PMC:7352545 / 44911-53918
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T385 | 262-267 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T386 | 477-482 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T387 | 524-529 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T388 | 536-548 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T389 | 608-623 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T390 | 693-700 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T391 | 713-717 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T392 | 718-728 | Body_part | denotes | epithelium | http://purl.org/sig/ont/fma/fma9639 |
| T393 | 768-784 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T394 | 779-784 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T395 | 799-803 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T396 | 804-829 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T397 | 824-829 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T398 | 1073-1083 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T399 | 1138-1148 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T400 | 1400-1411 | Body_part | denotes | cytoplasmic | http://purl.org/sig/ont/fma/fma66835 |
| T401 | 1427-1431 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T402 | 1446-1456 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T403 | 1915-1924 | Body_part | denotes | G protein | http://purl.org/sig/ont/fma/fma61788 |
| T404 | 2100-2104 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T405 | 2231-2239 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T406 | 2293-2297 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T407 | 2338-2348 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T408 | 3095-3099 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T409 | 3192-3196 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T410 | 3343-3351 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T411 | 3554-3566 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T412 | 3898-3906 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T413 | 4219-4226 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T414 | 4386-4391 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T415 | 4455-4460 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T416 | 4662-4674 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T417 | 4690-4700 | Body_part | denotes | Intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T418 | 4719-4723 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T419 | 4819-4824 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T420 | 4829-4838 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T421 | 5040-5044 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T422 | 5045-5070 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T423 | 5065-5070 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T424 | 5116-5132 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T425 | 5127-5132 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T426 | 5388-5392 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T427 | 5432-5444 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T428 | 5673-5679 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T429 | 5770-5774 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T430 | 5787-5797 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T431 | 5812-5820 | Body_part | denotes | androgen | http://purl.org/sig/ont/fma/fma83375 |
| T432 | 5925-5933 | Body_part | denotes | androgen | http://purl.org/sig/ont/fma/fma83375 |
| T433 | 5964-5968 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T434 | 5981-5992 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T435 | 6232-6242 | Body_part | denotes | hepatocyte | http://purl.org/sig/ont/fma/fma14515 |
| T436 | 6353-6365 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T437 | 6455-6461 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T438 | 6473-6479 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T439 | 6525-6534 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T440 | 6569-6574 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T441 | 6612-6621 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T442 | 6650-6657 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T443 | 6724-6733 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T444 | 6760-6775 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T445 | 6839-6845 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T446 | 6937-6943 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T447 | 7078-7083 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T448 | 7141-7153 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T449 | 7240-7252 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T450 | 7267-7272 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T451 | 7308-7320 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T452 | 7408-7413 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T453 | 7755-7761 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T454 | 7816-7820 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T455 | 7876-7881 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T456 | 8050-8056 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T457 | 8072-8077 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T458 | 8095-8098 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T459 | 8119-8124 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T460 | 8185-8195 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T461 | 8235-8240 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T462 | 8250-8256 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T13 | 412-436 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T14 | 438-441 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T15 | 713-728 | Body_part | denotes | lung epithelium | http://purl.obolibrary.org/obo/UBERON_0000115 |
| T16 | 713-717 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T17 | 718-728 | Body_part | denotes | epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T18 | 799-803 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T19 | 1412-1416 | Body_part | denotes | tail | http://purl.obolibrary.org/obo/UBERON_0002415 |
| T20 | 1732-1738 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T21 | 2293-2297 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T22 | 4719-4723 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T23 | 4829-4838 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T24 | 5040-5044 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T25 | 8050-8056 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T151 | 53-61 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T152 | 108-116 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T153 | 131-139 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T154 | 335-343 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T155 | 369-377 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T156 | 498-502 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T157 | 1334-1342 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T158 | 2131-2154 | Disease | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/MONDO_0004995 |
| T159 | 2211-2219 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T160 | 2298-2304 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T161 | 2705-2708 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
| T162 | 2834-2842 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T163 | 2846-2854 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T164 | 2872-2890 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T165 | 2881-2890 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T166 | 2927-2935 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T167 | 3543-3551 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T168 | 4042-4063 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T169 | 4212-4216 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T170 | 4361-4369 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T171 | 4430-4438 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T172 | 4545-4553 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T173 | 4556-4565 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T174 | 4567-4575 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T175 | 4578-4587 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T176 | 4678-4686 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 4784-4792 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 4796-4804 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 4890-4898 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T180 | 4965-4973 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T181 | 5072-5080 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 5085-5093 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T183 | 5264-5272 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T184 | 5329-5337 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T185 | 5351-5361 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T186 | 5363-5371 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T187 | 5457-5466 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T188 | 5479-5488 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T189 | 5493-5507 | Disease | denotes | H1N1 influenza | http://purl.obolibrary.org/obo/MONDO_0005460 |
| T190 | 5498-5507 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T191 | 6315-6323 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T192 | 6342-6350 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T193 | 6436-6439 | Disease | denotes | HAT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T194 | 6550-6558 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T195 | 6900-6918 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T196 | 6909-6918 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T197 | 7053-7061 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T198 | 7130-7138 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T199 | 7229-7237 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T200 | 7297-7305 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T201 | 7360-7368 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T202 | 7440-7448 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T203 | 7459-7468 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T204 | 7498-7502 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T205 | 7517-7527 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T206 | 7725-7733 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T207 | 7790-7799 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T208 | 7898-7906 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T209 | 7950-7958 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T210 | 8139-8148 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T211 | 8317-8326 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T212 | 8408-8416 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T213 | 8451-8459 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T214 | 8519-8529 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T215 | 8533-8541 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T216 | 8689-8698 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T217 | 8710-8719 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T218 | 8775-8783 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T219 | 8797-8807 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T220 | 8997-9006 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T603 | 187-192 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T604 | 237-238 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T605 | 256-267 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T606 | 295-300 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T607 | 477-482 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T608 | 524-529 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T609 | 608-614 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T610 | 615-623 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T611 | 639-644 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T612 | 713-728 | http://purl.obolibrary.org/obo/UBERON_0000115 | denotes | lung epithelium |
| T613 | 768-778 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T614 | 779-793 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells and type |
| T615 | 799-803 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T616 | 799-803 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T617 | 813-823 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T618 | 824-829 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T619 | 909-910 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T620 | 1027-1028 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T621 | 1029-1037 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T622 | 1073-1092 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T623 | 1073-1092 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T624 | 1138-1157 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T625 | 1138-1157 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T626 | 1161-1162 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T627 | 1163-1169 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T628 | 1170-1177 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T629 | 1204-1205 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T630 | 1213-1221 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T631 | 1321-1322 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T632 | 1381-1382 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T633 | 1412-1416 | http://purl.obolibrary.org/obo/UBERON_0002415 | denotes | tail |
| T634 | 1427-1431 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T635 | 1489-1490 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T636 | 1491-1499 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T637 | 1515-1516 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T638 | 1732-1738 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
| T639 | 1745-1748 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T640 | 1787-1788 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T641 | 1806-1811 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T642 | 1822-1830 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T643 | 1915-1941 | http://purl.obolibrary.org/obo/PR_000030035 | denotes | G protein-coupled receptor |
| T644 | 1943-1947 | http://purl.obolibrary.org/obo/PR_000030035 | denotes | GPCR |
| T645 | 1956-1964 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T646 | 2054-2063 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T647 | 2108-2109 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T648 | 2293-2297 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T649 | 2293-2297 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T650 | 2308-2314 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T651 | 2329-2330 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T652 | 2338-2356 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residue |
| T653 | 2338-2356 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residue |
| T654 | 2535-2538 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T655 | 2539-2540 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T656 | 2614-2615 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T657 | 3095-3099 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T658 | 3192-3196 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
| T659 | 3242-3243 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T660 | 3334-3342 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T661 | 3378-3379 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T662 | 3567-3576 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T663 | 3620-3625 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T664 | 3768-3776 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T665 | 3827-3835 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T666 | 3869-3870 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T667 | 4386-4391 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T668 | 4455-4460 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T669 | 4526-4531 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T670 | 4597-4605 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T671 | 4690-4700 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | Intestinal |
| T672 | 4690-4700 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | Intestinal |
| T673 | 4701-4709 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T674 | 4719-4723 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T675 | 4719-4723 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T676 | 4819-4824 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T677 | 4829-4838 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T678 | 4829-4838 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T679 | 5040-5044 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T680 | 5040-5044 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T681 | 5054-5064 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T682 | 5065-5070 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T683 | 5116-5126 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T684 | 5127-5132 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T685 | 5248-5249 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T686 | 5388-5392 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T687 | 5508-5509 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T688 | 5518-5525 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T689 | 5614-5615 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T690 | 5699-5700 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T691 | 5756-5761 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T692 | 5770-5774 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T693 | 5812-5829 | http://purl.obolibrary.org/obo/PR_000004191 | denotes | androgen receptor |
| T694 | 5964-5968 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T695 | 6038-6046 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T696 | 6088-6097 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T697 | 6107-6116 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T698 | 6140-6149 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T699 | 6222-6231 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T700 | 6258-6261 | http://purl.obolibrary.org/obo/CLO_0003740 | denotes | HGF |
| T701 | 6286-6295 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T702 | 6305-6314 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T703 | 6400-6405 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T704 | 6406-6412 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T705 | 6547-6548 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T706 | 6569-6574 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T707 | 6634-6635 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T708 | 6642-6647 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T709 | 6760-6766 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T710 | 6767-6775 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T711 | 7078-7083 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T712 | 7215-7224 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T713 | 7267-7272 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T714 | 7350-7359 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T715 | 7391-7396 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T716 | 7408-7413 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T717 | 7581-7582 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T718 | 7753-7754 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T719 | 7800-7805 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T720 | 7816-7820 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T721 | 7869-7881 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T722 | 7869-7881 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T723 | 7869-7881 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T724 | 7869-7881 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T725 | 7869-7881 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T726 | 7869-7875 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T727 | 7974-7975 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T728 | 8043-8049 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkey |
| T729 | 8050-8056 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T730 | 8050-8056 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T731 | 8050-8056 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T732 | 8058-8062 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T733 | 8058-8062 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T734 | 8072-8077 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T735 | 8112-8124 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T736 | 8112-8124 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T737 | 8112-8124 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T738 | 8112-8124 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T739 | 8112-8124 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T740 | 8112-8118 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T741 | 8163-8164 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T742 | 8185-8204 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T743 | 8185-8204 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T744 | 8235-8240 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T745 | 8720-8725 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T746 | 8737-8738 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T747 | 8757-8758 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T748 | 8945-8946 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1431 | 7-18 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T1432 | 418-429 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T1433 | 438-441 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T1434 | 536-548 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1435 | 796-798 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1436 | 1073-1083 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T1437 | 1073-1078 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T1438 | 1079-1083 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1439 | 1100-1109 | Chemical | denotes | captopril | http://purl.obolibrary.org/obo/CHEBI_3380 |
| T1440 | 1138-1148 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T1441 | 1138-1143 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T1442 | 1144-1148 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1443 | 1170-1177 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T1444 | 1310-1319 | Chemical | denotes | N-glycans | http://purl.obolibrary.org/obo/CHEBI_59520 |
| T1445 | 1312-1319 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T1446 | 1543-1554 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T1447 | 1582-1584 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1448 | 1590-1592 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1449 | 1612-1614 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1450 | 1705-1709 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
| T1452 | 1838-1840 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1453 | 1917-1924 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1454 | 2051-2053 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1455 | 2231-2239 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1456 | 2252-2254 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1457 | 2338-2356 | Chemical | denotes | amino acid residue | http://purl.obolibrary.org/obo/CHEBI_33708 |
| T1458 | 2338-2348 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T1459 | 2338-2343 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T1460 | 2344-2348 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1461 | 2366-2368 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1462 | 2382-2393 | Chemical | denotes | vasodilator | http://purl.obolibrary.org/obo/CHEBI_35620 |
| T1463 | 2456-2458 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1464 | 2568-2582 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T1465 | 2572-2582 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T1466 | 2679-2693 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T1467 | 2683-2693 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T1468 | 2702-2704 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1469 | 2818-2828 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T1470 | 3006-3008 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1471 | 3118-3132 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T1472 | 3122-3132 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T1473 | 3136-3150 | Chemical | denotes | Angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T1474 | 3148-3150 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T52126 | 3301-3303 | Chemical | denotes | Zn | http://purl.obolibrary.org/obo/CHEBI_27363 |
| T21109 | 3343-3351 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T46115 | 3554-3566 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T4 | 3988-3998 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T5 | 4219-4226 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T6 | 4662-4674 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T7 | 5037-5039 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T77723 | 5113-5115 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T89893 | 5432-5444 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T10 | 5626-5635 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T41117 | 5673-5679 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T12 | 5706-5708 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T59805 | 5709-5711 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T15 | 5712-5715 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T17 | 5812-5820 | Chemical | denotes | androgen | http://purl.obolibrary.org/obo/CHEBI_50113 |
| T53240 | 5925-5933 | Chemical | denotes | androgen | http://purl.obolibrary.org/obo/CHEBI_50113 |
| T19 | 5981-5992 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T85427 | 5981-5986 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T76775 | 5987-5992 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T22 | 6196-6199 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T24 | 6207-6210 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T26 | 6273-6276 | Chemical | denotes | Met | http://purl.obolibrary.org/obo/CHEBI_16044|http://purl.obolibrary.org/obo/CHEBI_16643|http://purl.obolibrary.org/obo/CHEBI_16811 |
| T29 | 6353-6365 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T30 | 6442-6444 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T32 | 6455-6461 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T49801 | 6473-6479 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T34 | 6650-6657 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T72751 | 6839-6864 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T36 | 6839-6845 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T68391 | 6846-6864 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T39 | 6855-6864 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T40 | 6865-6873 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T41 | 6937-6943 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T61271 | 6967-6977 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T43553 | 7141-7153 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T20578 | 7240-7252 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T80689 | 7308-7320 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T46 | 7645-7648 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T48 | 7649-7668 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T50 | 7658-7668 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T51 | 7677-7694 | Chemical | denotes | camostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T76162 | 7743-7751 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T53 | 7755-7780 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T54 | 7755-7761 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T55 | 7762-7780 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T23789 | 7771-7780 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T43182 | 7830-7838 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T59 | 7995-8003 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T60 | 