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PMC:7352545 / 44988-48096 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T385 185-190 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T386 400-405 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T387 447-452 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T388 459-471 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T389 531-546 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T390 616-623 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T391 636-640 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T392 641-651 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T393 691-707 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T394 702-707 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T395 722-726 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T396 727-752 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T397 747-752 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T398 996-1006 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T399 1061-1071 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T400 1323-1334 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T401 1350-1354 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T402 1369-1379 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T403 1838-1847 Body_part denotes G protein http://purl.org/sig/ont/fma/fma61788
T404 2023-2027 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T405 2154-2162 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T406 2216-2220 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T407 2261-2271 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T408 3018-3022 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T13 335-359 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T14 361-364 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T15 636-651 Body_part denotes lung epithelium http://purl.obolibrary.org/obo/UBERON_0000115
T16 636-640 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T17 641-651 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T18 722-726 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 1335-1339 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T20 1655-1661 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T21 2216-2220 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T152 31-39 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T153 54-62 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 258-266 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 292-300 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T156 421-425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 1257-1265 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T158 2054-2077 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T159 2134-2142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T160 2221-2227 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T161 2628-2631 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T162 2757-2765 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T163 2769-2777 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 2795-2813 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T165 2804-2813 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T166 2850-2858 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T603 110-115 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T604 160-161 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T605 179-190 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T606 218-223 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T607 400-405 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T608 447-452 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T609 531-537 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T610 538-546 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T611 562-567 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T612 636-651 http://purl.obolibrary.org/obo/UBERON_0000115 denotes lung epithelium
T613 691-701 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T614 702-716 http://purl.obolibrary.org/obo/CL_0000000 denotes cells and type
T615 722-726 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T616 722-726 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T617 736-746 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T618 747-752 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T619 832-833 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T620 950-951 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T621 952-960 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T622 996-1015 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T623 996-1015 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T624 1061-1080 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T625 1061-1080 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T626 1084-1085 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T627 1086-1092 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T628 1093-1100 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T629 1127-1128 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T630 1136-1144 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T631 1244-1245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T632 1304-1305 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 1335-1339 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T634 1350-1354 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T635 1412-1413 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T636 1414-1422 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T637 1438-1439 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T638 1655-1661 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T639 1668-1671 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T640 1710-1711 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T641 1729-1734 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T642 1745-1753 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T643 1838-1864 http://purl.obolibrary.org/obo/PR_000030035 denotes G protein-coupled receptor
T644 1866-1870 http://purl.obolibrary.org/obo/PR_000030035 denotes GPCR
T645 1879-1887 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T646 1977-1986 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T647 2031-2032 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T648 2216-2220 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T649 2216-2220 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T650 2231-2237 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T651 2252-2253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T652 2261-2279 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T653 2261-2279 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T654 2458-2461 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T655 2462-2463 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 2537-2538 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T657 3018-3022 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1432 341-352 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T1433 361-364 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T1434 459-471 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T1435 719-721 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1436 996-1006 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T1437 996-1001 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1438 1002-1006 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T1439 1023-1032 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T1440 1061-1071 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T1441 1061-1066 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1442 1067-1071 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T1443 1093-1100 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T1444 1233-1242 Chemical denotes N-glycans http://purl.obolibrary.org/obo/CHEBI_59520
T1445 1235-1242 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T1446 1466-1477 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T1447 1505-1507 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1448 1513-1515 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1449 1535-1537 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1450 1628-1632 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T1452 1761-1763 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1453 1840-1847 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1454 1974-1976 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1455 2154-2162 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T1456 2175-2177 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1457 2261-2279 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T1458 2261-2271 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T1459 2261-2266 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1460 2267-2271 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T1461 2289-2291 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1462 2305-2316 Chemical denotes vasodilator http://purl.obolibrary.org/obo/CHEBI_35620
T1463 2379-2381 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1464 2491-2505 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T1465 2495-2505 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1466 2602-2616 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T1467 2606-2616 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1468 2625-2627 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1469 2741-2751 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1470 2929-2931 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1471 3041-3055 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T1472 3045-3055 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1473 3059-3073 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T1474 3071-3073 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T71 431-446 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host
T72 1597-1613 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T73 1633-1642 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T74 1977-1986 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T75 2585-2597 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T76 2866-2873 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T430 0-53 Sentence denotes Structure and Role of the Host SARS-CoV Receptor ACE2
T431 54-86 Sentence denotes SARS-CoV-2 needs ACE2 for entry.
T432 87-217 Sentence denotes Host proteases such as human ACE2 help viral entry through removement of a barrier to enter human cells through unknown receptors.
T433 218-310 Sentence denotes Human ACE2 is known for its role as the SARS-CoV-2 entry receptor and the SARS-CoV receptor.
T434 311-406 Sentence denotes The enzyme ACE-2 in the renin-angiotensin system (RAS) is associated with CoV entry into lungs.
T435 407-507 Sentence denotes ACE2 mediates SARS-2002 entry into host cells via S glycoprotein interaction with the ACE2 receptor.
T436 508-580 Sentence denotes The ACE2 levels on the plasma membrane correlate with virus infectivity.
T437 581-652 Sentence denotes ACE2 expression is present in most tissues such as the lung epithelium.
T438 653-758 Sentence denotes It is highly expressed by respiratory epithelial cells and type I/II lung alveolar epithelial cells [88].
T439 759-821 Sentence denotes The host receptor is not linked to the classification of CoVs.
T440 822-878 Sentence denotes MERS-CoV, a β-CoV, does not recognize the ACE2 receptor.
T441 879-941 Sentence denotes In contrast, the α-CoV HCoV-NL63 recognizes the ACE2 receptor.
T442 942-1045 Sentence denotes ACE2 is a membrane-anchored carboxypeptidase with 805 amino acid residues and is captopril-insensitive.
T443 1046-1340 Sentence denotes It contains 17 amino acid residues as a signal peptide in the N-terminal region, a type I membrane-anchored domain in the C-terminal region, an extracellular N-terminal domain with heavy N-glycans, a N-terminal SARS-CoV-binding and carboxypeptidase site and a short C-terminal cytoplasmic tail.
T444 1341-1385 Sentence denotes The ACE2 gene is located on chromosome Xp22.
T445 1386-1453 Sentence denotes Two ACE2 forms are known, a membrane-bound form and a soluble form.
T446 1454-1508 Sentence denotes ACE cleaves angiotensin I (Ang I) substrate to Ang II.
T447 1509-1662 Sentence denotes Ang II recognizes the Ang II receptor type 1 (AT1R), contributing to systemic and local vasoconstriction, fibrosis and salt retention in vascular organs.
T448 1663-1701 Sentence denotes ACE2 has the opposite function of ACE.
T449 1702-1739 Sentence denotes ACE2 is a close homolog to human ACE.
T450 1740-1808 Sentence denotes ACE2 activity on Ang II is about 400-fold higher than that on Ang I.
T451 1809-1987 Sentence denotes Ang-1 to Ang-7 recognize the G protein-coupled receptor (GPCR) Mas to activate vasorelaxation, cardioprotection, antioxidative action, antiinflammation and anti-Ang II-signaling.
T452 1988-2078 Sentence denotes Therefore, the ACE2-Ang-1 to Ang-7 axis is a target candidate for cardiovascular diseases.
T453 2079-2143 Sentence denotes ACE2 shows similar binding structures between nCoV and SARS-CoV.
T454 2144-2238 Sentence denotes The three proteins of ACE, Ang II and AT1R contribute to progression of lung injury in humans.
T455 2239-2336 Sentence denotes ACE2 removes a single amino acid residue from Ang II to yield the vasodilator, named Ang 1-Ang 7.
T456 2337-2400 Sentence denotes ACE2 cleaves Ang-I to Ang 1–Ang 9 and Ang II to Ang-1 to Ang-7.
T457 2401-2506 Sentence denotes The biggest difference between ACE2 and ACE is that ACE2 has a non-inhibitory property by ACE inhibitors.
T458 2507-2598 Sentence denotes Pulmonary ACE2 is potentially a candidate target in CoV-involved inflammatory pathogenesis.
T459 2599-2681 Sentence denotes If ACE inhibitors and Ang II-AT1 blockers are dosed, ACE2 expression is increased.
T460 2682-2786 Sentence denotes However, currently we have no conclusive evidence that the inhibitors help SARS-CoV or SARS-CoV-2 entry.
T461 2787-2838 Sentence denotes Rather, SARS-CoV infection reduces ACE2 expression.
T462 2839-2908 Sentence denotes Therefore, SARS-CoV-2 host tropism is not related to ACE2 expression.
T463 2909-2983 Sentence denotes ACE2 levels and ANG II/ANG 1–7 levels regulate the pathogenic progression.
T464 2984-3108 Sentence denotes ACE2 expression is upregulated by gene polymorphisms and ACE inhibitors or Angiotensin II receptor blockers such as sartans.

2_test

Id Subject Object Predicate Lexical cue
32604730-32305506-51944046 754-756 32305506 denotes 88
T75465 754-756 32305506 denotes 88

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T13 2054-2077 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626