782 | 193-198 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | heads |
T783 | 193-198 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | heads |
T784 | 206-211 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T785 | 257-261 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T786 | 301-309 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T787 | 451-459 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T788 | 538-543 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T789 | 551-555 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T790 | 577-579 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T791 | 667-672 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T792 | 693-695 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T793 | 700-703 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T794 | 704-705 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T795 | 736-741 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T796 | 779-781 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T797 | 817-819 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T798 | 861-867 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a cell |
T799 | 1056-1060 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T800 | 1081-1083 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T801 | 1097-1101 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T802 | 1114-1116 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T803 | 1149-1153 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T804 | 1224-1226 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T805 | 1292-1300 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T806 | 1302-1305 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
T807 | 1579-1587 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T808 | 1606-1611 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T125 | 39-52 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
T81226 | 87-94 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T99806 | 136-148 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T128 | 235-244 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T86776 | 263-274 | Chemical | denotes | Cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
T46368 | 349-354 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
T37044 | 397-404 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T11862 | 517-528 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
T50236 | 742-751 | Chemical | denotes | galactose | http://purl.obolibrary.org/obo/CHEBI_28260 |
T134 | 877-884 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T39590 | 939-941 | Chemical | denotes | EM | http://purl.obolibrary.org/obo/CHEBI_73507 |
T136 | 1084-1096 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T137 | 1117-1124 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T138 | 1227-1234 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T139 | 1529-1531 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
T144 | 1540-1548 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T87 | 104-119 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T88 | 301-316 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T89 | 451-466 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T90 | 863-876 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
T91 | 1592-1605 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T534 | 0-120 | Sentence | denotes | Entry of host cells needs binding of S glycoproteins to the CEACAM receptor, forming S-protein-mediated membrane fusion. |
T535 | 121-179 | Sentence | denotes | The trimeric S glycoprotein bears three S1 receptor heads. |
T536 | 180-262 | Sentence | denotes | The three S1 heads of the virus bind to three receptor molecules on the host cell. |
T537 | 263-472 | Sentence | denotes | Cholesterol is indirectly involved in membrane fusion through CEACAM engagement into “lipid raft” microdomains, increasing multiple S protein interaction with the receptors and triggering membrane fusion [97]. |
T538 | 473-565 | Sentence | denotes | The enveloped CoV, MHV, binds to CEACAMs on cholesterol-depleted cells in BHK cell cultures. |
T539 | 566-599 | Sentence | denotes | The NTD of S1 recognizes CEACAM1. |
T540 | 600-684 | Sentence | denotes | For MERS-CoV, another CEACAM5 isoform is the attachment factor for virus entry [75]. |
T541 | 685-774 | Sentence | denotes | The CoV S1 NTD has a similar tertiary structure to human galactose-recognizing galectins. |
T542 | 775-848 | Sentence | denotes | MHV S1 NTD binds murine CEACAM1a and BCoV S1 NTD binds sugar [98,99,100]. |
T543 | 849-929 | Sentence | denotes | CEACAM1a is a cell adhesion protein (CAM) and its mRNA is alternatively spliced. |
T544 | 930-1006 | Sentence | denotes | The cryo-EM structure of MHV S complexed with CEACAM1a was elucidated [101]. |
T545 | 1007-1219 | Sentence | denotes | Thus, HCoVs evolutionarily combined the galectin gene of hosts into their S1 glycoprotein gene, while BCoV S1 protein is present without such gene recombination but contains the sugar-recognizing lectin capacity. |
T546 | 1220-1307 | Sentence | denotes | MHV S1 protein also evolutionarily acquired murine CEACAM1a-recognizing activity [102]. |
T547 | 1308-1424 | Sentence | denotes | Therefore, CoVs are under evolution to adapt their host receptor interaction to infect cross-species hosts [80,103]. |
T548 | 1425-1612 | Sentence | denotes | On the host side, to escape the lethal pressure from CoV infections, hosts have also evolved to acquire SA-binding proteins such as siglecs to inhibit or activate the innate immune cells. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32604730-14990688-51944062 | 468-470 | 14990688 | denotes | 97 |
32604730-28923942-51944063 | 680-682 | 28923942 | denotes | 75 |
32604730-21670291-51944064 | 837-839 | 21670291 | denotes | 98 |
32604730-26855426-51944065 | 840-842 | 26855426 | denotes | 99 |
32604730-32150576-51944066 | 1001-1004 | 32150576 | denotes | 101 |
32604730-27578435-51944067 | 1419-1422 | 27578435 | denotes | 103 |
T11901 | 468-470 | 14990688 | denotes | 97 |
T94239 | 680-682 | 28923942 | denotes | 75 |
T60974 | 837-839 | 21670291 | denotes | 98 |
T40239 | 840-842 | 26855426 | denotes | 99 |
T95315 | 1001-1004 | 32150576 | denotes | 101 |
T82445 | 1419-1422 | 27578435 | denotes | 103 |