8165-8176 | Chemical | denotes | polypeptide | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T61 | 8185-8195 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T62 | 8185-8190 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T62698 | 8191-8195 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T64 | 8250-8275 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T65 | 8250-8256 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T66 | 8257-8275 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T57087 | 8266-8275 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T93241 | 8277-8287 | Chemical | denotes | nafamostat | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T70 | 8355-8374 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T84586 | 8428-8430 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T74 | 8474-8493 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T75 | 8579-8588 | Chemical | denotes | mucolytic | http://purl.obolibrary.org/obo/CHEBI_77034 |
| T76 | 8589-8606 | Chemical | denotes | cough suppressant | http://purl.obolibrary.org/obo/CHEBI_51177 |
| T77 | 8608-8632 | Chemical | denotes | Bromhexine hydrochloride | http://purl.obolibrary.org/obo/CHEBI_31303 |
| T78217 | 8619-8632 | Chemical | denotes | hydrochloride | http://purl.obolibrary.org/obo/CHEBI_36807 |
| T79 | 8830-8840 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T71 | 508-523 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T72 | 1674-1690 | http://purl.obolibrary.org/obo/GO_0042310 | denotes | vasoconstriction |
| T73 | 1710-1719 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | retention |
| T74 | 2054-2063 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T75 | 2662-2674 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T76 | 2943-2950 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T77 | 3950-3976 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | anti-inflammatory response |
| T78 | 3955-3976 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T79 | 4370-4385 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T80 | 4439-4454 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T81 | 4469-4480 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T82 | 6243-6249 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T83 | 6286-6295 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T84 | 7062-7077 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T85 | 8095-8108 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T86 | 8099-8108 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T428 | 0-6 | Sentence | denotes | 6.3.1. |
| T429 | 7-75 | Sentence | denotes | Angiotensin-Converting Enzyme 2 (ACE2) as the SARS-CoV Host Receptor |
| T430 | 77-130 | Sentence | denotes | Structure and Role of the Host SARS-CoV Receptor ACE2 |
| T431 | 131-163 | Sentence | denotes | SARS-CoV-2 needs ACE2 for entry. |
| T432 | 164-294 | Sentence | denotes | Host proteases such as human ACE2 help viral entry through removement of a barrier to enter human cells through unknown receptors. |
| T433 | 295-387 | Sentence | denotes | Human ACE2 is known for its role as the SARS-CoV-2 entry receptor and the SARS-CoV receptor. |
| T434 | 388-483 | Sentence | denotes | The enzyme ACE-2 in the renin-angiotensin system (RAS) is associated with CoV entry into lungs. |
| T435 | 484-584 | Sentence | denotes | ACE2 mediates SARS-2002 entry into host cells via S glycoprotein interaction with the ACE2 receptor. |
| T436 | 585-657 | Sentence | denotes | The ACE2 levels on the plasma membrane correlate with virus infectivity. |
| T437 | 658-729 | Sentence | denotes | ACE2 expression is present in most tissues such as the lung epithelium. |
| T438 | 730-835 | Sentence | denotes | It is highly expressed by respiratory epithelial cells and type I/II lung alveolar epithelial cells [88]. |
| T439 | 836-898 | Sentence | denotes | The host receptor is not linked to the classification of CoVs. |
| T440 | 899-955 | Sentence | denotes | MERS-CoV, a β-CoV, does not recognize the ACE2 receptor. |
| T441 | 956-1018 | Sentence | denotes | In contrast, the α-CoV HCoV-NL63 recognizes the ACE2 receptor. |
| T442 | 1019-1122 | Sentence | denotes | ACE2 is a membrane-anchored carboxypeptidase with 805 amino acid residues and is captopril-insensitive. |
| T443 | 1123-1417 | Sentence | denotes | It contains 17 amino acid residues as a signal peptide in the N-terminal region, a type I membrane-anchored domain in the C-terminal region, an extracellular N-terminal domain with heavy N-glycans, a N-terminal SARS-CoV-binding and carboxypeptidase site and a short C-terminal cytoplasmic tail. |
| T444 | 1418-1462 | Sentence | denotes | The ACE2 gene is located on chromosome Xp22. |
| T445 | 1463-1530 | Sentence | denotes | Two ACE2 forms are known, a membrane-bound form and a soluble form. |
| T446 | 1531-1585 | Sentence | denotes | ACE cleaves angiotensin I (Ang I) substrate to Ang II. |
| T447 | 1586-1739 | Sentence | denotes | Ang II recognizes the Ang II receptor type 1 (AT1R), contributing to systemic and local vasoconstriction, fibrosis and salt retention in vascular organs. |
| T448 | 1740-1778 | Sentence | denotes | ACE2 has the opposite function of ACE. |
| T449 | 1779-1816 | Sentence | denotes | ACE2 is a close homolog to human ACE. |
| T450 | 1817-1885 | Sentence | denotes | ACE2 activity on Ang II is about 400-fold higher than that on Ang I. |
| T451 | 1886-2064 | Sentence | denotes | Ang-1 to Ang-7 recognize the G protein-coupled receptor (GPCR) Mas to activate vasorelaxation, cardioprotection, antioxidative action, antiinflammation and anti-Ang II-signaling. |
| T452 | 2065-2155 | Sentence | denotes | Therefore, the ACE2-Ang-1 to Ang-7 axis is a target candidate for cardiovascular diseases. |
