PMC:7352545 / 52395-53918
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T453 | 271-277 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T454 | 332-336 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T455 | 392-397 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T456 | 566-572 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T457 | 588-593 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T458 | 611-614 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T459 | 635-640 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T460 | 701-711 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T461 | 751-756 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T462 | 766-772 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T25 | 566-572 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T204 | 14-18 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T205 | 33-43 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T206 | 241-249 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T207 | 306-315 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T208 | 414-422 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T209 | 466-474 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T210 | 655-664 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T211 | 833-842 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T212 | 924-932 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T213 | 967-975 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T214 | 1035-1045 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T215 | 1049-1057 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T216 | 1205-1214 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T217 | 1226-1235 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T218 | 1291-1299 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T219 | 1313-1323 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T220 | 1513-1522 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T717 | 97-98 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T718 | 269-270 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T719 | 316-321 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T720 | 332-336 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T721 | 385-397 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T722 | 385-397 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T723 | 385-397 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T724 | 385-397 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T725 | 385-397 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T726 | 385-391 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T727 | 490-491 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T728 | 559-565 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkey |
| T729 | 566-572 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T730 | 566-572 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T731 | 566-572 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T732 | 574-578 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T733 | 574-578 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T734 | 588-593 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T735 | 628-640 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T736 | 628-640 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T737 | 628-640 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T738 | 628-640 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T739 | 628-640 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T740 | 628-634 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T741 | 679-680 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T742 | 701-720 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T743 | 701-720 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T744 | 751-756 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T745 | 1236-1241 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T746 | 1253-1254 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T747 | 1273-1274 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T748 | 1461-1462 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T46 | 161-164 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T48 | 165-184 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T50 | 174-184 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T51 | 193-210 | Chemical | denotes | camostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T76162 | 259-267 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T53 | 271-296 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T54 | 271-277 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T55 | 278-296 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T23789 | 287-296 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T43182 | 346-354 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T59 | 511-519 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T60 | 681-692 | Chemical | denotes | polypeptide | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T61 | 701-711 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T62 | 701-706 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T62698 | 707-711 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T64 | 766-791 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T65 | 766-772 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T66 | 773-791 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T57087 | 782-791 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T93241 | 793-803 | Chemical | denotes | nafamostat | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T70 | 871-890 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T84586 | 944-946 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T74 | 990-1009 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T75 | 1095-1104 | Chemical | denotes | mucolytic | http://purl.obolibrary.org/obo/CHEBI_77034 |
| T76 | 1105-1122 | Chemical | denotes | cough suppressant | http://purl.obolibrary.org/obo/CHEBI_51177 |
| T77 | 1124-1148 | Chemical | denotes | Bromhexine hydrochloride | http://purl.obolibrary.org/obo/CHEBI_31303 |
| T78217 | 1135-1148 | Chemical | denotes | hydrochloride | http://purl.obolibrary.org/obo/CHEBI_36807 |
| T79 | 1346-1356 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T85 | 611-624 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T86 | 615-624 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T509 | 0-139 | Sentence | denotes | The fact that SARS- and MERS-CoV infections are potentiated by TMPRSS2 indicates that TMPRSS2 is a promising target for therapeutic agents. |
| T510 | 140-489 | Sentence | denotes | For example, several Ser protease inhibitors such as camostat mesylate inhibit TMPRSS2–ACE2-involved SARS-CoV-2 entry. camostat, a serine protease inhibitor, reduces influenza virus titers in cell culture. camostat-treated TMPRSS2 inhibition in Calu-3 cells greatly reduces SARS-CoV viral titers and improves survival rate in SARS-CoV infected mice. |
| T511 | 490-665 | Sentence | denotes | A treatment of 10-μM camostat blocks MERS-CoV entry to African green monkey kidney (Vero)-TMPRSS2 cells and blocks viral RNA synthesis in Calu-3 cells upon MERS-CoV infection. |
| T512 | 666-757 | Sentence | denotes | Aprotinin is a polypeptide with 58 amino acid residues that was isolated from bovine lungs. |
| T513 | 758-1067 | Sentence | denotes | Another serine protease inhibitor, nafamostat, inhibits MERS-CoV entry and infection by TMPRSS2 inhibition [93]. nafamostat mesylate blocks the TMPRSS2–ACE2-involved SARS-CoV-2 envelope–PM fusion and prevents SARS-CoV-2 entry [95]. nafamostat mesylate inhibits viral entry and thrombosis in COVID-19 patients. |
| T514 | 1068-1242 | Sentence | denotes | Similarly, an FDA-approved mucolytic cough suppressant, Bromhexine hydrochloride (BHH), inhibits TMPRSS2 (IC50 0.75 μM) and hence blocks infection of CoV and influenza virus. |
| T515 | 1243-1324 | Sentence | denotes | MPRSS2 as a host factor plays a pivotal role in SARS-CoV and MERS-CoV infections. |
| T516 | 1325-1383 | Sentence | denotes | FDA-approved TMPRSS2 inhibitors are yet under development. |
| T517 | 1384-1523 | Sentence | denotes | Because TMPRSS2 mediates efficient viral entry and replication, it should be a promising target for new therapeutics against CoV infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-10485450-51944057 | 866-868 | 10485450 | denotes | 93 |
| 32604730-32139904-51944058 | 985-987 | 32139904 | denotes | 95 |
| T88382 | 866-868 | 10485450 | denotes | 93 |
| T92226 | 985-987 | 32139904 | denotes | 95 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T14 | 1105-1110 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |