PMC:7352545 / 42058-43134
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T178 | 244-246 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T179 | 265-267 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T180 | 278-280 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T181 | 467-469 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T182 | 519-523 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | SLeX |
| T183 | 601-603 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T184 | 636-638 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T185 | 1011-1013 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T352 | 11-23 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T353 | 49-61 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T354 | 110-126 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T355 | 121-126 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T356 | 139-151 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T357 | 309-321 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T358 | 338-350 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T359 | 423-435 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T360 | 423-427 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T361 | 556-569 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T362 | 769-781 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T363 | 879-883 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T364 | 1022-1034 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T146 | 950-959 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T568 | 43-48 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T569 | 49-61 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T570 | 75-80 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T571 | 92-97 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T572 | 110-120 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T573 | 121-126 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T574 | 214-217 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T575 | 401-404 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T576 | 423-427 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T577 | 477-478 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T578 | 502-505 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T579 | 726-728 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T580 | 738-740 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T581 | 763-768 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T582 | 769-781 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T583 | 879-883 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T584 | 942-945 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T585 | 972-973 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1339 | 11-23 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1340 | 139-151 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1341 | 205-213 | Chemical | denotes | glycolyl | http://purl.obolibrary.org/obo/CHEBI_30884 |
| T1342 | 244-246 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1347 | 265-267 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1352 | 278-280 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1357 | 309-321 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1358 | 338-350 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1359 | 467-469 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1364 | 556-569 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1365 | 601-603 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1370 | 636-638 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1375 | 939-941 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1377 | 1011-1013 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1382 | 1022-1034 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T1383 | 1035-1042 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T67 | 821-829 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
| T68 | 884-891 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T403 | 0-127 | Sentence | denotes | MERS-CoV S glycoprotein can hemagglutinate human erythrocytes and mediates virus entry into human respiratory epithelial cells. |
| T404 | 128-277 | Sentence | denotes | MERS-CoV S glycoprotein attachment is not observed for 9-O-acetylated or 5-N-glycolyl SAs, but is observed for α2,3-SA linkage over α2,6-SA linkages. |
| T405 | 278-441 | Sentence | denotes | SA-binding sites of MERS-CoV S glycoprotein and HCoV-OC43 S glycoprotein are not conserved [78], although they engage α2,3-SAs on the avian host cell surface [79]. |
| T406 | 442-547 | Sentence | denotes | MERS-CoV recognizes α2,3-SA and to a lesser extent the α2,6-SAs and sulfated SLeX for binding preference. |
| T407 | 548-616 | Sentence | denotes | Thus, S glycoproteins may have independently evolved SA recognition. |
| T408 | 617-900 | Sentence | denotes | The acquisition of SA-binding ability of MERS-CoV S seems to be an evolutionarily recent event, because HKU4 S1 and HKU5 S1 cannot hemagglutinate human erythrocytes [75], indicating flexible evolutionary exchange allowing cross-species transmission towards host cell tropism of CoVs. |
| T409 | 901-1076 | Sentence | denotes | In conclusion, CoV recognition of 9-O-Ac-SAs for infection is based on a conserved sequence for engagement of SA-related carbohydrate ligands across CoVs and orthomyxoviruses. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-29684066-51944035 | 370-372 | 29684066 | denotes | 78 |
| 32604730-21697468-51944036 | 437-439 | 21697468 | denotes | 79 |
| 32604730-28923942-51944037 | 783-785 | 28923942 | denotes | 75 |
| T81260 | 370-372 | 29684066 | denotes | 78 |
| T98799 | 437-439 | 21697468 | denotes | 79 |
| T76930 | 783-785 | 28923942 | denotes | 75 |