| T453 | 2156-2220 | Sentence | denotes | ACE2 shows similar binding structures between nCoV and SARS-CoV. |
| T454 | 2221-2315 | Sentence | denotes | The three proteins of ACE, Ang II and AT1R contribute to progression of lung injury in humans. |
| T455 | 2316-2413 | Sentence | denotes | ACE2 removes a single amino acid residue from Ang II to yield the vasodilator, named Ang 1-Ang 7. |
| T456 | 2414-2477 | Sentence | denotes | ACE2 cleaves Ang-I to Ang 1–Ang 9 and Ang II to Ang-1 to Ang-7. |
| T457 | 2478-2583 | Sentence | denotes | The biggest difference between ACE2 and ACE is that ACE2 has a non-inhibitory property by ACE inhibitors. |
| T458 | 2584-2675 | Sentence | denotes | Pulmonary ACE2 is potentially a candidate target in CoV-involved inflammatory pathogenesis. |
| T459 | 2676-2758 | Sentence | denotes | If ACE inhibitors and Ang II-AT1 blockers are dosed, ACE2 expression is increased. |
| T460 | 2759-2863 | Sentence | denotes | However, currently we have no conclusive evidence that the inhibitors help SARS-CoV or SARS-CoV-2 entry. |
| T461 | 2864-2915 | Sentence | denotes | Rather, SARS-CoV infection reduces ACE2 expression. |
| T462 | 2916-2985 | Sentence | denotes | Therefore, SARS-CoV-2 host tropism is not related to ACE2 expression. |
| T463 | 2986-3060 | Sentence | denotes | ACE2 levels and ANG II/ANG 1–7 levels regulate the pathogenic progression. |
| T464 | 3061-3185 | Sentence | denotes | ACE2 expression is upregulated by gene polymorphisms and ACE inhibitors or Angiotensin II receptor blockers such as sartans. |
| T465 | 3187-3241 | Sentence | denotes | Host Cell ADAM17 and TMPRSS2 Competitively Cleave ACE2 |
| T466 | 3242-3352 | Sentence | denotes | A disintegrin and metallopeptidase domain (ADAM) family of Zn-metalloproteinases belongs to membrane proteins. |
| T467 | 3353-3442 | Sentence | denotes | The well-known ADAM17 is a TNF-α-converting enzyme (TACE), called the sheddase for TNF-α. |
| T468 | 3443-3511 | Sentence | denotes | Other ADAM sheddase family members include ADAM9, ADAM10 and ADAM12. |
| T469 | 3512-3542 | Sentence | denotes | ADAM17 mediates ACE2 shedding. |
| T470 | 3543-3632 | Sentence | denotes | SARS-CoV S glycoprotein activates cellular TACE and consequently facilitates virus entry. |
| T471 | 3633-3782 | Sentence | denotes | Soluble ACE2 as the N-terminal carboxypeptidase domain form is derived from the original ACE2 form by an ADAM17 metalloprotease in the membrane [89]. |
| T472 | 3783-3907 | Sentence | denotes | ADAM17 is indeed an enzyme that can convert membrane type pro-TNF-α to soluble TNF-α, a functional proinflammatory cytokine. |
| T473 | 3908-4064 | Sentence | denotes | Therefore, ADAM17 inhibition indicates an anti-inflammatory response and ADAM17 inhibitors are promising candidates for TNF-α-induced inflammatory diseases. |
| T474 | 4065-4134 | Sentence | denotes | The short C-terminal domain of ACE2 is removed by ADAM17 and TMPRSS2. |
| T475 | 4135-4211 | Sentence | denotes | However, TMPRSS2 cleaves ACE2 competitively with the ADAM17 metalloprotease. |
| T476 | 4212-4400 | Sentence | denotes | SARS-S protein-ACE2 binding leads to ADAM17/TNF-α-converting enzyme (TACE)-cleavage of ACE2, facilitating extracellular ACE2 shedding and consequent SARS-CoV entry into host cells [90,91]. |
| T477 | 4401-4492 | Sentence | denotes | Only TMPRSS2 cleavage allows SARS-CoV entry into host cells through endocytosis and fusion. |
| T478 | 4493-4566 | Sentence | denotes | Soluble ACE2 also recognizes the virus and prevents SARS-CoV-2 infection. |
| T479 | 4567-4623 | Sentence | denotes | SARS-CoV-2 infection requires membrane ACE2 and TMPRSS2. |
| T480 | 4624-4689 | Sentence | denotes | The ACE2–B0AT1 complex binds to the S glycoprotein of SARS-CoV-2. |
| T481 | 4690-4795 | Sentence | denotes | Intestinal membrane ACE2 and lung TMPRSS2-shedded ACE2 can act as alternative entry sites for SARS-CoV-2. |
| T482 | 4796-4864 | Sentence | denotes | SARS-CoV-2 infects the lungs and intestine via TMPRSS2-cleaved ACE2. |
| T483 | 4865-4985 | Sentence | denotes | If TMPRSS2 is engaged in SARS-CoV-2 entry and ACE2 downregulation, TMPRSS2 inhibition would lead to COVID-19 prevention. |
| T484 | 4986-5169 | Sentence | denotes | Although ACE2 is expressed both in type I and type II lung alveolar epithelial cells, SARS-CoV and SARS-CoV-2 target only type II epithelial cells due to the ACE2–TMPRSS2 interaction. |
| T485 | 5170-5292 | Sentence | denotes | Therefore, supplementation of ACE2 (soluble ACE2) or Ang-1 to Ang-7 should be a way to reduce SARS-CoV-2-related symptoms. |
| T486 | 5293-5362 | Sentence | denotes | TMPRSS2-cleaved ACE2 is involved in SARS-CoV and MERS-CoV infections. |
| T487 | 5363-5456 | Sentence | denotes | SARS-CoV-2 uses ACE2 for cell entry through TMPRSS2 priming of the S glycoprotein (Figure 7). |
| T488 | 5457-5568 | Sentence | denotes | Infection of the H7N9 influenza and H1N1 influenza A subtype viruses are also mediated by TMPRSS2-cleaved ACE2. |
| T489 | 5569-5649 | Sentence | denotes | This implies that TMPRSS2 can be targeted as a strategic antiviral therapy [92]. |
| T490 | 5650-5751 | Sentence | denotes | Transmembrane protease serine 2, termed TMPRSS2, a type II TM Ser protease (TTSP), also cleaves ACE2. |
| T491 | 5752-5886 | Sentence | denotes | The human TMPRSS2 gene, located on chromosome 21, comprises androgen receptor elements (AREs) in the upstream 5′-flanking region [93]. |
| T492 | 5887-5951 | Sentence | denotes | TMPRSS2 expression is regulated in an androgen-dependent manner. |
| T493 | 5952-5993 | Sentence | denotes | The TMPRSS2 gene encodes 492 amino acids. |
| T494 | 5994-6079 | Sentence | denotes | The original form is cleaved into the major membrane form and the minor soluble form. |
