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PMC:7352545 / 34893-36719 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T147 247-249 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T148 353-355 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T149 384-386 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T150 736-738 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T151 1054-1056 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T152 1101-1103 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T153 1631-1633 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T154 1730-1732 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T282 420-432 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T283 533-537 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T284 1150-1162 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T285 1178-1183 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T286 1202-1209 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T287 1283-1295 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T288 1349-1361 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T289 1423-1435 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T290 1485-1492 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T291 1505-1517 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T292 1542-1554 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T293 1599-1606 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T294 1642-1649 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T295 1782-1789 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T296 1808-1820 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T125 91-94 Disease denotes CBD http://purl.obolibrary.org/obo/MONDO_0010564
T126 889-898 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T127 1005-1020 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T128 1011-1020 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T473 47-50 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T474 138-141 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T475 215-218 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T476 329-339 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T477 343-344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T478 533-537 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T479 736-740 http://purl.obolibrary.org/obo/UBERON_0009856 denotes SA C
T480 899-906 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T481 923-931 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T482 1115-1116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T483 1150-1162 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T484 1178-1183 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T485 1210-1213 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T486 1219-1227 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T487 1283-1295 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T488 1349-1361 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T489 1415-1422 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T490 1423-1435 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T491 1534-1541 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T492 1542-1554 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T493 1556-1558 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T494 1677-1680 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T495 1741-1749 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1069 44-46 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1071 135-137 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1073 212-214 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1075 225-227 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1076 247-249 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1081 353-355 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1086 384-386 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1091 420-432 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T1092 708-722 Chemical denotes acetyl residue http://purl.obolibrary.org/obo/CHEBI_40574
T1093 708-714 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T1094 736-738 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1099 779-785 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T1101 786-791 Chemical denotes NeuAc http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018
T1103 952-979 Chemical denotes diisopropyl fluorophosphate http://purl.obolibrary.org/obo/CHEBI_17941
T1104 952-963 Chemical denotes diisopropyl http://purl.obolibrary.org/obo/CHEBI_141560
T1105 1054-1056 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1110 1098-1100 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1112 1101-1103 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1117 1202-1209 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1118 1250-1252 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T1119 1485-1492 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1120 1505-1517 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T1121 1587-1589 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T1122 1599-1606 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1123 1631-1633 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1128 1642-1649 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1129 1674-1676 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1131 1730-1732 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1136 1782-1789 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1137 1808-1820 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T57 1005-1020 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T342 0-111 Sentence denotes In β-CoV, HE mediates viral attachment to O-Ac-SAs and its function relies on the combined CBD and RDE domains.
T343 112-229 Sentence denotes Most β-CoVs target 9-O-Ac-SAs (type I), but certain strains switched to alternatively targeting 4-O-Ac-SAs (type II).
T344 230-379 Sentence denotes For example, the SA-acetylesterase enzyme in BCoVs and HCoV-OC43 is known to have hemagglutinizing activities as a type of SA-9-O-acetylesterase [8].
T345 380-441 Sentence denotes The SA-acetylesterase is the HE surface glycoprotein in BCoV.
T346 442-525 Sentence denotes The three-dimensional structure of BCoV HE is similar to other viral esterases [9].
T347 526-571 Sentence denotes The HE gene is found only in the β-CoV genus.
T348 572-743 Sentence denotes The acetylesterase of murine CoVs differs in its substrate binding specificity from that of BCoV and HCoV-OC43, which is specific for O-acetyl residue release from SA C-9.
T349 744-797 Sentence denotes Murine CoVs prefer to esterize 4-O-acetyl-NeuAc [64].
T350 798-907 Sentence denotes The β-CoV acetylesterase destroys the receptors and this specificity is similar to that of influenza viruses.
T351 908-1033 Sentence denotes Acetylesterase activity can be inhibited by diisopropyl fluorophosphate and this agent decreases viral infection levels [65].
T352 1034-1189 Sentence denotes As deduced from the SA acetylesterase of HCoV-OC43 [8], the 9-O-Ac-SA species is a receptor binding determinant for erythrocytes and entry into cells [59].
T353 1190-1257 Sentence denotes The BCoV HE protein has dual activity of acetylesterase and HA [9].
T354 1258-1379 Sentence denotes BCoV widely agglutinates erythrocytes and purified HE only agglutinates Neu5,9Ac2-enriched erythrocytes of rats and mice.
T355 1380-1462 Sentence denotes BCoV and HCoV-OC43 can agglutinate chicken erythrocytes, while purified HE cannot.
T356 1463-1650 Sentence denotes In contrast to the HE protein, purified S glycoprotein can agglutinate chicken erythrocytes [52], indicating that the major HA is the S protein which acts as the major SA-binding protein.
T357 1651-1826 Sentence denotes However, the role of O-Ac-SAs is not certain to be essential in receptors, and SA-binding activity may be essential only to the HE protein, but not to the S glycoprotein [54].

2_test

Id Subject Object Predicate Lexical cue
32604730-3380803-51944011 376-377 3380803 denotes 8
32604730-1984649-51944012 522-523 1984649 denotes 9
32604730-15507445-51944013 793-795 15507445 denotes 64
32604730-1642550-51944014 1029-1031 1642550 denotes 65
32604730-3380803-51944015 1086-1087 3380803 denotes 8
32604730-1321878-51944016 1185-1187 1321878 denotes 59
32604730-1984649-51944017 1254-1255 1984649 denotes 9
32604730-1920630-51944018 1556-1558 1920630 denotes 52
32604730-20538854-51944019 1822-1824 20538854 denotes 54
T44213 376-377 3380803 denotes 8
T13264 522-523 1984649 denotes 9
T44537 793-795 15507445 denotes 64
T62016 1029-1031 1642550 denotes 65
T99141 1086-1087 3380803 denotes 8
T76354 1185-1187 1321878 denotes 59
T91684 1254-1255 1984649 denotes 9
T34666 1556-1558 1920630 denotes 52
T90252 1822-1824 20538854 denotes 54