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PMC:7352545 / 50204-52394 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T426 95-99 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T427 139-151 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T428 380-386 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T429 477-481 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T430 494-504 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T431 519-527 Body_part denotes androgen http://purl.org/sig/ont/fma/fma83375
T432 632-640 Body_part denotes androgen http://purl.org/sig/ont/fma/fma83375
T433 671-675 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T434 688-699 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T435 939-949 Body_part denotes hepatocyte http://purl.org/sig/ont/fma/fma14515
T436 1060-1072 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T437 1162-1168 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T438 1180-1186 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T439 1232-1241 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T440 1276-1281 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T441 1319-1328 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T442 1357-1364 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T443 1431-1440 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T444 1467-1482 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T445 1546-1552 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T446 1644-1650 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T447 1785-1790 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T448 1848-1860 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T449 1947-1959 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T450 1974-1979 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T451 2015-2027 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T452 2115-2120 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T184 36-44 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T185 58-68 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T186 70-78 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 164-173 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T188 186-195 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T189 200-214 Disease denotes H1N1 influenza http://purl.obolibrary.org/obo/MONDO_0005460
T190 205-214 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T191 1022-1030 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T192 1049-1057 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 1143-1146 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T194 1257-1265 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T195 1607-1625 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T196 1616-1625 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T197 1760-1768 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T198 1837-1845 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T199 1936-1944 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T200 2004-2012 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 2067-2075 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T202 2147-2155 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T203 2166-2175 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T686 95-99 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T687 215-216 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T688 225-232 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T689 321-322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T690 406-407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T691 463-468 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T692 477-481 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T693 519-536 http://purl.obolibrary.org/obo/PR_000004191 denotes androgen receptor
T694 671-675 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T695 745-753 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T696 795-804 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T697 814-823 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T698 847-856 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T699 929-938 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T700 965-968 http://purl.obolibrary.org/obo/CLO_0003740 denotes HGF
T701 993-1002 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T702 1012-1021 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T703 1107-1112 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T704 1113-1119 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T705 1254-1255 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T706 1276-1281 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T707 1341-1342 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T708 1349-1354 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T709 1467-1473 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T710 1474-1482 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T711 1785-1790 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T712 1922-1931 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T713 1974-1979 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T714 2057-2066 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T715 2098-2103 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T716 2115-2120 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T89893 139-151 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T10 333-342 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T41117 380-386 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T12 413-415 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T59805 416-418 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T15 419-422 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T17 519-527 Chemical denotes androgen http://purl.obolibrary.org/obo/CHEBI_50113
T53240 632-640 Chemical denotes androgen http://purl.obolibrary.org/obo/CHEBI_50113
T19 688-699 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T85427 688-693 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T76775 694-699 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T22 903-906 Chemical denotes MMP http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761
T24 914-917 Chemical denotes MMP http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761
T26 980-983 Chemical denotes Met http://purl.obolibrary.org/obo/CHEBI_16044|http://purl.obolibrary.org/obo/CHEBI_16643|http://purl.obolibrary.org/obo/CHEBI_16811
T29 1060-1072 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T30 1149-1151 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T32 1162-1168 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T49801 1180-1186 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T34 1357-1364 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72751 1546-1571 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T36 1546-1552 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T68391 1553-1571 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T39 1562-1571 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T40 1572-1580 Chemical denotes camostat http://purl.obolibrary.org/obo/CHEBI_135632
T41 1644-1650 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T61271 1674-1684 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T43553 1848-1860 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T20578 1947-1959 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T80689 2015-2027 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T82 950-956 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T83 993-1002 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T84 1769-1784 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T486 0-69 Sentence denotes TMPRSS2-cleaved ACE2 is involved in SARS-CoV and MERS-CoV infections.
T487 70-163 Sentence denotes SARS-CoV-2 uses ACE2 for cell entry through TMPRSS2 priming of the S glycoprotein (Figure 7).