| T495 | 6080-6213 | Sentence | denotes | TMPRSS2 activates protease activated receptor 2 (PAR-2) and activated PAR-2 upregulates matrix metalloproteinase-2 (MMP-2) and MMP-9. |
| T496 | 6214-6296 | Sentence | denotes | TMPRSS2-activated hepatocyte growth factor (HGF) induces c-Met receptor signaling. |
| T497 | 6297-6337 | Sentence | denotes | TMPRSS2 activates SARS-CoV and MERS-CoV. |
| T498 | 6338-6549 | Sentence | denotes | The SARS-CoV S glycoprotein is cleaved by host-borne TMPRSS2, human airway trypsin-like protease (HAT), TM protease, serine 13 (MSPL), serine protease DESC1 (DESC1), furin, factor Xa and endosomal cathepsin L/B. |
| T499 | 6550-6641 | Sentence | denotes | SARS-CoV can enter cells upon cleavage by protease TMPRSS2 or endosomal cathepsin L/B [90]. |
| T500 | 6642-6697 | Sentence | denotes | Virus S protein precursor is cleaved by host proteases. |
| T501 | 6698-6834 | Sentence | denotes | The spikes are cleaved by endosomal cathepsin and by Golgi or plasma membrane TMPRSS2 in the step of assembly or attachment and release. |
| T502 | 6835-6927 | Sentence | denotes | The serine protease inhibitor camostat effectively blocks lethal SARS-CoV infection to mice. |
| T503 | 6928-6996 | Sentence | denotes | However, serine protease and cathepsin inhibitors are not effective. |
| T504 | 6997-7106 | Sentence | denotes | Thus, TMPRSS2 is suggested to be an acting protease for SARS-CoV entry into host cells, but not by cathepsin. |
| T505 | 7107-7199 | Sentence | denotes | Cis-cleavage liberates SARS-CoV S glycoprotein fragments into the extracellular supernatant. |
| T506 | 7200-7341 | Sentence | denotes | Trans-cleavage activates the SARS-CoV S glycoprotein on the target cells, potentiating efficient SARS-CoV S glycoprotein-driven viral fusion. |
| T507 | 7342-7414 | Sentence | denotes | TMPRSS2-activated SARS-CoV facilitates enveloped virus entry into cells. |
| T508 | 7415-7483 | Sentence | denotes | TMPRSS2 is important for SARS-CoV entry and infection [81,94,95,96]. |
| T509 | 7484-7623 | Sentence | denotes | The fact that SARS- and MERS-CoV infections are potentiated by TMPRSS2 indicates that TMPRSS2 is a promising target for therapeutic agents. |
| T510 | 7624-7973 | Sentence | denotes | For example, several Ser protease inhibitors such as camostat mesylate inhibit TMPRSS2–ACE2-involved SARS-CoV-2 entry. camostat, a serine protease inhibitor, reduces influenza virus titers in cell culture. camostat-treated TMPRSS2 inhibition in Calu-3 cells greatly reduces SARS-CoV viral titers and improves survival rate in SARS-CoV infected mice. |
| T511 | 7974-8149 | Sentence | denotes | A treatment of 10-μM camostat blocks MERS-CoV entry to African green monkey kidney (Vero)-TMPRSS2 cells and blocks viral RNA synthesis in Calu-3 cells upon MERS-CoV infection. |
| T512 | 8150-8241 | Sentence | denotes | Aprotinin is a polypeptide with 58 amino acid residues that was isolated from bovine lungs. |
| T513 | 8242-8551 | Sentence | denotes | Another serine protease inhibitor, nafamostat, inhibits MERS-CoV entry and infection by TMPRSS2 inhibition [93]. nafamostat mesylate blocks the TMPRSS2–ACE2-involved SARS-CoV-2 envelope–PM fusion and prevents SARS-CoV-2 entry [95]. nafamostat mesylate inhibits viral entry and thrombosis in COVID-19 patients. |
| T514 | 8552-8726 | Sentence | denotes | Similarly, an FDA-approved mucolytic cough suppressant, Bromhexine hydrochloride (BHH), inhibits TMPRSS2 (IC50 0.75 μM) and hence blocks infection of CoV and influenza virus. |
| T515 | 8727-8808 | Sentence | denotes | MPRSS2 as a host factor plays a pivotal role in SARS-CoV and MERS-CoV infections. |
| T516 | 8809-8867 | Sentence | denotes | FDA-approved TMPRSS2 inhibitors are yet under development. |
| T517 | 8868-9007 | Sentence | denotes | Because TMPRSS2 mediates efficient viral entry and replication, it should be a promising target for new therapeutics against CoV infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-32305506-51944046 | 831-833 | 32305506 | denotes | 88 |
| 32604730-10924499-51944047 | 3778-3780 | 10924499 | denotes | 89 |
| 32604730-24227843-51944048 | 4393-4395 | 24227843 | denotes | 90 |
| 32604730-19995578-51944049 | 4396-4398 | 19995578 | denotes | 91 |
| 32604730-28778717-51944050 | 5645-5647 | 28778717 | denotes | 92 |
| 32604730-10485450-51944051 | 5882-5884 | 10485450 | denotes | 93 |
| 32604730-24227843-51944052 | 6637-6639 | 24227843 | denotes | 90 |
| 32604730-23486063-51944053 | 7470-7472 | 23486063 | denotes | 81 |
| 32604730-27550352-51944054 | 7473-7475 | 27550352 | denotes | 94 |
| 32604730-32139904-51944055 | 7476-7478 | 32139904 | denotes | 95 |
| 32604730-27791014-51944056 | 7479-7481 | 27791014 | denotes | 96 |
| 32604730-10485450-51944057 | 8350-8352 | 10485450 | denotes | 93 |
| 32604730-32139904-51944058 | 8469-8471 | 32139904 | denotes | 95 |
| T75465 | 831-833 | 32305506 | denotes | 88 |
| T58896 | 3778-3780 | 10924499 | denotes | 89 |
| T39582 | 4393-4395 | 24227843 | denotes | 90 |
| T57089 | 4396-4398 | 19995578 | denotes | 91 |
| T40327 | 5645-5647 | 28778717 | denotes | 92 |
| T67110 | 5882-5884 | 10485450 | denotes | 93 |
| T4756 | 6637-6639 | 24227843 | denotes | 90 |
| T32605 | 7470-7472 | 23486063 | denotes | 81 |
| T99544 | 7473-7475 | 27550352 | denotes | 94 |
| T97300 | 7476-7478 | 32139904 | denotes | 95 |
| T93094 | 7479-7481 | 27791014 | denotes | 96 |
| T88382 | 8350-8352 | 10485450 | denotes | 93 |
| T92226 | 8469-8471 | 32139904 | denotes | 95 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T13 | 2131-2154 | Phenotype | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/HP_0001626 |
| T14 | 8589-8594 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |