PMC:7352545 / 34872-36719
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T147 | 268-270 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T148 | 374-376 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T149 | 405-407 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T150 | 757-759 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T151 | 1075-1077 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T152 | 1122-1124 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T153 | 1652-1654 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T154 | 1751-1753 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T282 | 441-453 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T283 | 554-558 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T284 | 1171-1183 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T285 | 1199-1204 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T286 | 1223-1230 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T287 | 1304-1316 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T288 | 1370-1382 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T289 | 1444-1456 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T290 | 1506-1513 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T291 | 1526-1538 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T292 | 1563-1575 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T293 | 1620-1627 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T294 | 1663-1670 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T295 | 1803-1810 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T296 | 1829-1841 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T125 | 112-115 | Disease | denotes | CBD | http://purl.obolibrary.org/obo/MONDO_0010564 |
| T126 | 910-919 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T127 | 1026-1041 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T128 | 1032-1041 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T473 | 68-71 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T474 | 159-162 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T475 | 236-239 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T476 | 350-360 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T477 | 364-365 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T478 | 554-558 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T479 | 757-761 | http://purl.obolibrary.org/obo/UBERON_0009856 | denotes | SA C |
| T480 | 920-927 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T481 | 944-952 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T482 | 1136-1137 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T483 | 1171-1183 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T484 | 1199-1204 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T485 | 1231-1234 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T486 | 1240-1248 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T487 | 1304-1316 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T488 | 1370-1382 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T489 | 1436-1443 | http://purl.obolibrary.org/obo/NCBITaxon_9031 | denotes | chicken |
| T490 | 1444-1456 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T491 | 1555-1562 | http://purl.obolibrary.org/obo/NCBITaxon_9031 | denotes | chicken |
| T492 | 1563-1575 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T493 | 1577-1579 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T494 | 1698-1701 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T495 | 1762-1770 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1069 | 65-67 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1071 | 156-158 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1073 | 233-235 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1075 | 246-248 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T1076 | 268-270 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1081 | 374-376 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1086 | 405-407 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1091 | 441-453 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1092 | 729-743 | Chemical | denotes | acetyl residue | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1093 | 729-735 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T1094 | 757-759 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1099 | 800-806 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T1101 | 807-812 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T1103 | 973-1000 | Chemical | denotes | diisopropyl fluorophosphate | http://purl.obolibrary.org/obo/CHEBI_17941 |
| T1104 | 973-984 | Chemical | denotes | diisopropyl | http://purl.obolibrary.org/obo/CHEBI_141560 |
| T1105 | 1075-1077 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1110 | 1119-1121 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1112 | 1122-1124 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1117 | 1223-1230 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1118 | 1271-1273 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1119 | 1506-1513 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1120 | 1526-1538 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1121 | 1608-1610 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1122 | 1620-1627 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1123 | 1652-1654 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1128 | 1663-1670 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1129 | 1695-1697 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T1131 | 1751-1753 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1136 | 1803-1810 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1137 | 1829-1841 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T57 | 1026-1041 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T341 | 0-20 | Sentence | denotes | 6.1.2. β-Coronavirus |
| T342 | 21-132 | Sentence | denotes | In β-CoV, HE mediates viral attachment to O-Ac-SAs and its function relies on the combined CBD and RDE domains. |
| T343 | 133-250 | Sentence | denotes | Most β-CoVs target 9-O-Ac-SAs (type I), but certain strains switched to alternatively targeting 4-O-Ac-SAs (type II). |
| T344 | 251-400 | Sentence | denotes | For example, the SA-acetylesterase enzyme in BCoVs and HCoV-OC43 is known to have hemagglutinizing activities as a type of SA-9-O-acetylesterase [8]. |
| T345 | 401-462 | Sentence | denotes | The SA-acetylesterase is the HE surface glycoprotein in BCoV. |
| T346 | 463-546 | Sentence | denotes | The three-dimensional structure of BCoV HE is similar to other viral esterases [9]. |
| T347 | 547-592 | Sentence | denotes | The HE gene is found only in the β-CoV genus. |
| T348 | 593-764 | Sentence | denotes | The acetylesterase of murine CoVs differs in its substrate binding specificity from that of BCoV and HCoV-OC43, which is specific for O-acetyl residue release from SA C-9. |
| T349 | 765-818 | Sentence | denotes | Murine CoVs prefer to esterize 4-O-acetyl-NeuAc [64]. |
| T350 | 819-928 | Sentence | denotes | The β-CoV acetylesterase destroys the receptors and this specificity is similar to that of influenza viruses. |
| T351 | 929-1054 | Sentence | denotes | Acetylesterase activity can be inhibited by diisopropyl fluorophosphate and this agent decreases viral infection levels [65]. |
| T352 | 1055-1210 | Sentence | denotes | As deduced from the SA acetylesterase of HCoV-OC43 [8], the 9-O-Ac-SA species is a receptor binding determinant for erythrocytes and entry into cells [59]. |
| T353 | 1211-1278 | Sentence | denotes | The BCoV HE protein has dual activity of acetylesterase and HA [9]. |
| T354 | 1279-1400 | Sentence | denotes | BCoV widely agglutinates erythrocytes and purified HE only agglutinates Neu5,9Ac2-enriched erythrocytes of rats and mice. |
| T355 | 1401-1483 | Sentence | denotes | BCoV and HCoV-OC43 can agglutinate chicken erythrocytes, while purified HE cannot. |
| T356 | 1484-1671 | Sentence | denotes | In contrast to the HE protein, purified S glycoprotein can agglutinate chicken erythrocytes [52], indicating that the major HA is the S protein which acts as the major SA-binding protein. |
| T357 | 1672-1847 | Sentence | denotes | However, the role of O-Ac-SAs is not certain to be essential in receptors, and SA-binding activity may be essential only to the HE protein, but not to the S glycoprotein [54]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-3380803-51944011 | 397-398 | 3380803 | denotes | 8 |
| 32604730-1984649-51944012 | 543-544 | 1984649 | denotes | 9 |
| 32604730-15507445-51944013 | 814-816 | 15507445 | denotes | 64 |
| 32604730-1642550-51944014 | 1050-1052 | 1642550 | denotes | 65 |
| 32604730-3380803-51944015 | 1107-1108 | 3380803 | denotes | 8 |
| 32604730-1321878-51944016 | 1206-1208 | 1321878 | denotes | 59 |
| 32604730-1984649-51944017 | 1275-1276 | 1984649 | denotes | 9 |
| 32604730-1920630-51944018 | 1577-1579 | 1920630 | denotes | 52 |
| 32604730-20538854-51944019 | 1843-1845 | 20538854 | denotes | 54 |
| T44213 | 397-398 | 3380803 | denotes | 8 |
| T13264 | 543-544 | 1984649 | denotes | 9 |
| T44537 | 814-816 | 15507445 | denotes | 64 |
| T62016 | 1050-1052 | 1642550 | denotes | 65 |
| T99141 | 1107-1108 | 3380803 | denotes | 8 |
| T76354 | 1206-1208 | 1321878 | denotes | 59 |
| T91684 | 1275-1276 | 1984649 | denotes | 9 |
| T34666 | 1577-1579 | 1920630 | denotes | 52 |
| T90252 | 1843-1845 | 20538854 | denotes | 54 |