T488 164-275 Sentence denotes Infection of the H7N9 influenza and H1N1 influenza A subtype viruses are also mediated by TMPRSS2-cleaved ACE2.
T489 276-356 Sentence denotes This implies that TMPRSS2 can be targeted as a strategic antiviral therapy [92].
T490 357-458 Sentence denotes Transmembrane protease serine 2, termed TMPRSS2, a type II TM Ser protease (TTSP), also cleaves ACE2.
T491 459-593 Sentence denotes The human TMPRSS2 gene, located on chromosome 21, comprises androgen receptor elements (AREs) in the upstream 5′-flanking region [93].
T492 594-658 Sentence denotes TMPRSS2 expression is regulated in an androgen-dependent manner.
T493 659-700 Sentence denotes The TMPRSS2 gene encodes 492 amino acids.
T494 701-786 Sentence denotes The original form is cleaved into the major membrane form and the minor soluble form.
T495 787-920 Sentence denotes TMPRSS2 activates protease activated receptor 2 (PAR-2) and activated PAR-2 upregulates matrix metalloproteinase-2 (MMP-2) and MMP-9.
T496 921-1003 Sentence denotes TMPRSS2-activated hepatocyte growth factor (HGF) induces c-Met receptor signaling.
T497 1004-1044 Sentence denotes TMPRSS2 activates SARS-CoV and MERS-CoV.
T498 1045-1256 Sentence denotes The SARS-CoV S glycoprotein is cleaved by host-borne TMPRSS2, human airway trypsin-like protease (HAT), TM protease, serine 13 (MSPL), serine protease DESC1 (DESC1), furin, factor Xa and endosomal cathepsin L/B.
T499 1257-1348 Sentence denotes SARS-CoV can enter cells upon cleavage by protease TMPRSS2 or endosomal cathepsin L/B [90].
T500 1349-1404 Sentence denotes Virus S protein precursor is cleaved by host proteases.
T501 1405-1541 Sentence denotes The spikes are cleaved by endosomal cathepsin and by Golgi or plasma membrane TMPRSS2 in the step of assembly or attachment and release.
T502 1542-1634 Sentence denotes The serine protease inhibitor camostat effectively blocks lethal SARS-CoV infection to mice.
T503 1635-1703 Sentence denotes However, serine protease and cathepsin inhibitors are not effective.
T504 1704-1813 Sentence denotes Thus, TMPRSS2 is suggested to be an acting protease for SARS-CoV entry into host cells, but not by cathepsin.
T505 1814-1906 Sentence denotes Cis-cleavage liberates SARS-CoV S glycoprotein fragments into the extracellular supernatant.
T506 1907-2048 Sentence denotes Trans-cleavage activates the SARS-CoV S glycoprotein on the target cells, potentiating efficient SARS-CoV S glycoprotein-driven viral fusion.
T507 2049-2121 Sentence denotes TMPRSS2-activated SARS-CoV facilitates enveloped virus entry into cells.
T508 2122-2190 Sentence denotes TMPRSS2 is important for SARS-CoV entry and infection [81,94,95,96].

2_test

Id Subject Object Predicate Lexical cue
32604730-28778717-51944050 352-354 28778717 denotes 92
32604730-10485450-51944051 589-591 10485450 denotes 93
32604730-24227843-51944052 1344-1346 24227843 denotes 90
32604730-23486063-51944053 2177-2179 23486063 denotes 81
32604730-27550352-51944054 2180-2182 27550352 denotes 94
32604730-32139904-51944055 2183-2185 32139904 denotes 95
32604730-27791014-51944056 2186-2188 27791014 denotes 96
T40327 352-354 28778717 denotes 92
T67110 589-591 10485450 denotes 93
T4756 1344-1346 24227843 denotes 90
T32605 2177-2179 23486063 denotes 81
T99544 2180-2182 27550352 denotes 94
T97300 2183-2185 32139904 denotes 95
T93094 2186-2188 27791014 denotes 96