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PMC:7352545 / 34872-36719 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T147 268-270 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T148 374-376 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T149 405-407 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T150 757-759 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T151 1075-1077 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T152 1122-1124 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T153 1652-1654 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T154 1751-1753 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T282 441-453 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T283 554-558 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T284 1171-1183 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T285 1199-1204 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T286 1223-1230 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T287 1304-1316 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T288 1370-1382 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T289 1444-1456 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T290 1506-1513 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T291 1526-1538 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T292 1563-1575 Body_part denotes erythrocytes http://purl.org/sig/ont/fma/fma62845
T293 1620-1627 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T294 1663-1670 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T295 1803-1810 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T296 1829-1841 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T125 112-115 Disease denotes CBD http://purl.obolibrary.org/obo/MONDO_0010564
T126 910-919 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T127 1026-1041 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T128 1032-1041 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T473 68-71 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T474 159-162 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T475 236-239 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T476 350-360 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T477 364-365 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T478 554-558 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T479 757-761 http://purl.obolibrary.org/obo/UBERON_0009856 denotes SA C
T480 920-927 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T481 944-952 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T482 1136-1137 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T483 1171-1183 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T484 1199-1204 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T485 1231-1234 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T486 1240-1248 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T487 1304-1316 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T488 1370-1382 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T489 1436-1443 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T490 1444-1456 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T491 1555-1562 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T492 1563-1575 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocytes
T493 1577-1579 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T494 1698-1701 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T495 1762-1770 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1069 65-67 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1071 156-158 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1073 233-235 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1075 246-248 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T1076 268-270 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1081 374-376 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1086 405-407 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1091 441-453 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T1092 729-743 Chemical denotes acetyl residue http://purl.obolibrary.org/obo/CHEBI_40574
T1093 729-735 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T1094 757-759 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1099 800-806 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T1101 807-812 Chemical denotes NeuAc http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018
T1103 973-1000 Chemical denotes diisopropyl fluorophosphate http://purl.obolibrary.org/obo/CHEBI_17941
T1104 973-984 Chemical denotes diisopropyl http://purl.obolibrary.org/obo/CHEBI_141560
T1105 1075-1077 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1110 1119-1121 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1112 1122-1124 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1117 1223-1230 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1118 1271-1273 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T1119 1506-1513 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1120 1526-1538 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T1121 1608-1610 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T1122 1620-1627 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1123 1652-1654 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1128 1663-1670 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1129 1695-1697 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T1131 1751-1753 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T1136 1803-1810 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T1137 1829-1841 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T57 1026-1041 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T341 0-20 Sentence denotes 6.1.2. β-Coronavirus
T342 21-132 Sentence denotes In β-CoV, HE mediates viral attachment to O-Ac-SAs and its function relies on the combined CBD and RDE domains.
T343 133-250 Sentence denotes Most β-CoVs target 9-O-Ac-SAs (type I), but certain strains switched to alternatively targeting 4-O-Ac-SAs (type II).
T344 251-400 Sentence denotes For example, the SA-acetylesterase enzyme in BCoVs and HCoV-OC43 is known to have hemagglutinizing activities as a type of SA-9-O-acetylesterase [8].
T345 401-462 Sentence denotes The SA-acetylesterase is the HE surface glycoprotein in BCoV.
T346 463-546 Sentence denotes The three-dimensional structure of BCoV HE is similar to other viral esterases [9].
T347 547-592 Sentence denotes The HE gene is found only in the β-CoV genus.
T348 593-764 Sentence denotes The acetylesterase of murine CoVs differs in its substrate binding specificity from that of BCoV and HCoV-OC43, which is specific for O-acetyl residue release from SA C-9.
T349 765-818 Sentence denotes Murine CoVs prefer to esterize 4-O-acetyl-NeuAc [64].
T350 819-928 Sentence denotes The β-CoV acetylesterase destroys the receptors and this specificity is similar to that of influenza viruses.
T351 929-1054 Sentence denotes Acetylesterase activity can be inhibited by diisopropyl fluorophosphate and this agent decreases viral infection levels [65].
T352 1055-1210 Sentence denotes As deduced from the SA acetylesterase of HCoV-OC43 [8], the 9-O-Ac-SA species is a receptor binding determinant for erythrocytes and entry into cells [59].
T353 1211-1278 Sentence denotes The BCoV HE protein has dual activity of acetylesterase and HA [9].
T354 1279-1400 Sentence denotes BCoV widely agglutinates erythrocytes and purified HE only agglutinates Neu5,9Ac2-enriched erythrocytes of rats and mice.
T355 1401-1483 Sentence denotes BCoV and HCoV-OC43 can agglutinate chicken erythrocytes, while purified HE cannot.
T356 1484-1671 Sentence denotes In contrast to the HE protein, purified S glycoprotein can agglutinate chicken erythrocytes [52], indicating that the major HA is the S protein which acts as the major SA-binding protein.
T357 1672-1847 Sentence denotes However, the role of O-Ac-SAs is not certain to be essential in receptors, and SA-binding activity may be essential only to the HE protein, but not to the S glycoprotein [54].

2_test

Id Subject Object Predicate Lexical cue
32604730-3380803-51944011 397-398 3380803 denotes 8
32604730-1984649-51944012 543-544 1984649 denotes 9
32604730-15507445-51944013 814-816 15507445 denotes 64
32604730-1642550-51944014 1050-1052 1642550 denotes 65
32604730-3380803-51944015 1107-1108 3380803 denotes 8
32604730-1321878-51944016 1206-1208 1321878 denotes 59
32604730-1984649-51944017 1275-1276 1984649 denotes 9
32604730-1920630-51944018 1577-1579 1920630 denotes 52
32604730-20538854-51944019 1843-1845 20538854 denotes 54
T44213 397-398 3380803 denotes 8
T13264 543-544 1984649 denotes 9
T44537 814-816 15507445 denotes 64
T62016 1050-1052 1642550 denotes 65
T99141 1107-1108 3380803 denotes 8
T76354 1206-1208 1321878 denotes 59
T91684 1275-1276 1984649 denotes 9
T34666 1577-1579 1920630 denotes 52
T90252 1843-1845 20538854 denotes 54