PMC:7352545 / 26631-27890
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T93 | 65-67 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T94 | 374-376 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T95 | 453-459 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T96 | 476-478 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T97 | 604-610 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T98 | 770-772 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T99 | 945-947 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T226 | 696-700 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T227 | 1164-1170 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T103 | 7-16 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T104 | 110-119 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T105 | 350-359 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T106 | 511-520 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T107 | 659-668 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T108 | 1016-1025 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T349 | 19-24 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T350 | 101-102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T351 | 103-104 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T352 | 122-127 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T353 | 176-177 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T354 | 362-367 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T355 | 482-483 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T356 | 523-528 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T357 | 576-584 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T358 | 612-614 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T359 | 669-674 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T360 | 696-700 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T361 | 1005-1012 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T362 | 1028-1033 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T363 | 1142-1143 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T364 | 1255-1257 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T722 | 25-27 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T723 | 65-67 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T728 | 267-279 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T729 | 267-273 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T730 | 274-279 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T731 | 374-376 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T736 | 419-425 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T738 | 430-435 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T740 | 453-459 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T742 | 469-475 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T744 | 476-478 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T749 | 594-600 | Chemical | denotes | Neu5Gc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T750 | 604-610 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T752 | 753-758 | Chemical | denotes | D-Gal | http://purl.obolibrary.org/obo/CHEBI_12936 |
| T753 | 755-758 | Chemical | denotes | Gal | http://purl.obolibrary.org/obo/CHEBI_28260 |
| T754 | 762-768 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T756 | 770-772 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T761 | 810-816 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T763 | 845-850 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T764 | 869-884 | Chemical | denotes | guanidino group | http://purl.obolibrary.org/obo/CHEBI_48551 |
| T765 | 879-884 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T766 | 913-918 | Chemical | denotes | CH3CO | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T767 | 919-927 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
| T768 | 928-934 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T769 | 945-947 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 567-584 | http://purl.obolibrary.org/obo/GO_0038024 | denotes | receptor activity |
| T47 | 701-708 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T259 | 0-6 | Sentence | denotes | 5.1.2. |
| T260 | 7-31 | Sentence | denotes | Influenza C virus HA-HEF |
| T261 | 32-85 | Sentence | denotes | HEF is indeed an ancient type of SA-O-acetylesterase. |
| T262 | 86-194 | Sentence | denotes | In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46]. |
| T263 | 195-280 | Sentence | denotes | Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group. |
| T264 | 281-341 | Sentence | denotes | In parallel, another modification of O-acetylation is found. |
| T265 | 342-460 | Sentence | denotes | Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac. |
| T266 | 461-616 | Sentence | denotes | The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48]. |
| T267 | 617-709 | Sentence | denotes | Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism. |
| T268 | 710-769 | Sentence | denotes | NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc. |
| T269 | 770-837 | Sentence | denotes | SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5). |
| T270 | 838-940 | Sentence | denotes | The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49]. |
| T271 | 941-1080 | Sentence | denotes | HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47]. |
| T272 | 1081-1259 | Sentence | denotes | The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-3660588-51943986 | 190-192 | 3660588 | denotes | 46 |
| 32604730-2411539-51943987 | 395-397 | 2411539 | denotes | 47 |
| 32604730-9817207-51943988 | 936-938 | 9817207 | denotes | 49 |
| 32604730-2411539-51943989 | 1076-1078 | 2411539 | denotes | 47 |
| T4072 | 190-192 | 3660588 | denotes | 46 |
| T45662 | 395-397 | 2411539 | denotes | 47 |
| T64932 | 936-938 | 9817207 | denotes | 49 |
| T56258 | 1076-1078 | 2411539 | denotes | 47 |